JPS5527116A - Preparation of organic sulfur compound - Google Patents
Preparation of organic sulfur compoundInfo
- Publication number
- JPS5527116A JPS5527116A JP9863878A JP9863878A JPS5527116A JP S5527116 A JPS5527116 A JP S5527116A JP 9863878 A JP9863878 A JP 9863878A JP 9863878 A JP9863878 A JP 9863878A JP S5527116 A JPS5527116 A JP S5527116A
- Authority
- JP
- Japan
- Prior art keywords
- halogen
- reagent
- compound
- sulfur
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare an organic sulfur compound, easily, in high yield, without emitting ill odor, by the direct reaction of an organic compound having an eliminable halogen group with a mercapto-introducing reagent comprising a nucleophilic reagent obtained from a Grignard reagent and sulfur.
CONSTITUTION: The objective compound is prepared by reacting (A) a nuclephilic reagent prepared by the reaction of a Grignard reagent of formula RMgX (R is aliphatic, aromatic, araliphatic group; X is halogen) with sulfur, with (B) an organic compound having an eliminable halogen atom (e.g. halogen-substituted hydrocarbon carboxylic acid, etc.), thereby substituting the halogen atom with the aliphatic, aromatic or araliphatic mercapto group. The objective compound is, e.g. 3-(p-tolythio)-propionic acid.
EFFECT: Non-irritant to the skin. Harmless to working environment and the health of workers.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9863878A JPS5527116A (en) | 1978-08-15 | 1978-08-15 | Preparation of organic sulfur compound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9863878A JPS5527116A (en) | 1978-08-15 | 1978-08-15 | Preparation of organic sulfur compound |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5527116A true JPS5527116A (en) | 1980-02-27 |
Family
ID=14225042
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9863878A Pending JPS5527116A (en) | 1978-08-15 | 1978-08-15 | Preparation of organic sulfur compound |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5527116A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0780386A1 (en) * | 1995-12-20 | 1997-06-25 | F. Hoffmann-La Roche Ag | Matrix metalloprotease inhibitors |
CN106146233A (en) * | 2016-06-24 | 2016-11-23 | 嘉兴学院 | A kind of preparation method of (Z) 2 alkyl 3 pi-allyl sulfenyl 3 aryl allyl alcohol compounds |
CN111302993A (en) * | 2018-12-12 | 2020-06-19 | 新发药业有限公司 | Preparation method of 4-phenylmercaptothiophenol |
-
1978
- 1978-08-15 JP JP9863878A patent/JPS5527116A/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0780386A1 (en) * | 1995-12-20 | 1997-06-25 | F. Hoffmann-La Roche Ag | Matrix metalloprotease inhibitors |
CN106146233A (en) * | 2016-06-24 | 2016-11-23 | 嘉兴学院 | A kind of preparation method of (Z) 2 alkyl 3 pi-allyl sulfenyl 3 aryl allyl alcohol compounds |
CN111302993A (en) * | 2018-12-12 | 2020-06-19 | 新发药业有限公司 | Preparation method of 4-phenylmercaptothiophenol |
CN111302993B (en) * | 2018-12-12 | 2022-10-21 | 新发药业有限公司 | Preparation method of 4-phenylmercaptothiophenol |
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