JPS52136157A - Preparation of steroid 17-esters - Google Patents
Preparation of steroid 17-estersInfo
- Publication number
- JPS52136157A JPS52136157A JP4209176A JP4209176A JPS52136157A JP S52136157 A JPS52136157 A JP S52136157A JP 4209176 A JP4209176 A JP 4209176A JP 4209176 A JP4209176 A JP 4209176A JP S52136157 A JPS52136157 A JP S52136157A
- Authority
- JP
- Japan
- Prior art keywords
- steroid
- esters
- preparation
- dimethylformamide
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003431 steroids Chemical class 0.000 title abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- JWMFYGXQPXQEEM-NUNROCCHSA-N 5β-pregnane Chemical compound C([C@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](CC)[C@@]2(C)CC1 JWMFYGXQPXQEEM-NUNROCCHSA-N 0.000 abstract 1
- 239000003470 adrenal cortex hormone Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- JBWKIWSBJXDJDT-UHFFFAOYSA-N triphenylmethyl chloride Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(Cl)C1=CC=CC=C1 JBWKIWSBJXDJDT-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
PURPOSE: Steroid 17-esters, useful as adrenal cortical hormone agents, are easily prepared by the reaction of 17α, 21-cyclic orthoester in pregnane type steroid with triphenylmethyl chloride in dimethylformamide.
COPYRIGHT: (C)1977,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4209176A JPS52136157A (en) | 1976-04-14 | 1976-04-14 | Preparation of steroid 17-esters |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4209176A JPS52136157A (en) | 1976-04-14 | 1976-04-14 | Preparation of steroid 17-esters |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS52136157A true JPS52136157A (en) | 1977-11-14 |
JPS5516520B2 JPS5516520B2 (en) | 1980-05-02 |
Family
ID=12626334
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4209176A Granted JPS52136157A (en) | 1976-04-14 | 1976-04-14 | Preparation of steroid 17-esters |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS52136157A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5640700A (en) * | 1979-09-10 | 1981-04-16 | Kobayashi Yakugaku Kogyo Kk | Preparation of steroid 17-ester |
EP0393658A2 (en) * | 1989-04-19 | 1990-10-24 | Ss Pharmaceutical Co., Ltd. | Novel steroid derivatives |
JP2014533274A (en) * | 2011-11-11 | 2014-12-11 | アラーガン インコーポレイテッドAllergan,Incorporated | 4-Pregenene-11SS-17-21-triol-3,20-dione derivatives for the treatment of ophthalmic conditions |
WO2015089471A3 (en) * | 2013-12-13 | 2015-11-19 | Allergan, Inc. | Polymorphic and amorphous forms of cortisol 17-alpha-benzoate and methods for the preparation and use thereof |
-
1976
- 1976-04-14 JP JP4209176A patent/JPS52136157A/en active Granted
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5640700A (en) * | 1979-09-10 | 1981-04-16 | Kobayashi Yakugaku Kogyo Kk | Preparation of steroid 17-ester |
JPS6365678B2 (en) * | 1979-09-10 | 1988-12-16 | Kobayashi Yakugaku Kogyo Kk | |
EP0393658A2 (en) * | 1989-04-19 | 1990-10-24 | Ss Pharmaceutical Co., Ltd. | Novel steroid derivatives |
EP0393658B1 (en) * | 1989-04-19 | 1995-03-22 | Ss Pharmaceutical Co., Ltd. | Novel steroid derivatives |
US9717743B2 (en) | 2011-11-11 | 2017-08-01 | Allergan, Inc. | Pharmaceutical compositions and methods of use of 4-pregenen-11β-17-21-triol-3,20-dione derivatives |
JP2014533275A (en) * | 2011-11-11 | 2014-12-11 | アラーガン インコーポレイテッドAllergan,Incorporated | Pharmaceutical composition and method of use of 4-pregenen-11β-17-21-triol-3,20-dione derivative |
JP2014533274A (en) * | 2011-11-11 | 2014-12-11 | アラーガン インコーポレイテッドAllergan,Incorporated | 4-Pregenene-11SS-17-21-triol-3,20-dione derivatives for the treatment of ophthalmic conditions |
US10188667B2 (en) | 2011-11-11 | 2019-01-29 | Allergan, Inc. | Pharmaceutical compositions and methods of use of 4-pregenen-11β-17-21-triol-3,20-dione derivatives |
US10493082B2 (en) | 2011-11-11 | 2019-12-03 | Allergan, Inc. | 4-pregenen-11β-17-21-triol-3,20-dione derivatives |
WO2015089471A3 (en) * | 2013-12-13 | 2015-11-19 | Allergan, Inc. | Polymorphic and amorphous forms of cortisol 17-alpha-benzoate and methods for the preparation and use thereof |
CN105814071A (en) * | 2013-12-13 | 2016-07-27 | 阿勒根公司 | Polymorphic forms of a steroid-like compound and methods for the preparation and use thereof |
JP2016540001A (en) * | 2013-12-13 | 2016-12-22 | アラーガン、インコーポレイテッドAllergan,Incorporated | Polymorphic form of steroid-like compound, process for its production and use thereof |
US10065984B2 (en) | 2013-12-13 | 2018-09-04 | Allergan, Inc. | Polymorphic forms of a steroid-like compound and methods for the preparation and use thereof |
TWI659041B (en) * | 2013-12-13 | 2019-05-11 | 美商歐樂根公司 | Polymorphic forms of a steroid-like compound and methods for the preparation and use thereof |
AU2014361790B2 (en) * | 2013-12-13 | 2019-05-23 | Allergan, Inc. | Polymorphic and amorphous forms of cortisol 17-alpha-benzoate and methods for the preparation and use thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS5516520B2 (en) | 1980-05-02 |
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