JPS56113735A - Preparation of 3-chloro-4-allyloxyphenylacetic acid - Google Patents

Preparation of 3-chloro-4-allyloxyphenylacetic acid

Info

Publication number
JPS56113735A
JPS56113735A JP1570780A JP1570780A JPS56113735A JP S56113735 A JPS56113735 A JP S56113735A JP 1570780 A JP1570780 A JP 1570780A JP 1570780 A JP1570780 A JP 1570780A JP S56113735 A JPS56113735 A JP S56113735A
Authority
JP
Japan
Prior art keywords
chloro
acid
molar amount
allyl chloride
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1570780A
Other languages
Japanese (ja)
Other versions
JPS634530B2 (en
Inventor
Hideto Ichikawa
Kiyoji Mizukami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SAKAI YAKUHIN KK
Original Assignee
SAKAI YAKUHIN KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SAKAI YAKUHIN KK filed Critical SAKAI YAKUHIN KK
Priority to JP1570780A priority Critical patent/JPS56113735A/en
Publication of JPS56113735A publication Critical patent/JPS56113735A/en
Publication of JPS634530B2 publication Critical patent/JPS634530B2/ja
Granted legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the titled compound having an anti-inflammatory and an analgesic actions in one stage in high yield, by reacting an alkaline metallic acid of an easily available 3-chloro-4-hydroxyphenylacetic acid as a raw material with allyl chloride in methanol solvent.
CONSTITUTION: 3-Chloro-4-hydroxyphenylacetic acid and an alkaline metallic hydroxide in a molar amount of 2 times or more, preferably 2.1W2.5 times, of that of the 3-chloro-4-hydroxyphenylacetic acid are dissolved in methanol, and allyl chloride in a molar amount of preferably 1.5W2.5 times of that of the acetic acid is added thereto. The resultant reaction mixture is reacted at 40W45°C for 4W6hr under heating and refluxing to give 3-chloro-4-allyloxyphenylacetic acid of the formula which is used clinically in the common name of alclofenac.
COPYRIGHT: (C)1981,JPO&Japio
JP1570780A 1980-02-12 1980-02-12 Preparation of 3-chloro-4-allyloxyphenylacetic acid Granted JPS56113735A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1570780A JPS56113735A (en) 1980-02-12 1980-02-12 Preparation of 3-chloro-4-allyloxyphenylacetic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1570780A JPS56113735A (en) 1980-02-12 1980-02-12 Preparation of 3-chloro-4-allyloxyphenylacetic acid

Publications (2)

Publication Number Publication Date
JPS56113735A true JPS56113735A (en) 1981-09-07
JPS634530B2 JPS634530B2 (en) 1988-01-29

Family

ID=11896232

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1570780A Granted JPS56113735A (en) 1980-02-12 1980-02-12 Preparation of 3-chloro-4-allyloxyphenylacetic acid

Country Status (1)

Country Link
JP (1) JPS56113735A (en)

Also Published As

Publication number Publication date
JPS634530B2 (en) 1988-01-29

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