JPH11243914A - Food or beverage promoting calcium absorption - Google Patents
Food or beverage promoting calcium absorptionInfo
- Publication number
- JPH11243914A JPH11243914A JP10066071A JP6607198A JPH11243914A JP H11243914 A JPH11243914 A JP H11243914A JP 10066071 A JP10066071 A JP 10066071A JP 6607198 A JP6607198 A JP 6607198A JP H11243914 A JPH11243914 A JP H11243914A
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- Prior art keywords
- calcium
- acetic acid
- food
- group
- absorption
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Coloring Foods And Improving Nutritive Qualities (AREA)
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Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明はカルシウム吸収促進
作用を有する飲食物に関する。さらに詳しくは、カルシ
ウムと共に０．０１〜０．２５重量％の濃度の酢酸を含
有することを特徴とするカルシウムの吸収促進作用を有
する飲食物に関する。TECHNICAL FIELD The present invention relates to a food or drink having a calcium absorption promoting action. More specifically, the present invention relates to a food and drink having a calcium absorption promoting action, comprising acetic acid at a concentration of 0.01 to 0.25% by weight together with calcium.
【０００２】[0002]
【従来の技術】カルシウムの成人１日当たりの栄養所要
量は約６００ｍｇとされているのに対して、平均摂取量
は約５４０ｍｇでほぼ横ばい状態であり、所要量に満た
ない唯一の栄養素となっている。その上、腸管における
カルシウム吸収率の低下などの種々の要因により、生体
のカルシウム不足が引き起こされることが指摘されてい
る。2. Description of the Related Art The daily nutritional requirement of calcium for an adult is about 600 mg, while the average intake is about 540 mg, which is almost flat, and is the only nutrient less than the required amount. I have. In addition, it has been pointed out that various factors such as a decrease in the calcium absorption rate in the intestinal tract cause calcium deficiency in a living body.
【０００３】例えば、高齢者に高頻度で発生しやすい骨
粗鬆症は、カルシウムの吸収と***のバランスが崩れる
ことが主な要因であり、特に閉経後の女性に多く発症す
る。これは、女性ホルモン（エストロゲン）の分泌が著
しく低下し、小腸からのカルシウムの吸収率が低下する
ことが原因の一つであると考えられている。[0003] For example, osteoporosis, which frequently occurs in the elderly, is mainly caused by an imbalance between the absorption and excretion of calcium, and particularly occurs frequently in postmenopausal women. This is considered to be one of the causes of the remarkable decrease in the secretion of female hormones (estrogens) and the decrease in the rate of calcium absorption from the small intestine.
【０００４】このようなカルシウム吸収率の低下の解決
策として、より吸収されやすい形態のカルシウムを摂取
するとかカルシウムの腸管吸収を促進する成分をカルシ
ウムと同時に摂取することなどが研究され、クエン酸リ
ンゴ酸カルシウム（ＣＣＭ）やカゼインフォスフォペプ
チド（ＣＰＰ）が実用化されている。ＣＣＭやＣＰＰは
いずれも腸管内のイオン性あるいは可溶性のカルシウム
量を増大させることにより、腸管吸収を高めることによ
ってカルシウム吸収を促進することが明らかにされてい
る。しかし、これらの物質は容易に入手できなかった
り、高価であったり、また食品の香味に影響を与えるこ
となどから、食品として使用するには制限があった。As a solution to such a decrease in the calcium absorption rate, studies have been made on ingestion of calcium in a form that is more easily absorbed and ingestion of calcium and a component that promotes intestinal absorption of calcium at the same time as calcium. Calcium acid (CCM) and casein phosphopeptide (CPP) have been put to practical use. It has been shown that both CCM and CPP promote calcium absorption by increasing intestinal absorption by increasing the amount of ionic or soluble calcium in the intestinal tract. However, these substances are not easily available, are expensive, and affect the flavor of foods, so that their use as foods is limited.
【０００５】また、従来から各種の不溶性カルシウムを
食酢に浸漬することによって可溶性のカルシウム量を増
大させ、カルシウムの摂取量自体を増加させようとする
ことが種々検討されている。しかし、これらは、いずれ
も吸収促進を目的としたものではなく、カルシウムの溶
解量を増大させることを目的としていたことから、官能
的に酸味を強く感じるような、より高濃度での使用例し
かなかった。同様に、民間療法として生卵を食酢漬けし
た酢卵のカルシウムの生体利用性が高いことが報告され
ている。しかし、食酢中の主成分である酢酸と卵殻のカ
ルシウムとが結合して生成する酢酸カルシウムでは、カ
ルシウムの吸収が促進されないことから、酢酸以外の食
酢成分あるいは卵の成分に効果があるものと推定されて
いる。[0005] In addition, various studies have conventionally been made to increase the amount of soluble calcium by immersing various insoluble calcium in vinegar to increase the amount of calcium intake itself. However, these are not intended to promote absorption, but to increase the amount of calcium dissolved, so that only use examples at higher concentrations that strongly feel a sour taste organoleptically. Did not. Similarly, as a folk remedy, it has been reported that the bioavailability of calcium in vinegared eggs prepared by pickling raw eggs with vinegar is high. However, calcium acetate, which is formed by combining acetic acid, which is the main component of vinegar, with calcium in eggshell, does not promote calcium absorption, so it is estimated that vinegar components other than acetic acid or egg components are effective. Have been.
【０００６】ところで、不溶性カルシウムを酢酸で溶解
させた場合に生成する酢酸カルシウムは、各種カルシウ
ム塩の中では溶解度が非常に高いことが知られている。
そこで、酢酸カルシウムを用いた出納試験でのカルシウ
ム吸収率の比較や放射性同位体カルシウム（45Ｃａ）で
ラベルした酢酸カルシウムを使用した腸管組織での吸収
実験が行われている。その結果、期待に反して、酢酸カ
ルシウムは他のカルシウム塩と同程度の吸収率であると
報告されている。[0006] It is known that calcium acetate produced when insoluble calcium is dissolved with acetic acid has extremely high solubility among various calcium salts.
Therefore, absorption experiments in intestinal tissue using the calcium acetate labeled with comparison and radioactive isotopes calcium calcium absorption rate (45 Ca) in teller test using calcium acetate is performed. As a result, contrary to expectations, it has been reported that calcium acetate has a similar absorption rate to other calcium salts.
【０００７】[0007]
【発明が解決しようとする課題】本発明の目的は、容易
に入手可能であり、より安価で、食品の香味に影響を与
えず、かつ安全で幅広く食品に利用でき得るカルシウム
吸収促進成分を開発し、これを用いてカルシウムの吸収
を促進する作用を有する飲食物を提供することである。SUMMARY OF THE INVENTION An object of the present invention is to develop a calcium absorption promoting component which is easily available, cheaper, does not affect the flavor of food, and is safe and can be widely used in food. It is another object of the present invention to provide a food or drink having an action of promoting calcium absorption using the same.
【０００８】[0008]
【課題を解決するための手段】そこで本発明者らは、従
来全く検討されていなかった、食品の香味を損なうこと
がない低濃度の酢酸について、カルシウムの腸管吸収に
対する影響を鋭意検討したところ、カルシウムの吸収が
顕著に向上することを見出した。さらに、このような低
濃度の酢酸とカルシウムを長期間にわたって摂取するこ
とにより、骨代謝を改善できることを見出した。また、
食酢でも同等の効果を有することを見出し、本発明を完
成するに至ったのである。すなわち、一般にカルシウム
塩の溶解度が高いほど吸収率が高いと考えられているこ
とから、本発明者らは、酢酸が不溶性のカルシウムを可
溶化した場合に生成する酢酸カルシウムの溶解度が非常
に高いことに着目して検討し、従来実施されていた酢酸
濃度よりも低濃度の領域において、酢酸に顕著なカルシ
ウム吸収促進効果があることを見出すと共に、酢酸が主
成分であり、かつ安価で容易に入手可能な食酢において
も同等の効果を有することを見出して本発明を完成する
に至ったのである。Means for Solving the Problems The present inventors have conducted intensive studies on the effects of calcium acetate on the intestinal absorption of low-concentration acetic acid which has not been studied at all and which does not impair the flavor of food. It has been found that calcium absorption is significantly improved. Further, they have found that bone metabolism can be improved by taking such low concentrations of acetic acid and calcium for a long period of time. Also,
The inventors have found that vinegar has the same effect, and have completed the present invention. That is, since it is generally considered that the higher the solubility of the calcium salt is, the higher the absorption rate, the present inventors have found that the solubility of calcium acetate generated when acetic acid solubilizes insoluble calcium is extremely high. Investigations focused on acetic acid and found that acetic acid has a remarkable calcium absorption promoting effect in the region of acetic acid concentration lower than the concentration conventionally used, and acetic acid is the main component, and it is cheap and easily available The present inventors have found that even possible vinegar has the same effect, and have completed the present invention.
【０００９】請求項１記載の本発明は、カルシウムと共
に０．０１〜０．２５重量％の濃度の酢酸を含有するこ
とを特徴とするカルシウムの吸収促進作用を有する飲食
物である。請求項２記載の本発明は、酢酸が食酢由来で
あることを特徴とする請求項１記載のカルシウムの吸収
促進作用を有する飲食物である。請求項３記載の本発明
は、飲食物が飲料であることを特徴とする請求項１又は
２記載のカルシウムの吸収促進作用を有する飲食物であ
る。The present invention according to claim 1 is a food or drink having a calcium absorption promoting action characterized by containing acetic acid at a concentration of 0.01 to 0.25% by weight together with calcium. According to a second aspect of the present invention, there is provided the food and drink having an action of promoting calcium absorption according to the first aspect, wherein the acetic acid is derived from vinegar. According to a third aspect of the present invention, there is provided the food or drink having a calcium absorption promoting action according to the first or second aspect, wherein the food or drink is a beverage.
【００１０】[0010]
【発明の実施の形態】以下、本発明について詳細に説明
する。本発明で用いる酢酸は、その製造法に特に限定は
なく、発酵法で製造されたものでもよいし、合成法によ
って製造されたものでもよい。しかし、食品への利用適
性を考慮すると、特に酢酸を主成分として含有する食酢
は好適であり、なかでも香味に大きな影響を及ぼさない
穀物酢や好ましい香味を有するリンゴ酢などは特に好ま
しい。BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail. Acetic acid used in the present invention is not particularly limited in its production method, and may be one produced by a fermentation method or one produced by a synthesis method. However, considering the suitability for use in foods, vinegar containing acetic acid as a main component is particularly suitable, and among them, cereal vinegar which does not significantly affect the flavor and apple vinegar having a preferable flavor are particularly preferable.
【００１１】本発明において、飲食物中の酢酸濃度は、
０．０１〜０．２５重量％とすべきである。酢酸濃度が
０．０１重量％より低い濃度では、カルシウム吸収促進
効果がほとんど期待できない。一方、酢酸濃度が０．２
５重量％を超えると、カルシウム吸収率が減退すると共
に酸味を強く感じる。In the present invention, the acetic acid concentration in food and drink is
It should be 0.01-0.25% by weight. If the acetic acid concentration is lower than 0.01% by weight, the effect of promoting calcium absorption can hardly be expected. On the other hand, when the acetic acid concentration is 0.2
If it exceeds 5% by weight, the calcium absorption rate decreases and the sour taste is strongly felt.
【００１２】上記の酢酸濃度は、従来からカルシウムの
溶解を促進するために食酢（酢酸濃度４．２重量／容量
％以上）を用いた場合などと比較して非常に低い濃度で
あり、従来のカルシウム酢や酢卵液とは全く異なってい
る。また、調味や防腐殺菌効果を目的にするような場合
の濃度は、通常０．３重量％以上であり、これらの場合
とも明確に異なる。The above acetic acid concentration is much lower than that in the case where vinegar (acetic acid concentration of 4.2% by weight / volume or more) is conventionally used to promote the dissolution of calcium. It is completely different from calcium vinegar and egg vinegar. The concentration for the purpose of seasoning and preservative sterilization is usually 0.3% by weight or more, which is clearly different from these cases.
【００１３】本発明で用いるカルシウムの形態に制限は
なく、例えば炭酸カルシウム，水酸化カルシウム，クエ
ン酸カルシウム，塩化カルシウム，グリセロリン酸カル
シウム，グルコン酸カルシウム，乳酸カルシウム，酢酸
カルシウムなどの食品添加物や牛乳，牛骨粉，卵殻粉，
サンゴ粉，貝殻粉などの天然物由来のものでもよいが、
特にクエン酸カルシウム，乳酸カルシウム，グルコン酸
カルシウムは、溶解性が高く、官能的にも良好で好適で
ある。カルシウムの濃度は、１日のカルシウム摂取不足
量とされる５０〜１００ｍｇが容易に摂取できるように
０．０２重量％以上とするのが好ましい。There is no limitation on the form of calcium used in the present invention, and for example, food additives such as calcium carbonate, calcium hydroxide, calcium citrate, calcium chloride, calcium glycerophosphate, calcium gluconate, calcium lactate, calcium acetate and milk, Beef bone powder, eggshell powder,
It may be derived from natural products such as coral powder and shell powder,
In particular, calcium citrate, calcium lactate, and calcium gluconate have high solubility and are functionally favorable and suitable. The concentration of calcium is preferably 0.02% by weight or more so that 50 to 100 mg, which is considered to be insufficient daily calcium intake, can be easily taken.
【００１４】次に、本発明の飲食物の形態としては特に
制限がなく、例えば炭酸飲料，乳酸飲料，スポーツドリ
ンクなどの飲料、錠菓，ビスケット，ゼリーなどの菓
子、みりん，味噌，醤油などの調味料、中華風合わせ調
味料，粉末スープなどの液体、粉末または固形の調味加
工食品、納豆、豆腐、畜肉及び魚肉加工品などが挙げら
れるが、カルシウム及び酢酸の摂取しやすさの観点など
からして飲料の形態にするのが好ましい。There is no particular limitation on the form of the food and drink of the present invention. For example, drinks such as carbonated drinks, lactic acid drinks and sports drinks, confectionery such as tablet confections, biscuits and jelly, mirin, miso, soy sauce and the like can be used. Examples include seasonings, Chinese-style seasonings, liquids such as powdered soups, powdered or solid seasoned processed foods, natto, tofu, animal meat and fish meat products, etc., from the viewpoint of easy intake of calcium and acetic acid. It is preferable to form the beverage.
【００１５】酢酸の添加方法についても特に制限はな
く、通常の方法によれば良いが、蛋白質のように酸性下
で変性を起こす可能性のある食品素材を使用する食品で
は、あらかじめ他の食品素材と混合した後、酢酸を加え
て混合することが望ましい。The method of adding acetic acid is not particularly limited, and any method may be used according to a usual method. However, in the case of foods which may be denatured under acidic conditions such as proteins, other food materials may be added in advance. It is desirable to add and mix acetic acid after mixing.
【００１６】[0016]
【実施例】以下に本発明の実施例を示すが、本発明の範
囲はこれにより何ら制限されるものではない。 実施例１（酢酸によるカルシウムの吸収促進） ７週齢のＳＤ系雌ラットの卵巣を摘除手術を施した後、
８週齢から標準飼料ＡＩＮ−７６（American Institute
of Nutrition, J. Nutrition, Vol.107, P.1340-1348,
1977)に準じた組成の対照飼料（蛋白源として卵白アル
ブミンを、またカルシウム源として炭酸カルシウム０．
７５重量％添加）で１０日間ミールフィーディングを行
い、摂食時間を制限したのち、１１日目に４群（１群１
６匹）に分けた。飼育条件は明暗１２時間、湿度５０
％、室温２３℃とした。EXAMPLES Examples of the present invention will be shown below, but the scope of the present invention is not limited by these examples. Example 1 (Acceleration of Calcium Absorption by Acetic Acid) Ovaries were removed from 7-week-old SD female rats,
From 8 weeks of age, standard feed AIN-76 (American Institute
of Nutrition, J. Nutrition, Vol. 107, P. 1340-1348,
1977) (controlling feed with ovalbumin as a protein source and calcium carbonate 0.1 as a calcium source).
75% by weight) for 10 days, and after restricting the eating time, 4 groups (1 group 1 day) were taken on the 11th day.
6 animals). Rearing conditions are 12 hours light and dark, 50 humidity.
%, Room temperature 23 ° C.
【００１７】１１日目の朝に、４群はそれぞれ対照飼
料、対照飼料に各種酢酸を添加した酢酸０．０６７２％
添加飼料、酢酸０．２１％添加飼料または酢酸０．２７
％添加飼料をそれぞれ５ｇづつ１．５時間摂取させた。
各飼料には45ＣａＣｌ2 を１μＣｉ／ｇ添加した。各飼
料群は飼料摂取終了直後、さらに２群（各群８匹）に分
け、１群は直ちに屠殺し、他の１群は１時間後に屠殺し
た。屠殺した後、血中の45Ｃａ及び総Ｃａ濃度、第四腰
椎及び左大腿骨の45Ｃａ量を分析した。結果を第１表及
び第２表に示す。On the morning of the eleventh day, the four groups each had a control feed, and 0.0672% acetic acid obtained by adding various acetic acids to the control feed.
Feed supplement, acetic acid 0.21% supplement feed or acetic acid 0.27
5% of each feed was taken for 1.5 hours.
1 μCi / g of 45 CaCl 2 was added to each feed. Each feed group was divided into two groups (8 per group) immediately after the end of feed intake, one group was sacrificed immediately, and the other group was sacrificed one hour later. After sacrificing, 45 Ca and total Ca concentration in the blood was analyzed 45 Ca of the fourth lumbar vertebra and the left femur. The results are shown in Tables 1 and 2.
【００１８】[0018]
【表１】 [Table 1]
【００１９】[0019]
【表２】 [Table 2]
【００２０】第１表の血中45Ｃａ及びＣａ濃度の測定結
果では、酢酸を飼料に添加した場合には腸管でのカルシ
ウム吸収が促進され、吸収された45Ｃａが血中に移行す
ることにより、１時間後の血中45Ｃａ濃度は直後よりも
高かった。なお、これらの血中45Ｃａ濃度の増加効果
は、酢酸０．０６７％添加飼料群、酢酸０．２１％添加
飼料群が高く、酢酸０．２７％添加飼料群ではかなり低
下する傾向が認められた。一方、対照飼料群では直後と
１時間後ではほとんど血中45Ｃａ濃度は変化しなかっ
た。なお、血中総カルシウム量は生体では厳密に制御さ
れているため、各飼料群間で差はほとんどなかった。The results of the measurement of blood 45 Ca and Ca concentration in Table 1 show that when acetic acid is added to the feed, calcium absorption in the intestinal tract is promoted and the absorbed 45 Ca is transferred to the blood. One hour later, the blood 45 Ca concentration was higher than immediately after. The effect of increasing the blood 45 Ca concentration was higher in the feed group supplemented with 0.067% acetic acid and the feed group supplemented with 0.21% acetic acid, and tended to decrease significantly in the feed group supplemented with 0.27% acetic acid. Was. On the other hand, in the control diet group, the blood 45 Ca concentration hardly changed immediately and one hour later. In addition, since the total calcium in the blood was strictly controlled in the living body, there was almost no difference between each feed group.
【００２１】また、第２表の第四腰椎や大腿骨中の45Ｃ
ａ量の測定結果から判断して、吸収されたカルシウムは
血中から骨に移行したと考えられた。さらに、骨への移
行程度は酢酸を飼料に添加した場合には対照飼料群に比
べて高くなっており、かつ酢酸０．０６７％添加飼料
群、酢酸０．２１％添加飼料群でより高く、これらに比
べて酢酸０．２７％添加飼料群ではやや低下する傾向が
認められた。[0021] In addition, 45 C of the second table fourth lumbar spine and femur
Judging from the measurement results of the amount a, it was considered that the absorbed calcium migrated from the blood to the bone. Further, the degree of transfer to bone was higher when acetic acid was added to the feed than in the control feed group, and higher in the feed group with 0.067% acetic acid and the feed group with 0.21% acetic acid, Compared to these, the feed group with 0.27% acetic acid added tended to decrease slightly.
【００２２】実施例２（動物試験による骨代謝改善効
果） ＳＤ系雌ラット（７週齢）を３群（１群８匹）に分け、
１群は偽手術（Ｓｈａｍ群）、他の２群は卵巣の摘除手
術を施した後、標準飼料ＡＩＮ−７６に準じた組成の対
照飼料（蛋白源として卵白アルブミンを、またカルシウ
ム源として炭酸カルシウム０．７５重量％添加）で８週
齢から給餌した。Ｓｈａｍ群は対照飼料で６週間飼育し
た。卵巣を摘除した２群については、１群は対照飼料で
（ＯＶＸ−Ｃ）、他の１群は酢酸を０．０６７２％添加
した対照飼料（ＯＶＸ−Ａ）で６週間飼育した。Example 2 (Improvement of bone metabolism by animal test) SD female rats (7 weeks old) were divided into 3 groups (8 rats per group).
One group was subjected to sham operation (Sham group), and the other two groups were subjected to ovarian excision operation, and then a control feed (ovalbumin was used as a protein source, and calcium carbonate was used as a calcium source). (0.75% by weight added) at 8 weeks of age. The Sham group was bred on a control diet for 6 weeks. Of the two groups from which the ovaries were removed, one group was bred for 6 weeks on a control diet (OVX-C), and the other group was fed on a control diet (OVX-A) supplemented with 0.0672% acetic acid.
【００２３】飼育終了の前日は代謝ケージで飼育し、尿
を採取した。飼育終了後に血中成分、尿中成分、第四腰
椎の骨塩量及び骨密度を分析した。結果を第３表及び第
４表に示した。The day before breeding was completed, the animals were bred in metabolic cages and urine was collected. After the rearing, blood components, urine components, bone mineral density and bone density of the fourth lumbar vertebra were analyzed. The results are shown in Tables 3 and 4.
【００２４】[0024]
【表３】 [Table 3]
【００２５】[0025]
【表４】 [Table 4]
【００２６】第３表に示した如く、卵巣摘除に伴ってＯ
ＶＸ−Ｃ群ではＳｈａｍ群と比較して、第四腰椎の骨塩
量や骨密度の低下が見られたが、酢酸を添加した飼料で
飼育したＯＶＸ−Ａ群では骨塩量や骨密度の低下が抑制
された。As shown in Table 3, Ovariectomy was accompanied by ovariectomy.
In the VX-C group, a decrease in the bone mineral density and bone density of the fourth lumbar vertebra was observed as compared with the Sham group, but in the OVX-A group reared on a diet supplemented with acetic acid, the bone mineral density and the bone mineral density decreased. The decline was suppressed.
【００２７】第４表のうち、骨形成の代謝マーカーであ
るアルカリフォスファターゼとオステオカルシンの量
は、卵巣摘除に伴う骨代謝亢進により、Ｓｈａｍ群と比
較してＯＶＸ−Ｃ群で上昇したが、ＯＶＸ−Ａ群ではＯ
ＶＸ−Ｃ群よりさらに高値であった。一方、骨吸収の代
謝マーカーである酒石酸耐性酸性フォスファターゼの量
は、Ｓｈａｍ群とＯＶＸ−Ｃ群では差がなかったが、Ｏ
ＶＸ−Ａ群で低い傾向にあった。また、尿中デオキシピ
リジノリン／ピリジノリン比は、卵巣摘除による骨吸収
亢進のため、Ｓｈａｍ群に比較しＯＶＸ−Ｃ群で顕著に
増加したが、ＯＶＸ−Ｃ群とＯＶＸ−Ａ群の間ではほと
んど差は見られなかった。In Table 4, the amounts of alkaline phosphatase and osteocalcin, which are metabolic markers for bone formation, increased in the OVX-C group compared to the Sham group due to the increase in bone metabolism accompanying ovariectomy. O in group A
It was even higher than the VX-C group. On the other hand, the amount of tartrate-resistant acid phosphatase, which is a metabolic marker for bone resorption, was not different between the Sham group and the OVX-C group.
The tendency was low in the VX-A group. In addition, the urinary deoxypyridinoline / pyridinoline ratio was significantly increased in the OVX-C group as compared to the Sham group due to enhancement of bone resorption by ovariectomy, but between the OVX-C group and the OVX-A group. Little difference was seen.
【００２８】これらの結果から、酢酸を飼料に添加する
ことによって生体中へのカルシウムの吸収が促進され、
その結果、主として骨形成が促進されて骨代謝が改善さ
れ、卵巣摘除に伴う骨塩量や骨密度の低下が抑制された
と考えられる。From these results, the addition of acetic acid to the feed promotes the absorption of calcium into the living body,
As a result, it is considered that bone formation was mainly promoted, bone metabolism was improved, and a decrease in bone mineral density and bone density accompanying ovariectomy was suppressed.
【００２９】実施例３（穀物酢でのカルシウム出納動物
試験） ＳＤ系雌ラット（７週齢）を卵巣の摘除手術を施した
後、標準飼料ＡＩＮ−７６に準じた組成の対照飼料（蛋
白源として精製大豆蛋白を、またカルシウム源として炭
酸カルシウム０．７５重量％添加）で８週齢から給餌し
た。その後、３群（１群８匹）に分け、１群は対照飼料
で（ＯＶＸ−Ｃ群）、他の１群は市販穀物酢を０．４％
（酢酸０．０１６８％に相当）添加した対照飼料（ＯＶ
Ｘ−ＬＶ群）、残りの１群は市販穀物酢を１．６％（酢
酸０．０６７２％に相当）添加した対照飼料（ＯＶＸ−
ＨＶ群）で４週間飼育した。Example 3 (Calcium balance animal test with cereal vinegar) SD female rats (7 weeks old) were subjected to ovarian excision surgery, and then a control diet (protein source) having a composition according to the standard diet AIN-76 was used. , Purified soybean protein, and 0.75% by weight of calcium carbonate as a calcium source). Thereafter, the animals were divided into three groups (eight animals per group), one group was a control feed (OVX-C group), and the other group was 0.4% of commercially available cereal vinegar.
(Equivalent to 0.0168% of acetic acid)
X-LV group), and the other group was a control feed (OVX-) supplemented with 1.6% (corresponding to 0.0672% acetic acid) commercial grain vinegar.
HV group) for 4 weeks.
【００３０】飼育終了直前の４日間は、代謝ケージで飼
育し、採糞及び採尿し、糞中及び尿中のカルシウム量を
分析し、当該期間中の餌からのカルシウム摂取量から糞
中総カルシウム量を差し引いた差を求め、カルシウム摂
取量で割った値に１００を乗じて見かけのカルシウム吸
収率とした。また、飼料からのカルシウム摂取量から糞
中及び尿中のカルシウムの総量を差し引いた差をカルシ
ウム摂取量で割った値に１００を乗じて見かけのカルシ
ウム保有率を求めた。さらに、飼育終了後に屠殺し、左
大腿骨を分析した。これらの結果を第５表及び第６表に
示した。For 4 days immediately before the end of the rearing, the animals were reared in metabolic cages, feces and urine were collected, the amount of calcium in the feces and urine was analyzed, and the total amount of The difference obtained by subtracting the amount was obtained, and the value obtained by dividing the difference by the calcium intake was multiplied by 100 to obtain an apparent calcium absorption rate. The apparent calcium retention was determined by multiplying the difference obtained by subtracting the total amount of calcium in feces and urine from the amount of calcium intake from the feed by the amount of calcium intake and multiplying by 100. Furthermore, the animals were sacrificed after the rearing, and the left femur was analyzed. The results are shown in Tables 5 and 6.
【００３１】[0031]
【表５】 [Table 5]
【００３２】[0032]
【表６】 [Table 6]
【００３３】第５表に示したように、市販穀物酢を添加
した飼料で飼育した場合には、食酢の添加量が多くなる
ほど、見かけの吸収率及び保有率とも向上した。また、
第６表のように、大腿骨のカルシウム含量も飼料への食
酢添加量に応じて顕著に増加したが、リン含量はほとん
ど増加しなかった。これらの結果から、カルシウムと共
に非常に低濃度で食酢を含有する食品を摂取することに
より、カルシウムの吸収が促進され、骨のカルシウム含
量を高められることがわかる。As shown in Table 5, when bred with feed supplemented with commercially available cereal vinegar, the apparent absorption and retention increased as the amount of vinegar added increased. Also,
As shown in Table 6, the calcium content of the femur increased remarkably in accordance with the amount of vinegar added to the feed, but the phosphorus content hardly increased. From these results, it can be seen that intake of a food containing vinegar at a very low concentration together with calcium promotes absorption of calcium and increases the calcium content of bone.
【００３４】以上の実施例１、実施例２及び実施例３の
結果から判断して、カルシウムの吸収を促進しうる酢酸
の有効濃度は０．０１〜０．２５重量％であると判断さ
れ、かつ同濃度の酢酸濃度になるように食酢を添加した
場合でも、同等の効果が得られることが確認された。Judging from the results of Examples 1, 2 and 3, it was determined that the effective concentration of acetic acid capable of promoting calcium absorption was 0.01 to 0.25% by weight. Also, it was confirmed that the same effect was obtained even when vinegar was added so as to have the same acetic acid concentration.
【００３５】実施例４（飲料への適用例） 以下の組成比で各種成分を配合した。すなわち、果糖ぶ
どう糖液糖４６ｇ、５倍濃縮リンゴ果汁１０ｇ、蜂蜜９
ｇ、クエン酸（無水）５ｇ、リンゴ酸１ｇ、市販リンゴ
酢（酢酸酸度５重量／容量％）１４ｍｌ、グルコン酸カ
ルシウム４ｇ、リンゴフレーバー香料１ｇに水を加えて
１０００ｇとし、混合溶解して飲料を調製した。この飲
料の酢酸濃度は０．０７重量％で、カルシウム濃度は
０．０３５６重量％であった。該飲料は適度の酸味を呈
する清涼感のある可飲適性に優れた飲料であり、カルシ
ウムとともに所定量の酢酸を含有しており、摂取したカ
ルシウムは効率よく吸収されるものと考えられる。Example 4 (Example of Application to Beverage) Various components were blended at the following composition ratio. That is, fructose glucose liquid sugar 46 g, 5 times concentrated apple juice 10 g, honey 9
g, citric acid (anhydrous) 5 g, malic acid 1 g, commercially available apple cider vinegar (acetic acid content 5% by weight / volume%) 14 ml, calcium gluconate 4 g, apple flavor flavor 1 g to 1000 g by adding water, mixing and dissolving the beverage. Prepared. The acetic acid concentration of this beverage was 0.07% by weight, and the calcium concentration was 0.0356% by weight. The beverage is a refreshing drink having a refreshing sensation exhibiting moderate sourness and contains a predetermined amount of acetic acid together with calcium, and it is considered that the ingested calcium is efficiently absorbed.
【００３６】[0036]
【発明の効果】本発明により、カルシウムと共に０．０
１〜０．２５重量％の濃度の酢酸を含有する飲食物が提
供される。この飲食物を摂取することにより、カルシウ
ムの体内への吸収率を向上させ、骨形成能が増加するこ
とによってカルシウムの吸収が促進され、成長期の児童
のカルシウム補強、老年期の骨粗鬆症などの骨疾患の防
止などの効果が期待できる。According to the present invention, 0.0% is added together with calcium.
Food and beverages containing acetic acid at a concentration of 1 to 0.25% by weight are provided. By ingesting this food and drink, the rate of absorption of calcium into the body is improved, and the ability to form bone is increased, thereby promoting the absorption of calcium, and strengthening calcium in growing children and osteoporosis in old age. An effect such as prevention of disease can be expected.
Claims (3)
量％の濃度の酢酸を含有することを特徴とするカルシウ
ムの吸収促進作用を有する飲食物。1. A food and drink having a calcium absorption promoting action, comprising acetic acid at a concentration of 0.01 to 0.25% by weight together with calcium.
請求項１記載のカルシウムの吸収促進作用を有する飲食
物。2. The food or drink having calcium absorption promoting action according to claim 1, wherein the acetic acid is derived from vinegar.
求項１又は２記載のカルシウムの吸収促進作用を有する
飲食物。3. The food or drink having a calcium absorption promoting action according to claim 1 or 2, wherein the food or drink is a beverage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10066071A JPH11243914A (en) | 1998-03-03 | 1998-03-03 | Food or beverage promoting calcium absorption |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10066071A JPH11243914A (en) | 1998-03-03 | 1998-03-03 | Food or beverage promoting calcium absorption |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006278254A Division JP4085118B2 (en) | 2006-10-12 | 2006-10-12 | Vinegar beverage having calcium absorption promoting action and method for producing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH11243914A true JPH11243914A (en) | 1999-09-14 |
Family
ID=13305255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10066071A Pending JPH11243914A (en) | 1998-03-03 | 1998-03-03 | Food or beverage promoting calcium absorption |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH11243914A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100499619B1 (en) * | 2002-11-13 | 2005-07-05 | 주식회사 계명푸덱스 | Method for production of retreated calcium-powder with high solubility |
| JP2011152095A (en) * | 2010-01-28 | 2011-08-11 | House Foods Corp | Method for improving apple flavor of apple flavor food composition |
| JP2021193978A (en) * | 2020-06-18 | 2021-12-27 | 株式会社Mizkan Holdings | Food and beverage products containing acetic acid |
-
1998
- 1998-03-03 JP JP10066071A patent/JPH11243914A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100499619B1 (en) * | 2002-11-13 | 2005-07-05 | 주식회사 계명푸덱스 | Method for production of retreated calcium-powder with high solubility |
| JP2011152095A (en) * | 2010-01-28 | 2011-08-11 | House Foods Corp | Method for improving apple flavor of apple flavor food composition |
| JP2021193978A (en) * | 2020-06-18 | 2021-12-27 | 株式会社Mizkan Holdings | Food and beverage products containing acetic acid |
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