JPS54151984A - Preparation of aminocarbostyril derivative - Google Patents

Preparation of aminocarbostyril derivative

Info

Publication number
JPS54151984A
JPS54151984A JP5934678A JP5934678A JPS54151984A JP S54151984 A JPS54151984 A JP S54151984A JP 5934678 A JP5934678 A JP 5934678A JP 5934678 A JP5934678 A JP 5934678A JP S54151984 A JPS54151984 A JP S54151984A
Authority
JP
Japan
Prior art keywords
derivative
formula
arylamine
blocker
aminocarbostyril
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5934678A
Other languages
Japanese (ja)
Other versions
JPS6126785B2 (en
Inventor
Michiaki Tominaga
Hitoshi Tone
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP5934678A priority Critical patent/JPS54151984A/en
Publication of JPS54151984A publication Critical patent/JPS54151984A/en
Publication of JPS6126785B2 publication Critical patent/JPS6126785B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: A hydroxycarbostyril derivative is coupled with the diazonium salt of arylamine and followed by reduction, thus preparing title compound useful as an intermediate for β-blocker in high yield.
CONSTITUTION: The coupling reaction between a diazonium salt of arylamine and a hydroxycarbostyril derivative of formula I (either one of R1 and R2 is OH and the other is H; the carbon-carbon linkage between 3 and 4 positions is single or double bond) is effected and the product, diazocarbosytril derivative of formula II [either of R3 or R4 is OH and the other is -N=N-R5 (R5 is aryl)], is reduced to prepare amincarbostyril derivative of formula III (either one of R6 and R7 is OH and the other is amino) and its salt. The compound of formula III can be led to the compound of formula IV, a β-blocker.
COPYRIGHT: (C)1979,JPO&Japio
JP5934678A 1978-05-17 1978-05-17 Preparation of aminocarbostyril derivative Granted JPS54151984A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5934678A JPS54151984A (en) 1978-05-17 1978-05-17 Preparation of aminocarbostyril derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5934678A JPS54151984A (en) 1978-05-17 1978-05-17 Preparation of aminocarbostyril derivative

Publications (2)

Publication Number Publication Date
JPS54151984A true JPS54151984A (en) 1979-11-29
JPS6126785B2 JPS6126785B2 (en) 1986-06-21

Family

ID=13110634

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5934678A Granted JPS54151984A (en) 1978-05-17 1978-05-17 Preparation of aminocarbostyril derivative

Country Status (1)

Country Link
JP (1) JPS54151984A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236140A2 (en) * 1986-03-05 1987-09-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236140A2 (en) * 1986-03-05 1987-09-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives

Also Published As

Publication number Publication date
JPS6126785B2 (en) 1986-06-21

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