JPS56120615A - Preparation of lyophilized powder of cephalothin - Google Patents
Preparation of lyophilized powder of cephalothinInfo
- Publication number
- JPS56120615A JPS56120615A JP2269280A JP2269280A JPS56120615A JP S56120615 A JPS56120615 A JP S56120615A JP 2269280 A JP2269280 A JP 2269280A JP 2269280 A JP2269280 A JP 2269280A JP S56120615 A JPS56120615 A JP S56120615A
- Authority
- JP
- Japan
- Prior art keywords
- cephalothin
- aqueous solution
- sodium cephalothin
- sterly
- lyophilizing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To obtain the titled powder capable of being stored for a long time by a simple means, by cooling an aqueous solution of sodium cephalothin containing an organic solvent so that crystal of sodium cephalothin is precipitated, followed by lyophilizing it.
CONSTITUTION: After an aqueous solution of sodium cephalothin containing an organic solvent (e.g., methanol, ethanol, etc.) is filtered sterly, and fed to a vial sterly, and cooled quickly to not higher than -40°C in a lyophilizing dryer. After the aqueous solution is frozen, its temperature is raised to about -10°C. The solution is again cooled to about -40°C, vacuum drying is carried out carefully while the temperature of a shelf is raised, to give crystalline powder of sodium cephalothin. The time needed for crystalization is shorten extremely, the shape of the crystal is smaller than that of the conventional method, and it is very stable.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2269280A JPS56120615A (en) | 1980-02-27 | 1980-02-27 | Preparation of lyophilized powder of cephalothin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2269280A JPS56120615A (en) | 1980-02-27 | 1980-02-27 | Preparation of lyophilized powder of cephalothin |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56120615A true JPS56120615A (en) | 1981-09-22 |
Family
ID=12089919
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2269280A Pending JPS56120615A (en) | 1980-02-27 | 1980-02-27 | Preparation of lyophilized powder of cephalothin |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56120615A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6011491A (en) * | 1983-03-04 | 1985-01-21 | Shionogi & Co Ltd | Preparation of crystalline lyophilized powder of cephalothin sodium |
JPS60255723A (en) * | 1984-05-31 | 1985-12-17 | Ono Pharmaceut Co Ltd | Freeze-dried crystalline preparation of gabexate mesylate, and its production |
US5286856A (en) * | 1991-09-20 | 1994-02-15 | Takeda Chemical Industries, Ltd. | Production of crystalline penem |
-
1980
- 1980-02-27 JP JP2269280A patent/JPS56120615A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6011491A (en) * | 1983-03-04 | 1985-01-21 | Shionogi & Co Ltd | Preparation of crystalline lyophilized powder of cephalothin sodium |
JPS60255723A (en) * | 1984-05-31 | 1985-12-17 | Ono Pharmaceut Co Ltd | Freeze-dried crystalline preparation of gabexate mesylate, and its production |
JPH0374643B2 (en) * | 1984-05-31 | 1991-11-27 | ||
US5286856A (en) * | 1991-09-20 | 1994-02-15 | Takeda Chemical Industries, Ltd. | Production of crystalline penem |
US5424069A (en) * | 1991-09-20 | 1995-06-13 | Takeda Chemical Industries, Ltd. | Production of crystalline penem |
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