JPS55129227A - Antibacterial composition - Google Patents
Antibacterial compositionInfo
- Publication number
- JPS55129227A JPS55129227A JP3722279A JP3722279A JPS55129227A JP S55129227 A JPS55129227 A JP S55129227A JP 3722279 A JP3722279 A JP 3722279A JP 3722279 A JP3722279 A JP 3722279A JP S55129227 A JPS55129227 A JP S55129227A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- piromidic acid
- trimethoprim
- piromidic
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To reduce the dose of piromidic acid, and to suppress the side effects of a piromidic acid antibacterial composition such as renal disorder as far as possible, by compounding piromidic acid with trimethoprim.
CONSTITUTION: A composition composed of (A) 1pt.wt. of piromidic acid of formula I and (B) 0.25W0.02 part of trimethoprim of formula II. Piromidic acid which is a known chemotherapeutic agent having strong antibacterial activity against gram-negative bacteria, has a disadvantage of causing side effects such as renal disorder. On the other hand, trimethoprim inhibits the metabolism of di-hydrogen folic acid to tetra-hydrogen folic acid. An excellent synergistic effect can be attained by the combined use of both compounds, which results in the reduction of the dose of piromidic acid. It can be administered as capsules or tablets.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3722279A JPS55129227A (en) | 1979-03-28 | 1979-03-28 | Antibacterial composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3722279A JPS55129227A (en) | 1979-03-28 | 1979-03-28 | Antibacterial composition |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55129227A true JPS55129227A (en) | 1980-10-06 |
Family
ID=12491557
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3722279A Pending JPS55129227A (en) | 1979-03-28 | 1979-03-28 | Antibacterial composition |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55129227A (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5522671A (en) * | 1978-07-13 | 1980-02-18 | Sigma Tau Ind Farmaceuti | Pharmacologic antibacterial |
-
1979
- 1979-03-28 JP JP3722279A patent/JPS55129227A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5522671A (en) * | 1978-07-13 | 1980-02-18 | Sigma Tau Ind Farmaceuti | Pharmacologic antibacterial |
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