JPS5424845A - Novel bio-active peptide and its derivative - Google Patents

Novel bio-active peptide and its derivative

Info

Publication number
JPS5424845A
JPS5424845A JP8872977A JP8872977A JPS5424845A JP S5424845 A JPS5424845 A JP S5424845A JP 8872977 A JP8872977 A JP 8872977A JP 8872977 A JP8872977 A JP 8872977A JP S5424845 A JPS5424845 A JP S5424845A
Authority
JP
Japan
Prior art keywords
derivative
active peptide
novel bio
methylhexanoyl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8872977A
Other languages
Japanese (ja)
Other versions
JPS568829B2 (en
Inventor
Hamao Umezawa
Takaaki Aoyanagi
Tomio Takeuchi
Masa Hamada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP8872977A priority Critical patent/JPS5424845A/en
Priority to US05/834,635 priority patent/US4126606A/en
Priority to CA287,411A priority patent/CA1098850A/en
Priority to DE2813507A priority patent/DE2813507C3/en
Priority to BE186462A priority patent/BE865565A/en
Priority to ES468457A priority patent/ES468457A1/en
Priority to FR7809710A priority patent/FR2398048A1/en
Priority to GB12875/78A priority patent/GB1553656A/en
Priority to AU34709/78A priority patent/AU511023B2/en
Priority to IT67722/78A priority patent/IT1108029B/en
Priority to US05/916,184 priority patent/US4167448A/en
Publication of JPS5424845A publication Critical patent/JPS5424845A/en
Publication of JPS568829B2 publication Critical patent/JPS568829B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

PURPOSE: Tetrapetides or their salts and esters of the formula (X is 3amino-2-hydroxy-5-methylhexanoyl, or 3-amino-2-hydroxy-4-methylhexanoyl; Val is L-valyl; when X is 3-amino-2-hydroxy-5-methylhexanoyl, y is aspartic acid, etc. and when X is 3-amino-2-hydroxy-4-methylhexanoyl, y is glutamic acid, ttc.).
COPYRIGHT: (C)1979,JPO&Japio
JP8872977A 1976-10-04 1977-07-22 Novel bio-active peptide and its derivative Granted JPS5424845A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP8872977A JPS5424845A (en) 1977-07-22 1977-07-22 Novel bio-active peptide and its derivative
US05/834,635 US4126606A (en) 1976-10-04 1977-09-19 Physiologically active peptides and a process for preparation thereof
CA287,411A CA1098850A (en) 1976-10-04 1977-09-23 Physiologically active peptides and a process for preparation thereof
DE2813507A DE2813507C3 (en) 1977-07-22 1978-03-29 Amastatins, processes for their production and pharmaceutical preparations containing them
BE186462A BE865565A (en) 1977-07-22 1978-03-31 PHYSIOLOGICALLY ACTIVE PEPTIDES AND THEIR PREPARATION PROCESS
ES468457A ES468457A1 (en) 1977-07-22 1978-03-31 Physiologically active peptides and a process for the preparation thereof
FR7809710A FR2398048A1 (en) 1977-07-22 1978-03-31 NEW PHYSIOLOGICALLY ACTIVE PEPTIDES, PROCESS FOR THE PREPARATION OF THEY AND PHARMACEUTICAL COMPOSITION INCLUDING APPLICATION
GB12875/78A GB1553656A (en) 1977-07-22 1978-04-03 Physiologically active peptides and a process for the preparation thereof
AU34709/78A AU511023B2 (en) 1977-05-22 1978-04-03 Physiologically active peptides
IT67722/78A IT1108029B (en) 1977-07-22 1978-04-03 PHYSIOLOGICALLY ACTIVE PEPTIDES AND THEIR PREPARATION PROCEDURE
US05/916,184 US4167448A (en) 1976-10-04 1978-06-16 Process for preparation of physiologically active peptides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8872977A JPS5424845A (en) 1977-07-22 1977-07-22 Novel bio-active peptide and its derivative

Publications (2)

Publication Number Publication Date
JPS5424845A true JPS5424845A (en) 1979-02-24
JPS568829B2 JPS568829B2 (en) 1981-02-25

Family

ID=13950997

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8872977A Granted JPS5424845A (en) 1976-10-04 1977-07-22 Novel bio-active peptide and its derivative

Country Status (8)

Country Link
JP (1) JPS5424845A (en)
AU (1) AU511023B2 (en)
BE (1) BE865565A (en)
DE (1) DE2813507C3 (en)
ES (1) ES468457A1 (en)
FR (1) FR2398048A1 (en)
GB (1) GB1553656A (en)
IT (1) IT1108029B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0313548Y2 (en) * 1984-09-13 1991-03-27
FR2609501B1 (en) * 1987-01-09 1991-01-11 Peugeot INTERNAL COMBUSTION ENGINE PROVIDED WITH IMPROVED MEANS FOR COOLING THE CYLINDER BLOCK

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2506601C3 (en) * 1974-02-28 1980-12-11 Sanraku-Ocean Co., Ltd., Tokio Tetrapeptides and processes for their preparation
US4091093A (en) * 1975-09-12 1978-05-23 Sumitomo Chemical Company Limited Protease inhibitors

Also Published As

Publication number Publication date
DE2813507C3 (en) 1980-09-11
FR2398048B1 (en) 1984-07-13
FR2398048A1 (en) 1979-02-16
AU3470978A (en) 1979-10-11
BE865565A (en) 1978-07-17
IT7867722A0 (en) 1978-04-03
IT1108029B (en) 1985-12-02
DE2813507B2 (en) 1980-01-17
ES468457A1 (en) 1980-01-01
JPS568829B2 (en) 1981-02-25
GB1553656A (en) 1979-09-26
DE2813507A1 (en) 1979-01-25
AU511023B2 (en) 1980-07-24

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