JPS5585394A - Production of nnsubstituted derivative of 11desoxynozilimycin - Google Patents
Production of nnsubstituted derivative of 11desoxynozilimycinInfo
- Publication number
- JPS5585394A JPS5585394A JP15930379A JP15930379A JPS5585394A JP S5585394 A JPS5585394 A JP S5585394A JP 15930379 A JP15930379 A JP 15930379A JP 15930379 A JP15930379 A JP 15930379A JP S5585394 A JPS5585394 A JP S5585394A
- Authority
- JP
- Japan
- Prior art keywords
- nnsubstituted
- derivative
- production
- nnsubstituted derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Hydrogenated Pyridines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19782853573 DE2853573A1 (de) | 1978-12-12 | 1978-12-12 | Herstellung von n-substituierten derivaten des l-desoxynojirimycins |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5585394A true JPS5585394A (en) | 1980-06-27 |
JPH0121958B2 JPH0121958B2 (ja) | 1989-04-24 |
Family
ID=6056917
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15930379A Granted JPS5585394A (en) | 1978-12-12 | 1979-12-10 | Production of nnsubstituted derivative of 11desoxynozilimycin |
Country Status (4)
Country | Link |
---|---|
US (1) | US4266025A (ja) |
EP (1) | EP0012278B1 (ja) |
JP (1) | JPS5585394A (ja) |
DE (2) | DE2853573A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62242663A (ja) * | 1986-04-09 | 1987-10-23 | バイエル・アクチエンゲゼルシヤフト | 1−デオキシノジリマイシンおよびそれのn−誘導体を製造する方法 |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2064527B (en) * | 1979-12-08 | 1984-05-02 | Nippon Shinyaku Co Ltd | Moranoline derivatives and process for preparation thereof |
DE3038901A1 (de) * | 1980-10-15 | 1982-05-06 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins |
JPS6055078B2 (ja) * | 1980-12-01 | 1985-12-03 | 日本新薬株式会社 | モラノリンの誘導体 |
US4758510A (en) * | 1981-12-30 | 1988-07-19 | S.V.S. Laboratories, Inc. | Simplified in-vitro interferon production |
JPS6019139A (ja) * | 1983-07-14 | 1985-01-31 | Fuji Photo Film Co Ltd | カラ−拡散転写用写真要素 |
DE3507019A1 (de) * | 1985-02-28 | 1986-08-28 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung |
US5329025A (en) * | 1988-09-21 | 1994-07-12 | G. D. Searle & Co. | 3-azido compound |
US5536732A (en) * | 1990-04-27 | 1996-07-16 | Merrell Pharmaceuticals Inc. | N-derivatives of 1-deoxy nojirimycin |
US5252587A (en) * | 1990-04-27 | 1993-10-12 | Merrell Dow Pharmaceuticals, Inc. | N-derivatives of 1-deoxy nojirimycin |
DE69119010T2 (de) * | 1990-09-20 | 1996-11-28 | Monsanto Co | Verfahren zur Herstellung von N-substituiertem 1-Deoxynojirimycin |
US5401645A (en) * | 1992-03-16 | 1995-03-28 | Monsanto Company | Process for producing n-substituted polyhydroxy nitrogen-containing heterocycles utilizing acetobacteraceae and corynebacterium |
AU1876095A (en) * | 1994-02-25 | 1995-09-11 | G.D. Searle & Co. | Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus |
US6465488B1 (en) | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
EP1037636A4 (en) | 1997-12-11 | 2004-08-18 | Univ Oxford | INHIBITATION OF MEMBRANE-TIED VIRAL REPLICATION |
GB9909066D0 (en) * | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
US20050032841A1 (en) * | 1999-04-20 | 2005-02-10 | Steven Walkley | Therapeutic compositions and methods of treating glycolipid storage related disorders |
AU1840101A (en) * | 1999-08-10 | 2001-03-05 | Chancellor, Masters And Scholars Of The University Of Oxford, The | Long chain n-alkyl compounds and oxo-derivatives thereof |
US7256005B2 (en) | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
GB0229476D0 (en) * | 2002-12-17 | 2003-01-22 | Oxford Glycosciences Uk Ltd | Novel process |
JP3535151B1 (ja) * | 2003-07-10 | 2004-06-07 | 株式会社ミナキアドバンス | 生酵母菌を成分とする液剤の製造方法及びその液剤 |
US9181184B2 (en) | 2005-05-17 | 2015-11-10 | Amicus Therapeutics, Inc. | Method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives |
GB0614947D0 (en) * | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
US20080138351A1 (en) * | 2006-08-02 | 2008-06-12 | United Therapeutics Corporation | Liposome treatment of viral infections |
WO2008063727A2 (en) * | 2006-08-21 | 2008-05-29 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
ES2298057B1 (es) * | 2006-09-01 | 2009-08-07 | Consejo Superior Investig. Cientificas | Procedimiento quimo-enzimatico para la sintesis de iminociclitoles e iminociclitoles asi obtenidos. |
CN101289418B (zh) * | 2007-04-19 | 2011-02-02 | 浙江医药股份有限公司新昌制药厂 | 米格列醇晶体及其制备方法 |
US8097728B2 (en) * | 2007-04-30 | 2012-01-17 | Philadelphia Health & Education Corporation | Iminosugar compounds with antiflavirus activity |
WO2009118658A2 (en) * | 2008-03-26 | 2009-10-01 | University Of Oxford | Endoplasmic reticulum targeting liposomes |
CA2753195C (en) | 2009-02-23 | 2015-06-02 | United Therapeutics Corporation | Iminosugars and methods of treating viral diseases |
KR20170117614A (ko) * | 2009-02-24 | 2017-10-23 | 유나이티드 세러퓨틱스 코오포레이션 | 이미노슈가 및 아레나바이러스성 감염을 치료하는 방법 |
WO2010109330A2 (en) * | 2009-03-27 | 2010-09-30 | University Of Oxford | Cholesterol level lowering liposomes |
EP2440205B1 (en) | 2009-06-12 | 2014-08-27 | United Therapeutics Corporation | Iminosugars for use in the treatment of bunyaviral and togaviral diseases |
US20110065752A1 (en) * | 2009-09-04 | 2011-03-17 | United Therapeutics Corporation | Methods of treating orthomyxoviral infections |
US20110065753A1 (en) * | 2009-09-04 | 2011-03-17 | United Therapeutics Corporation | Methods of treating poxviral infections |
EP2473046B1 (en) | 2009-09-04 | 2014-10-22 | United Therapeutics Corporation | Iminosugars for their use in the treatment of filoviral diseases |
US20110136868A1 (en) * | 2009-12-07 | 2011-06-09 | University Of Oxford | Agents for inhibiting osteoclastogenesis and/or osteoclast activation |
AP2016009125A0 (en) | 2013-09-16 | 2016-04-30 | Emergent Virology Llc | Deoxynojirimycin derivatives and methods of their using |
JP6826986B2 (ja) | 2014-11-05 | 2021-02-10 | エマージェント バイロロジー エルエルシー | ウィルス性疾患の治療に有用なイミノ糖類 |
EP3318277A1 (en) | 2016-11-04 | 2018-05-09 | Institut du Cerveau et de la Moelle Epiniere-ICM | Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3998698A (en) * | 1976-04-08 | 1976-12-21 | The Upjohn Company | Process for producing antibiotic U-51,640 |
GB2009152B (en) * | 1977-11-10 | 1982-01-06 | Nippon Shinyaku Co Ltd | Method for producing moranoline and n-methylmoranoline |
DE2830469A1 (de) * | 1978-07-11 | 1980-01-24 | Bayer Ag | Herstellung von l-desoxy-nojirimycin und n-substituierten derivaten |
-
1978
- 1978-12-12 DE DE19782853573 patent/DE2853573A1/de not_active Withdrawn
-
1979
- 1979-11-23 US US06/097,099 patent/US4266025A/en not_active Expired - Lifetime
- 1979-11-29 EP EP79104762A patent/EP0012278B1/de not_active Expired
- 1979-11-29 DE DE7979104762T patent/DE2962923D1/de not_active Expired
- 1979-12-10 JP JP15930379A patent/JPS5585394A/ja active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62242663A (ja) * | 1986-04-09 | 1987-10-23 | バイエル・アクチエンゲゼルシヤフト | 1−デオキシノジリマイシンおよびそれのn−誘導体を製造する方法 |
Also Published As
Publication number | Publication date |
---|---|
DE2962923D1 (en) | 1982-07-08 |
US4266025A (en) | 1981-05-05 |
EP0012278A3 (en) | 1980-07-09 |
DE2853573A1 (de) | 1980-07-03 |
JPH0121958B2 (ja) | 1989-04-24 |
EP0012278B1 (de) | 1982-05-19 |
EP0012278A2 (de) | 1980-06-25 |
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