JPS517672B2 - - Google Patents

Info

Publication number
JPS517672B2
JPS517672B2 JP47037181A JP3718172A JPS517672B2 JP S517672 B2 JPS517672 B2 JP S517672B2 JP 47037181 A JP47037181 A JP 47037181A JP 3718172 A JP3718172 A JP 3718172A JP S517672 B2 JPS517672 B2 JP S517672B2
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP47037181A
Other languages
Japanese (ja)
Other versions
JPS48103589A (de
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP47037181A priority Critical patent/JPS517672B2/ja
Priority to JP47037182A priority patent/JPS48103590A/ja
Application filed filed Critical
Priority claimed from JP9255772A external-priority patent/JPS5324431B2/ja
Priority claimed from JP47092558A external-priority patent/JPS5241268B2/ja
Priority claimed from JP47092560A external-priority patent/JPS5246231B2/ja
Priority to JP47120953A priority patent/JPS5229745B2/ja
Priority to JP47125858A priority patent/JPS5239036B2/ja
Priority to JP47128972A priority patent/JPS5241269B2/ja
Priority to DK2773AA priority patent/DK141603B/da
Priority to ZA730077A priority patent/ZA7377B/xx
Priority to NO73105A priority patent/NO140589C/no
Priority to FR7300739A priority patent/FR2179715B1/fr
Priority to CA161,000A priority patent/CA1025447A/en
Priority to DE2302027A priority patent/DE2302027C2/de
Priority to YU15073A priority patent/YU39001B/xx
Priority to US324905A priority patent/US3910924A/en
Priority to SU731873456A priority patent/SU580835A3/ru
Priority to GB325173A priority patent/GB1424571A/en
Priority to GB3417075A priority patent/GB1424572A/en
Priority to BE794669D priority patent/BE794669A/xx
Priority to FI279/73A priority patent/FI53703C/fi
Priority to DD178082*A priority patent/DD112446A5/xx
Priority to DD168643A priority patent/DD108293A5/xx
Priority to SE7301863A priority patent/SE380018B/xx
Priority to AR246548A priority patent/AR209575A1/es
Priority to NL7302353.A priority patent/NL158176B/xx
Priority to ES412484A priority patent/ES412484A1/es
Priority to CH1554675A priority patent/CH574930A5/fr
Priority to CH393973A priority patent/CH575929A5/xx
Priority to AT244373A priority patent/AT337703B/de
Priority to BR254373A priority patent/BR7302543D0/pt
Priority to AU54386/73A priority patent/AU475964B2/en
Publication of JPS48103589A publication Critical patent/JPS48103589A/ja
Priority to AT699775A priority patent/AT337704B/de
Publication of JPS517672B2 publication Critical patent/JPS517672B2/ja
Priority to DK138076A priority patent/DK152492C/da
Priority to DK137976A priority patent/DK137976A/da
Priority to CA257,001A priority patent/CA1025453A/en
Priority to FI770713A priority patent/FI61894C/fi
Priority to YU2549/79A priority patent/YU41187B/xx
Priority to HK194/81A priority patent/HK19481A/xx
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP47037181A 1972-04-13 1972-04-13 Expired JPS517672B2 (de)

Priority Applications (36)

Application Number Priority Date Filing Date Title
JP47037181A JPS517672B2 (de) 1972-04-13 1972-04-13
JP47037182A JPS48103590A (de) 1972-04-13 1972-04-13
JP47120953A JPS5229745B2 (de) 1972-04-13 1972-12-02
JP47125858A JPS5239036B2 (de) 1972-04-13 1972-12-14
JP47128972A JPS5241269B2 (de) 1972-04-13 1972-12-21
DK2773AA DK141603B (da) 1972-04-13 1973-01-03 Analogifremgangsmåde til fremstilling af 3,4-dihydrocarbostyril-derivater.
ZA730077A ZA7377B (en) 1972-04-13 1973-01-04 Process for preparing 3,4-dihydrocarbostyril derivatives
FR7300739A FR2179715B1 (de) 1972-04-13 1973-01-10
NO73105A NO140589C (no) 1972-04-13 1973-01-10 Analogifremgangsmaate for fremstilling av nye, terapeutisk aktive 3,4-dihydrokarbostyrilderivater
CA161,000A CA1025447A (en) 1972-04-13 1973-01-11 Process for preparing 3,4-dihydrocarbostyril derivatives
DE2302027A DE2302027C2 (de) 1972-04-13 1973-01-16 In 5- oder 8-Stellung substituierte 3,4-Dihydrocarbostyril-Derivate und ihre Salze, Verfahren zu ihrer Herstellung und Arzneimittel
YU15073A YU39001B (en) 1972-04-13 1973-01-18 Process for preparing new 3,4-dihydrocarbostyryl derivatives
US324905A US3910924A (en) 1972-04-13 1973-01-19 3,4-Dihydrocarbostyril derivatives and a process for preparing the same
SU731873456A SU580835A3 (ru) 1972-04-13 1973-01-20 Способ получени 3,4-дигидрокарбостирильных производных или их солей
GB325173A GB1424571A (en) 1972-04-13 1973-01-22 3,4-dihydrocarbostyril derivatives their preparation and pharmaceutical compositions thereof
GB3417075A GB1424572A (en) 1972-04-13 1973-01-22 3,4-dihydrocarbostyril derivatives and their preparation
BE794669D BE794669A (fr) 1972-04-13 1973-01-29 Derives de 3,4-dihydrocarbostyryle et leur procede de preparation
FI279/73A FI53703C (fi) 1972-04-13 1973-01-31 Foerfarande foer framstaellning av beta-adrenergiskt blockerande 3,4-dihydrokarbostyrilderivat
DD168643A DD108293A5 (de) 1972-04-13 1973-02-02
DD178082*A DD112446A5 (de) 1972-04-13 1973-02-02
SE7301863A SE380018B (de) 1972-04-13 1973-02-09
AR246548A AR209575A1 (es) 1972-04-13 1973-02-12 Un procedimiento para preparar nuevos derivados sustituidos de 5-,6-,7-u8-(3-amino-2-oxisustituido)-propoxi-3,4-dihidrocarbostirilo y de 5-,6-,7-u8-(3-amino-2-hidroxi)propoxi -3,4-dihidrocarbostirilo
NL7302353.A NL158176B (nl) 1972-04-13 1973-02-20 Werkwijze voor het bereiden van een geneesmiddel met (beta)-adrenenergisch blokkerende werking, gevormd geneesmiddel verkregen onder toepassing daarvan, alsmede werkwijze voor het bereiden van een verbinding geschikt voor toepassing bij voornoemde werkwijze.
ES412484A ES412484A1 (es) 1972-04-13 1973-03-09 Procedimiento para la preparacion de derivados carbostirili-cos.
CH1554675A CH574930A5 (en) 1972-04-13 1973-03-19 (2-hydroxy-3-amino)-propoxy-(3,4-dihydro)-carbostyril - derivs - beta-adrenergic blocking agents
CH393973A CH575929A5 (de) 1972-04-13 1973-03-19
AT244373A AT337703B (de) 1972-04-13 1973-03-20 Verfahren zur herstellung von neuen 3,4-dihydrocarbostyrilderivaten und deren salzen
BR254373A BR7302543D0 (pt) 1972-04-13 1973-04-09 Processo para obtencao de novos derivados de 3,4-di-hidro- carbo-estirila
AU54386/73A AU475964B2 (en) 1972-04-13 1973-04-11 Process for preparing 3,4-dihydrocarbostyril derivatives
AT699775A AT337704B (de) 1972-04-13 1975-09-11 Verfahren zur herstellung von neuen 3,4-dihydrocarbostyrilderivaten und deren salzen
DK137976A DK137976A (da) 1972-04-13 1976-03-29 Fremgangsmade til fremstilling af 2,4-dihydrocarbostyril-derivater
DK138076A DK152492C (da) 1972-04-13 1976-03-29 3,4-dihydrocarbostyril-derivater til anvendelse som mellemprodukter til fremstilling af biologisk aktive 3,4-dihydrocarbostyril-derivater
CA257,001A CA1025453A (en) 1972-04-13 1976-07-15 Process for preparing 3,4-dihydrocarbostyril derivatives
FI770713A FI61894C (fi) 1972-04-13 1977-03-07 Som mellanprodukter anvaendbara 1-substituerade eller 1-osubstituerade 5- 6- 7- eller 8-(2,3-substituerade)-propoxi-3,4-dihydroxikarbostyrilderivat
YU2549/79A YU41187B (en) 1972-04-13 1979-10-19 Process for preparing new 3,4-dihydrocarbostyrye derivatives
HK194/81A HK19481A (en) 1972-04-13 1981-05-14 3,4-dihydrocarbostyril derivatives,their preparation,and pharmaceutical compositions thereof

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP47037181A JPS517672B2 (de) 1972-04-13 1972-04-13
JP47037182A JPS48103590A (de) 1972-04-13 1972-04-13
JP9255772A JPS5324431B2 (de) 1972-09-14 1972-09-14
JP47092560A JPS5246231B2 (de) 1972-09-14 1972-09-14
JP47092558A JPS5241268B2 (de) 1972-09-14 1972-09-14
JP47120953A JPS5229745B2 (de) 1972-04-13 1972-12-02
JP47125858A JPS5239036B2 (de) 1972-04-13 1972-12-14
JP47128972A JPS5241269B2 (de) 1972-04-13 1972-12-21

Publications (2)

Publication Number Publication Date
JPS48103589A JPS48103589A (de) 1973-12-25
JPS517672B2 true JPS517672B2 (de) 1976-03-10

Family

ID=27572212

Family Applications (5)

Application Number Title Priority Date Filing Date
JP47037182A Pending JPS48103590A (de) 1972-04-13 1972-04-13
JP47037181A Expired JPS517672B2 (de) 1972-04-13 1972-04-13
JP47120953A Expired JPS5229745B2 (de) 1972-04-13 1972-12-02
JP47125858A Expired JPS5239036B2 (de) 1972-04-13 1972-12-14
JP47128972A Expired JPS5241269B2 (de) 1972-04-13 1972-12-21

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP47037182A Pending JPS48103590A (de) 1972-04-13 1972-04-13

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP47120953A Expired JPS5229745B2 (de) 1972-04-13 1972-12-02
JP47125858A Expired JPS5239036B2 (de) 1972-04-13 1972-12-14
JP47128972A Expired JPS5241269B2 (de) 1972-04-13 1972-12-21

Country Status (17)

Country Link
JP (5) JPS48103590A (de)
AR (1) AR209575A1 (de)
AU (1) AU475964B2 (de)
BE (1) BE794669A (de)
CA (1) CA1025447A (de)
CH (1) CH575929A5 (de)
DD (2) DD112446A5 (de)
DE (1) DE2302027C2 (de)
DK (1) DK141603B (de)
FI (1) FI53703C (de)
FR (1) FR2179715B1 (de)
GB (2) GB1424571A (de)
HK (1) HK19481A (de)
NL (1) NL158176B (de)
NO (1) NO140589C (de)
SE (1) SE380018B (de)
YU (1) YU41187B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5082218A (de) * 1973-11-10 1975-07-03
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
US4137331A (en) 1974-06-19 1979-01-30 Sandoz Ltd. 3-Piperidino-2-hydroxypropoxy substituted-2-indolinones
JPS516971A (en) * 1974-07-08 1976-01-20 Otsuka Pharma Co Ltd Nitoro 3*44 jihidorokarubosuchirirujudotaino seizoho
JPS5129486A (en) * 1974-09-02 1976-03-12 Otsuka Pharma Co Ltd * 33 arukiruamino 22 hidorokishi * purohokishi 3 44 jihidorokarubosuchirirujudotai no seizoho
JPS5148674A (en) * 1974-10-17 1976-04-26 Otsuka Pharma Co Ltd 3 44 jihidorokarubosuchirirujudotaino seizoho
JPS5152178A (ja) * 1974-10-31 1976-05-08 Otsuka Pharma Co Ltd Karubosuchirirujudotaino seizoho
JPS5152179A (ja) * 1974-10-31 1976-05-08 Otsuka Pharma Co Ltd Karubosuchirirujudotaino seizoho
JPS5152180A (ja) * 1974-10-31 1976-05-08 Otsuka Pharma Co Ltd Karubosuchirirujudotaino seizoho
FI58329C (fi) * 1974-11-08 1981-01-12 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av i 8-staellning substituerade 5-(3'-alkylamino-2'-hydroxi)propoxi-3,4-dihydrokarbostyrilderivat
US4081447A (en) * 1975-04-09 1978-03-28 Abbott Laboratories 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
CH619453A5 (de) * 1976-03-17 1980-09-30 Otsuka Pharma Co Ltd
DE2719562C2 (de) * 1976-05-08 1986-05-07 Otsuka Pharmaceutical Co. Ltd., Tokio/Tokyo 3, 4-Dihydrocarbostyrilderivate, Verfahren zu deren Herstellung und Arzneimittel, welche diese enthalten
US4146630A (en) * 1976-11-12 1979-03-27 Boehringer Mannheim Gmbh Blood pressure lowering and adrenergic β-receptor inhibiting 3-(4-phenoxymethylpiperidino)-propyl-phenyl ethers
JPS54130587A (en) * 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
EP0005828B1 (de) * 1978-06-06 1981-03-11 Hoechst Aktiengesellschaft Neue substituierte Phenylpiperazinderivate, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung
DE2827566A1 (de) * 1978-06-23 1980-01-10 Boehringer Mannheim Gmbh 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung
AU518814B2 (en) * 1979-01-30 1981-10-22 Otsuka Pharamaceutical Co. Glaucoma treatment
DE3034237A1 (de) * 1979-09-18 1981-04-16 Otsuka Pharmaceutical Co. Ltd., Tokyo Carbostyrilderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende, antihistaminisch wirkende mittel
JPS56122356A (en) * 1980-02-29 1981-09-25 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS58103343A (ja) * 1981-12-15 1983-06-20 Ota Seiyaku Kk プロパノ−ルアミン化合物の製造法
JPS597186A (ja) * 1982-07-02 1984-01-14 Ota Seiyaku Kk １，３，２−ジオキサチオラン２−オキシド誘導体
JPS63193086U (de) * 1987-05-30 1988-12-13
DE3808136A1 (de) * 1988-03-11 1989-09-21 Thomae Gmbh Dr K Arzneimittel, enthaltend chinolin-2,5-dione, neue chinolin-2,5-dione und verfahren zu ihrer herstellung
US5266577A (en) * 1988-08-10 1993-11-30 Otsuka Pharmaceutical Company Ltd. Method of treating congestive heart failure using carbostyril derivatives
US5053514A (en) * 1988-08-10 1991-10-01 Otsuka Pharmaceutical Company, Limited Cardiotonics
US5506239A (en) * 1991-08-23 1996-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative and platelets aggregation inhibitory agent
ES2048108B1 (es) * 1992-07-17 1994-10-01 Lusochimica Spa Procedimiento para la preparacion de 5-(3-terc-butilamino-2-hidroxipropoxi)-3,4-dihidrocarboestirilo.
IT1264816B1 (it) * 1993-07-28 1996-10-10 Pergam Srl Procedimento per la preparazione di derivati del procedimento per la preparazione di derivati del 3,4-diidrocarbostirile 3,4-diidrocarbostirile
CZ300351B6 (cs) * 2005-05-26 2009-04-29 Zentiva, A. S. Zpusob prípravy 7-hydroxy-3,4-dihydrokarbostyrilu

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1058822A (en) * 1963-07-30 1967-02-15 Ici Ltd 3-amino-2-hydroxypropoxy heterocyclic derivatives
CH534687A (de) * 1968-07-05 1973-03-15 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung von Derivaten des 2-Oxo-1,2-dihydro-chinolins

Also Published As

Publication number Publication date
SE380018B (de) 1975-10-27
AR209575A1 (es) 1977-05-13
DD108293A5 (de) 1974-09-12
CH575929A5 (de) 1976-05-31
DK141603B (da) 1980-05-05
NO140589C (no) 1979-10-03
FI53703B (de) 1978-03-31
DE2302027A1 (de) 1973-12-06
CA1025447A (en) 1978-01-31
JPS4982673A (de) 1974-08-08
JPS5241269B2 (de) 1977-10-17
DK141603C (de) 1980-10-06
HK19481A (en) 1981-05-22
FR2179715B1 (de) 1976-12-03
FR2179715A1 (de) 1973-11-23
NL158176B (nl) 1978-10-16
GB1424571A (en) 1976-02-11
DE2302027C2 (de) 1983-03-17
AU5438673A (en) 1974-10-17
JPS5229745B2 (de) 1977-08-03
YU41187B (en) 1986-12-31
BE794669A (fr) 1973-05-16
JPS5239036B2 (de) 1977-10-03
JPS4981373A (de) 1974-08-06
FI53703C (fi) 1978-07-10
DD112446A5 (de) 1975-04-12
AU475964B2 (en) 1976-09-09
YU254979A (en) 1982-10-31
GB1424572A (en) 1976-02-11
NL7302353A (de) 1973-10-16
JPS4976878A (de) 1974-07-24
JPS48103590A (de) 1973-12-25
JPS48103589A (de) 1973-12-25
NO140589B (no) 1979-06-25

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