JPS5495561A - Acylated pyrrole derivative and its preparation - Google Patents
Acylated pyrrole derivative and its preparationInfo
- Publication number
- JPS5495561A JPS5495561A JP80178A JP80178A JPS5495561A JP S5495561 A JPS5495561 A JP S5495561A JP 80178 A JP80178 A JP 80178A JP 80178 A JP80178 A JP 80178A JP S5495561 A JPS5495561 A JP S5495561A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- preparation
- acylated
- acyl
- pyrrole derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Acylated pyrrole derivatives of formula I (R1 is lower alkyl; R2 is H or lower alkyl; R3 is H or 2 - 10C acyl; Ar is 5 or 6 membered monoaromatic ring).
EXAMPLE: 2-]3-Benzoyl-2,5-dimethylpyrrole-1]-1-propanol.
USE: Analgesics, antiflammatory agents, antithrombotic agents, and antiarteriosclerosis.
PREPARATION: The condensation reaction of a pyrrole derivative of formula II (R31 is H or 2 - 10C acyl) with an acylating agent selected from the groups consisting of aromatic carboxylic acids, acid halides and anhydrides is effected in the presence of an acidic catalyst as sulfuric or Lewis acid, when necessary, followed by hydrolysis to prepare an acylated pyrrole of formula I.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP80178A JPS5495561A (en) | 1978-01-10 | 1978-01-10 | Acylated pyrrole derivative and its preparation |
US05/966,050 US4233309A (en) | 1977-12-06 | 1978-12-04 | Novel 1-substituted-3-acylpyrrole derivatives, platelet aggregation inhibitors containing them, as active ingredients, and processes for production of said derivatives |
EP78300757A EP0002392A3 (en) | 1977-12-06 | 1978-12-06 | 1-substituted-3-acylpyrrole derivatives, process for their preparation and platelet aggregation inhibiting agents containing them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP80178A JPS5495561A (en) | 1978-01-10 | 1978-01-10 | Acylated pyrrole derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5495561A true JPS5495561A (en) | 1979-07-28 |
Family
ID=11483779
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP80178A Pending JPS5495561A (en) | 1977-12-06 | 1978-01-10 | Acylated pyrrole derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5495561A (en) |
-
1978
- 1978-01-10 JP JP80178A patent/JPS5495561A/en active Pending
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