JPS5528903A - Preparation of piperidinoalkanol - Google Patents
Preparation of piperidinoalkanolInfo
- Publication number
- JPS5528903A JPS5528903A JP10068578A JP10068578A JPS5528903A JP S5528903 A JPS5528903 A JP S5528903A JP 10068578 A JP10068578 A JP 10068578A JP 10068578 A JP10068578 A JP 10068578A JP S5528903 A JPS5528903 A JP S5528903A
- Authority
- JP
- Japan
- Prior art keywords
- agent
- piperidinoalkanol
- benzylpiperidino
- benzyloxyphenyl
- propan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain piperidinoalkanol, etc, useful as an agent for circulatory system treating such as an agent for cerebral embolism sequela, or apoplexy sequela, etc., easily in high yield, by reducing a piperidinoalkanone in the presence of a metal hydride as a reducing agent.
CONSTITUTION: 1-(p-Hydroxy or benzyloxyphenyl)-2-(4-benzylpiperidino) propan- 1-one, of formula I (R is H or benzyl), is reduced to give 1-(para-hydroxy or benzyloxyphenyl)-2-(4-benzylpiperidino) propan-1-ol of formula II. A metal hydride (e.g. lithium alminum hydride, preferably sodium borohydride) is used as a reducing agent. The pharmaceutically active erythro form is obtained in larger quantities than the threo form.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10068578A JPS5951940B2 (en) | 1978-08-18 | 1978-08-18 | Method for producing piperidinoalkanols |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10068578A JPS5951940B2 (en) | 1978-08-18 | 1978-08-18 | Method for producing piperidinoalkanols |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1877583A Division JPS591467A (en) | 1983-02-09 | 1983-02-09 | Piperidinoalkanones, its salt and their preparation |
JP1877483A Division JPS591466A (en) | 1983-02-09 | 1983-02-09 | Production of piperidinoalkanols |
JP10171684A Division JPS601165A (en) | 1984-05-22 | 1984-05-22 | Piperidinoalkanol compound |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5528903A true JPS5528903A (en) | 1980-02-29 |
JPS5951940B2 JPS5951940B2 (en) | 1984-12-17 |
Family
ID=14280585
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10068578A Expired JPS5951940B2 (en) | 1978-08-18 | 1978-08-18 | Method for producing piperidinoalkanols |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5951940B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57106662A (en) * | 1980-12-24 | 1982-07-02 | Grelan Pharmaceut Co Ltd | Preparation of erythro 2-(4-benzylpiperidino)-1-(4- hydroxyphenyl)propanol |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0352246Y2 (en) * | 1985-08-26 | 1991-11-12 |
-
1978
- 1978-08-18 JP JP10068578A patent/JPS5951940B2/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57106662A (en) * | 1980-12-24 | 1982-07-02 | Grelan Pharmaceut Co Ltd | Preparation of erythro 2-(4-benzylpiperidino)-1-(4- hydroxyphenyl)propanol |
JPS6366313B2 (en) * | 1980-12-24 | 1988-12-20 | Grelan Pharmaceutical Co |
Also Published As
Publication number | Publication date |
---|---|
JPS5951940B2 (en) | 1984-12-17 |
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