JPS54151984A - Preparation of aminocarbostyril derivative - Google Patents
Preparation of aminocarbostyril derivativeInfo
- Publication number
- JPS54151984A JPS54151984A JP5934678A JP5934678A JPS54151984A JP S54151984 A JPS54151984 A JP S54151984A JP 5934678 A JP5934678 A JP 5934678A JP 5934678 A JP5934678 A JP 5934678A JP S54151984 A JPS54151984 A JP S54151984A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- formula
- arylamine
- blocker
- aminocarbostyril
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: A hydroxycarbostyril derivative is coupled with the diazonium salt of arylamine and followed by reduction, thus preparing title compound useful as an intermediate for β-blocker in high yield.
CONSTITUTION: The coupling reaction between a diazonium salt of arylamine and a hydroxycarbostyril derivative of formula I (either one of R1 and R2 is OH and the other is H; the carbon-carbon linkage between 3 and 4 positions is single or double bond) is effected and the product, diazocarbosytril derivative of formula II [either of R3 or R4 is OH and the other is -N=N-R5 (R5 is aryl)], is reduced to prepare amincarbostyril derivative of formula III (either one of R6 and R7 is OH and the other is amino) and its salt. The compound of formula III can be led to the compound of formula IV, a β-blocker.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5934678A JPS54151984A (en) | 1978-05-17 | 1978-05-17 | Preparation of aminocarbostyril derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5934678A JPS54151984A (en) | 1978-05-17 | 1978-05-17 | Preparation of aminocarbostyril derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54151984A true JPS54151984A (en) | 1979-11-29 |
JPS6126785B2 JPS6126785B2 (en) | 1986-06-21 |
Family
ID=13110634
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5934678A Granted JPS54151984A (en) | 1978-05-17 | 1978-05-17 | Preparation of aminocarbostyril derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54151984A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0236140A2 (en) * | 1986-03-05 | 1987-09-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives |
-
1978
- 1978-05-17 JP JP5934678A patent/JPS54151984A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0236140A2 (en) * | 1986-03-05 | 1987-09-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives |
Also Published As
Publication number | Publication date |
---|---|
JPS6126785B2 (en) | 1986-06-21 |
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