JPS5448745A - Preparation of n-2-fluorenesulfonylamino acid - Google Patents
Preparation of n-2-fluorenesulfonylamino acidInfo
- Publication number
- JPS5448745A JPS5448745A JP10593678A JP10593678A JPS5448745A JP S5448745 A JPS5448745 A JP S5448745A JP 10593678 A JP10593678 A JP 10593678A JP 10593678 A JP10593678 A JP 10593678A JP S5448745 A JPS5448745 A JP S5448745A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- fluorenesulfonylamino
- amino acid
- fluorenesulfonyl
- alanine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:N-2-Fluorenesulfonylamino acid.
EXAMPLE: N-2-Fluorenesulfonyl-L-alanine.
USE: Low toxic pharmaceutical having anti-influenza-viral activity.
PROCESS: An amino acid (alanine, isoleucine, triptohane, methionine and phenylglycine) is allowed to react with 2-fluorenesulfonyl halide (chloride, bromide, or iodide) in an aqueous solution in the presence of an alkali, e.g. NaOH, according to the Scotten-Baumann reaction method to give N-2-fluorenesulfonylamino acid corresponding to the starting amino acid. The reaction is conducted generally at room temp. When the starting amino acid is optically active, recemizaion can be substantially neglected at ≤50°C
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10593678A JPS5448745A (en) | 1978-08-30 | 1978-08-30 | Preparation of n-2-fluorenesulfonylamino acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10593678A JPS5448745A (en) | 1978-08-30 | 1978-08-30 | Preparation of n-2-fluorenesulfonylamino acid |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1427676A Division JPS51105048A (en) | 1976-02-12 | 1976-02-12 | SHINKINA AMINOSAN JUDOTAINOSEIZOHOHO |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5448745A true JPS5448745A (en) | 1979-04-17 |
JPS554741B2 JPS554741B2 (en) | 1980-01-31 |
Family
ID=14420725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10593678A Granted JPS5448745A (en) | 1978-08-30 | 1978-08-30 | Preparation of n-2-fluorenesulfonylamino acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5448745A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999059574A1 (en) * | 1998-05-21 | 1999-11-25 | Magainin Pharmaceuticals, Inc. | A method for stimulation of defensin production by exposure to isoleucin |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6020974Y2 (en) * | 1980-10-17 | 1985-06-22 | シャープ株式会社 | coffee maker |
JPH0321700Y2 (en) * | 1985-03-14 | 1991-05-13 |
-
1978
- 1978-08-30 JP JP10593678A patent/JPS5448745A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999059574A1 (en) * | 1998-05-21 | 1999-11-25 | Magainin Pharmaceuticals, Inc. | A method for stimulation of defensin production by exposure to isoleucin |
Also Published As
Publication number | Publication date |
---|---|
JPS554741B2 (en) | 1980-01-31 |
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