JPS56113735A - Preparation of 3-chloro-4-allyloxyphenylacetic acid - Google Patents
Preparation of 3-chloro-4-allyloxyphenylacetic acidInfo
- Publication number
- JPS56113735A JPS56113735A JP1570780A JP1570780A JPS56113735A JP S56113735 A JPS56113735 A JP S56113735A JP 1570780 A JP1570780 A JP 1570780A JP 1570780 A JP1570780 A JP 1570780A JP S56113735 A JPS56113735 A JP S56113735A
- Authority
- JP
- Japan
- Prior art keywords
- chloro
- acid
- molar amount
- allyl chloride
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the titled compound having an anti-inflammatory and an analgesic actions in one stage in high yield, by reacting an alkaline metallic acid of an easily available 3-chloro-4-hydroxyphenylacetic acid as a raw material with allyl chloride in methanol solvent.
CONSTITUTION: 3-Chloro-4-hydroxyphenylacetic acid and an alkaline metallic hydroxide in a molar amount of 2 times or more, preferably 2.1W2.5 times, of that of the 3-chloro-4-hydroxyphenylacetic acid are dissolved in methanol, and allyl chloride in a molar amount of preferably 1.5W2.5 times of that of the acetic acid is added thereto. The resultant reaction mixture is reacted at 40W45°C for 4W6hr under heating and refluxing to give 3-chloro-4-allyloxyphenylacetic acid of the formula which is used clinically in the common name of alclofenac.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1570780A JPS56113735A (en) | 1980-02-12 | 1980-02-12 | Preparation of 3-chloro-4-allyloxyphenylacetic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1570780A JPS56113735A (en) | 1980-02-12 | 1980-02-12 | Preparation of 3-chloro-4-allyloxyphenylacetic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56113735A true JPS56113735A (en) | 1981-09-07 |
JPS634530B2 JPS634530B2 (en) | 1988-01-29 |
Family
ID=11896232
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1570780A Granted JPS56113735A (en) | 1980-02-12 | 1980-02-12 | Preparation of 3-chloro-4-allyloxyphenylacetic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56113735A (en) |
-
1980
- 1980-02-12 JP JP1570780A patent/JPS56113735A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS634530B2 (en) | 1988-01-29 |
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