JPS55130948A - Asymmetric hydrogenation of alpha-aminoacrylic acid derivative - Google Patents
Asymmetric hydrogenation of alpha-aminoacrylic acid derivativeInfo
- Publication number
- JPS55130948A JPS55130948A JP3711679A JP3711679A JPS55130948A JP S55130948 A JPS55130948 A JP S55130948A JP 3711679 A JP3711679 A JP 3711679A JP 3711679 A JP3711679 A JP 3711679A JP S55130948 A JPS55130948 A JP S55130948A
- Authority
- JP
- Japan
- Prior art keywords
- acid derivative
- asymmetric hydrogenation
- aryl
- alkyl
- aminoacrylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Abstract
PURPOSE: To prepare an optically active α-amino acid having high optical purity, easily, in high yield, by the asymmetric hydrogenation of an α-aminoacrylic acid derivative in the presence of a specific cationic rhodium complex as a catalyst.
CONSTITUTION: An α-aminoacrylic acid derivative of formula I (R1,3 are H, alkyl, or aryl; R2 is alkyl or aryl) is subjected to the asymmetric hydrogenation reaction with hydrogen gas (0.5W3atm partial pressure), in the presence of a cationic rhodium complex catalyst of formula II (R4 is H, alkyl, aryl or alkoxy; X- is inorganic anion), in a solvent such as alcohol, ether, etc., at -20W+50°C, pref. at room temp. Addition of an amine such as triethylamine to the reaction system further improves the optical purity of the product.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3711679A JPS55130948A (en) | 1979-03-30 | 1979-03-30 | Asymmetric hydrogenation of alpha-aminoacrylic acid derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3711679A JPS55130948A (en) | 1979-03-30 | 1979-03-30 | Asymmetric hydrogenation of alpha-aminoacrylic acid derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS55130948A true JPS55130948A (en) | 1980-10-11 |
Family
ID=12488619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3711679A Pending JPS55130948A (en) | 1979-03-30 | 1979-03-30 | Asymmetric hydrogenation of alpha-aminoacrylic acid derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS55130948A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005247734A (en) * | 2004-03-03 | 2005-09-15 | Otsuka Chemical Co Ltd | Method for producing optically active amino acid derivative |
| CN104496735A (en) * | 2015-01-06 | 2015-04-08 | 武汉大学 | Asymmetric catalytic method of enamine compounds |
-
1979
- 1979-03-30 JP JP3711679A patent/JPS55130948A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005247734A (en) * | 2004-03-03 | 2005-09-15 | Otsuka Chemical Co Ltd | Method for producing optically active amino acid derivative |
| JP4560309B2 (en) * | 2004-03-03 | 2010-10-13 | 大塚化学株式会社 | Method for producing optically active amino acid derivative |
| CN104496735A (en) * | 2015-01-06 | 2015-04-08 | 武汉大学 | Asymmetric catalytic method of enamine compounds |
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