JPS5536429A - Preparation of (+)-2-(6-methoxy-2-naphthyl)propionic acid and its intermediate - Google Patents

Preparation of (+)-2-(6-methoxy-2-naphthyl)propionic acid and its intermediate

Info

Publication number
JPS5536429A
JPS5536429A JP10996778A JP10996778A JPS5536429A JP S5536429 A JPS5536429 A JP S5536429A JP 10996778 A JP10996778 A JP 10996778A JP 10996778 A JP10996778 A JP 10996778A JP S5536429 A JPS5536429 A JP S5536429A
Authority
JP
Japan
Prior art keywords
compound
methoxy
novel
naphthyl
propionic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10996778A
Other languages
Japanese (ja)
Other versions
JPS6116264B2 (en
Inventor
Chitsukazu Kita
Haruo Yamada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hamari Chemicals Ltd
Original Assignee
Hamari Chemicals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hamari Chemicals Ltd filed Critical Hamari Chemicals Ltd
Priority to JP10996778A priority Critical patent/JPS5536429A/en
Publication of JPS5536429A publication Critical patent/JPS5536429A/en
Publication of JPS6116264B2 publication Critical patent/JPS6116264B2/ja
Granted legal-status Critical Current

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  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the title compound useful as an antiinflammatory agent, an analgesic agent and an antipyretic agent, under mild conditions, in a short time, in high yield, economically, from an easily available 2-thioxo-4-oxothiazolidine via a novel intermediate.
CONSTITUTION: The objective (+)-2-(6-methoxy-2-naphthyl)-propionic acid is prepared by (1) condensing a compound I with 2-acetyl-6-methoxy-naphthalene by dehydration to obtain a novel compound II, (2) hydrolyzing the compound II to a novel compound III, (3) desulfurizing the compound III to obtain a compound IV, (4) converting the compound IV to a racemic compound V by oxidative decarbonation, (5) optically resolving the racemic compound pref. by treating with L-tyrosine hydrazide or L-α-phenylethylamine in an alcoholic solvent with heating, and cooling the reaction mixture, and (6) decomposing the separated diastereomer salt with a strong acid.
COPYRIGHT: (C)1980,JPO&Japio
JP10996778A 1978-09-06 1978-09-06 Preparation of (+)-2-(6-methoxy-2-naphthyl)propionic acid and its intermediate Granted JPS5536429A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10996778A JPS5536429A (en) 1978-09-06 1978-09-06 Preparation of (+)-2-(6-methoxy-2-naphthyl)propionic acid and its intermediate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10996778A JPS5536429A (en) 1978-09-06 1978-09-06 Preparation of (+)-2-(6-methoxy-2-naphthyl)propionic acid and its intermediate

Publications (2)

Publication Number Publication Date
JPS5536429A true JPS5536429A (en) 1980-03-14
JPS6116264B2 JPS6116264B2 (en) 1986-04-28

Family

ID=14523686

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10996778A Granted JPS5536429A (en) 1978-09-06 1978-09-06 Preparation of (+)-2-(6-methoxy-2-naphthyl)propionic acid and its intermediate

Country Status (1)

Country Link
JP (1) JPS5536429A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02143811A (en) * 1988-11-25 1990-06-01 Mitsubishi Heavy Ind Ltd Open and close apparatus for mold clamping split nut
WO2004007491A1 (en) * 2002-07-10 2004-01-22 Applied Research Systems Ars Holding N.V. Azolidinone-vinyl fused-benzene derivatives
KR101131649B1 (en) * 2002-07-10 2012-07-03 라보라토리스 세로노 에스.에이. Azolidinone-vinyl fused-benzene derivatives

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0451359U (en) * 1990-09-05 1992-04-30

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02143811A (en) * 1988-11-25 1990-06-01 Mitsubishi Heavy Ind Ltd Open and close apparatus for mold clamping split nut
WO2004007491A1 (en) * 2002-07-10 2004-01-22 Applied Research Systems Ars Holding N.V. Azolidinone-vinyl fused-benzene derivatives
JP2005538188A (en) * 2002-07-10 2005-12-15 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ Azolidinone-vinyl condensation-benzene derivative
EA011807B1 (en) * 2002-07-10 2009-06-30 Лаборатуар Сероно Са Azolidinone-vinyl fused-benzene derivatives
US7846925B2 (en) 2002-07-10 2010-12-07 Merck Serono Sa Azolidinone-vinyl fused-benzene derivatives
JP4782564B2 (en) * 2002-07-10 2011-09-28 メルク セローノ ソシエテ アノニム Azolidinone-vinyl condensation-benzene derivative
KR101131649B1 (en) * 2002-07-10 2012-07-03 라보라토리스 세로노 에스.에이. Azolidinone-vinyl fused-benzene derivatives

Also Published As

Publication number Publication date
JPS6116264B2 (en) 1986-04-28

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