JPS5522619A - Preparation of polypeptide - Google Patents

Preparation of polypeptide

Info

Publication number
JPS5522619A
JPS5522619A JP9492278A JP9492278A JPS5522619A JP S5522619 A JPS5522619 A JP S5522619A JP 9492278 A JP9492278 A JP 9492278A JP 9492278 A JP9492278 A JP 9492278A JP S5522619 A JPS5522619 A JP S5522619A
Authority
JP
Japan
Prior art keywords
protecting group
reacted
formula
polypeptide
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9492278A
Other languages
Japanese (ja)
Other versions
JPS6126919B2 (en
Inventor
Osamu Nagase
Minoru Kubota
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP9492278A priority Critical patent/JPS5522619A/en
Publication of JPS5522619A publication Critical patent/JPS5522619A/en
Publication of JPS6126919B2 publication Critical patent/JPS6126919B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain a polypeptide usable for medicines having a morphineagonistic activity and analgesic action at a low cost in large quantities, by condensing a tetradecapeptide having improved solubility in solvents and most suitable for liquid- phase method, with a penta peptide.
CONSTITUTION: A pentapeptide of formula I: (the amino acid configuration 1W5 has a pharmacological action per se) having a protecting group is reacted with a decapeptide of formula II having a protecting group by fragment condensation, and the protecting group of the nonadecapeptide thus obtained is eliminated to form the desired peptide of formulaIII. Preferably, the raw material is dissolved in a solvent, e.g. dimethyl formamide, and reacted with nitrous acid to give an azide.
EFFECT: High purity and yield with completely suppressed racemization.
COPYRIGHT: (C)1980,JPO&Japio
JP9492278A 1978-08-03 1978-08-03 Preparation of polypeptide Granted JPS5522619A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9492278A JPS5522619A (en) 1978-08-03 1978-08-03 Preparation of polypeptide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9492278A JPS5522619A (en) 1978-08-03 1978-08-03 Preparation of polypeptide

Publications (2)

Publication Number Publication Date
JPS5522619A true JPS5522619A (en) 1980-02-18
JPS6126919B2 JPS6126919B2 (en) 1986-06-23

Family

ID=14123465

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9492278A Granted JPS5522619A (en) 1978-08-03 1978-08-03 Preparation of polypeptide

Country Status (1)

Country Link
JP (1) JPS5522619A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57132038U (en) * 1981-02-13 1982-08-17

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57132038U (en) * 1981-02-13 1982-08-17

Also Published As

Publication number Publication date
JPS6126919B2 (en) 1986-06-23

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