JPS55147299A - 6"-deoxyamikacin or 4",6"-dideoxyamikacin, and their preparation - Google Patents

6"-deoxyamikacin or 4",6"-dideoxyamikacin, and their preparation

Info

Publication number
JPS55147299A
JPS55147299A JP5473379A JP5473379A JPS55147299A JP S55147299 A JPS55147299 A JP S55147299A JP 5473379 A JP5473379 A JP 5473379A JP 5473379 A JP5473379 A JP 5473379A JP S55147299 A JPS55147299 A JP S55147299A
Authority
JP
Japan
Prior art keywords
groups
protecting
protecting group
positions
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5473379A
Other languages
Japanese (ja)
Inventor
Hamao Umezawa
Shinichi Kondo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP5473379A priority Critical patent/JPS55147299A/en
Publication of JPS55147299A publication Critical patent/JPS55147299A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An amikacin derivative of formula I (R is OH or H) and its acid addition salt.
USE: Remedy for bacterial infectious diseases, causing little damages to the faculty of hearing.
PROCESS: The objective compound of formula I wherein R is H is prepared e.g. by (1) protecting the four NH2 groups of amikacin of formula II with amino-protecting groups, (2) protecting the two OH groups with one bivalent OH-protecting group, (3) protecting the remaining five OH groups at 2', 3', 4', 2", and 2''' positions or six OH groups at 5, 2', 3', 4', 2", and 2''' positions, with one OH-protecting group, (4) eliminating the OH-protecting groups at the 4" and 6" positions to obtain a compound of fomula III (A is H; B is monovalent amino-protecting group, etc.; D is acyl-type OH-protecting group; E is H or acyl-type OH-protecting group), (5) converting the 6" OH group or 4" and 6" OH groups to sulfonic acid ester, (6) iodizing the product, and (7) eliminating the iodine by catalytic reduction.
COPYRIGHT: (C)1980,JPO&Japio
JP5473379A 1979-05-07 1979-05-07 6"-deoxyamikacin or 4",6"-dideoxyamikacin, and their preparation Pending JPS55147299A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5473379A JPS55147299A (en) 1979-05-07 1979-05-07 6"-deoxyamikacin or 4",6"-dideoxyamikacin, and their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5473379A JPS55147299A (en) 1979-05-07 1979-05-07 6"-deoxyamikacin or 4",6"-dideoxyamikacin, and their preparation

Publications (1)

Publication Number Publication Date
JPS55147299A true JPS55147299A (en) 1980-11-17

Family

ID=12978990

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5473379A Pending JPS55147299A (en) 1979-05-07 1979-05-07 6"-deoxyamikacin or 4",6"-dideoxyamikacin, and their preparation

Country Status (1)

Country Link
JP (1) JPS55147299A (en)

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