JPS5562080A - Preparation of alpha-hydroxy-beta,beta-dimethyl-gamma-butyrolactone - Google Patents

Preparation of alpha-hydroxy-beta,beta-dimethyl-gamma-butyrolactone

Info

Publication number
JPS5562080A
JPS5562080A JP13590778A JP13590778A JPS5562080A JP S5562080 A JPS5562080 A JP S5562080A JP 13590778 A JP13590778 A JP 13590778A JP 13590778 A JP13590778 A JP 13590778A JP S5562080 A JPS5562080 A JP S5562080A
Authority
JP
Japan
Prior art keywords
beta
hydroxy
butyrolactone
gamma
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13590778A
Other languages
Japanese (ja)
Inventor
Mamoru Nakai
Yoshiaki Kuroki
Yoshikatsu Mori
Yoshimi Fujiwara
Noritaka Miyamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ube Corp
Original Assignee
Ube Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ube Industries Ltd filed Critical Ube Industries Ltd
Priority to JP13590778A priority Critical patent/JPS5562080A/en
Publication of JPS5562080A publication Critical patent/JPS5562080A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To prepare the title compound (pantolactone) useful as an intermediate of pantothenic acid, without using toxic cyanides, from glyoxylic acid and isobutylaldehyde, through α-hydroxy-β-formyl isovalerate.
CONSTITUTION: Glyoxylic acid is reacted with isobutylaldehyde in an alkali at ≤10°C to obtain α-hydroxy-β-formyl isovalerate, which is reacted with glyoxylic acid or formaldehyde in an alkali at ≥10°C to afford the title compound. By this procedure, pantolactone which is a precursor of pantothenic acid useful as a vitamin B complex, feed additive, medicine, etc., can be prepared without using toxic cyanides.
COPYRIGHT: (C)1980,JPO&Japio
JP13590778A 1978-11-06 1978-11-06 Preparation of alpha-hydroxy-beta,beta-dimethyl-gamma-butyrolactone Pending JPS5562080A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13590778A JPS5562080A (en) 1978-11-06 1978-11-06 Preparation of alpha-hydroxy-beta,beta-dimethyl-gamma-butyrolactone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13590778A JPS5562080A (en) 1978-11-06 1978-11-06 Preparation of alpha-hydroxy-beta,beta-dimethyl-gamma-butyrolactone

Publications (1)

Publication Number Publication Date
JPS5562080A true JPS5562080A (en) 1980-05-10

Family

ID=15162609

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13590778A Pending JPS5562080A (en) 1978-11-06 1978-11-06 Preparation of alpha-hydroxy-beta,beta-dimethyl-gamma-butyrolactone

Country Status (1)

Country Link
JP (1) JPS5562080A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0171046A2 (en) * 1984-08-10 1986-02-12 BASF Aktiengesellschaft Process for the preparation of pantolactone
CN106008413A (en) * 2016-06-15 2016-10-12 新发药业有限公司 Environment-friendly synthesis method of D-calcium pantothenate intermediate D, L-pantoyl lactone
WO2022001939A1 (en) 2020-06-28 2022-01-06 张科春 Methods for preparing pantoic acid, pantothenic acid and panthenol as well as salts thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0171046A2 (en) * 1984-08-10 1986-02-12 BASF Aktiengesellschaft Process for the preparation of pantolactone
CN106008413A (en) * 2016-06-15 2016-10-12 新发药业有限公司 Environment-friendly synthesis method of D-calcium pantothenate intermediate D, L-pantoyl lactone
WO2022001939A1 (en) 2020-06-28 2022-01-06 张科春 Methods for preparing pantoic acid, pantothenic acid and panthenol as well as salts thereof

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