JPS5285151A - Prostaglandin-like compounds, method of prepring same, and pharmaceuti cal composition containing same - Google Patents

Prostaglandin-like compounds, method of prepring same, and pharmaceuti cal composition containing same

Info

Publication number
JPS5285151A
JPS5285151A JP15628676A JP15628676A JPS5285151A JP S5285151 A JPS5285151 A JP S5285151A JP 15628676 A JP15628676 A JP 15628676A JP 15628676 A JP15628676 A JP 15628676A JP S5285151 A JPS5285151 A JP S5285151A
Authority
JP
Japan
Prior art keywords
same
compounds
prostaglandin
prepring
composition containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15628676A
Other languages
Japanese (ja)
Other versions
JPS5761276B2 (en
Inventor
Masaki Hayashi
Seiji Kori
Hirohisa Wakatsuka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/646,316 external-priority patent/US4052512A/en
Priority claimed from GB1598276A external-priority patent/GB1540427A/en
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Publication of JPS5285151A publication Critical patent/JPS5285151A/en
Publication of JPS5761276B2 publication Critical patent/JPS5761276B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C391/00—Compounds containing selenium
    • C07C391/02—Compounds containing selenium having selenium atoms bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/02—Lithium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5407—Acyclic saturated phosphonium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PURPOSE: Prostaglandin-like compounds of formula I (R is H, 1-4C alkyl; dotted lines represent bonding of OH group in α-or β-configuration; the double bonds at C2-C3 and C14-C14 are trans-configuration), or clathrate compounds thereof in cyclodextrin, or non-toxic salts thereof when R is H; for example, 9-oxo-11α, 15α-dihydroxy-16, 16-dimethylprosta-trans-2,trans-13dienoic acid.
COPYRIGHT: (C)1977,JPO&Japio
JP15628676A 1976-01-05 1976-12-27 Prostaglandin-like compounds, method of prepring same, and pharmaceuti cal composition containing same Granted JPS5285151A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/646,316 US4052512A (en) 1976-01-05 1976-01-05 Prostaglandin analogues
GB1598276A GB1540427A (en) 1972-12-29 1976-04-20 Prostaglandin analogues

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP57075304A Division JPS57206616A (en) 1976-01-05 1982-05-07 Menses inducer, feticidal or odynopoeia containing prostaglandin e1 analog

Publications (2)

Publication Number Publication Date
JPS5285151A true JPS5285151A (en) 1977-07-15
JPS5761276B2 JPS5761276B2 (en) 1982-12-23

Family

ID=26251676

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15628676A Granted JPS5285151A (en) 1976-01-05 1976-12-27 Prostaglandin-like compounds, method of prepring same, and pharmaceuti cal composition containing same

Country Status (6)

Country Link
JP (1) JPS5285151A (en)
AU (1) AU512644B2 (en)
DK (1) DK146025C (en)
IE (1) IE45491B1 (en)
LU (1) LU76513A1 (en)
NZ (1) NZ182968A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017195762A1 (en) 2016-05-09 2017-11-16 旭硝子株式会社 Novel prostaglandin derivative
WO2019087948A1 (en) 2017-10-31 2019-05-09 Ａｇｃ株式会社 Method for producing prostaglandin derivative

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017195762A1 (en) 2016-05-09 2017-11-16 旭硝子株式会社 Novel prostaglandin derivative
KR20190005172A (en) 2016-05-09 2019-01-15 에이지씨 가부시키가이샤 New prostaglandin derivatives
US10494338B2 (en) 2016-05-09 2019-12-03 AGC Inc. Prostaglandin derivative
WO2019087948A1 (en) 2017-10-31 2019-05-09 Ａｇｃ株式会社 Method for producing prostaglandin derivative
KR20200073228A (en) 2017-10-31 2020-06-23 에이지씨 가부시키가이샤 Method for producing prostaglandin derivatives
US11377413B2 (en) 2017-10-31 2022-07-05 AGC Inc. Method for producing prostaglandin derivative

Also Published As

Publication number Publication date
NZ182968A (en) 1978-12-18
IE45491B1 (en) 1982-09-08
IE45491L (en) 1977-07-05
AU512644B2 (en) 1980-10-23
AU2104477A (en) 1978-07-13
JPS5761276B2 (en) 1982-12-23
DK2577A (en) 1977-07-06
DK146025C (en) 1983-10-24
LU76513A1 (en) 1977-07-14
DK146025B (en) 1983-05-30

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