JPS5573690A - Novel penicillin derivative and antibacterial comprising it - Google Patents

Novel penicillin derivative and antibacterial comprising it

Info

Publication number
JPS5573690A
JPS5573690A JP14609878A JP14609878A JPS5573690A JP S5573690 A JPS5573690 A JP S5573690A JP 14609878 A JP14609878 A JP 14609878A JP 14609878 A JP14609878 A JP 14609878A JP S5573690 A JPS5573690 A JP S5573690A
Authority
JP
Japan
Prior art keywords
formula
derivative
compound
antibacterial
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14609878A
Other languages
Japanese (ja)
Inventor
Yoshimasa Machida
Isao Saito
Motosuke Yamanaka
Seiichiro Nomoto
Shigeto Negi
Norio Minami
Kichisaburo Hamamura
Yoji Yamagishi
Kyosuke Kito
Masaru Sato
Kamamasa Katsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Priority to JP14609878A priority Critical patent/JPS5573690A/en
Publication of JPS5573690A publication Critical patent/JPS5573690A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A penicillin derivative of formula I: [R1 is H, lower alkyl, or branched chain alkyl group; R2, R3, R4, and R5 are H, lower alkyl, or lower alkoxymethyl groups; A is H or hydroxyl group; B is direct bond, etc.; X is O, S, etc.; Y is O or methylene group; the dotted line in the ring is (un)saturated bond], and its non-toxic salt.
EXAMPLE: D( - )α-[ 6-( 2,2,5,7,8-Pentamethylchromanyloxy )-actamido ]-benzylpenicillin.
USE: Antibacterials, having a greater antibacterial activity and lower toxicity than ampicillin.
PROCESS: A phenylglycylpenicillanic acid derivative is reacted with a compound of formula III or its reactive derivative in the presence of a basic reagent or silylating agent in an inert solvent, e.g. tetrahydrofuran, acetone, or furan, to give the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP14609878A 1978-11-28 1978-11-28 Novel penicillin derivative and antibacterial comprising it Pending JPS5573690A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14609878A JPS5573690A (en) 1978-11-28 1978-11-28 Novel penicillin derivative and antibacterial comprising it

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14609878A JPS5573690A (en) 1978-11-28 1978-11-28 Novel penicillin derivative and antibacterial comprising it

Publications (1)

Publication Number Publication Date
JPS5573690A true JPS5573690A (en) 1980-06-03

Family

ID=15400087

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14609878A Pending JPS5573690A (en) 1978-11-28 1978-11-28 Novel penicillin derivative and antibacterial comprising it

Country Status (1)

Country Link
JP (1) JPS5573690A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8148424B2 (en) 1998-09-23 2012-04-03 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8148424B2 (en) 1998-09-23 2012-04-03 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
US8664264B2 (en) 1998-09-23 2014-03-04 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof

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