JPS5490179A - Antibiotic pseudomonic acid derivative and its preparation - Google Patents

Antibiotic pseudomonic acid derivative and its preparation

Info

Publication number
JPS5490179A
JPS5490179A JP16081177A JP16081177A JPS5490179A JP S5490179 A JPS5490179 A JP S5490179A JP 16081177 A JP16081177 A JP 16081177A JP 16081177 A JP16081177 A JP 16081177A JP S5490179 A JPS5490179 A JP S5490179A
Authority
JP
Japan
Prior art keywords
salt
formula
acid
pseudomonic acid
antibiotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16081177A
Other languages
Japanese (ja)
Other versions
JPS603311B2 (en
Inventor
Tomohiko Munakata
Takanori Oe
Mineo Tsuruta
Katsuyoshi Iimori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Priority to JP52160811A priority Critical patent/JPS603311B2/en
Publication of JPS5490179A publication Critical patent/JPS5490179A/en
Publication of JPS603311B2 publication Critical patent/JPS603311B2/en
Expired legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An antibiotic pseudomonic acid of the formula or its salt.
USE: Antibacterials, having a powerful effect on Gram-positive bacteria, e.g. Staphylococcus aureus, Streptococcus pyogenes, and also effective for penicillin- or macroleide-resistant bacteria with a long duration. Useful for treatment of microbisms of men and animals.
PROCESS: A well-known antibiotic pseudomonic acid or its reactive derivative, e.g. alkyl ester, such as methyl ester, acid halide, acid anhydride, mixed acid anhydride, is reacted with hydroxylamine in a solvent, e.g. tetrahydrofuran or ethyl acetate, at a temperature of preferably -50°C to room temperature to give the objective compound of the formula. An inorganic salt, e.g. sodium, potassium, or aluminum salt, is preferably used as the salt of formula.
COPYRIGHT: (C)1979,JPO&Japio
JP52160811A 1977-12-27 1977-12-27 Antibiotic pseudomonic acid derivatives and their production method Expired JPS603311B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP52160811A JPS603311B2 (en) 1977-12-27 1977-12-27 Antibiotic pseudomonic acid derivatives and their production method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP52160811A JPS603311B2 (en) 1977-12-27 1977-12-27 Antibiotic pseudomonic acid derivatives and their production method

Publications (2)

Publication Number Publication Date
JPS5490179A true JPS5490179A (en) 1979-07-17
JPS603311B2 JPS603311B2 (en) 1985-01-26

Family

ID=15722930

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52160811A Expired JPS603311B2 (en) 1977-12-27 1977-12-27 Antibiotic pseudomonic acid derivatives and their production method

Country Status (1)

Country Link
JP (1) JPS603311B2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5292892A (en) * 1991-05-07 1994-03-08 Sankyo Company, Limited Anti-bacterial compound and pharmaceutical compositions thereof
US5380723A (en) * 1991-10-07 1995-01-10 Nisshin Flour Milling Co., Ltd. Indole derivatives
US5399711A (en) * 1992-09-18 1995-03-21 Sankyo Company, Limited Thiomarinol compounds
JP2019073676A (en) * 2017-05-25 2019-05-16 三菱ケミカル株式会社 Epoxy resin, epoxy resin-containing composition, and cured product thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5292892A (en) * 1991-05-07 1994-03-08 Sankyo Company, Limited Anti-bacterial compound and pharmaceutical compositions thereof
US5405762A (en) * 1991-05-07 1995-04-11 Sankyo Company, Limited Culture of alteromonas and process of using the same to produce an antibacterial compound
US5380723A (en) * 1991-10-07 1995-01-10 Nisshin Flour Milling Co., Ltd. Indole derivatives
US5399711A (en) * 1992-09-18 1995-03-21 Sankyo Company, Limited Thiomarinol compounds
JP2019073676A (en) * 2017-05-25 2019-05-16 三菱ケミカル株式会社 Epoxy resin, epoxy resin-containing composition, and cured product thereof

Also Published As

Publication number Publication date
JPS603311B2 (en) 1985-01-26

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