JPH11508898A - 抗腫瘍性の2−アミノカルボニル−1,2−ビス(メチルスルホニル)−1−(置換)ヒドラジン類 - Google Patents
抗腫瘍性の2−アミノカルボニル−1,2−ビス(メチルスルホニル)−1−(置換)ヒドラジン類Info
- Publication number
- JPH11508898A JPH11508898A JP9505285A JP50528597A JPH11508898A JP H11508898 A JPH11508898 A JP H11508898A JP 9505285 A JP9505285 A JP 9505285A JP 50528597 A JP50528597 A JP 50528597A JP H11508898 A JPH11508898 A JP H11508898A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- tumor
- bis
- compounds
- cooc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/55—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 次の式: CH3SO2N(Y)N(CONHR)SO2CH3 (式中、Yは−CH3または−CH2CH2Clであり、Rは−C1〜C7アルキル、 シクロヘキシル、メチルシクロヘキシル、−CH2CH=CH2、−CH2CH2C l、−CH2CH2CH2Cl、−CH3COOC2H5、−CH(CH3)COOC2H5 または−CH(CH2C6H5)COOC2H5である。)で表される化合物。 2. Yが−CH2CH2Clであり、Rが−CH2CH2Cl、−CH2CH=C H2または−CH3である請求項1に記載の化合物。 3. Rが−CH2CH2Clまたは−CH3である請求項2に記載の化合物。 4. Rが−CH2CH2Clである請求項2に記載の化合物。 5. 上記C1〜C7アルキルがメチル、エチル、n−プロピル、イソプロピル 、n−ブチル、イソブチル、t−ブチル、n−ペンチル、イソペンチル、n−ヘ キシル、イソヘキシルまたは置換ヘキシルからなる群から選ばれる請求項1に記 載の化合物。 6. 次の式 CH3SO2N(Y)N(CONHR)SO2CH3 (式中、Yは−CH3または−CH2CH2Clであり、Rは−C1〜C7アルキル、 シクロヘキシル、メチルシクロヘキシル、−CH2CH=CH2、−CH2CH2C l、−CH2CH2CH2Cl、−CH2COOC2H5、−CH(CH3)COOC2H5 または−CH(CH2C6H5)COOC2H5である。)で表される化合物の治療有 効量からなる、哺乳動物の悪性腫瘍治療用製薬組成物。 7. さらに、製薬的に許容できる賦形剤、添加剤または担体を含有する請求 項6に記載の組成物。 8. Yが−CH2CH2Clであり、Rが−CH2CH2Cl、−CH2CH=C H2または− CH3である請求項6に記載の組成物。 9. Rが−CH2CH2Clまたは−CH3である請求項8に記載の組成物。 10. Rが−CH2CH2Clである請求項9に記載の組成物。 11. 上記C1〜C7アルキルがメチル、エチル、n−プロピル、イソプロピ ル、n−ブチル、イソブチル、t−ブチル、n−ペンチル、イソペンチル、n− ヘキシル、イソヘキシルおよび置換ヘキシルからなる群から選ばれる請求項6に 記載の組成物。 12. 静脈内投与剤形である請求項7に記載の組成物。 13. 筋肉内投与剤形である請求項7に記載の組成物。 14. 経口投与剤形である請求項7に記載の組成物。 15. 次の式 CH3SO2N(Y)N(CONHR)SO2CH3 (式中、Yは−CH3または−CH2CH2Clであり、Rは−C1〜C7アルキル、 シクロヘキシル、メチルシクロヘキシル、−CH2CH=CH2、−CH2CH2C l、−CH2CH2CH2Cl、−CH2COOC2H5、−CH(CH3)COOC2H5 または−CH(CH2C6H5)COOC2H5である。)で表される化合物の治療有 効量を投与することからなる哺乳動物の悪性腫瘍治療のための製薬組成物。 16. Yが−CH2CH2Clである請求項15に記載の組成物。 17. 上記C1〜C7アルキルがメチル、エチル、n−プロピル、イソプロピ ル、n−ブチル、イソブチル、t−ブチル、n−ペンチル、イソペンチル、n− ヘキシル、イソヘキシルまたは置換ヘキシルからなる群から選ばれる請求項15 に記載の組成物。 18. Yが−CH2CH2Clであり、Rが−CH2CH2Cl、−CH2CH= CH2または−CH3である請求項15に記載の組成物。 19. Rが−CH2CH2Clまたは−CH3である請求項18に記載の組成物 。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/497,931 | 1995-07-05 | ||
US08/497,931 US5637619A (en) | 1995-07-05 | 1995-07-05 | Antitumor 2-aminocarbonyl-1, 2-bis(methylsulfonyl)-1-(substituted)hydrazines |
PCT/US1996/011218 WO1997002029A1 (en) | 1995-07-05 | 1996-07-02 | Antitumor 2-aminocarbonyl-1,2-bis(methylsulfonyl)-1-(substituted)hydrazines |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH11508898A true JPH11508898A (ja) | 1999-08-03 |
JP3869007B2 JP3869007B2 (ja) | 2007-01-17 |
Family
ID=23978924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50528597A Expired - Fee Related JP3869007B2 (ja) | 1995-07-05 | 1996-07-02 | 抗腫瘍性の2−アミノカルボニル−1,2−ビス(メチルスルホニル)−1−(置換)ヒドラジン類 |
Country Status (16)
Country | Link |
---|---|
US (1) | US5637619A (ja) |
EP (1) | EP0841912B1 (ja) |
JP (1) | JP3869007B2 (ja) |
KR (1) | KR100372632B1 (ja) |
CN (2) | CN1095828C (ja) |
AT (1) | ATE224708T1 (ja) |
AU (1) | AU713128B2 (ja) |
BR (1) | BR9609620A (ja) |
CA (1) | CA2226331C (ja) |
DE (1) | DE69623969T2 (ja) |
DK (1) | DK0841912T3 (ja) |
ES (1) | ES2179204T3 (ja) |
HK (1) | HK1050892A1 (ja) |
PT (1) | PT841912E (ja) |
SI (1) | SI0841912T1 (ja) |
WO (1) | WO1997002029A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007516228A (ja) * | 2003-06-13 | 2007-06-21 | ヴァイオン ファーマシューティカルズ、インコーポレーテッド | 新規なアルキル化処置剤としての水溶性shp |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6040338A (en) * | 1997-11-03 | 2000-03-21 | Yale University | N,n-bis(sulfonyl)hydrazines useful as antineoplastic agents |
KR100578425B1 (ko) * | 1998-10-16 | 2007-01-11 | 씨제이 주식회사 | 캐테콜 히드라진 유도체, 이의 제조 방법 및 이를 함유한 약제학적 조성물 |
WO2005094282A2 (en) * | 2004-03-26 | 2005-10-13 | Vion Pharmaceuticals, Inc. | Combination therapy comprising cloretazinetm |
JP4814245B2 (ja) * | 2004-09-21 | 2011-11-16 | ヴァイオン ファーマシューティカルズ、インコーポレーテッド | 低酸素選択性抗腫瘍剤としてのスルホニルヒドラジンのリン酸含有プロドラッグ |
EP3549582A3 (en) * | 2014-08-29 | 2020-01-01 | The Board of Regents of The University of Texas System | Novel capsazepine analogs for the treatment of cancer and other proliferative diseases |
KR102643986B1 (ko) | 2017-09-29 | 2024-03-07 | 사빅 에스케이 넥슬렌 컴퍼니 피티이 엘티디 | 신규한 인덴계 전이금속 화합물, 이를 포함하는 전이금속 촉매 조성물, 및 이를 이용한 에틸렌 단독중합체 또는 에틸렌과 α-올레핀의 공중합체의 제조방법 |
KR102100142B1 (ko) | 2017-12-21 | 2020-04-14 | 사빅 에스케이 넥슬렌 컴퍼니 피티이 엘티디 | 금속-리간드 착체, 이를 포함하는 에틸렌계 중합용 촉매 조성물 및 이를 이용한 에틸렌계 중합체의 제조방법 |
KR20210069578A (ko) | 2019-12-03 | 2021-06-11 | 사빅 에스케이 넥슬렌 컴퍼니 피티이 엘티디 | 전이금속 화합물, 이를 포함하는 촉매 조성물 및 이를 이용하는 올레핀 중합체의 제조방법 |
KR20210086505A (ko) | 2019-12-30 | 2021-07-08 | 사빅 에스케이 넥슬렌 컴퍼니 피티이 엘티디 | 전자 당김 그룹을 갖는 금속-리간드 착체, 이를 포함하는 에틸렌계 중합체 제조용 촉매 조성물 및 이를 이용한 에틸렌계 중합체의 제조방법 |
KR20220094138A (ko) | 2020-12-28 | 2022-07-05 | 사빅 에스케이 넥슬렌 컴퍼니 피티이 엘티디 | 금속-리간드 착체, 이를 포함하는 에틸렌계 중합체 제조용 촉매 조성물 및 이를 이용한 에틸렌계 중합체의 제조방법 |
KR20230101717A (ko) | 2021-12-29 | 2023-07-06 | 사빅 에스케이 넥슬렌 컴퍼니 피티이 엘티디 | 금속-리간드 착체, 이를 포함하는 에틸렌계 중합체 제조용 촉매 조성물 및 이를 이용한 에틸렌계 중합체의 제조방법 |
KR20230101716A (ko) | 2021-12-29 | 2023-07-06 | 사빅 에스케이 넥슬렌 컴퍼니 피티이 엘티디 | 전이금속 화합물, 이를 포함하는 촉매 조성물 및 이를 이용하는 올레핀 중합체의 제조방법 |
KR20240049151A (ko) | 2022-10-07 | 2024-04-16 | 사빅 에스케이 넥슬렌 컴퍼니 피티이 엘티디 | 전이금속 화합물, 이를 포함하는 촉매 조성물 및 이를 이용하는 올레핀 중합체의 제조방법 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4175200A (en) * | 1975-04-11 | 1979-11-20 | Uniroyal, Inc. | N,N-Disubstituted sulfonyl hydrazines |
US4684747A (en) * | 1984-12-20 | 1987-08-04 | Yale University | N,N'-bis(sulfonyl)hydrazines having antineoplastic activity |
US4849563A (en) * | 1986-01-21 | 1989-07-18 | Yale University | Novel 1-alkyl-1-arenesulfonyl-2-alkoxycarbonylsulfenylhydrazines having antineoplastic activity |
US5214068A (en) * | 1989-09-06 | 1993-05-25 | Yale University | Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents |
US5101072A (en) * | 1989-09-06 | 1992-03-31 | Yale University | Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents |
US5256820A (en) * | 1991-11-08 | 1993-10-26 | Yale University | 1-alkyl-2-acyl-1,2-disulfonylhydrazines |
-
1995
- 1995-07-05 US US08/497,931 patent/US5637619A/en not_active Expired - Lifetime
-
1996
- 1996-07-02 EP EP96923609A patent/EP0841912B1/en not_active Expired - Lifetime
- 1996-07-02 CN CN96195781A patent/CN1095828C/zh not_active Expired - Lifetime
- 1996-07-02 SI SI9630502T patent/SI0841912T1/xx unknown
- 1996-07-02 ES ES96923609T patent/ES2179204T3/es not_active Expired - Lifetime
- 1996-07-02 AT AT96923609T patent/ATE224708T1/de not_active IP Right Cessation
- 1996-07-02 DE DE69623969T patent/DE69623969T2/de not_active Expired - Lifetime
- 1996-07-02 BR BR9609620-9A patent/BR9609620A/pt not_active IP Right Cessation
- 1996-07-02 DK DK96923609T patent/DK0841912T3/da active
- 1996-07-02 JP JP50528597A patent/JP3869007B2/ja not_active Expired - Fee Related
- 1996-07-02 PT PT96923609T patent/PT841912E/pt unknown
- 1996-07-02 WO PCT/US1996/011218 patent/WO1997002029A1/en active IP Right Grant
- 1996-07-02 AU AU11934/97A patent/AU713128B2/en not_active Expired
- 1996-07-02 CA CA002226331A patent/CA2226331C/en not_active Expired - Lifetime
- 1996-07-02 KR KR10-1998-0700031A patent/KR100372632B1/ko not_active IP Right Cessation
-
2002
- 2002-10-15 CN CNB021475601A patent/CN1176067C/zh not_active Expired - Lifetime
-
2003
- 2003-05-02 HK HK03103134A patent/HK1050892A1/xx not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007516228A (ja) * | 2003-06-13 | 2007-06-21 | ヴァイオン ファーマシューティカルズ、インコーポレーテッド | 新規なアルキル化処置剤としての水溶性shp |
Also Published As
Publication number | Publication date |
---|---|
EP0841912A4 (en) | 1998-10-14 |
CN1405152A (zh) | 2003-03-26 |
US5637619A (en) | 1997-06-10 |
CN1176067C (zh) | 2004-11-17 |
WO1997002029A1 (en) | 1997-01-23 |
KR19990028733A (ko) | 1999-04-15 |
PT841912E (pt) | 2003-01-31 |
CA2226331C (en) | 2009-05-26 |
ES2179204T3 (es) | 2003-01-16 |
CN1095828C (zh) | 2002-12-11 |
EP0841912A1 (en) | 1998-05-20 |
DE69623969D1 (en) | 2002-10-31 |
ATE224708T1 (de) | 2002-10-15 |
AU1193497A (en) | 1997-02-05 |
HK1050892A1 (en) | 2003-07-11 |
KR100372632B1 (ko) | 2003-05-12 |
MX9800129A (es) | 1998-03-31 |
AU713128B2 (en) | 1999-11-25 |
DE69623969T2 (de) | 2003-05-28 |
CA2226331A1 (en) | 1997-01-23 |
JP3869007B2 (ja) | 2007-01-17 |
CN1191482A (zh) | 1998-08-26 |
BR9609620A (pt) | 1999-12-21 |
DK0841912T3 (da) | 2002-11-11 |
SI0841912T1 (en) | 2002-12-31 |
EP0841912B1 (en) | 2002-09-25 |
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