JPS5459295A - Antibiotic ps-6, its derivative and their preparation - Google Patents
Antibiotic ps-6, its derivative and their preparationInfo
- Publication number
- JPS5459295A JPS5459295A JP12185777A JP12185777A JPS5459295A JP S5459295 A JPS5459295 A JP S5459295A JP 12185777 A JP12185777 A JP 12185777A JP 12185777 A JP12185777 A JP 12185777A JP S5459295 A JPS5459295 A JP S5459295A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- antibiotics
- preparation
- produce
- antibiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:compounds of the formula (R is H, lower alkyl, triphenylmethyl). EXAMPLE:PS - 6 of the formula where R is H. USE:Antibiotics: effective on gram-positive and negative bacteria, especially having strong antibiotic activity against bacteria resisting conventional beta-lactam antibiotics. PREPARATION:In an example, a novel mold of streptomyces SP, A 271 is aerobically cultivated in the medium containing L- and/or D-valine, L- and D-leucine at 4-9pH and 20-40 deg.C for 0-100hr to produce PS-6 of the formula where R is H and it is isolated. The resulting PS-6 or its salt is reacted with an ester-forming compound of RY (Y is removable group) or a lower diazoalkane to produce antibiotics other than R is H.
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12185777A JPS5459295A (en) | 1977-10-13 | 1977-10-13 | Antibiotic ps-6, its derivative and their preparation |
EP78100993A EP0001567B1 (en) | 1977-10-13 | 1978-09-26 | Thienamycin related antibiotics ps-6 and ps-7, process for their production and compositions containing them |
DE7878100993T DE2861413D1 (en) | 1977-10-13 | 1978-09-26 | Thienamycin related antibiotics ps-6 and ps-7, process for their production and compositions containing them |
YU235178A YU235178A (en) | 1977-10-13 | 1978-10-06 | Process for producing new antibiotics of a betta-lactamaseinhibiting activity |
US05/949,854 US4368203A (en) | 1977-10-13 | 1978-10-10 | Antibiotics and derivatives thereof having β-lactamase inhibitory activity and production thereof |
CA313,287A CA1113872A (en) | 1977-10-13 | 1978-10-12 | ANTIBIOTICS AND DERIVATIVES THEREOF HAVING .beta.-LACTAMASE INHIBITORY ACTIVITY AND PRODUCTION THEREOF |
SU782673547A SU1039446A3 (en) | 1977-10-13 | 1978-10-12 | Process for preparing antibiotic complex |
DK454378A DK145382C (en) | 1977-10-13 | 1978-10-12 | METHOD OF PREPARING BETA-LACTAMANTIBIOTICS CALLED PS-6 AND PS-7 OR SALTS OR ESTERS THEREOF |
HU78SA3138A HU179788B (en) | 1977-10-13 | 1978-10-12 | Process for preparing new carbopenem derivatives |
IT28782/78A IT1099738B (en) | 1977-10-13 | 1978-10-13 | ANTIBIOTICS, THEIR PREPARATION AND THEIR USE AS ANTI-MICROBIAL PRODUCTS |
YU2151/82A YU42049B (en) | 1977-10-13 | 1982-09-27 | Process for producing derivatives of new antibiotics of a beta lactamase inhibiting activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12185777A JPS5459295A (en) | 1977-10-13 | 1977-10-13 | Antibiotic ps-6, its derivative and their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5459295A true JPS5459295A (en) | 1979-05-12 |
JPS6215557B2 JPS6215557B2 (en) | 1987-04-08 |
Family
ID=14821641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12185777A Granted JPS5459295A (en) | 1977-10-13 | 1977-10-13 | Antibiotic ps-6, its derivative and their preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5459295A (en) |
-
1977
- 1977-10-13 JP JP12185777A patent/JPS5459295A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6215557B2 (en) | 1987-04-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IE802174L (en) | Penicillin compounds | |
JPS5459295A (en) | Antibiotic ps-6, its derivative and their preparation | |
AU563466B2 (en) | Antibiotic a 51568 factors a and b | |
AU629209B2 (en) | Cephalosporin compounds | |
ES482443A1 (en) | Antibiotic KA-7038 and compositions containing same | |
GB1361764A (en) | Fermentation for producing an antibiotic | |
JPS5671092A (en) | Optical active cephalosporin analogous derivative | |
PT78325B (en) | Process for preparing novel macrolides ptl-448 | |
ES8104416A1 (en) | Process for the preparation of penicillin derivatives. | |
JPS5762280A (en) | Novel antibiotic oa-6129a and its preparation | |
ES8406546A1 (en) | Macrolide antibiotics from streptomyces. | |
JPS5579394A (en) | Novel 7-methoxycephalosporin derivative | |
JPS57200380A (en) | Novel enzyme inhibitor mg 299-a substance and/or mg 299-b substance and their preparations | |
JPS5645484A (en) | C-15003pho and its preparation | |
JPS5620598A (en) | Novel antibiotic and its preparation | |
JPS568397A (en) | Novel fortimicin analog compound | |
JPS5783280A (en) | Bacteria producing novel antibiotic substance | |
JPS55143996A (en) | Novel antibiotic substance pa-32413-i | |
JPS55167297A (en) | Leucomycin derivative and its derivative |