Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co LtdfiledCriticalNippon Kayaku Co Ltd
Priority to JP2455579ApriorityCriticalpatent/JPS55120598A/en
Priority to GB8006894Aprioritypatent/GB2044262B/en
Priority to US06/126,123prioritypatent/US4267102A/en
Priority to FR8004779Aprioritypatent/FR2450843A1/en
Priority to DE19803008359prioritypatent/DE3008359A1/en
Publication of JPS55120598ApublicationCriticalpatent/JPS55120598A/en
Publication of JPS6260399B2publicationCriticalpatent/JPS6260399B2/ja
USE: Anti-tumor antibiotics inert to inactivating enzyme. Especially, carcinostatic agents for squamous cell carcinoma of the head or neck.
PROCESS: The antibiotic substance having a partial structure of formula I is prepared by subjecting a bleomycin-family antibiotic substance to reductive methylation reaction using, e.g. sodium cyanoborohydride as a reducing agent, thereby methylating the primary amine of the partial structure of formula II.
COPYRIGHT: (C)1980,JPO&Japio
JP2455579A1979-03-051979-03-05Preparation of novel bleomycin-family antibiotic
GrantedJPS55120598A
(en)
Compound obtained from microorganisms of the genus streptomyces, process for the preparation thereof and process for the preparation of anthelmintic and acaricidal compositions containing it