JPS5522619A - Preparation of polypeptide - Google Patents
Preparation of polypeptideInfo
- Publication number
- JPS5522619A JPS5522619A JP9492278A JP9492278A JPS5522619A JP S5522619 A JPS5522619 A JP S5522619A JP 9492278 A JP9492278 A JP 9492278A JP 9492278 A JP9492278 A JP 9492278A JP S5522619 A JPS5522619 A JP S5522619A
- Authority
- JP
- Japan
- Prior art keywords
- protecting group
- reacted
- formula
- polypeptide
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain a polypeptide usable for medicines having a morphineagonistic activity and analgesic action at a low cost in large quantities, by condensing a tetradecapeptide having improved solubility in solvents and most suitable for liquid- phase method, with a penta peptide.
CONSTITUTION: A pentapeptide of formula I: (the amino acid configuration 1W5 has a pharmacological action per se) having a protecting group is reacted with a decapeptide of formula II having a protecting group by fragment condensation, and the protecting group of the nonadecapeptide thus obtained is eliminated to form the desired peptide of formulaIII. Preferably, the raw material is dissolved in a solvent, e.g. dimethyl formamide, and reacted with nitrous acid to give an azide.
EFFECT: High purity and yield with completely suppressed racemization.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9492278A JPS5522619A (en) | 1978-08-03 | 1978-08-03 | Preparation of polypeptide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9492278A JPS5522619A (en) | 1978-08-03 | 1978-08-03 | Preparation of polypeptide |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5522619A true JPS5522619A (en) | 1980-02-18 |
JPS6126919B2 JPS6126919B2 (en) | 1986-06-23 |
Family
ID=14123465
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9492278A Granted JPS5522619A (en) | 1978-08-03 | 1978-08-03 | Preparation of polypeptide |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5522619A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57132038U (en) * | 1981-02-13 | 1982-08-17 |
-
1978
- 1978-08-03 JP JP9492278A patent/JPS5522619A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57132038U (en) * | 1981-02-13 | 1982-08-17 |
Also Published As
Publication number | Publication date |
---|---|
JPS6126919B2 (en) | 1986-06-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US4005063A (en) | [Des-gly]10 -GnRH nonapeptide anide analogs in position 6 having ovulation-inducing activity | |
US3862925A (en) | Preparation of somatotropin release inhibiting factor and intermediates therefor | |
SU1470199A3 (en) | Method of producing peptides of their acid-additive salts | |
US4431635A (en) | LH-RH Antagonists | |
FUJINO et al. | A new procedure for the pentachlorophenylation of N-protected amino acids | |
US3917578A (en) | Process for producing somatostatin and intermediates | |
US4337194A (en) | Process for the preparation of somatostatin | |
Schneider et al. | Synthesis of D-leucine-oxytocin, a biologically active diastereoisomer of oxytocin, and demonstration of its separability from oxytocin upon countercurrent distribution | |
JPS5657753A (en) | Novel glucagon fragment, and its use | |
DK149091C (en) | METHOD OF ANALOGUE FOR THE PREPARATION OF PEPTIDS CONTAINING 2-7 AMINO ACID RESIDUES, DESAMINODIPEPTIDES OR AMIDES THEREOF WITH UBIQUITIN SIMILAR ACTIVITY OR PHARMACEUTICAL ACCEPTABLE ACID ADDITIONAL SALTS | |
JPS5522619A (en) | Preparation of polypeptide | |
SE469032B (en) | GONADOLIBER INGREDIENTS AND PHARMACEUTICAL COMPOSITION CONTAINING THESE | |
EP0001449B1 (en) | Analogues of somatostatin, pharmaceutical compositions containing them and their preparation | |
DE2726276A1 (en) | POLYPEPTIDE | |
US3853834A (en) | 4-alanine lh-rh analog | |
US3888836A (en) | Pentapeptide intermediate of lhrh and derivatives thereof | |
JPS55145665A (en) | Agent for forming active ester of amino acid | |
CH422813A (en) | Process for the production of new polypeptides | |
Havran et al. | Oxytocin analogs with basic amino acid residues in positions 4 and 5. Synthesis and pharmacological properties of [4-ornithine]-and [5-ornithine]-oxytocin | |
JPS5484570A (en) | Preparation of polypeptide | |
US3790554A (en) | Heptapeptide intermediate to gonadotropin-releasing hormone | |
Walter et al. | 8-Alanine-oxytocin, 8-alanine-oxypressin, and their deamino analogs. Their synthesis and some of their pharmacological properties | |
Flouret et al. | Synthesis and some pharmacological activities of 4-L-norvaline-oxytocin and 4-L-norleucine-oxytocin and their deamino analogs | |
Wieland et al. | 4Phe-(6) Val-antamanide, an antitoxic cyclodecapeptide with C (2) symmetry. | |
Walter et al. | 5-Valine-oxytocin and 1-Deamino-5-valine-oxytocin: SYNTHESES AND SOME PHARMACOLOGICAL PROPERTIES |