JPS5448745A - Preparation of n-2-fluorenesulfonylamino acid - Google Patents

Preparation of n-2-fluorenesulfonylamino acid

Info

Publication number
JPS5448745A
JPS5448745A JP10593678A JP10593678A JPS5448745A JP S5448745 A JPS5448745 A JP S5448745A JP 10593678 A JP10593678 A JP 10593678A JP 10593678 A JP10593678 A JP 10593678A JP S5448745 A JPS5448745 A JP S5448745A
Authority
JP
Japan
Prior art keywords
acid
fluorenesulfonylamino
amino acid
fluorenesulfonyl
alanine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10593678A
Other languages
Japanese (ja)
Other versions
JPS554741B2 (en
Inventor
Shigeru Toyoshima
Seizo Kanao
Takeshi Toyoda
Tadashi Suyama
Akira Shimizu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to JP10593678A priority Critical patent/JPS5448745A/en
Publication of JPS5448745A publication Critical patent/JPS5448745A/en
Publication of JPS554741B2 publication Critical patent/JPS554741B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:N-2-Fluorenesulfonylamino acid.
EXAMPLE: N-2-Fluorenesulfonyl-L-alanine.
USE: Low toxic pharmaceutical having anti-influenza-viral activity.
PROCESS: An amino acid (alanine, isoleucine, triptohane, methionine and phenylglycine) is allowed to react with 2-fluorenesulfonyl halide (chloride, bromide, or iodide) in an aqueous solution in the presence of an alkali, e.g. NaOH, according to the Scotten-Baumann reaction method to give N-2-fluorenesulfonylamino acid corresponding to the starting amino acid. The reaction is conducted generally at room temp. When the starting amino acid is optically active, recemizaion can be substantially neglected at ≤50°C
COPYRIGHT: (C)1979,JPO&Japio
JP10593678A 1978-08-30 1978-08-30 Preparation of n-2-fluorenesulfonylamino acid Granted JPS5448745A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10593678A JPS5448745A (en) 1978-08-30 1978-08-30 Preparation of n-2-fluorenesulfonylamino acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10593678A JPS5448745A (en) 1978-08-30 1978-08-30 Preparation of n-2-fluorenesulfonylamino acid

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP1427676A Division JPS51105048A (en) 1976-02-12 1976-02-12 SHINKINA AMINOSAN JUDOTAINOSEIZOHOHO

Publications (2)

Publication Number Publication Date
JPS5448745A true JPS5448745A (en) 1979-04-17
JPS554741B2 JPS554741B2 (en) 1980-01-31

Family

ID=14420725

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10593678A Granted JPS5448745A (en) 1978-08-30 1978-08-30 Preparation of n-2-fluorenesulfonylamino acid

Country Status (1)

Country Link
JP (1) JPS5448745A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999059574A1 (en) * 1998-05-21 1999-11-25 Magainin Pharmaceuticals, Inc. A method for stimulation of defensin production by exposure to isoleucin

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6020974Y2 (en) * 1980-10-17 1985-06-22 シャープ株式会社 coffee maker
JPH0321700Y2 (en) * 1985-03-14 1991-05-13

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999059574A1 (en) * 1998-05-21 1999-11-25 Magainin Pharmaceuticals, Inc. A method for stimulation of defensin production by exposure to isoleucin

Also Published As

Publication number Publication date
JPS554741B2 (en) 1980-01-31

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