JPS55120598A - Preparation of novel bleomycin-family antibiotic - Google Patents

Preparation of novel bleomycin-family antibiotic

Info

Publication number
JPS55120598A
JPS55120598A JP2455579A JP2455579A JPS55120598A JP S55120598 A JPS55120598 A JP S55120598A JP 2455579 A JP2455579 A JP 2455579A JP 2455579 A JP2455579 A JP 2455579A JP S55120598 A JPS55120598 A JP S55120598A
Authority
JP
Japan
Prior art keywords
bleomycin
formula
partial structure
family
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2455579A
Other languages
Japanese (ja)
Other versions
JPS6260399B2 (en
Inventor
Akio Fujii
Yasuhiko Muraoka
Takeyo Fukuoka
Tomohisa Takita
Hamao Umezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Priority to JP2455579A priority Critical patent/JPS55120598A/en
Priority to GB8006894A priority patent/GB2044262B/en
Priority to US06/126,123 priority patent/US4267102A/en
Priority to FR8004779A priority patent/FR2450843A1/en
Priority to DE19803008359 priority patent/DE3008359A1/en
Publication of JPS55120598A publication Critical patent/JPS55120598A/en
Publication of JPS6260399B2 publication Critical patent/JPS6260399B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:Bleomycin-family antibiotics having a partial structure of formula I.
EXAMPLE: 3-[(S)-1'-phenylethylamino]propylamino-N-methylbleomycin.
USE: Anti-tumor antibiotics inert to inactivating enzyme. Especially, carcinostatic agents for squamous cell carcinoma of the head or neck.
PROCESS: The antibiotic substance having a partial structure of formula I is prepared by subjecting a bleomycin-family antibiotic substance to reductive methylation reaction using, e.g. sodium cyanoborohydride as a reducing agent, thereby methylating the primary amine of the partial structure of formula II.
COPYRIGHT: (C)1980,JPO&Japio
JP2455579A 1979-03-05 1979-03-05 Preparation of novel bleomycin-family antibiotic Granted JPS55120598A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2455579A JPS55120598A (en) 1979-03-05 1979-03-05 Preparation of novel bleomycin-family antibiotic
GB8006894A GB2044262B (en) 1979-03-05 1980-02-29 Bleomycin group antibiotics
US06/126,123 US4267102A (en) 1979-03-05 1980-02-29 Bleomycin group antibiotics
FR8004779A FR2450843A1 (en) 1979-03-05 1980-03-04 N-METHYLBLEOMYCINS AND THEIR THERAPEUTIC APPLICATION
DE19803008359 DE3008359A1 (en) 1979-03-05 1980-03-05 N-METHYLBLEOMYCIN ANTIBIOTICS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2455579A JPS55120598A (en) 1979-03-05 1979-03-05 Preparation of novel bleomycin-family antibiotic

Publications (2)

Publication Number Publication Date
JPS55120598A true JPS55120598A (en) 1980-09-17
JPS6260399B2 JPS6260399B2 (en) 1987-12-16

Family

ID=12141394

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2455579A Granted JPS55120598A (en) 1979-03-05 1979-03-05 Preparation of novel bleomycin-family antibiotic

Country Status (1)

Country Link
JP (1) JPS55120598A (en)

Also Published As

Publication number Publication date
JPS6260399B2 (en) 1987-12-16

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