JPH1160434A - Cosmetic for preventing skin aging - Google Patents
Cosmetic for preventing skin agingInfo
- Publication number
- JPH1160434A JPH1160434A JP23180397A JP23180397A JPH1160434A JP H1160434 A JPH1160434 A JP H1160434A JP 23180397 A JP23180397 A JP 23180397A JP 23180397 A JP23180397 A JP 23180397A JP H1160434 A JPH1160434 A JP H1160434A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- fatty acid
- acid
- activities
- cosmetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、皮膚老化防止化粧
料に関する。更に詳しくは、皮膚に細胞賦活作用を与え
る成分と、皮膚の水分保持機能を持続的に亢進、維持す
る成分との相乗効果により、荒れ肌改善効果、角質改善
効果、角質層のターンオーバー速度を早くする効果、美
肌効果等に優れた新規な皮膚化粧料に関する。TECHNICAL FIELD The present invention relates to a cosmetic for preventing skin aging. More specifically, the synergistic effect of a component that gives the cell a cell activating effect to the skin and a component that continuously enhances and maintains the moisture retention function of the skin increases the rough skin improving effect, the keratin improving effect, and the turnover speed of the horny layer. The present invention relates to a novel skin cosmetic having an excellent skin effect and a beautiful skin effect.
【０００２】[0002]
【従来の技術及び発明が解決しようとする課題】老化皮
膚とは、乾燥して滑らかさのない荒れ肌で、角質細胞剥
離現象が認められ、しわが多く、更に角質層のターンオ
ーバー速度が遅い皮膚をいう。本出願人は、先に、ジイ
ソプロピルアミンジクロロアセテート、γ−アミノ酪酸
及びその塩、γ−アミノ−β−ヒドロキシ酪酸及びその
塩、ニコチン酸アミド、Ｎ−メチル−Ｌ−セリン及びそ
の塩が、皮膚機能を亢進し、老化防止効果を持つことを
見出し、提案した（特公昭５８−２６７２６号公報、特
開平３−２１５９３２号公報、特開平９−２９５２号公
報）。2. Description of the Related Art Aged skin is rough skin that is dry and non-smooth, in which exfoliation of keratinocytes is observed, wrinkles are increased, and the turnover speed of the horny layer is slow. Say. Applicants have previously reported that diisopropylamine dichloroacetate, γ-aminobutyric acid and its salts, γ-amino-β-hydroxybutyric acid and its salts, nicotinamide, N-methyl-L-serine and its salts They have found that they have enhanced functions and have an antiaging effect, and have proposed them (Japanese Patent Publication No. 58-26726, Japanese Patent Application Laid-Open No. 3-215932, and Japanese Patent Application Laid-Open No. 9-2952).
【０００３】実用上、これらの皮膚機能を亢進する細胞
賦括剤を単独で用いても、皮膚の組織機能を修復又は改
善するような効果は遅効性で、皮膚が元来保有する機能
を回復させるような効果を現すためには充分満足し得る
ものではなく、改良の余地を残しているのが実情であっ
た。[0003] In practice, even if these cell stimulating agents that enhance skin function are used alone, the effect of restoring or improving the tissue function of skin is delayed, and the function originally possessed by skin is restored. In order to achieve such an effect, it is not sufficiently satisfactory, and there is still room for improvement.
【０００４】一方、イソ型脂肪酸及び／又はアンテイソ
型脂肪酸のコレステロールエステルは抱水性が高く、こ
れを配合した皮膚化粧料は皮膚の水分保持機能を持続的
に亢進、維持することにより、老化防止効果が期待され
る。On the other hand, cholesterol esters of iso-fatty acids and / or anteiso-fatty acids have a high water hydration property, and skin cosmetics containing the cholesterol esters have an antiaging effect by continuously enhancing and maintaining the moisture retention function of the skin. There is expected.
【０００５】本発明は、皮膚に細胞賦活作用を与える成
分と、更には皮膚の水分保持機能を持続的に亢進、維持
する成分との相乗効果により、新規な皮膚老化防止化粧
料を提供することを目的とする。An object of the present invention is to provide a novel skin aging preventive cosmetic which has a synergistic effect of a component that gives a cell activating effect to the skin and a component that continuously enhances and maintains the water retention function of the skin. With the goal.
【０００６】[0006]
【課題を解決するための手段】本発明者は、ジイソプロ
ピルアミンジクロロアセテート、γ−アミノ酪酸及びそ
の塩、γ−アミノ−β−ヒドロキシ酪酸及びその塩、ニ
コチン酸アミド、Ｎ−メチル−Ｌ−セリン及びその塩の
群から選ばれる少なくとも一種並びに、一般式（１）で
表されるイソ型脂肪酸のコレステロールエステル及び／
又は一般式（２）で表されるアンテイソ型脂肪酸のコレ
ステロールエステルの少なくとも一種とを含有すること
を特徴とする皮膚老化防止化粧料が、本目的を達成でき
ることを見出した。Means for Solving the Problems The present inventors have developed diisopropylamine dichloroacetate, γ-aminobutyric acid and its salts, γ-amino-β-hydroxybutyric acid and its salts, nicotinamide, N-methyl-L-serine. And at least one selected from the group of salts thereof, and cholesterol esters of iso fatty acids represented by the general formula (1) and / or
Alternatively, it has been found that a skin aging preventive cosmetic comprising at least one cholesterol ester of anteiso fatty acid represented by the general formula (2) can achieve the object.
【０００７】[0007]
【化３】 Embedded image
【０００８】（但し、ｎは６〜３２で示される。）(However, n is represented by 6 to 32.)
【０００９】[0009]
【化４】 Embedded image
【００１０】（但し、ｎは６〜３２で示される。）(However, n is represented by 6 to 32.)
【００１１】[0011]
【００１２】以下、本発明の実施の形態を詳述する。Hereinafter, embodiments of the present invention will be described in detail.
【００１３】本発明で用いる、ジイソプロピルアミンジ
クロロアセテート、γ−アミノ酪酸及びその塩、γ−ア
ミノ−β−ヒドロキシ酪酸及びその塩、ニコチン酸アミ
ド、Ｎ−メチル−Ｌ−セリン及びその塩は、いずれも細
胞賦活剤として公知の物質である。その配合量は皮膚老
化防止化粧料の総量を基準にして０．０１〜５重量％
（以下、ｗｔ％と略す）が好ましい。[0013] Diisopropylamine dichloroacetate, γ-aminobutyric acid and its salts, γ-amino-β-hydroxybutyric acid and its salts, nicotinamide, N-methyl-L-serine and its salts used in the present invention can be any of Is also a substance known as a cell activator. The compounding amount is 0.01 to 5% by weight based on the total amount of the skin aging preventive cosmetic.
(Hereinafter abbreviated as wt%).
【００１４】従来より化粧品原料として用いられている
分岐脂肪酸コレステロールエステルは、イソステアリン
酸によって構成される。このイソステアリン酸は、分岐
位置及び分岐アルキル鎖長は特定されていないが、ほと
んどは２−ヘプチルウンデカン酸である。一方、本発明
に用いる分岐脂肪酸コレステロールエステルは、イソ
型、アンテイソ型脂肪酸によって構成される。すなわ
ち、それぞれ末端より２位〔前記一般式（１）〕、及び
末端より３位〔前記一般式（２）〕にメチル基を有する
脂肪酸に限定される。分岐位置及び分岐アルキル鎖長が
特定されている点で、従来公知化合物の分岐脂肪酸コレ
ステロールエステルとは異なる。[0014] The branched fatty acid cholesterol ester conventionally used as a cosmetic raw material is composed of isostearic acid. This isostearic acid is 2-heptylundecanoic acid, although the branch position and the branched alkyl chain length are not specified. On the other hand, the branched fatty acid cholesterol ester used in the present invention is composed of iso-type and anteiso-type fatty acids. That is, it is limited to fatty acids having a methyl group at the 2-position from the terminal [the above-mentioned general formula (1)] and the 3-position from the terminal [the above-mentioned general formula (2)]. It differs from the conventionally known branched fatty acid cholesterol ester in that the branch position and the branched alkyl chain length are specified.
【００１５】本発明に用いるイソ型脂肪酸及び／又はア
ンテイソ型脂肪酸のコレステロールエステルは、例え
ば、株式会社日本精化のＹＯＦＣＯ ＣＬＥ−ＮＨ（イ
ソ型脂肪酸及びアンテイソ型脂肪酸のコレステロールエ
ステルを含有）等を挙げることができるが、これに限定
されるものではない。なお、本発明に用いる分岐脂肪酸
コレステロールエステルはイソ型、アンテイソ型に分離
する必要はないが、分離して用いても良い。また、これ
らの分岐脂肪酸コレステロールエステルは他の脂肪酸コ
レステロールエステルとの混合物で良いが、分岐脂肪酸
コレステロールエステルのみからなるものでも良い。こ
れらのイソ型脂肪酸及びアンテイソ型脂肪酸の総炭素数
は融点が低く、液晶構造を形成する範囲である、６〜３
２であり、好ましくは総炭素数１２〜２８である。上記
分岐脂肪酸コレステロールエステルの配合量は、皮膚老
化防止化粧料の総量を基準にして０．００５〜２０ｗｔ
が好ましい。The cholesterol ester of an iso-type fatty acid and / or anteiso-type fatty acid used in the present invention includes, for example, YOFCO CLE-NH (containing cholesterol ester of iso-type fatty acid and anteiso-type fatty acid) of Nippon Seika. However, the present invention is not limited to this. The branched fatty acid cholesterol ester used in the present invention does not need to be separated into an iso form and an ante iso form, but may be used separately. In addition, these branched fatty acid cholesterol esters may be a mixture with other fatty acid cholesterol esters, or may be composed of only branched fatty acid cholesterol esters. The total number of carbon atoms of these iso-type fatty acids and anteiso-type fatty acids has a low melting point and is in a range for forming a liquid crystal structure.
2, preferably 12 to 28 carbon atoms in total. The blending amount of the branched fatty acid cholesterol ester is 0.005 to 20 wt% based on the total amount of the skin aging preventive cosmetic.
Is preferred.
【００１６】本発明の化粧料には、上記原料の他にター
ル系色素、酸化鉄などの着色顔料、パラベン、フェノキ
シエタノールなどの防腐剤、ジメチルポリシロキサン、
メチルフェニルポリシロキサン等のシリコーン油、流動
パラフィン、スクワラン、パラフィン、ワセリン等の炭
化水素類、ミツロウ、ホホバ油、カルナバロウ等のロウ
類、トリイソステアリン酸グリセリル、トリオクタン酸
グリセリル、トリ−２−エチルヘキサン酸グリセリルな
どのトリグリセリド類、ミリスチン酸オクチルドデシ
ル、ミリスチン酸イソセチル、ジオクタン酸ネオペンチ
ルグリコール、パルミチン酸セチル等のエステル油、セ
タノール、ベヘニルアルコール、ステアリルアルコール
等の高級アルコール類、コレステロール、フィトステロ
ール等のステロール類、オリーブ油、マカデミアナッツ
油、ヒマシ油等の植物油類、硬化油等の加工油類、ステ
アリン酸、ミリスチン酸、イソステアリン酸等の脂肪
酸、セチル硫酸ナトリウム、Ｎ−ステアロイル−Ｌ−グ
ルタミン酸塩、グリチルリチン酸塩などの陰イオン界面
活性剤、ポリオキシエチレンアルキルエーテル、ポリオ
キシエチレン脂肪酸エステル、ポリオキシエチレン多価
アルコール脂肪酸エステル、ポリオキシエチレン硬化ヒ
マシ油、多価アルコール脂肪酸エステル、ポリグリセリ
ン脂肪酸エステル、変性シリコーン、蔗糖エステルなど
の非イオン界面活性剤、テトラアルキルアンモニウム塩
などの陽イオン界面活性剤、ベタイン型、スルホベタイ
ン型、スルホアミノ酸型、Ｎ−ステアロイル−Ｌ−グル
タミン酸ナトリウムなどの両性界面活性剤、レシチン、
リゾフォスファチジルコリンなどの天然系界面活性剤、
酸化チタン、酸化亜鉛などの顔料、ジブチルヒドロキシ
トルエンなどの抗酸化剤、グリセリン、１，３−ブチレ
ングリコール、ジプロピレングリコール、プロピレング
リコール、ソルビトール、マルビトール、ジグリセリン
等の多価アルコール、エデト酸等のキレート剤、キサン
タンガム、カルボキシビニルポリマー、カラギーナン等
の増粘剤、水酸化カリウム、ジイソプロパノールアミ
ン、トリエタノールアミン等の中和剤、ヒアルロン酸、
コラーゲン等の生体高分子、カミツレ、アロエ、モモ、
カロット、甘草等の植物エキス、セリン、スレオニン等
のアミノ酸、ヒドロキシメトキシベンゾフェノンスルフ
ォン酸塩等の紫外線吸収剤などを、本発明の目的を達成
する範囲内で適宜配合することができる。In the cosmetic of the present invention, in addition to the above-mentioned raw materials, tar pigments, coloring pigments such as iron oxide, preservatives such as paraben and phenoxyethanol, dimethylpolysiloxane,
Silicone oils such as methylphenylpolysiloxane, hydrocarbons such as liquid paraffin, squalane, paraffin, petrolatum, waxes such as beeswax, jojoba oil, carnauba wax, glyceryl triisostearate, glyceryl trioctanoate, tri-2-ethylhexanoic acid Triglycerides such as glyceryl, octyldodecyl myristate, isocetyl myristate, neopentyl glycol dioctanoate, ester oils such as cetyl palmitate, higher alcohols such as cetanol, behenyl alcohol, stearyl alcohol, sterols such as cholesterol and phytosterol, olive oil , Vegetable oils such as macadamia nut oil and castor oil, processing oils such as hardened oil, fatty acids such as stearic acid, myristic acid and isostearic acid, sodium cetyl sulfate Anionic surfactants such as N-stearoyl-L-glutamate, glycyrrhizinate, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene polyhydric alcohol fatty acid ester, polyoxyethylene hydrogenated castor oil, Nonionic surfactants such as polyhydric alcohol fatty acid esters, polyglycerin fatty acid esters, modified silicones, sucrose esters, etc., cationic surfactants such as tetraalkylammonium salts, betaine type, sulfobetaine type, sulfoamino acid type, N-stearoyl -Amphoteric surfactants such as sodium L-glutamate, lecithin,
Natural surfactants such as lysophosphatidylcholine,
Pigments such as titanium oxide and zinc oxide, antioxidants such as dibutylhydroxytoluene, glycerin, polyhydric alcohols such as 1,3-butylene glycol, dipropylene glycol, propylene glycol, sorbitol, malbitol and diglycerin, edetic acid, etc. Chelating agents, xanthan gum, carboxyvinyl polymer, thickeners such as carrageenan, potassium hydroxide, diisopropanolamine, neutralizing agents such as triethanolamine, hyaluronic acid,
Biopolymers such as collagen, chamomile, aloe, peach,
Plant extracts such as carrot and licorice, amino acids such as serine and threonine, ultraviolet absorbers such as hydroxymethoxybenzophenone sulfonate, and the like can be appropriately compounded within a range that achieves the object of the present invention.
【００１７】本発明の皮膚老化防止化粧料の剤型として
は、クリーム、乳液、化粧水、パック、マッサージ料、
メイクアップ料、浴用剤などが挙げられる。[0017] The dosage forms of the skin aging preventive cosmetic of the present invention include creams, emulsions, lotions, packs, massages,
Examples include make-up charges and bath agents.
【００１８】[0018]
【実施例】以下、実施例及び比較例に基づいて本発明を
詳細に説明する。なお、実施例に記載の（１）保湿性試
験（角質層水分量測定）、（２）角質層のターンオーバ
ー速度測定試験、（３）荒れ肌改善効果試験、（４）角
質改善効果試験、（５）官能テストは下記の通りであ
る。The present invention will be described below in detail based on examples and comparative examples. In addition, (1) moisturizing test (measurement of the water content of the stratum corneum), (2) test for measuring the turnover speed of the stratum corneum, (3) test for improving the rough skin, (4) test for improving the stratum corneum, and 5) The sensory test is as follows.
【００１９】（１）保湿性試験（角質層水分量測定） ２０人の上腕部において、試料塗布前及び塗布１５分後
の角質水分量を田上らの方法（日本香粧品科学会誌：１
６巻、２号、１００−１０６頁、１９８２年）に基づき
Ｓｋｉｃｏｎ−２００型水分量測定器（ＩＢＳ製）を用
いて測定し、角質水分量の上昇した人数で評価を行っ
た。(1) Moisturizing test (measurement of water content of stratum corneum) In 20 upper arms, the water content of keratin before and 15 minutes after application of the sample was determined by the method of Tagami et al. (Journal of the Japan Cosmetic Science Society: 1)
Vol. 6, No. 2, pp. 100-106, 1982) using a Skicon-200 type moisture meter (manufactured by IBS), and evaluated by the number of persons whose keratin moisture content increased.
【００２０】（２）角質層のターンオーバー速度測定試
験 蛍光色素のダンシルクロライドを白色ワセリン中に５ｗ
ｔ％配合した軟膏を作り、被験者１０名の前腕部の皮膚
に２４時間閉塞貼付し、角質層にダンシルクロリドを浸
透結合させた。その後、同じ部位に１日２回（朝、夕）
被験試料を約０．２g 塗布し、毎日１回暗所で紫外線Ａ
ランプを用いて、ダンシルクロライドの蛍光を調べ、そ
の蛍光が消滅するまでの日数を皮膚角質層のターンオー
バー速度とした。なお、測定結果は各被験者の日数の平
均値で示す。(2) Test for measuring the turnover rate of the stratum corneum The fluorescent dye dansyl chloride was added to white petrolatum for 5w.
An ointment containing t% was prepared, and closed and adhered to the skin of the forearm of 10 subjects for 24 hours, and dansyl chloride was osmotically bonded to the stratum corneum. Then twice a day at the same site (morning and evening)
Approximately 0.2 g of a test sample is applied, and ultraviolet light A is applied once a day in a dark place.
The fluorescence of dansyl chloride was examined using a lamp, and the number of days until the fluorescence disappeared was defined as the turnover speed of the stratum corneum of the skin. The measurement results are shown as the average of the number of days for each subject.
【００２１】（３）荒れ肌改善効果試験 下脚に荒れ肌を持つ、中高年被験者２０名を対象として
４週間連続塗布試験を実施した。被験者の左側脚試験部
位に１日２回・約１g の試料を塗布し、試験開始前及び
終了後の皮膚の状態を表１の判定基準により判定した。
なお、右側下脚は試料を塗布せず対照とした。(3) Rough Skin Improving Effect Test A continuous application test was conducted for 20 weeks on 20 middle-aged and elderly subjects having rough skin on the lower leg. About 1 g of a sample was applied to the test site of the left leg twice a day twice a day, and the skin condition before and after the start of the test was determined according to the criteria shown in Table 1.
The lower leg on the right side was used as a control without applying the sample.
【００２２】[0022]
【表１】 [Table 1]
【００２３】試験前後の試験部位と対照部位の判定結果
を比較し、皮膚乾燥度が２段階以上改善された場合（例
えば＋→−，＋＋→±）を「有効」、１段階改善された
場合を「やや有効」、変化が無かった場合を「無効」と
した。試験結果は「有効」、「やや有効」となった被験
者の人数で示した。The results of the judgment of the test site and the control site before and after the test are compared, and when the degree of dryness of the skin is improved by two or more stages (for example, + →-, ++ → ±), “effective” and one stage of improvement Is "slightly effective", and when there is no change is "invalid". The test results were indicated by the number of subjects who became “effective” and “slightly effective”.
【００２４】（４）角質改善効果試験（角質細胞の抗剥
離性増大） 前述の、荒れ肌改善効果試験終了後の被験部皮膚にスコ
ッチテープ（ニチバンメンディングテープ）を接着し、
これを剥離した時テープに付着した角質細胞の状態を走
査型電子顕微鏡によって詳細に調べ、表２の判定基準に
よって皮膚角質層細胞剥離性を分類し、角質改善効果を
求めた。(4) Keratin improvement effect test (increase in anti-peeling properties of keratinocytes) Scotch tape (Nichiban Mending tape) was adhered to the skin of the test part after the above-mentioned rough skin improvement effect test was completed.
The state of the keratinous cells adhered to the tape when this was peeled was examined in detail by a scanning electron microscope, and the keratinous cell peeling properties of the skin were classified according to the criteria shown in Table 2, and the keratin improving effect was obtained.
【００２５】[0025]
【表２】 [Table 2]
【００２６】評価は４週間連続塗布終了後の試験部位の
評価点と対照部位のそれとの差が２点以上の場合を「有
効」、１点の場合を「やや有効」、０点の場合を「無
効」とした。試験結果は「有効」、「やや有効」となっ
た被験者の人数で示した。The evaluation was evaluated as "valid" when the difference between the evaluation point of the test site and that of the control site after two consecutive weeks of application was 2 or more, "valid" when 1 point, and "0" when 0 point. "Invalid". The test results were indicated by the number of subjects who became “effective” and “slightly effective”.
【００２７】（５）官能テスト（美肌効果試験） 荒れ肌、小じわ、乾燥肌等を訴える女子被験者（３５〜
５５才）２０人に試料を１日２回（朝、夕）約１g 連続
３ケ月間塗布して、１，２，３ケ月後の効果を評価し
た。試験結果は、皮膚の湿潤性、平滑性、弾力性の各項
目に対して、「皮膚に潤いが生じた」，「皮膚が滑らか
になった」，「皮膚に張りが生じた」と回答した人数で
示した。(5) Sensory Test (Beautiful Skin Effect Test) Female subjects complaining of rough skin, fine lines, dry skin, etc.
The sample was applied to 20 persons (55 years old) twice a day (morning and evening) for about three consecutive months, and the effect after 1, 2, and 3 months was evaluated. In the test results, for each item of skin wettability, smoothness, and elasticity, the respondents answered that "the skin was moistened", "the skin became smooth", and "the skin became taut" Indicated by the number of people.
【００２８】実施例１〜９、比較例１〜３［スキンクリ
ーム］ 表３の組成でスキンクリームを調製し、前記の諸試験を
実施した。なお、本試験においてイソ型脂肪酸及び／又
はアンテイソ型脂肪酸のコレステロールエステルとし
て、株式会社日本精化製（ＹＯＦＣＯ ＣＬＥ−ＮＨ、
以下これをＮＨと略す）を用いるが、本発明はこれに限
定されるものではない。また、ジイソプロピルアミンジ
クロロアセテートはＤＡＤＡ、γ−アミノ酪酸はＧＡＢ
Ａ、γ−アミノ酪酸の塩としては、同ナトリウム塩はＧ
ＡＢＯＢ−Ｎａ、γ−アミノ−β−ヒドロキシ酪酸はＧ
ＡＢＯＢ、γ−アミノ酪酸−β−ヒドロキシ酪酸の塩と
しては、同ナトリウム塩はＧＡＢＯＢ−Ｎａ、ニコチン
酸アミドはＮＡＡ、Ｎ−メチル−Ｌ−セリンはＮＭＳの
ように略す。Examples 1 to 9 and Comparative Examples 1 to 3 [Skin creams] Skin creams were prepared according to the compositions shown in Table 3, and the above-mentioned tests were carried out. In this test, cholesterol esters of iso-fatty acids and / or anteiso-fatty acids were manufactured by Nippon Seika Co., Ltd. (YOOFCO CLE-NH,
Hereinafter, this is abbreviated as NH), but the present invention is not limited to this. Diisopropylamine dichloroacetate is DADA, γ-aminobutyric acid is GAB
A, As a salt of γ-aminobutyric acid, the sodium salt is G
ABOB-Na and γ-amino-β-hydroxybutyric acid are G
ABOB and γ-aminobutyric acid-β-hydroxybutyrate are abbreviated as GABOB-Na for sodium salt, NAA for nicotinamide, and NMS for N-methyl-L-serine.
【００２９】[0029]
【表３】 [Table 3]
【００３０】（２）調製法 （Ａ）成分及び（Ｂ）成分を各々８０℃に加熱溶解した
後、（Ａ）成分中に（Ｂ）成分を加え混合して、攪拌し
つつ３０℃まで冷却して、各スキンクリームを調製し
た。(2) Preparation Method After the components (A) and (B) are each heated and dissolved at 80 ° C., the component (B) is added to the component (A), mixed, and cooled to 30 ° C. with stirring. Then, each skin cream was prepared.
【００３１】（３）特性 各スキンクリームの諸試験を実施した結果を表３に併せ
て記載した。表３に示すように、比較例１〜３の細胞賦
活剤又はＮＨを単独で配合したスキンクリームは諸特性
において充分なる効果は得られなかった。これに対し、
本発明の実施例１〜９のスキンクリームは諸特性におい
て顕著な効果が見られ、官能テストでは試料塗布後１〜
２ケ月で優れた美肌効果を示した。(3) Characteristics The results of various tests conducted on each skin cream are shown in Table 3. As shown in Table 3, the skin creams containing the cell activator or NH alone in Comparative Examples 1 to 3 did not show sufficient effects in various properties. In contrast,
The skin creams of Examples 1 to 9 of the present invention have remarkable effects in various properties.
Excellent skin effect was shown in 2 months.
【００３２】[0032]
【発明の効果】以上記載のように、本発明は、細胞賦活
剤の作用及び皮膚の水分保持機能を持続的に亢進、維持
することにより、皮膚老化防止効果（荒れ肌改善効果、
角質改善効果、角質層のターンオーバー速度を早くする
効果、美肌効果等）の優れた皮膚老化防止化粧料を提供
することができる。As described above, according to the present invention, the effect of a cell activator and the function of retaining skin moisture are continuously enhanced and maintained, thereby preventing skin aging (effect of improving rough skin,
It is possible to provide a skin aging preventive cosmetic having excellent keratin improving effects, an effect of increasing the turnover speed of the horny layer, and a beautiful skin effect.
─────────────────────────────────────────────────────
────────────────────────────────────────────────── ───
【手続補正書】[Procedure amendment]
【提出日】平成９年１０月２０日[Submission date] October 20, 1997
【手続補正１】[Procedure amendment 1]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】００１５[Correction target item name] 0015
【補正方法】変更[Correction method] Change
【補正内容】[Correction contents]
【００１５】本発明に用いるイソ型脂肪酸及び／又はア
ンテイソ型脂肪酸のコレステロールエステルは、例え
ば、株式会社日本精化のＹＯＦＣＯ ＣＬＥ−ＮＨ（イ
ソ型脂肪酸及びアンテイソ型脂肪酸のコレステロールエ
ステルを含有）等を挙げることができるが、これに限定
されるものではない。なお、本発明に用いる分岐脂肪酸
コレステロールエステルはイソ型、アンテイソ型に分離
する必要はないが、分離して用いても良い。また、これ
らの分岐脂肪酸コレステロールエステルは他の脂肪酸コ
レステロールエステルとの混合物でも良いが、分岐脂肪
酸コレステロールエステルのみからなるものでも良い。
これらのイソ型脂肪酸及びアンテイソ型脂肪酸の総炭素
数は融点が低く、液晶構造を形成する範囲である、１０
〜３７であり、好ましくは総炭素数１２〜２８である。
上記分岐脂肪酸コレステロールエステルの配合量は、皮
膚老化防止化粧料の総量を基準として０．００５〜２０
ｗｔ％が好ましい。The cholesterol ester of an iso-type fatty acid and / or anteiso-type fatty acid used in the present invention includes, for example, YOFCO CLE-NH (containing cholesterol ester of iso-type fatty acid and anteiso-type fatty acid) of Nippon Seika. However, the present invention is not limited to this. The branched fatty acid cholesterol ester used in the present invention does not need to be separated into an iso form and an ante iso form, but may be used separately. These branched fatty acid cholesterol ester may be a mixture with other fatty acid cholesterol ester, or may consist solely of branched fatty acid cholesterol ester.
The total number of carbon atoms of these isoforms fatty acids and anteiso fatty acids have low melting point, a range for forming a liquid crystal structure, 10
To 37 , and preferably 12 to 28 carbon atoms in total.
The blending amount of the branched fatty acid cholesterol ester is 0.005 to 20 based on the total amount of the skin aging preventive cosmetic.
wt% is preferred.
Claims (1)
ト、γ−アミノ酪酸及びその塩、γ−アミノ−β−ヒド
ロキシ酪酸及びその塩、ニコチン酸アミド、Ｎ−メチル
−Ｌ−セリン及びその塩の群から選ばれる少なくとも一
種並びに、一般式（１） 【化１】 （但し、ｎは６〜３２で示される。）で表されるイソ型
脂肪酸のコレステロールエステル及び／又は一般式
（２） 【化２】 （但し、ｎは６〜３２で示される。）で表されるアンテ
イソ型脂肪酸のコレステロールエステルの少なくとも一
種とを含有することを特徴とする皮膚老化防止化粧料。At least one selected from the group consisting of diisopropylamine dichloroacetate, γ-aminobutyric acid and salts thereof, γ-amino-β-hydroxybutyric acid and salts thereof, nicotinamide, N-methyl-L-serine and salts thereof. One kind and the general formula (1) (Where n is 6 to 32) cholesterol ester of iso-fatty acid and / or general formula (2) (Where n is 6 to 32). A skin aging preventive cosmetic comprising at least one cholesterol ester of anteiso fatty acid represented by the formula:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23180397A JPH1160434A (en) | 1997-08-12 | 1997-08-12 | Cosmetic for preventing skin aging |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23180397A JPH1160434A (en) | 1997-08-12 | 1997-08-12 | Cosmetic for preventing skin aging |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH1160434A true JPH1160434A (en) | 1999-03-02 |
Family
ID=16929275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP23180397A Pending JPH1160434A (en) | 1997-08-12 | 1997-08-12 | Cosmetic for preventing skin aging |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH1160434A (en) |
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-
1997
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