JPS5573690A - Novel penicillin derivative and antibacterial comprising it - Google Patents
Novel penicillin derivative and antibacterial comprising itInfo
- Publication number
- JPS5573690A JPS5573690A JP14609878A JP14609878A JPS5573690A JP S5573690 A JPS5573690 A JP S5573690A JP 14609878 A JP14609878 A JP 14609878A JP 14609878 A JP14609878 A JP 14609878A JP S5573690 A JPS5573690 A JP S5573690A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- derivative
- compound
- antibacterial
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A penicillin derivative of formula I: [R1 is H, lower alkyl, or branched chain alkyl group; R2, R3, R4, and R5 are H, lower alkyl, or lower alkoxymethyl groups; A is H or hydroxyl group; B is direct bond, etc.; X is O, S, etc.; Y is O or methylene group; the dotted line in the ring is (un)saturated bond], and its non-toxic salt.
EXAMPLE: D( - )α-[ 6-( 2,2,5,7,8-Pentamethylchromanyloxy )-actamido ]-benzylpenicillin.
USE: Antibacterials, having a greater antibacterial activity and lower toxicity than ampicillin.
PROCESS: A phenylglycylpenicillanic acid derivative is reacted with a compound of formula III or its reactive derivative in the presence of a basic reagent or silylating agent in an inert solvent, e.g. tetrahydrofuran, acetone, or furan, to give the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14609878A JPS5573690A (en) | 1978-11-28 | 1978-11-28 | Novel penicillin derivative and antibacterial comprising it |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14609878A JPS5573690A (en) | 1978-11-28 | 1978-11-28 | Novel penicillin derivative and antibacterial comprising it |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5573690A true JPS5573690A (en) | 1980-06-03 |
Family
ID=15400087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14609878A Pending JPS5573690A (en) | 1978-11-28 | 1978-11-28 | Novel penicillin derivative and antibacterial comprising it |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5573690A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8148424B2 (en) | 1998-09-23 | 2012-04-03 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
-
1978
- 1978-11-28 JP JP14609878A patent/JPS5573690A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8148424B2 (en) | 1998-09-23 | 2012-04-03 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
US8664264B2 (en) | 1998-09-23 | 2014-03-04 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
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