JPS5382752A - Improved method of preparing alphaa aspartyl l phenylalanin methyl ester - Google Patents

Improved method of preparing alphaa aspartyl l phenylalanin methyl ester

Info

Publication number
JPS5382752A
JPS5382752A JP15575577A JP15575577A JPS5382752A JP S5382752 A JPS5382752 A JP S5382752A JP 15575577 A JP15575577 A JP 15575577A JP 15575577 A JP15575577 A JP 15575577A JP S5382752 A JPS5382752 A JP S5382752A
Authority
JP
Japan
Prior art keywords
alphaa
phenylalanin
aspartyl
preparing
methyl ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15575577A
Other languages
Japanese (ja)
Other versions
JPS6050200B2 (en
Inventor
Rii Batsuchiman Jierarudo
Deiru Binyaado Birii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of JPS5382752A publication Critical patent/JPS5382752A/en
Publication of JPS6050200B2 publication Critical patent/JPS6050200B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Seasonings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP52155755A 1976-12-27 1977-12-26 Improved production method of α-L-aspartyl-L-phenylalanine methyl ester Expired JPS6050200B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75429776A 1976-12-27 1976-12-27
US754297 2004-01-09

Publications (2)

Publication Number Publication Date
JPS5382752A true JPS5382752A (en) 1978-07-21
JPS6050200B2 JPS6050200B2 (en) 1985-11-07

Family

ID=25034194

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52155755A Expired JPS6050200B2 (en) 1976-12-27 1977-12-26 Improved production method of α-L-aspartyl-L-phenylalanine methyl ester

Country Status (18)

Country Link
JP (1) JPS6050200B2 (en)
AU (1) AU515038B2 (en)
BE (1) BE862258A (en)
BR (1) BR7708632A (en)
CA (1) CA1100487A (en)
CH (1) CH631435A5 (en)
DE (1) DE2757771A1 (en)
DK (1) DK149432C (en)
FR (1) FR2375194A1 (en)
GB (1) GB1546979A (en)
HU (1) HU179735B (en)
IT (1) IT1088938B (en)
MX (1) MX4704E (en)
NL (1) NL185211C (en)
NO (1) NO148069C (en)
SE (1) SE440506B (en)
SU (1) SU884564A3 (en)
ZA (1) ZA777614B (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59219258A (en) * 1983-05-28 1984-12-10 Ajinomoto Co Inc Preparation of alpha-l-aspartyl-l-phenylalanine methyl ester or its hydrochloride
JPS59225152A (en) * 1983-06-02 1984-12-18 Ajinomoto Co Inc Preparation of alpha-l-aspartyl-l-phenylalanine-methyl ester of its hydrochloride
JPS6383098A (en) * 1986-09-27 1988-04-13 Ajinomoto Co Inc Production of alpha-l-aspartyl-l-phenylalanine or derivative thereof
US4745210A (en) * 1984-12-17 1988-05-17 Mitsui Toatsu Chemicals, Incorporated Preparation process of N-formyl-α-aspartyl phenylalanine
US4778916A (en) * 1985-03-26 1988-10-18 Mitsui Toatsu Chemicals, Inc. Preparation process of α-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof
US4780561A (en) * 1985-03-29 1988-10-25 Mitsui Toatsu Chemicals, Inc. Preparation process of α-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof
US4801732A (en) * 1984-12-27 1989-01-31 Mitsui Toatsu Chemicals, Incorporated Preparation process of α-L-aspartyl-L-phenylalanine methyl ester
US4918216A (en) * 1986-12-05 1990-04-17 Mitsui Toatsu Chemicals, Incorporated Preparation process of α-l-aspartyl-l-phenyl-alanine methyl ester or hydrohalide thereof
US4962222A (en) * 1986-12-19 1990-10-09 Mitsui Toatsu Chemicals, Incorporated Preparation process of α-l-aspartyl-l-phenylalanine methyl ester having low hygroscopicity

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4618695A (en) * 1983-06-02 1986-10-21 Ajinomoto Co., Inc. Method of preparing methyl ester and its hydrochloride
GB8321802D0 (en) * 1983-08-12 1983-09-14 Erba Farmitalia Aspartame synthesis
DE3600731A1 (en) * 1986-01-13 1987-07-16 Green Cross Korea METHOD FOR PRODUCING (ALPHA) -L-ASPARTYL-L-PHENYLALANINE METHYLESTER
JPS6411999U (en) * 1987-07-13 1989-01-23

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4941425A (en) * 1972-07-20 1974-04-18
JPS5071642A (en) * 1973-11-05 1975-06-13

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5223001A (en) * 1975-08-14 1977-02-21 Ajinomoto Co Inc Process for elimination of formyl group

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4941425A (en) * 1972-07-20 1974-04-18
JPS5071642A (en) * 1973-11-05 1975-06-13

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59219258A (en) * 1983-05-28 1984-12-10 Ajinomoto Co Inc Preparation of alpha-l-aspartyl-l-phenylalanine methyl ester or its hydrochloride
JPH0363556B2 (en) * 1983-05-28 1991-10-01 Ajinomoto Kk
JPS59225152A (en) * 1983-06-02 1984-12-18 Ajinomoto Co Inc Preparation of alpha-l-aspartyl-l-phenylalanine-methyl ester of its hydrochloride
JPH0441155B2 (en) * 1983-06-02 1992-07-07 Ajinomoto Kk
US4745210A (en) * 1984-12-17 1988-05-17 Mitsui Toatsu Chemicals, Incorporated Preparation process of N-formyl-α-aspartyl phenylalanine
US4801732A (en) * 1984-12-27 1989-01-31 Mitsui Toatsu Chemicals, Incorporated Preparation process of α-L-aspartyl-L-phenylalanine methyl ester
US4778916A (en) * 1985-03-26 1988-10-18 Mitsui Toatsu Chemicals, Inc. Preparation process of α-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof
US4780561A (en) * 1985-03-29 1988-10-25 Mitsui Toatsu Chemicals, Inc. Preparation process of α-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof
JPS6383098A (en) * 1986-09-27 1988-04-13 Ajinomoto Co Inc Production of alpha-l-aspartyl-l-phenylalanine or derivative thereof
US4918216A (en) * 1986-12-05 1990-04-17 Mitsui Toatsu Chemicals, Incorporated Preparation process of α-l-aspartyl-l-phenyl-alanine methyl ester or hydrohalide thereof
US4962222A (en) * 1986-12-19 1990-10-09 Mitsui Toatsu Chemicals, Incorporated Preparation process of α-l-aspartyl-l-phenylalanine methyl ester having low hygroscopicity

Also Published As

Publication number Publication date
IT1088938B (en) 1985-06-10
NO148069B (en) 1983-04-25
DE2757771A1 (en) 1978-07-06
NO148069C (en) 1983-08-03
CH631435A5 (en) 1982-08-13
DE2757771C2 (en) 1988-08-25
DK149432B (en) 1986-06-09
NL185211B (en) 1989-09-18
DK149432C (en) 1987-04-21
HU179735B (en) 1982-12-28
JPS6050200B2 (en) 1985-11-07
NL7714351A (en) 1978-06-29
ZA777614B (en) 1978-10-25
FR2375194B1 (en) 1984-04-13
BR7708632A (en) 1978-08-22
AU515038B2 (en) 1981-03-12
SE7714709L (en) 1978-06-28
NO774440L (en) 1978-06-28
DK577977A (en) 1978-06-28
SE440506B (en) 1985-08-05
AU3201477A (en) 1979-06-28
FR2375194A1 (en) 1978-07-21
NL185211C (en) 1990-02-16
BE862258A (en) 1978-06-23
MX4704E (en) 1982-08-04
CA1100487A (en) 1981-05-05
SU884564A3 (en) 1981-11-23
GB1546979A (en) 1979-06-06

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