JPS5528903A - Preparation of piperidinoalkanol - Google Patents

Preparation of piperidinoalkanol

Info

Publication number
JPS5528903A
JPS5528903A JP10068578A JP10068578A JPS5528903A JP S5528903 A JPS5528903 A JP S5528903A JP 10068578 A JP10068578 A JP 10068578A JP 10068578 A JP10068578 A JP 10068578A JP S5528903 A JPS5528903 A JP S5528903A
Authority
JP
Japan
Prior art keywords
agent
piperidinoalkanol
benzylpiperidino
benzyloxyphenyl
propan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10068578A
Other languages
Japanese (ja)
Other versions
JPS5951940B2 (en
Inventor
Kazuo Kikazawa
Mineji Hiiragi
Nagatoshi Azuma
Toshitaka Kohagisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Grelan Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grelan Pharmaceutical Co Ltd filed Critical Grelan Pharmaceutical Co Ltd
Priority to JP10068578A priority Critical patent/JPS5951940B2/en
Publication of JPS5528903A publication Critical patent/JPS5528903A/en
Publication of JPS5951940B2 publication Critical patent/JPS5951940B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain piperidinoalkanol, etc, useful as an agent for circulatory system treating such as an agent for cerebral embolism sequela, or apoplexy sequela, etc., easily in high yield, by reducing a piperidinoalkanone in the presence of a metal hydride as a reducing agent.
CONSTITUTION: 1-(p-Hydroxy or benzyloxyphenyl)-2-(4-benzylpiperidino) propan- 1-one, of formula I (R is H or benzyl), is reduced to give 1-(para-hydroxy or benzyloxyphenyl)-2-(4-benzylpiperidino) propan-1-ol of formula II. A metal hydride (e.g. lithium alminum hydride, preferably sodium borohydride) is used as a reducing agent. The pharmaceutically active erythro form is obtained in larger quantities than the threo form.
COPYRIGHT: (C)1980,JPO&Japio
JP10068578A 1978-08-18 1978-08-18 Method for producing piperidinoalkanols Expired JPS5951940B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10068578A JPS5951940B2 (en) 1978-08-18 1978-08-18 Method for producing piperidinoalkanols

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10068578A JPS5951940B2 (en) 1978-08-18 1978-08-18 Method for producing piperidinoalkanols

Related Child Applications (3)

Application Number Title Priority Date Filing Date
JP1877583A Division JPS591467A (en) 1983-02-09 1983-02-09 Piperidinoalkanones, its salt and their preparation
JP1877483A Division JPS591466A (en) 1983-02-09 1983-02-09 Production of piperidinoalkanols
JP10171684A Division JPS601165A (en) 1984-05-22 1984-05-22 Piperidinoalkanol compound

Publications (2)

Publication Number Publication Date
JPS5528903A true JPS5528903A (en) 1980-02-29
JPS5951940B2 JPS5951940B2 (en) 1984-12-17

Family

ID=14280585

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10068578A Expired JPS5951940B2 (en) 1978-08-18 1978-08-18 Method for producing piperidinoalkanols

Country Status (1)

Country Link
JP (1) JPS5951940B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57106662A (en) * 1980-12-24 1982-07-02 Grelan Pharmaceut Co Ltd Preparation of erythro 2-(4-benzylpiperidino)-1-(4- hydroxyphenyl)propanol

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0352246Y2 (en) * 1985-08-26 1991-11-12

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57106662A (en) * 1980-12-24 1982-07-02 Grelan Pharmaceut Co Ltd Preparation of erythro 2-(4-benzylpiperidino)-1-(4- hydroxyphenyl)propanol
JPS6366313B2 (en) * 1980-12-24 1988-12-20 Grelan Pharmaceutical Co

Also Published As

Publication number Publication date
JPS5951940B2 (en) 1984-12-17

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