JPS53124297A - D*1*55methyltetrahydrochlorophylate and process for preparing same - Google Patents

D*1*55methyltetrahydrochlorophylate and process for preparing same

Info

Publication number
JPS53124297A
JPS53124297A JP1863778A JP1863778A JPS53124297A JP S53124297 A JPS53124297 A JP S53124297A JP 1863778 A JP1863778 A JP 1863778A JP 1863778 A JP1863778 A JP 1863778A JP S53124297 A JPS53124297 A JP S53124297A
Authority
JP
Japan
Prior art keywords
preparing same
preparing
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1863778A
Other languages
Japanese (ja)
Other versions
JPS5831353B2 (en
Inventor
Gennari Fuederiko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIORESEARCH Sas
Original Assignee
BIORESEARCH Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIORESEARCH Sas filed Critical BIORESEARCH Sas
Publication of JPS53124297A publication Critical patent/JPS53124297A/en
Publication of JPS5831353B2 publication Critical patent/JPS5831353B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
JP53018637A 1977-02-22 1978-02-22 Method for producing d,l↓-5↓-methyltetrahydrofolic acid and its salts Expired JPS5831353B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7290/77A GB1572137A (en) 1977-02-22 1977-02-22 Stable compositions for therapeutic use based on d,1-5-methyltetrahydrofolic acid and its salts

Publications (2)

Publication Number Publication Date
JPS53124297A true JPS53124297A (en) 1978-10-30
JPS5831353B2 JPS5831353B2 (en) 1983-07-05

Family

ID=9830275

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53018637A Expired JPS5831353B2 (en) 1977-02-22 1978-02-22 Method for producing d,l↓-5↓-methyltetrahydrofolic acid and its salts

Country Status (32)

Country Link
JP (1) JPS5831353B2 (en)
AR (1) AR215162A1 (en)
AT (1) AT380020B (en)
AU (1) AU520715B2 (en)
BE (1) BE863808A (en)
CA (1) CA1093554A (en)
CH (1) CH635344A5 (en)
CZ (1) CZ279815B6 (en)
DD (1) DD134099A5 (en)
DE (1) DE2807393A1 (en)
DK (1) DK144944C (en)
EG (1) EG13399A (en)
ES (1) ES467153A1 (en)
FI (1) FI67082C (en)
FR (2) FR2381047A1 (en)
GB (1) GB1572137A (en)
GR (1) GR71704B (en)
HU (1) HU179422B (en)
IE (1) IE46402B1 (en)
IL (1) IL54052A (en)
IN (1) IN149574B (en)
LU (1) LU79067A1 (en)
MX (1) MX5288E (en)
NL (1) NL190285C (en)
NO (1) NO147793C (en)
NZ (1) NZ186465A (en)
PL (1) PL118654B1 (en)
PT (1) PT67656B (en)
SE (1) SE437028B (en)
SU (1) SU747427A3 (en)
YU (1) YU40505B (en)
ZA (1) ZA78837B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5838285A (en) * 1981-08-25 1983-03-05 Kanegafuchi Chem Ind Co Ltd Preparation of 5-methyl-(6rs)-5,6,7,8-tetrahydro-l-folic acid magnesium salt or its free acid
JP2010528059A (en) * 2007-05-30 2010-08-19 セルビオス ファルマ エス アー Process for producing stable, amorphous calcium salt of (6S) -N (5) -methyl-5,6,7,8-tetrahydrofolic acid
JP2013047279A (en) * 1999-04-15 2013-03-07 Merck Eprova Ag Stable crystalline 5-methyltetrahydrofolate salt

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
IT1229517B (en) * 1989-01-31 1991-09-03 Bioresearch Spa USE OF 5-METHYLTETRAHYDROPHOLIC ACID, OF 5 FORMYLTHETRAHYDROPHOLIC ACID, AND OF THEIR PHARMACEUTICALLY ACCEPTABLE SALTS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS IN THE FORM OF CONTROLLED RELEASE SUITABLE FOR BEING EMPLOYED IN THE TREATMENT OF DISORDERS IN THE TREATMENT OF DISORDERS.
IT1229203B (en) * 1989-03-22 1991-07-25 Bioresearch Spa USE OF 5 METHYLTHETRAHYDROPHOLIC ACID, 5 FORMYLTHETRAHYDROPHOLIC ACID AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS IN THE FORM OF CONTROLLED RELEASE ACTIVE IN THE THERAPY OF MENTAL AND ORGANIC DISORDERS.
NL8901432A (en) * 1989-06-06 1991-01-02 Pharmachemie Bv STABLE AQUEOUS FOLINATE SOLUTION AT REFRIGERATOR TEMPERATURE, AND METHOD FOR PREPARING THAT.
CH680731A5 (en) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
US5217974A (en) * 1991-03-29 1993-06-08 Eli Lilly And Company Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity
CH683261A5 (en) * 1991-10-10 1994-02-15 Applied Pharma Res A process for the preparation of Methyltetrahydrofolic in the form (6 (R, S) (-)) N-5 and separation of the active diastereoisomer (6 (S) (-)) N-5) in the form of salts.
CH682665A5 (en) * 1991-10-29 1993-10-29 Sapec Fine Chemicals Process for the purification of crude alkaline earth metal salts from N (5) -methyl-5,6,7,8-tetrahydrofolic acid.
US6162914A (en) * 1998-04-24 2000-12-19 Cerbios-Pharma S.A. Process for the reduction of pterins
CN103214487A (en) * 2013-04-12 2013-07-24 张家港威胜生物医药有限公司 Synthesis of important medical chemical raw material (6S)-5-methyl tetrahydrofolate
WO2015193778A1 (en) 2014-06-16 2015-12-23 Mylan Laboratories Ltd. Crystalline form of levomefolate calcium

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL80276C (en) *
GB1293541A (en) * 1969-03-18 1972-10-18 John Alexander Blair Folic acid derivatives
US3856959A (en) * 1972-07-24 1974-12-24 Department Of Health Education Inhibition of leukemia utilizing 5-methyltetrahydrohomofolate
US4148999A (en) * 1977-08-22 1979-04-10 The Government Of The United States Of America Preparation and purification of citrovorum factor
CH649550A5 (en) * 1984-02-09 1985-05-31 Eprova Ag Process for the preparation of alkaline earth metal salts of 5-methyltetrahydrofolic acid

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTACTS=1975 *
CHEMICAL ABSTRACTS=1974 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5838285A (en) * 1981-08-25 1983-03-05 Kanegafuchi Chem Ind Co Ltd Preparation of 5-methyl-(6rs)-5,6,7,8-tetrahydro-l-folic acid magnesium salt or its free acid
JP2013047279A (en) * 1999-04-15 2013-03-07 Merck Eprova Ag Stable crystalline 5-methyltetrahydrofolate salt
JP2013047280A (en) * 1999-04-15 2013-03-07 Merck Eprova Ag Stable crystalline 5-methyltetrahydrofolate salt
JP2013047278A (en) * 1999-04-15 2013-03-07 Merck Eprova Ag Stable crystalline 5-methyltetrahydrofolate salt
JP2010528059A (en) * 2007-05-30 2010-08-19 セルビオス ファルマ エス アー Process for producing stable, amorphous calcium salt of (6S) -N (5) -methyl-5,6,7,8-tetrahydrofolic acid

Also Published As

Publication number Publication date
FI67082B (en) 1984-09-28
CH635344A5 (en) 1983-03-31
YU40505B (en) 1986-02-28
PL118654B1 (en) 1981-10-31
SU747427A3 (en) 1980-07-23
FI67082C (en) 1985-01-10
FR2381047A1 (en) 1978-09-15
IE46402B1 (en) 1983-06-01
NL7801775A (en) 1978-08-24
GB1572137A (en) 1980-07-23
CZ112978A3 (en) 1995-02-15
JPS5831353B2 (en) 1983-07-05
FI780565A (en) 1978-08-23
EG13399A (en) 1981-12-31
LU79067A1 (en) 1978-06-27
NO780594L (en) 1978-08-23
AU520715B2 (en) 1982-02-25
FR2381047B1 (en) 1981-07-24
NL190285C (en) 1994-01-03
CZ279815B6 (en) 1995-07-12
FR2385397A1 (en) 1978-10-27
ES467153A1 (en) 1978-11-16
DE2807393A1 (en) 1978-09-07
NZ186465A (en) 1980-10-08
CA1093554A (en) 1981-01-13
NO147793B (en) 1983-03-07
IE780285L (en) 1978-08-22
AR215162A1 (en) 1979-09-14
FR2385397B1 (en) 1981-07-17
SE437028B (en) 1985-02-04
BE863808A (en) 1978-05-29
NL190285B (en) 1993-08-02
ZA78837B (en) 1979-09-26
PT67656A (en) 1978-03-01
MX5288E (en) 1983-06-06
SE7801973L (en) 1978-08-23
DE2807393C2 (en) 1990-06-13
PL204747A1 (en) 1979-03-12
DD134099A5 (en) 1979-02-07
IN149574B (en) 1982-01-30
IL54052A0 (en) 1978-04-30
NO147793C (en) 1983-06-15
DK144944B (en) 1982-07-12
DK76578A (en) 1978-08-23
HU179422B (en) 1982-10-28
PT67656B (en) 1979-07-19
YU37978A (en) 1983-01-21
IL54052A (en) 1981-07-31
DK144944C (en) 1982-11-29
AU3343078A (en) 1979-08-30
AT380020B (en) 1986-03-25
ATA90378A (en) 1985-08-15
GR71704B (en) 1983-06-21

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