JPS56103198A - 3',4',6''-trideoxyamikacin and its preparation - Google Patents
3',4',6''-trideoxyamikacin and its preparationInfo
- Publication number
- JPS56103198A JPS56103198A JP565780A JP565780A JPS56103198A JP S56103198 A JPS56103198 A JP S56103198A JP 565780 A JP565780 A JP 565780A JP 565780 A JP565780 A JP 565780A JP S56103198 A JPS56103198 A JP S56103198A
- Authority
- JP
- Japan
- Prior art keywords
- groups
- hydroxyl
- positions
- protecting groups
- protecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
NEW MATERIAL:A compound expressed by formula I and an acid addition salt thereof.
EXAMPLE: 3',4',6''-Trideoxyamikacin carbonate.
USE: An antimicrobial agent having low toxicity to an organ of hearing.
PROCESS: Four amino groups of 3',4'-dideoxyamikacin expressed by formula II are protected by protecting groups thereof, and three hydroxyl groups at the 2',2'' and 2'''-positions or four hydroxyl groups at the 5, 2',2'''-positions are protected by monovalent protecting groups to give compound of formula III (A is H; B is monovalent protecting group of the amino groups; A and B together form bivalent protecting groups of the amino groups; X and Y are H, alkyl, aryl, etc.; D is acyl group; E is H or acyl groups). The protecting groups at the 4'' and 6''-positions are then removed, and the hydroxyl group at the 6''-position is selectively sulfonated, iodinated and dehalogenated by the catalytic reduction. The remaining protecting groups of the hydroxyl and amino groups are then removed.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP565780A JPS56103198A (en) | 1980-01-23 | 1980-01-23 | 3',4',6''-trideoxyamikacin and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP565780A JPS56103198A (en) | 1980-01-23 | 1980-01-23 | 3',4',6''-trideoxyamikacin and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56103198A true JPS56103198A (en) | 1981-08-18 |
| JPS631954B2 JPS631954B2 (en) | 1988-01-14 |
Family
ID=11617178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP565780A Granted JPS56103198A (en) | 1980-01-23 | 1980-01-23 | 3',4',6''-trideoxyamikacin and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56103198A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05161527A (en) * | 1991-12-11 | 1993-06-29 | Yamashita Kogyo Kenkyusho:Kk | Tool holder |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01121754U (en) * | 1988-02-15 | 1989-08-17 | ||
| JPH0262148U (en) * | 1988-10-31 | 1990-05-09 | ||
| EP3640317B1 (en) | 2017-06-14 | 2024-05-29 | Nisshin Pharma Inc. | Method for producing polyunsaturated fatty acid-containing composition |
| CA3125090A1 (en) | 2018-12-26 | 2020-07-02 | Nisshin Pharma Inc. | Eicosapentaenoic acid alkyl ester-containing composition and method for producing same |
| WO2020196749A1 (en) | 2019-03-26 | 2020-10-01 | 日清ファルマ株式会社 | Eicosapentaenoic acid alkyl ester-containing composition and method for producing same |
-
1980
- 1980-01-23 JP JP565780A patent/JPS56103198A/en active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05161527A (en) * | 1991-12-11 | 1993-06-29 | Yamashita Kogyo Kenkyusho:Kk | Tool holder |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS631954B2 (en) | 1988-01-14 |
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