JPS5562080A - Preparation of alpha-hydroxy-beta,beta-dimethyl-gamma-butyrolactone - Google Patents
Preparation of alpha-hydroxy-beta,beta-dimethyl-gamma-butyrolactoneInfo
- Publication number
- JPS5562080A JPS5562080A JP13590778A JP13590778A JPS5562080A JP S5562080 A JPS5562080 A JP S5562080A JP 13590778 A JP13590778 A JP 13590778A JP 13590778 A JP13590778 A JP 13590778A JP S5562080 A JPS5562080 A JP S5562080A
- Authority
- JP
- Japan
- Prior art keywords
- beta
- hydroxy
- butyrolactone
- gamma
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare the title compound (pantolactone) useful as an intermediate of pantothenic acid, without using toxic cyanides, from glyoxylic acid and isobutylaldehyde, through α-hydroxy-β-formyl isovalerate.
CONSTITUTION: Glyoxylic acid is reacted with isobutylaldehyde in an alkali at ≤10°C to obtain α-hydroxy-β-formyl isovalerate, which is reacted with glyoxylic acid or formaldehyde in an alkali at ≥10°C to afford the title compound. By this procedure, pantolactone which is a precursor of pantothenic acid useful as a vitamin B complex, feed additive, medicine, etc., can be prepared without using toxic cyanides.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13590778A JPS5562080A (en) | 1978-11-06 | 1978-11-06 | Preparation of alpha-hydroxy-beta,beta-dimethyl-gamma-butyrolactone |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13590778A JPS5562080A (en) | 1978-11-06 | 1978-11-06 | Preparation of alpha-hydroxy-beta,beta-dimethyl-gamma-butyrolactone |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5562080A true JPS5562080A (en) | 1980-05-10 |
Family
ID=15162609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13590778A Pending JPS5562080A (en) | 1978-11-06 | 1978-11-06 | Preparation of alpha-hydroxy-beta,beta-dimethyl-gamma-butyrolactone |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5562080A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0171046A2 (en) * | 1984-08-10 | 1986-02-12 | BASF Aktiengesellschaft | Process for the preparation of pantolactone |
CN106008413A (en) * | 2016-06-15 | 2016-10-12 | 新发药业有限公司 | Environment-friendly synthesis method of D-calcium pantothenate intermediate D, L-pantoyl lactone |
WO2022001939A1 (en) | 2020-06-28 | 2022-01-06 | 张科春 | Methods for preparing pantoic acid, pantothenic acid and panthenol as well as salts thereof |
-
1978
- 1978-11-06 JP JP13590778A patent/JPS5562080A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0171046A2 (en) * | 1984-08-10 | 1986-02-12 | BASF Aktiengesellschaft | Process for the preparation of pantolactone |
CN106008413A (en) * | 2016-06-15 | 2016-10-12 | 新发药业有限公司 | Environment-friendly synthesis method of D-calcium pantothenate intermediate D, L-pantoyl lactone |
WO2022001939A1 (en) | 2020-06-28 | 2022-01-06 | 张科春 | Methods for preparing pantoic acid, pantothenic acid and panthenol as well as salts thereof |
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