JPS5547682A - 7-dithienylmethylene-indolizidine derivative - Google Patents
7-dithienylmethylene-indolizidine derivativeInfo
- Publication number
- JPS5547682A JPS5547682A JP11990678A JP11990678A JPS5547682A JP S5547682 A JPS5547682 A JP S5547682A JP 11990678 A JP11990678 A JP 11990678A JP 11990678 A JP11990678 A JP 11990678A JP S5547682 A JPS5547682 A JP S5547682A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- indolizidine
- dithienylmethylene
- antiacetylcholine
- actions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- MZYPEZKYNHJEMJ-UHFFFAOYSA-N 7-(dithiophen-2-ylmethylidene)-2,3,5,6,8,8a-hexahydro-1H-indolizine Chemical class S1C(=CC=C1)C(=C1CCN2CCCC2C1)C=1SC=CC=1 MZYPEZKYNHJEMJ-UHFFFAOYSA-N 0.000 title abstract 2
- 230000001004 anti-acetylcholinic effect Effects 0.000 abstract 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 2
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 230000002921 anti-spasmodic effect Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940124575 antispasmodic agent Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- FWJSBTHLZHCSIO-UHFFFAOYSA-N ethyl 1,2,3,5,6,7,8,8a-octahydroindolizine-7-carboxylate Chemical compound C(C)OC(=O)C1CCN2CCCC2C1 FWJSBTHLZHCSIO-UHFFFAOYSA-N 0.000 abstract 1
- 229910000765 intermetallic Inorganic materials 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Substances OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 7-dithienylmethylene-indolizidine of formula I, its acid addition salt, or quaternary ammonium salt of formula II.
USE: Antispasmodics and antitumor agents having anti-histamine and strong antiacetylcholine actions, particularly quaternary ammonium salts having a strong antiacetylcholine actions.
PROCESS: An indolizidine-7-carboxylic ethyl ester of formula II is reacted with a metallic compound to give novel α,α-dithienylindolizidine-7-methanol of formula IV, which is dehydrated to give the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11990678A JPS5547682A (en) | 1978-09-30 | 1978-09-30 | 7-dithienylmethylene-indolizidine derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11990678A JPS5547682A (en) | 1978-09-30 | 1978-09-30 | 7-dithienylmethylene-indolizidine derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5547682A true JPS5547682A (en) | 1980-04-04 |
| JPS5638157B2 JPS5638157B2 (en) | 1981-09-04 |
Family
ID=14773124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11990678A Granted JPS5547682A (en) | 1978-09-30 | 1978-09-30 | 7-dithienylmethylene-indolizidine derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5547682A (en) |
-
1978
- 1978-09-30 JP JP11990678A patent/JPS5547682A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5638157B2 (en) | 1981-09-04 |
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