JPS55104299A - Anthracycline compounds and their preparation - Google Patents

Anthracycline compounds and their preparation

Info

Publication number
JPS55104299A
JPS55104299A JP1170279A JP1170279A JPS55104299A JP S55104299 A JPS55104299 A JP S55104299A JP 1170279 A JP1170279 A JP 1170279A JP 1170279 A JP1170279 A JP 1170279A JP S55104299 A JPS55104299 A JP S55104299A
Authority
JP
Japan
Prior art keywords
compound
reacting
tetrahydropyranyladriamycin
dissolving
adriamycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1170279A
Other languages
Japanese (ja)
Other versions
JPS5713558B2 (en
Inventor
Hamao Umezawa
Tomio Takeuchi
Hiroshi Osanawa
Kuniaki Tatsuta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP1170279A priority Critical patent/JPS55104299A/en
Priority to DK11480A priority patent/DK160616C/en
Priority to ZA00800337A priority patent/ZA80337B/en
Priority to DE8080100352T priority patent/DE3063557D1/en
Priority to EP19800100352 priority patent/EP0014853B1/en
Priority to PH23547A priority patent/PH18200A/en
Priority to AU54895/80A priority patent/AU518278B2/en
Priority to NZ19275880A priority patent/NZ192758A/en
Priority to AR27981080A priority patent/AR226694A1/en
Priority to AT0051180A priority patent/AT369384B/en
Priority to US06/117,163 priority patent/US4303785A/en
Priority to ES488209A priority patent/ES488209A0/en
Priority to CA000344911A priority patent/CA1136618A/en
Priority to FI800298A priority patent/FI68057C/en
Publication of JPS55104299A publication Critical patent/JPS55104299A/en
Publication of JPS5713558B2 publication Critical patent/JPS5713558B2/ja
Granted legal-status Critical Current

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  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:14-O-Acetyl-4'-O-tetrahydropyranyladriamycin a and b of the formula I.
USE: An antitumor agent having high carcinostatic effect and low toxicity compared with adriamycin. An intermediate of highly active, low-toxic carcinostatic agent, 4'-O-tetrahydropyranyladriamycin a and b (disclosed in the specification of Japanese Patent Application No.54-30146).
PROCESS: The title compound is prepared by (1) dissolving daunomycin of formula II in a lower alcohol or a mixed solvent containing lower alcohol, (2) reacting with bromine at room temperature, (3) dispersing the resulting 14-bromodaunomycin- dimethylketal compound in an inert solvent, (4) reacting with dried alkali acetate, (5) dissolving the resulting 14-O-acetyladriamycin compound in an aprotic polar solvent, and (6) reacting with 3,4-dihydro-2H-pyran in the presence of an acid catalyst to introduce tetrahydropyranyl group to the adriamycin compound.
COPYRIGHT: (C)1980,JPO&Japio
JP1170279A 1978-08-05 1979-02-03 Anthracycline compounds and their preparation Granted JPS55104299A (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
JP1170279A JPS55104299A (en) 1979-02-03 1979-02-03 Anthracycline compounds and their preparation
DK11480A DK160616C (en) 1979-02-03 1980-01-10 PROCEDURE FOR PREPARING ANTHRACYCLINE DERIVATIVES OR ACID ADDITIONAL SALTS THEREOF
ZA00800337A ZA80337B (en) 1979-02-03 1980-01-21 New anthracycline derivatives and a process for the preparation thereof
DE8080100352T DE3063557D1 (en) 1979-02-03 1980-01-23 Anthracycline derivatives, a process for their preparation and pharmaceutical compositions containing them
EP19800100352 EP0014853B1 (en) 1979-02-03 1980-01-23 Anthracycline derivatives, a process for their preparation and pharmaceutical compositions containing them
PH23547A PH18200A (en) 1979-02-03 1980-01-24 New anthracycline derivatives and compositions containing the same
AU54895/80A AU518278B2 (en) 1979-02-03 1980-01-24 Anthracycline derivatives
NZ19275880A NZ192758A (en) 1979-02-03 1980-01-30 Anthracycline glycosides and pharmaceutical compositions
AR27981080A AR226694A1 (en) 1979-02-03 1980-01-31 PROCEDURE FOR OBTAINING NEW ANTHRACICLINE DERIVATIVES
AT0051180A AT369384B (en) 1979-02-03 1980-01-31 METHOD FOR PRODUCING ANTHRACYCLINE DERIVATIVES
US06/117,163 US4303785A (en) 1978-08-05 1980-01-31 Antitumor anthracycline antibiotics
ES488209A ES488209A0 (en) 1979-02-03 1980-02-01 A PROCEDURE FOR THE PRODUCTION OF AN ANTI-CYCLINE DERIVATIVE
CA000344911A CA1136618A (en) 1979-02-03 1980-02-01 Antitumor anthracycline derivatives
FI800298A FI68057C (en) 1979-02-03 1980-02-01 FOERFARANDE FOER FRAMSTAELLNING AV ANTRACYKLINDERIVAT

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1170279A JPS55104299A (en) 1979-02-03 1979-02-03 Anthracycline compounds and their preparation

Publications (2)

Publication Number Publication Date
JPS55104299A true JPS55104299A (en) 1980-08-09
JPS5713558B2 JPS5713558B2 (en) 1982-03-17

Family

ID=11785368

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1170279A Granted JPS55104299A (en) 1978-08-05 1979-02-03 Anthracycline compounds and their preparation

Country Status (2)

Country Link
JP (1) JPS55104299A (en)
ZA (1) ZA80337B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5991262U (en) * 1982-12-14 1984-06-20 株式会社東芝 Elevator car operation panel
JPH02239080A (en) * 1989-03-13 1990-09-21 Mitsubishi Electric Corp Elevator position indicator

Also Published As

Publication number Publication date
ZA80337B (en) 1981-01-28
JPS5713558B2 (en) 1982-03-17

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