JPS54106402A - Amylase inhibitor tai-a - Google Patents

Amylase inhibitor tai-a

Info

Publication number
JPS54106402A
JPS54106402A JP1440778A JP1440778A JPS54106402A JP S54106402 A JPS54106402 A JP S54106402A JP 1440778 A JP1440778 A JP 1440778A JP 1440778 A JP1440778 A JP 1440778A JP S54106402 A JPS54106402 A JP S54106402A
Authority
JP
Japan
Prior art keywords
tai
reaction
amylase
inhibitor
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1440778A
Other languages
Japanese (ja)
Inventor
Kunio Kamigouri
Shinjiyuurou Namiki
Takatoshi Nagate
Kazuhiko Sugita
Sadafumi Omura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Priority to JP1440778A priority Critical patent/JPS54106402A/en
Priority to GB7902373A priority patent/GB2016497A/en
Priority to DE19792903710 priority patent/DE2903710A1/en
Priority to FR7902795A priority patent/FR2416949A1/en
Priority to US06/009,157 priority patent/US4197292A/en
Priority to CH114079A priority patent/CH637542A5/en
Priority to BE0/193352A priority patent/BE874037A/en
Priority to IT47956/79A priority patent/IT1114532B/en
Priority to CA321,167A priority patent/CA1131146A/en
Publication of JPS54106402A publication Critical patent/JPS54106402A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

NEW MATERIAL:Anylase inhibitor TAI-A. Elemental analysis: C 41.44%, H 6.27%, N 1.32%, O 46.32%; molecular weight: 950W1050; [α]23D: +157.3° (c=0.5%, water); solubility; soluble in water and DMSO, insoluble in methanol, ethanol, etc.; color reaction: positive to Molisch's reaction and anthrone reaction; pKa: 4.2 (in an aqueous solution), basic; appearance: white powder.
USE: Amylase inhibitor. Effective to obesity, hyperlipemia, diabetes, a gastric ulcer, etc. because said substance inhibits the activity of amylase and suppresses the amount of glucose in blood.
PROCESS: Streptomyces calvus var. TM-521 (FERM-P No.4283) belonging to Streptomyces genus, is cultured under aerobic conditions, to obtain TAI-A.
COPYRIGHT: (C)1979,JPO&Japio
JP1440778A 1978-02-10 1978-02-10 Amylase inhibitor tai-a Pending JPS54106402A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP1440778A JPS54106402A (en) 1978-02-10 1978-02-10 Amylase inhibitor tai-a
GB7902373A GB2016497A (en) 1978-02-10 1979-01-23 Microbiological production of amylase inhibitor
DE19792903710 DE2903710A1 (en) 1978-02-10 1979-01-31 NEW AMYLASE INHIBITORS AND METHOD FOR THE PRODUCTION THEREOF
FR7902795A FR2416949A1 (en) 1978-02-10 1979-02-02 PROCESS FOR THE PREPARATION OF AMYLASE INHIBITORS, NEW PRODUCTS THUS OBTAINED AND THEIR PHARMACEUTICAL USES, ESPECIALLY FOR FIGHTING OBESITY AND HYPERGLYCEMIA
US06/009,157 US4197292A (en) 1978-02-10 1979-02-02 Novel amylase inhibitors
CH114079A CH637542A5 (en) 1978-02-10 1979-02-06 PROCESS FOR THE PREPARATION OF AMYLASE INHIBITORS, PRODUCTS THUS OBTAINED AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
BE0/193352A BE874037A (en) 1978-02-10 1979-02-08 PROCESS FOR PREPARING AMYLASE INHIBITORS, NEW PRODUCTS THUS OBTAINED AND THEIR PHARMACEUTICAL USES, ESPECIALLY FOR COMBATTING OBESITY AND HYPERGLYCEMIA
IT47956/79A IT1114532B (en) 1978-02-10 1979-02-09 IMPROVEMENT IN AMYLASE INHIBITIVE COMPOSITIONS AND PREPARATION PROCEDURE
CA321,167A CA1131146A (en) 1978-02-10 1979-02-09 Amylase inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1440778A JPS54106402A (en) 1978-02-10 1978-02-10 Amylase inhibitor tai-a

Publications (1)

Publication Number Publication Date
JPS54106402A true JPS54106402A (en) 1979-08-21

Family

ID=11860187

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1440778A Pending JPS54106402A (en) 1978-02-10 1978-02-10 Amylase inhibitor tai-a

Country Status (2)

Country Link
JP (1) JPS54106402A (en)
BE (1) BE874037A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5846013A (en) * 1981-09-01 1983-03-17 バイエル・アクチエンゲゼルシヤフト Novel drug preparation of glycoside hydrolase inhibitor
EP0209118A2 (en) 1985-07-17 1987-01-21 Konica Corporation Silver halide photographic material

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5846013A (en) * 1981-09-01 1983-03-17 バイエル・アクチエンゲゼルシヤフト Novel drug preparation of glycoside hydrolase inhibitor
EP0209118A2 (en) 1985-07-17 1987-01-21 Konica Corporation Silver halide photographic material

Also Published As

Publication number Publication date
BE874037A (en) 1979-08-08

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