JPS55104299A - Anthracycline compounds and their preparation - Google Patents
Anthracycline compounds and their preparationInfo
- Publication number
- JPS55104299A JPS55104299A JP1170279A JP1170279A JPS55104299A JP S55104299 A JPS55104299 A JP S55104299A JP 1170279 A JP1170279 A JP 1170279A JP 1170279 A JP1170279 A JP 1170279A JP S55104299 A JPS55104299 A JP S55104299A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- reacting
- tetrahydropyranyladriamycin
- dissolving
- adriamycin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:14-O-Acetyl-4'-O-tetrahydropyranyladriamycin a and b of the formula I.
USE: An antitumor agent having high carcinostatic effect and low toxicity compared with adriamycin. An intermediate of highly active, low-toxic carcinostatic agent, 4'-O-tetrahydropyranyladriamycin a and b (disclosed in the specification of Japanese Patent Application No.54-30146).
PROCESS: The title compound is prepared by (1) dissolving daunomycin of formula II in a lower alcohol or a mixed solvent containing lower alcohol, (2) reacting with bromine at room temperature, (3) dispersing the resulting 14-bromodaunomycin- dimethylketal compound in an inert solvent, (4) reacting with dried alkali acetate, (5) dissolving the resulting 14-O-acetyladriamycin compound in an aprotic polar solvent, and (6) reacting with 3,4-dihydro-2H-pyran in the presence of an acid catalyst to introduce tetrahydropyranyl group to the adriamycin compound.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1170279A JPS55104299A (en) | 1979-02-03 | 1979-02-03 | Anthracycline compounds and their preparation |
DK11480A DK160616C (en) | 1979-02-03 | 1980-01-10 | PROCEDURE FOR PREPARING ANTHRACYCLINE DERIVATIVES OR ACID ADDITIONAL SALTS THEREOF |
ZA00800337A ZA80337B (en) | 1979-02-03 | 1980-01-21 | New anthracycline derivatives and a process for the preparation thereof |
DE8080100352T DE3063557D1 (en) | 1979-02-03 | 1980-01-23 | Anthracycline derivatives, a process for their preparation and pharmaceutical compositions containing them |
EP19800100352 EP0014853B1 (en) | 1979-02-03 | 1980-01-23 | Anthracycline derivatives, a process for their preparation and pharmaceutical compositions containing them |
PH23547A PH18200A (en) | 1979-02-03 | 1980-01-24 | New anthracycline derivatives and compositions containing the same |
AU54895/80A AU518278B2 (en) | 1979-02-03 | 1980-01-24 | Anthracycline derivatives |
NZ19275880A NZ192758A (en) | 1979-02-03 | 1980-01-30 | Anthracycline glycosides and pharmaceutical compositions |
AR27981080A AR226694A1 (en) | 1979-02-03 | 1980-01-31 | PROCEDURE FOR OBTAINING NEW ANTHRACICLINE DERIVATIVES |
AT0051180A AT369384B (en) | 1979-02-03 | 1980-01-31 | METHOD FOR PRODUCING ANTHRACYCLINE DERIVATIVES |
US06/117,163 US4303785A (en) | 1978-08-05 | 1980-01-31 | Antitumor anthracycline antibiotics |
ES488209A ES488209A0 (en) | 1979-02-03 | 1980-02-01 | A PROCEDURE FOR THE PRODUCTION OF AN ANTI-CYCLINE DERIVATIVE |
CA000344911A CA1136618A (en) | 1979-02-03 | 1980-02-01 | Antitumor anthracycline derivatives |
FI800298A FI68057C (en) | 1979-02-03 | 1980-02-01 | FOERFARANDE FOER FRAMSTAELLNING AV ANTRACYKLINDERIVAT |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1170279A JPS55104299A (en) | 1979-02-03 | 1979-02-03 | Anthracycline compounds and their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55104299A true JPS55104299A (en) | 1980-08-09 |
JPS5713558B2 JPS5713558B2 (en) | 1982-03-17 |
Family
ID=11785368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1170279A Granted JPS55104299A (en) | 1978-08-05 | 1979-02-03 | Anthracycline compounds and their preparation |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPS55104299A (en) |
ZA (1) | ZA80337B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5991262U (en) * | 1982-12-14 | 1984-06-20 | 株式会社東芝 | Elevator car operation panel |
JPH02239080A (en) * | 1989-03-13 | 1990-09-21 | Mitsubishi Electric Corp | Elevator position indicator |
-
1979
- 1979-02-03 JP JP1170279A patent/JPS55104299A/en active Granted
-
1980
- 1980-01-21 ZA ZA00800337A patent/ZA80337B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA80337B (en) | 1981-01-28 |
JPS5713558B2 (en) | 1982-03-17 |
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