JPS5495721A - Nifedipine preparation - Google Patents

Nifedipine preparation

Info

Publication number
JPS5495721A
JPS5495721A JP111778A JP111778A JPS5495721A JP S5495721 A JPS5495721 A JP S5495721A JP 111778 A JP111778 A JP 111778A JP 111778 A JP111778 A JP 111778A JP S5495721 A JPS5495721 A JP S5495721A
Authority
JP
Japan
Prior art keywords
nifedipine
glycerine
mixture
dimethyl
propylene glycol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP111778A
Other languages
Japanese (ja)
Other versions
JPS612046B2 (en
Inventor
Masato Satake
Takashi Terada
Koichi Yoshida
Yasuhiko Furuta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Priority to JP111778A priority Critical patent/JPS5495721A/en
Publication of JPS5495721A publication Critical patent/JPS5495721A/en
Publication of JPS612046B2 publication Critical patent/JPS612046B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To provide a rapid-acting nifedipine preparation which produces precipitate in water, by dissolving nifedipine which is a coronary vessel dilator, in a mixture of polyoxyethylene derivative, glycerine, and propylene glycol.
CONSTITUTION: One part of dimethyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)- 3,5-pyridine dicarboxylate (nifedipine) is added to 20-40 parts of a mixture composed of 10-90% of a polyoxyethylene derivative, pref. having an HLB of 10-20, e.g. polyoxyethylene hardened castor oil derivative, and 90-10% of glycerine or a mixture of glycerine and propylene glycol, and slowly heated to 60-70°C to obtain a clear liquid. The liquid thus obtained is used as it is, or, if necessary, encapsulated with soft carsule or hard capsule, or absorbed to hydrous or anhydrous silicic acid.
COPYRIGHT: (C)1979,JPO&Japio
JP111778A 1978-01-11 1978-01-11 Nifedipine preparation Granted JPS5495721A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP111778A JPS5495721A (en) 1978-01-11 1978-01-11 Nifedipine preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP111778A JPS5495721A (en) 1978-01-11 1978-01-11 Nifedipine preparation

Publications (2)

Publication Number Publication Date
JPS5495721A true JPS5495721A (en) 1979-07-28
JPS612046B2 JPS612046B2 (en) 1986-01-22

Family

ID=11492506

Family Applications (1)

Application Number Title Priority Date Filing Date
JP111778A Granted JPS5495721A (en) 1978-01-11 1978-01-11 Nifedipine preparation

Country Status (1)

Country Link
JP (1) JPS5495721A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5777626A (en) * 1980-06-25 1982-05-15 Procter & Gamble Palatable composition containing oil or oily substance
JPS62242613A (en) * 1986-04-11 1987-10-23 アクチエボラゲツト・ヘツスレ Slow release novel medicine
EP0277459A2 (en) * 1987-02-02 1988-08-10 Mepha AG Sustained release drug
WO2003094897A1 (en) 2002-05-09 2003-11-20 Chugai Seiyaku Kabushiki Kaisha Photostabilized soft capsule

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5777626A (en) * 1980-06-25 1982-05-15 Procter & Gamble Palatable composition containing oil or oily substance
JPH049768B2 (en) * 1980-06-25 1992-02-21
JPS62242613A (en) * 1986-04-11 1987-10-23 アクチエボラゲツト・ヘツスレ Slow release novel medicine
EP0277459A2 (en) * 1987-02-02 1988-08-10 Mepha AG Sustained release drug
WO2003094897A1 (en) 2002-05-09 2003-11-20 Chugai Seiyaku Kabushiki Kaisha Photostabilized soft capsule

Also Published As

Publication number Publication date
JPS612046B2 (en) 1986-01-22

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