JPH11240839A - Preparation of solid formulation comprising colloid of platinum and palladium as main raw material, and its use - Google Patents

Preparation of solid formulation comprising colloid of platinum and palladium as main raw material, and its use

Info

Publication number
JPH11240839A
JPH11240839A JP10080098A JP8009898A JPH11240839A JP H11240839 A JPH11240839 A JP H11240839A JP 10080098 A JP10080098 A JP 10080098A JP 8009898 A JP8009898 A JP 8009898A JP H11240839 A JPH11240839 A JP H11240839A
Authority
JP
Japan
Prior art keywords
platinum
palladium
colloid
preparation
chitosan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10080098A
Other languages
Japanese (ja)
Inventor
Hiroshi Kazama
博 風間
Ichiro Yamazaki
一郎 山崎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OTSUKA YAKUHIN KOGYO KK
Original Assignee
OTSUKA YAKUHIN KOGYO KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by OTSUKA YAKUHIN KOGYO KK filed Critical OTSUKA YAKUHIN KOGYO KK
Priority to JP10080098A priority Critical patent/JPH11240839A/en
Priority to PCT/JP1998/002621 priority patent/WO1999042112A1/en
Publication of JPH11240839A publication Critical patent/JPH11240839A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

PROBLEM TO BE SOLVED: To prepare a solid formulation by using a colloid solution of platinum and palladium and further to provide a method for preparing the solid formulation. SOLUTION: A colloid formulation of platinum and palladium is encapsulated with a capsule material having the inner surface coated with a chitosan. The concentration of the chitosan used is 0.1-3%. As a result, the colloid formulation of tht platinum and the palladium, conventionally present only in a form of an ample can be formed into a soid form, and the formulation easily and conveniently carried and used becomes available.

Description

【発明の詳細な説明】DETAILED DESCRIPTION OF THE INVENTION

【０００１】[0001]

【発明の属する技術分野】本発明は、白金とパラジウム
のコロイド溶液を用いた固形製剤とその製造方法に関す
るものである。TECHNICAL FIELD The present invention relates to a solid preparation using a colloidal solution of platinum and palladium and a method for producing the same.

【０００２】[0002]

【従来の技術及び発明の解決しようとする課題】人の健
康や生命を脅かす疾患には様々なものがあり、その原因
も又様々である。最近の研究によると人体の臓器・血管
・細胞から遺伝子レベルにまで様々な影響を与えている
ものに活性酸素があり、この活性酸素は生体内で様々な
疾患の原因となることが最近の研究で明らかになった。
この様な背景から人の生命や、健康維持回復のためこの
活性酸素を消去する製剤が要望され、いろいろな製剤が
活性酸素消去のため抗酸化剤として用いられている。BACKGROUND OF THE INVENTION There are a variety of diseases that threaten human health and life, and the causes are also various. According to recent research, active oxygen has various effects on organs, blood vessels and cells of the human body, as well as on the gene level.Recent research has shown that this active oxygen can cause various diseases in vivo. It became clear.
Against such a background, preparations for eliminating active oxygen are required for human life and health maintenance and recovery, and various preparations are used as antioxidants for eliminating active oxygen.

【０００３】現在は、ビタミンＣ、Ｅを筆頭にβ−カロ
チン、ポリフェノール類、カテキン類、生薬エキスな
ど、その抗酸化もしくは活性酸素消去の力の大小はある
ものの様々な形で様々な物が用いられている。その中で
も、医聖といわれた野口英世博士の発想による白金とパ
ラジウムのコロイド製剤は、その活性酸素を消去して疾
病の治療及び予防、人体の活力増強、健康増進に驚くべ
き作用があることは、既に知られていることである。[0003] At present, various substances such as β-carotene, polyphenols, catechins, and crude drug extracts, such as vitamin C and E, are used in various forms, although their antioxidant or active oxygen scavenging power is large or small. Have been. Among them, colloidal preparations of platinum and palladium based on the idea of Dr. Hideyo Noguchi, who is said to be medicinal, have a surprising effect on the treatment and prevention of diseases, enhance the vitality of the human body, and promote health by eliminating active oxygen. Is already known.

【０００４】それは、白金とパラジウムのコロイド溶液
をガラス製アンプルに充填した経口剤で、医薬品として
の許可もあり、広く使用されている。その活性酸素消去
の力は標準となるビタミンＣの百倍近くもあり、しかも
とりすぎ等による悪影響もない安全な製剤である。[0004] It is an oral preparation in which a colloidal solution of platinum and palladium is filled into a glass ampoule, which has been approved as a pharmaceutical and is widely used. The active oxygen scavenging power is nearly 100 times higher than that of the standard vitamin C, and it is a safe preparation with no adverse effects due to excessive intake.

【０００５】しかしこの製剤は効力特性の酸化還元力が
非常に強く、従来その効力安定のために空気や酸素を遮
断する必要があるため、形態がガラス製アンプルになら
ざるをえず、その携帯が不便で使用時にガラスの破片な
どによる危険性があることが指摘されている。そのため
手軽に携帯・使用できる製剤が強く求められていた。液
状のものを固形化する手段の一つに軟カプセルがある
が、白金とパラジウムのコロイドは水分を多く含んでお
り、水溶液は軟カプセル化が出来なかったので、このよ
うな金属コロイドを空気や酸素と遮断して酸化還元力を
保ったまま、人に経口投与する事が出来ず、従って空気
と遮断して酸化還元力を保ったまま、人が経口投与出来
るような固形製剤化は今までできなかった。[0005] However, this preparation has a very strong effect of redox power, and it is necessary to shut off air and oxygen in order to stabilize its efficacy. Therefore, it has to be formed into a glass ampule. However, it is pointed out that there is a danger due to broken glass at the time of use due to inconvenience. Therefore, a preparation that can be easily carried and used has been strongly demanded. One of the means for solidifying a liquid is a soft capsule, but the colloid of platinum and palladium contains a large amount of water, and the aqueous solution could not be softly encapsulated. It has not been possible to orally administer to humans while keeping the oxidation-reduction power blocked by oxygen. could not.

【０００６】[0006]

【課題を解決するための手段】本発明は、白金とパラジ
ウムのコロイドを空気及び酸素から保護し遮断する手段
として、カプセルの内面すなわち水溶液と接触する面に
溶解したキトサンを噴霧して、カプセルの内面をコーテ
ィングすることによりなされる。According to the present invention, as a means for protecting and blocking the colloid of platinum and palladium from air and oxygen, the chitosan dissolved in the inner surface of the capsule, that is, the surface in contact with the aqueous solution, is sprayed. This is done by coating the inner surface.

【０００７】すなわち、ｐＨ４以下の酸性の条件下で溶
解した分子量１００〜１００００好ましくは５００〜５
０００のキトサン０．１％〜３％好ましくは２％程度の
酸性溶液を軟カプセルを作るためのゼラチン膜の内面に
あたる面に噴霧し、軽く乾燥させる。キトサンが３％よ
り濃いと、そのままゲル化してしまい、噴霧等の加工が
できない。逆に０．１％より薄いと、キトサンが膜状に
ならないだけでなく、噴霧した時点でゼラチン膜が溶解
してしまい、カプセルの材料とはならない。キトサンを
酸性溶液としたのは、酸性で無ければキトサンが溶解し
ないからである。なお酸性の条件には、様々な酸を用い
て行うことができるが、食品添加物として認められてい
る有機酸を用いるのが好ましい。That is, the molecular weight dissolved under acidic conditions of pH 4 or less is 100 to 10,000, preferably 500 to 5
An acidic solution of 0.1% to 3%, preferably about 2% of 000 chitosan is sprayed on a surface corresponding to an inner surface of a gelatin film for making a soft capsule and lightly dried. If the chitosan is more than 3%, it gels as it is and cannot be processed by spraying or the like. Conversely, if the thickness is less than 0.1%, not only does the chitosan not form a film, but also the gelatin film dissolves at the time of spraying, and it does not become a capsule material. The reason why chitosan was used as an acidic solution is that chitosan would not be dissolved unless it was acidic. The acidic condition can be carried out using various acids, but it is preferable to use an organic acid recognized as a food additive.

【０００８】この内面をキトサンでコーティングした剤
皮を用いて軟カプセルを作ることにより、白金とパラジ
ウムのコロイド溶液のような水溶液を封入し、空気から
遮断することのできる軟カプセルが作成可能となる。な
お、キトサン膜は胃の中で酸性によって溶解するので、
カプセルの溶解に問題は生じない。[0008] By making a soft capsule using the skin whose inner surface is coated with chitosan, an aqueous solution such as a colloidal solution of platinum and palladium can be sealed and a soft capsule that can be shielded from air can be made. . In addition, since the chitosan membrane is dissolved by acidity in the stomach,
There is no problem in dissolving the capsule.

【０００９】[0009]

【実施例】ゼラチン ２５０ｇ、水 ３００ｇ、グリセ
リン ４５０ｇを混合・溶解し平らに固化する。この表
面に２％酢酸で溶解したキトサン２％水溶液を噴霧し温
室で乾燥させて軟カプセル用ゼラチン膜が得られる。
得られたゼラチン膜を用いて窒素気流下で白金とパラジ
ウムのコロイド液を注入し圧縮成型する事により、固形
製剤のひとつである軟カプセル剤が得られた。EXAMPLE 250 g of gelatin, 300 g of water and 450 g of glycerin are mixed and dissolved and solidified flat. A 2% aqueous solution of chitosan dissolved in 2% acetic acid is sprayed on the surface and dried in a greenhouse to obtain a gelatin film for soft capsules.
Using the obtained gelatin film, a colloidal solution of platinum and palladium was injected under a stream of nitrogen and compression-molded to obtain a soft capsule as one of the solid preparations.

【００１０】[0010]

【発明の効果】本発明により、今まで液体のガラス製ア
ンプルしか無かった白金及びパラジウムのコロイド製剤
をカプセル化することが可能となり、携帯と使用が手軽
で便利な固形剤をつくれるようになる。According to the present invention, it is possible to encapsulate a colloidal preparation of platinum and palladium, which has been available only in a liquid glass ampoule, so that a solid preparation which is easy to carry and use can be made.

Claims (2)

【特許請求の範囲】[Claims] 【請求項１】 内面をキトサンでコーティングしたカプ
セル材料で、白金とパラジウムのコロイド製剤を封入す
ることを特徴とした固形剤とその製造方法1. A solid preparation characterized by encapsulating a colloidal preparation of platinum and palladium in a capsule material having an inner surface coated with chitosan, and a method for producing the same. 【請求項２】 用いるキトサンの濃度が０．１％〜３％
であることを特徴とする請求項１の製剤及びその製造方
法2. The concentration of chitosan used is 0.1% to 3%.
2. The preparation according to claim 1 and a method for producing the same.
JP10080098A 1998-02-23 1998-02-23 Preparation of solid formulation comprising colloid of platinum and palladium as main raw material, and its use Pending JPH11240839A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP10080098A JPH11240839A (en) 1998-02-23 1998-02-23 Preparation of solid formulation comprising colloid of platinum and palladium as main raw material, and its use
PCT/JP1998/002621 WO1999042112A1 (en) 1998-02-23 1998-06-15 Process for preparing solid preparation by using colloid of platinum and palladium as main raw material and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10080098A JPH11240839A (en) 1998-02-23 1998-02-23 Preparation of solid formulation comprising colloid of platinum and palladium as main raw material, and its use

Publications (1)

Publication Number Publication Date
JPH11240839A true JPH11240839A (en) 1999-09-07

Family

ID=13708723

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10080098A Pending JPH11240839A (en) 1998-02-23 1998-02-23 Preparation of solid formulation comprising colloid of platinum and palladium as main raw material, and its use

Country Status (2)

Country Link
JP (1) JPH11240839A (en)
WO (1) WO1999042112A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2004073723A1 (en) * 2003-02-20 2006-06-01 株式会社シーテック Medicine containing noble metal fine particles
JP2020019739A (en) * 2018-07-31 2020-02-06 株式会社東洋厚生製薬所 Natural killer cell activator

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004073722A1 (en) * 2003-02-20 2004-09-02 Shetech Co., Ltd. Superoxide anion decomposing agent
US7588747B2 (en) 2003-08-22 2009-09-15 Kose Corporation Singlet oxygen quencher and composition using the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4816606B1 (en) * 1970-12-28 1973-05-23
JP2555520B2 (en) * 1992-12-14 1996-11-20 アイセロ化学株式会社 Chitosan hard capsule and manufacturing method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2004073723A1 (en) * 2003-02-20 2006-06-01 株式会社シーテック Medicine containing noble metal fine particles
JP2020019739A (en) * 2018-07-31 2020-02-06 株式会社東洋厚生製薬所 Natural killer cell activator

Also Published As

Publication number Publication date
WO1999042112A1 (en) 1999-08-26

Similar Documents

Publication Publication Date Title
US8980331B2 (en) Extended production of nitric oxide from microencapsulated chemical reactants
KR101584824B1 (en) Osmolyte-containing Preparation for the Treatment of Dry Mucous Membranes
CN103781489B (en) For the oral delivery of the carrier of oxygen based on hemoglobin
ES2395555T3 (en) Liposomal formulation for oral administration of glutathione (reduced)
CN107028919B (en) Compound aescin A, B liposome hydrogel patch
Garg et al. Ancient and advanced approaches for the treatment of an inflammatory autoimmune disease− psoriasis
JP2014088453A (en) One-dosage formation of medicament with different physical property
JP2016514694A (en) Fine dry particulate retinoid active agent composition and topical formulation containing the same
JPH08268905A (en) Colloidal silk fibroin and composition containing the same
JP5622775B2 (en) Composition for treating dermatosis, formulation using the same, and preparation method thereof
CN108938501A (en) Chinese medicine composition and oral care product applied to oral care product
JPH04149126A (en) Pharmaceutical composition for transmucous administration
CN102766548A (en) Medicated soap with antibacterial, antiphlogistic and skin-care effects and preparation method thereof
JPH11240839A (en) Preparation of solid formulation comprising colloid of platinum and palladium as main raw material, and its use
CN111388421A (en) Oral-nasal-throat bi-component spray with antibacterial and antiviral functions and preparation method thereof
CN106620673A (en) Hydrogel for treating infant dental ulcer and preparation method of hydrogel
CN106362141A (en) Safe and multi-effect freckle removing agent and preparation method thereof
RU2479318C1 (en) Method for preparing drug and biologically active preparations
CN111000871A (en) Oral cavity spray and preparation method thereof
KR20200141214A (en) Hydrogel composition, preparing method for hydrogel composition and cosmetic composition including the same
CN1813681A (en) Sodium vitamin C powder for injection and its preparing method
SK284306B6 (en) Topical preparation for introducing peptidaceous pharmacons in living organisms
KR100573743B1 (en) Localizable tumor targeting by drug release from anionic temperature-sensitive liposome in chitosan gel
CN109044974A (en) Coat nano vesicle preparations and its application of vitamin D and vitamin K
KR20120022293A (en) Pharmaceutical composition for injection into blood vessel comprising sanyang wild jinseng extracts

Legal Events

Date Code Title Description
A521 Written amendment

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050520

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20050629

R150 Certificate of patent (=grant) or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (prs date is renewal date of database)

Year of fee payment: 6

Free format text: PAYMENT UNTIL: 20110722

FPAY Renewal fee payment (prs date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120722

Year of fee payment: 7

FPAY Renewal fee payment (prs date is renewal date of database)

Year of fee payment: 10

Free format text: PAYMENT UNTIL: 20150722