JPH111436A - Iron-containing liquid agent - Google Patents
Iron-containing liquid agentInfo
- Publication number
- JPH111436A JPH111436A JP9156403A JP15640397A JPH111436A JP H111436 A JPH111436 A JP H111436A JP 9156403 A JP9156403 A JP 9156403A JP 15640397 A JP15640397 A JP 15640397A JP H111436 A JPH111436 A JP H111436A
- Authority
- JP
- Japan
- Prior art keywords
- iron
- extract
- component
- mol
- crude drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims abstract description 106
- 229910052742 iron Inorganic materials 0.000 title claims abstract description 53
- 239000007788 liquid Substances 0.000 title claims abstract description 12
- 239000003795 chemical substances by application Substances 0.000 title abstract 4
- 239000000796 flavoring agent Substances 0.000 claims abstract description 22
- 235000019634 flavors Nutrition 0.000 claims abstract description 22
- 239000000284 extract Substances 0.000 claims abstract description 21
- 239000003814 drug Substances 0.000 claims abstract description 19
- 229940079593 drug Drugs 0.000 claims abstract description 18
- 239000011790 ferrous sulphate Substances 0.000 claims abstract description 5
- 235000003891 ferrous sulphate Nutrition 0.000 claims abstract description 5
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims abstract description 5
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims abstract description 5
- 229910021578 Iron(III) chloride Inorganic materials 0.000 claims abstract description 4
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 6
- PLKYGPRDCKGEJH-UHFFFAOYSA-N azane;2-hydroxypropane-1,2,3-tricarboxylic acid;iron Chemical compound N.[Fe].OC(=O)CC(O)(C(O)=O)CC(O)=O PLKYGPRDCKGEJH-UHFFFAOYSA-N 0.000 claims description 5
- 239000012669 liquid formulation Substances 0.000 claims description 3
- KXFFQVUPQCREHA-UHFFFAOYSA-K sodium;2-hydroxypropane-1,2,3-tricarboxylate;iron(2+) Chemical compound [Na+].[Fe+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KXFFQVUPQCREHA-UHFFFAOYSA-K 0.000 claims description 3
- 239000004313 iron ammonium citrate Substances 0.000 abstract description 4
- 235000000011 iron ammonium citrate Nutrition 0.000 abstract description 4
- 208000007502 anemia Diseases 0.000 abstract description 2
- 235000013305 food Nutrition 0.000 abstract description 2
- 208000024891 symptom Diseases 0.000 abstract description 2
- 241000405911 Rehmannia glutinosa Species 0.000 abstract 2
- MBOSIQQMKNDSDJ-UHFFFAOYSA-N 4,5-dichloro-2-(2,4-dichlorophenyl)pyridazin-3-one Chemical compound ClC1=CC(Cl)=CC=C1N1C(=O)C(Cl)=C(Cl)C=N1 MBOSIQQMKNDSDJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- FRHBOQMZUOWXQL-UHFFFAOYSA-L ammonium ferric citrate Chemical compound [NH4+].[Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FRHBOQMZUOWXQL-UHFFFAOYSA-L 0.000 abstract 1
- 229960004642 ferric ammonium citrate Drugs 0.000 abstract 1
- 229940032296 ferric chloride Drugs 0.000 abstract 1
- 229940057527 ferric sodium citrate Drugs 0.000 abstract 1
- 229960001781 ferrous sulfate Drugs 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 21
- 239000000243 solution Substances 0.000 description 12
- 239000000203 mixture Substances 0.000 description 10
- 239000008213 purified water Substances 0.000 description 10
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 8
- 238000009472 formulation Methods 0.000 description 8
- 235000015165 citric acid Nutrition 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- NPFOYSMITVOQOS-UHFFFAOYSA-K iron(III) citrate Chemical compound [Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NPFOYSMITVOQOS-UHFFFAOYSA-K 0.000 description 6
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 5
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 5
- 229930003471 Vitamin B2 Natural products 0.000 description 5
- 229960002477 riboflavin Drugs 0.000 description 5
- 229960003080 taurine Drugs 0.000 description 5
- 235000019164 vitamin B2 Nutrition 0.000 description 5
- 239000011716 vitamin B2 Substances 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- 244000269722 Thea sinensis Species 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 4
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 4
- 239000001509 sodium citrate Substances 0.000 description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
- 244000144730 Amygdalus persica Species 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
- 235000006040 Prunus persica var persica Nutrition 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 229930003268 Vitamin C Natural products 0.000 description 3
- 229960001948 caffeine Drugs 0.000 description 3
- 229960001983 magnesium aspartate Drugs 0.000 description 3
- RXMQCXCANMAVIO-CEOVSRFSSA-L magnesium;(2s)-2-amino-4-hydroxy-4-oxobutanoate Chemical compound [H+].[H+].[Mg+2].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O RXMQCXCANMAVIO-CEOVSRFSSA-L 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- -1 polyoxyethylene Polymers 0.000 description 3
- 229960002920 sorbitol Drugs 0.000 description 3
- 235000019154 vitamin C Nutrition 0.000 description 3
- 239000011718 vitamin C Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- 241001672694 Citrus reticulata Species 0.000 description 2
- 239000004386 Erythritol Substances 0.000 description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 2
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 2
- 244000228451 Stevia rebaudiana Species 0.000 description 2
- 229930003779 Vitamin B12 Natural products 0.000 description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
- GLMQHZPGHAPYIO-UHFFFAOYSA-L azanium;2-hydroxypropane-1,2,3-tricarboxylate;iron(2+) Chemical compound [NH4+].[Fe+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O GLMQHZPGHAPYIO-UHFFFAOYSA-L 0.000 description 2
- 229940046414 biotin 1 mg Drugs 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 239000004227 calcium gluconate Substances 0.000 description 2
- 235000013927 calcium gluconate Nutrition 0.000 description 2
- 229960004494 calcium gluconate Drugs 0.000 description 2
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 2
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 2
- 235000019414 erythritol Nutrition 0.000 description 2
- 229940009714 erythritol Drugs 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 229960000367 inositol Drugs 0.000 description 2
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 2
- 239000001630 malic acid Substances 0.000 description 2
- 235000011090 malic acid Nutrition 0.000 description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
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- 239000011570 nicotinamide Substances 0.000 description 2
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 2
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 2
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 2
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- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 2
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- YNVZDODIHZTHOZ-UHFFFAOYSA-K 2-hydroxypropanoate;iron(3+) Chemical compound [Fe+3].CC(O)C([O-])=O.CC(O)C([O-])=O.CC(O)C([O-])=O YNVZDODIHZTHOZ-UHFFFAOYSA-K 0.000 description 1
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 1
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- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 239000004376 Sucralose Substances 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 235000006468 Thea sinensis Nutrition 0.000 description 1
- 235000009470 Theobroma cacao Nutrition 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 240000006909 Tilia x europaea Species 0.000 description 1
- 240000000851 Vaccinium corymbosum Species 0.000 description 1
- 235000003095 Vaccinium corymbosum Nutrition 0.000 description 1
- 235000017537 Vaccinium myrtillus Nutrition 0.000 description 1
- 235000009499 Vanilla fragrans Nutrition 0.000 description 1
- 244000263375 Vanilla tahitensis Species 0.000 description 1
- 235000012036 Vanilla tahitensis Nutrition 0.000 description 1
- 229930003451 Vitamin B1 Natural products 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 235000020224 almond Nutrition 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 235000020279 black tea Nutrition 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 235000021014 blueberries Nutrition 0.000 description 1
- 235000013532 brandy Nutrition 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 229960005069 calcium Drugs 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- PHIQHXFUZVPYII-UHFFFAOYSA-N carnitine Chemical compound C[N+](C)(C)CC(O)CC([O-])=O PHIQHXFUZVPYII-UHFFFAOYSA-N 0.000 description 1
- 229960000678 carnitine chloride Drugs 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 229960001777 castor oil Drugs 0.000 description 1
- 235000019693 cherries Nutrition 0.000 description 1
- 229940099352 cholate Drugs 0.000 description 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- YKZPPPNXRZHVGX-PXYKVGKMSA-L dipotassium;(2s)-2-aminobutanedioate;hydron;hydrate Chemical compound [H+].[H+].O.[K+].[K+].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O YKZPPPNXRZHVGX-PXYKVGKMSA-L 0.000 description 1
- WPUMTJGUQUYPIV-JIZZDEOASA-L disodium (S)-malate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](O)CC([O-])=O WPUMTJGUQUYPIV-JIZZDEOASA-L 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 229960002413 ferric citrate Drugs 0.000 description 1
- 239000004222 ferrous gluconate Substances 0.000 description 1
- 235000013924 ferrous gluconate Nutrition 0.000 description 1
- 229960001645 ferrous gluconate Drugs 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 229960002737 fructose Drugs 0.000 description 1
- 239000008369 fruit flavor Substances 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 229950006836 fursultiamine Drugs 0.000 description 1
- JTLXCMOFVBXEKD-FOWTUZBSSA-N fursultiamine Chemical compound C1CCOC1CSSC(\CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N JTLXCMOFVBXEKD-FOWTUZBSSA-N 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229960001031 glucose Drugs 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- ATEAWHILRRXHPW-UHFFFAOYSA-J iron(2+);phosphonato phosphate Chemical compound [Fe+2].[Fe+2].[O-]P([O-])(=O)OP([O-])([O-])=O ATEAWHILRRXHPW-UHFFFAOYSA-J 0.000 description 1
- VRIVJOXICYMTAG-IYEMJOQQSA-L iron(ii) gluconate Chemical compound [Fe+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O VRIVJOXICYMTAG-IYEMJOQQSA-L 0.000 description 1
- 238000006317 isomerization reaction Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229960001375 lactose Drugs 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 235000020094 liqueur Nutrition 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229960001855 mannitol Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000014571 nuts Nutrition 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 229940068988 potassium aspartate Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229940109850 royal jelly Drugs 0.000 description 1
- 235000013533 rum Nutrition 0.000 description 1
- 235000019265 sodium DL-malate Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000001394 sodium malate Substances 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 239000001570 sorbitan monopalmitate Substances 0.000 description 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 description 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 239000000892 thaumatin Substances 0.000 description 1
- 235000010436 thaumatin Nutrition 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 229940065427 vitamin b6 100 mg Drugs 0.000 description 1
- 229940023308 vitamin b6 20 mg Drugs 0.000 description 1
- 229940023323 vitamin b6 200 mg Drugs 0.000 description 1
- 235000015041 whisky Nutrition 0.000 description 1
- 235000014101 wine Nutrition 0.000 description 1
- 239000009538 yokuinin Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、風味が改善された
鉄分含有液剤に関する。TECHNICAL FIELD The present invention relates to an iron-containing liquid having an improved flavor.
【０００２】[0002]
【従来の技術】鉄は生体の必須成分であり、不足すると
貧血や倦怠感などの症状が発生する。そこで、鉄不足の
解消を目的に、最近では鉄分を含有した医薬品、食品な
どが発売されている。しかし、鉄分を配合した内服液剤
には、いわゆる鉄臭さというような鉄独特の風味があ
り、その独特の風味は経時的に増加するという欠点があ
った。2. Description of the Related Art Iron is an essential component of living organisms, and when it is deficient, symptoms such as anemia and malaise occur. Therefore, in order to eliminate iron deficiency, drugs and foods containing iron have recently been put on the market. However, the oral liquid formulation containing iron has a unique flavor such as iron so-called iron odor, and has a drawback that the unique flavor increases with time.
【０００３】そのような鉄独特の風味を改善する方法と
しては、フルーツジュースを配合する方法（特開昭６４
−８６８５８号公報）、アルコール成分を配合する方法
（特開平４−２７３６９号）、香料を配合する方法など
が知られているが、いずれも経時的に増加する不快風味
の改善は充分ではなかった。[0003] As a method for improving such a unique flavor of iron, a method of blending fruit juice (JP-A-64
JP-A-86858), a method of blending an alcohol component (JP-A-4-27369), and a method of blending a fragrance are known, but none of these methods has sufficiently improved the unpleasant flavor that increases with time. .
【０００４】[0004]
【発明が解決しようとする課題】本発明は、鉄分配合液
剤において経時的に増加する鉄独特の不快風味を改善す
ることを目的とする。SUMMARY OF THE INVENTION An object of the present invention is to improve the iron-specific unpleasant taste which increases with time in an iron-containing solution.
【０００５】[0005]
【課題を解決するための手段】本発明者らは、上記目的
を達成するため種々検討した結果、鉄分を配合した液剤
中に地黄または熟地黄のエキスを配合し、特定のｐＨに
調節すると、経時的に増加する鉄独特の不快風味の増加
を抑え、長期間経過後にも風味が劣化しないことを見出
し本発明を完成した。Means for Solving the Problems The inventors of the present invention have conducted various studies to achieve the above object. As a result, when an extract of ground yellow or mature ground yellow is added to a solution containing iron and adjusted to a specific pH, The present inventors have found that an increase in the unpleasant flavor peculiar to iron, which increases with time, is suppressed, and that the flavor does not deteriorate even after a long period of time, thereby completing the present invention.
【０００６】すなわち本発明は、鉄分および地黄または
熟地黄のエキスを配合し、ｐＨが２〜４．５であること
を特徴とする鉄分含有液剤である。[0006] That is, the present invention is an iron-containing liquid formulation containing an iron component and an extract of ground yellow or mature ground yellow, and having a pH of 2 to 4.5.
【０００７】[0007]
【発明の実施の形態】本発明において、鉄分は塩化第二
鉄、クエン酸鉄、クエン酸鉄アンモニウム、クエン酸鉄
ナトリウム、グルコン酸第一鉄、乳酸鉄、ピルリン酸第
一鉄、ピロリン酸第二鉄、硫酸第一鉄など、内服液剤に
配合可能な鉄含有化合物であれば特に限定されないが、
風味の改善効果の点から、クエン酸鉄アンモニウム、ク
エン酸鉄ナトリウム、塩化第二鉄、硫酸第一鉄などが好
ましく、最も好ましいものはクエン酸鉄アンモニウムで
ある。BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, iron content is ferric chloride, iron citrate, iron ammonium citrate, iron sodium citrate, ferrous gluconate, iron lactate, ferrous pyrphosphate and ferrous pyrophosphate. There is no particular limitation as long as it is an iron-containing compound that can be blended in an oral liquid, such as ferrous sulfate and ferrous sulfate.
From the viewpoint of the flavor improving effect, ammonium iron citrate, sodium iron citrate, ferric chloride, ferrous sulfate and the like are preferable, and the most preferable one is ammonium ferric citrate.
【０００８】鉄分の配合量は鉄量として液剤の０．００
０５〜０．０５mol/lの割合で配合した場合に本発明の
効果が顕著に発現する。０．０００５mol/l未満であれ
ば本発明によらなくとも風味の改善が可能であり、０．
０５mol/lを越えて配合すると本発明によっても風味の
改善が満足できないからである。[0008] The compounding amount of iron is 0.00
The effect of the present invention is remarkably exhibited when blended at a ratio of from 0.05 to 0.05 mol / l. If it is less than 0.0005 mol / l, the flavor can be improved without using the present invention.
If the amount is more than 0.05 mol / l, the improvement of flavor cannot be satisfied even by the present invention.
【０００９】本発明で用いる地黄または熟地黄のエキス
は、通常の方法で製造したエキスまたは乾燥エキスであ
り、市販されているものも使用することができる。[0009] The extract of earthy yellow or mature earth yellow used in the present invention is an extract produced by a usual method or a dried extract, and commercially available ones can also be used.
【００１０】地黄または熟地黄のエキスの配合量は、鉄
分として０．０１molに対して、原生薬換算量で４０〜
４０００mg、好ましくは８０〜２３００mgである。配合
量が４０mg未満であると鉄の独特の風味の改善効果が十
分でなく、４０００mgを越えて配合すると生薬自身の味
が目立って、液剤全体の風味が損なわれるからである。The amount of the extract of ground yellow or mature ground yellow is 40 to 40% in terms of the amount of a crude drug per 0.01 mol of iron.
It is 4000 mg, preferably 80-2300 mg. If the amount is less than 40 mg, the effect of improving the unique flavor of iron is not sufficient. If the amount exceeds 4000 mg, the taste of the crude drug itself becomes conspicuous and the flavor of the whole liquid preparation is impaired.
【００１１】本発明の鉄分含有液剤は、風味改善効果の
点からｐＨを２〜４．５の範囲に調節する必要があり、
好ましいｐＨは３〜４の範囲である。[0011] The iron-containing solution of the present invention must be adjusted to have a pH in the range of 2 to 4.5 from the viewpoint of flavor improving effect.
The preferred pH is in the range of 3-4.
【００１２】本発明の鉄分含有液剤は、液剤製造の通常
の方法で製造することができる。また、風味を損なわな
い限り甘味剤（エリスリトール、マルチトール、マンニ
トール、キシリトール、ソルビトール、ブドウ糖、ショ
糖、果糖、乳糖、ステビア、ソーマチン、シュクラロー
スなど）、ｐＨ調節剤（クエン酸、リンゴ酸、酒石酸、
アスコルビン酸、コハク酸など）、界面活性剤（ポリオ
キシエチレン硬化ヒマシ油、モノステアリン酸ソルビタ
ン、モノパルミチン酸ソルビタン、モノラウリン酸ソル
ビタン、ポリオキシエチレンポリオキシプロピレンブロ
ックコポリマー、ポリソルベート類、ラウリル硫酸ナト
リウム、マクロゴール類、ショ糖脂肪酸エステルな
ど）、保存剤（パラベン類、安息香酸塩類など）、香料
（オレンジ、グレープフルーツ、レモン、ライム、タン
ジェリン、ユズ、ウンシュウミカン、ナツミカン、ブド
ウ、イチゴ、パイナップル、バナナ、モモ、メロン、ス
イカ、プラム、チェリー、ペア、アプリコット、カーラ
ント、ウメ、マンゴ、マンゴスチン、グアバ、ラズベリ
ー、ブルーベリーなどの果実系フレーバー、緑茶、包種
茶、紅茶、ココア、チョコレート、コーヒー、アーモン
ド、メイプル、バニラ、ウイスキー、ブランデー、ラ
ム、ワイン、リキュール、カクテル、ミックスフレーバ
ー）などの通常液剤に配合される成分を配合することが
できる。The iron-containing solution of the present invention can be produced by a usual method for producing a solution. In addition, as long as the flavor is not impaired, sweeteners (erythritol, maltitol, mannitol, xylitol, sorbitol, glucose, sucrose, fructose, lactose, stevia, thaumatin, sucralose, etc.), pH regulators (citric acid, malic acid, tartaric acid) ,
Ascorbic acid, succinic acid, etc., surfactants (polyoxyethylene hydrogenated castor oil, sorbitan monostearate, sorbitan monopalmitate, sorbitan monolaurate, polyoxyethylene polyoxypropylene block copolymers, polysorbates, sodium lauryl sulfate, macro Galls, sucrose fatty acid esters, etc.), preservatives (parabens, benzoates, etc.), fragrances (orange, grapefruit, lemon, lime, tangerine, yuzu, unshiu mandarin, nuts orange, grape, strawberry, pineapple, banana, peach) , Melon, watermelon, plum, cherry, pair, apricot, currant, plum, mango, mangosteen, guava, raspberry, blueberry and other fruit flavors, green tea, wrapped tea, black tea, cocoa, tea Cholate, can be blended coffee, almond, maple, vanilla, whiskey, brandy, rum, wine, liqueur, cocktail, normal components blended in solution in such mix flavors).
【００１３】[0013]
【発明の効果】本発明により、風味の良い鉄配合液剤を
提供することが可能になった。According to the present invention, it has become possible to provide a flavorful iron-containing solution.
【００１４】[0014]
【実施例】以下、実施例および試験例により本発明をさ
らに詳細に説明する。The present invention will be described in more detail with reference to the following Examples and Test Examples.
【００１５】 実施例１ クエン酸鉄アンモニウム ６００mg 熟地黄エキス １g（原生薬換算） タウリン １０g アスパラギン酸マグネシウム １０g グルコン酸カルシウム ２０g ビタミンＢ２ １００mg ビタミンＢ６ １００mg カフェイン １g イノシトール １g ニコチン酸アミド １g 上記処方ならびに異性化糖１５０ｇ、Ｄ−ソルビトール
３６ｇおよびクエン酸６ｇを精製水に溶解した。クエン
酸ナトリウムにてｐＨを２．５に調整後、精製水を加
え、１ｌ液剤（鉄濃度０．００６２５mol/l）とした。Example 1 Iron ammonium citrate 600 mg Ripe ground yellow extract 1 g (equivalent to crude drug) Taurine 10 g Magnesium aspartate 10 g Calcium gluconate 20 g Vitamin B2 100 mg Vitamin B6 100 mg Caffeine 1 g Inositol 1 g Nicotinamide 1 g Prescription and isomerization 150 g of sugar, 36 g of D-sorbitol and 6 g of citric acid were dissolved in purified water. After adjusting the pH to 2.5 with sodium citrate, purified water was added to obtain a 1-liter solution (iron concentration: 0.00625 mol / l).
【００１６】 実施例２ クエン酸第二鉄 ２１．６ｇ 地黄エキス ６００ｇ（原生薬換算） ムイラプアマエキス ６０ｇ（原生薬換算） タウリン １２０ｇ 炭酸カルシウム ６０ｇ 炭酸マグネシウム １００ｇ 塩酸フルスルチアミン １．２ｇ ビタミンＢ１２ １２mg ビオチン １．２ｇ ビタミンＣ ６００ｇ 塩化カルニチン １．２ｇ ビタミンＢ２ １．２ｇ ビタミンＢ６ １．２ｇ 葉酸 １２０mg 無水カフェイン ２４ｇ 上記処方ならびに異性化糖７．２ｋｇ、ステビア１８ｇ
およびクエン酸１２０ｇを精製水に溶解した。クエン酸
ナトリウムにてｐＨを３．５に調整後、精製水を加え、
６０ｌ液剤（鉄濃度０．００３８mol/l）とした。Example 2 Ferric citrate 21.6 g Jiwang extract 600 g (equivalent to crude drug) Muirapuama extract 60 g (equivalent to crude drug) Taurine 120 g Calcium carbonate 60 g Magnesium carbonate 100 g Fursultiamine hydrochloride 1.2 g Vitamin B12 12 mg Biotin 1 0.2g Vitamin C 600g Carnitine chloride 1.2g Vitamin B2 1.2g Vitamin B6 1.2g Folic acid 120mg Anhydrous caffeine 24g The above formula and isomerized sugar 7.2kg, Stevia 18g
And 120 g of citric acid were dissolved in purified water. After adjusting the pH to 3.5 with sodium citrate, purified water was added,
A 60-liter solution (iron concentration 0.0038 mol / l) was used.
【００１７】 実施例３ クエン酸鉄 ６mg 地黄エキス ２０mg（原生薬換算） アスパラギン酸マグネシウム ４００mg アスパラギン酸カリウム ４００mg タウリン ４００mg 塩酸ジセチアミン ５mg ビタミンＢ２ ２０mg ビタミンＢ６ ２０mg ビタミンＣ ２ｇ ビタミンＥ １００mg ビタミンＤ３ ２０００I.U. グルコン酸カルシウム ２００ｍｇ 上記処方ならびにショ糖１４ｇ、Ｄ−ソルビトール２．
５ｇ、ニッコールＨＣＯ６０（商品名）５０ｍｇおよび
クエン酸５０mgを精製水に溶解した。その後クエン酸ナ
トリウムにてｐＨを４．０に調整後、精製水を加え、１
００ml液剤（鉄濃度０．０００６２５mol/l）とした。Example 3 6 mg of iron citrate 20 mg of ground yellow extract (in terms of crude drug) Magnesium aspartate 400 mg Potassium aspartate 400 mg Taurine 400 mg Dicetiamine hydrochloride 5 mg Vitamin B2 20 mg Vitamin B6 20 mg Vitamin C 2 g Vitamin E 100 mg Vitamin D3 2000 I.U. Calcium acid 200mg The above formulation, sucrose 14g, D-sorbitol 2.
5 g, Nikkor HCO60 (trade name) 50 mg and citric acid 50 mg were dissolved in purified water. Thereafter, the pH was adjusted to 4.0 with sodium citrate, and purified water was added to the solution.
The solution was a 00 ml liquid (iron concentration 0.000625 mol / l).
【００１８】 実施例４ クエン酸鉄アンモニウム ２４ｇ イノシトール ２ｇ アルギニン ２００ｇ 熟地黄エキス ５６０ｇ（原生薬換算） ヨクイニン ５０ｇ（原生薬換算） 人参 ２０ｇ（原生薬換算） ローヤルゼリー １００ｇ タウリン ４００ｇ グルコン酸カルシウム １００ｇ アスパラギン酸マグネシウム ２００ｇ ビタミンＢ１ ６ｇ ビタミンＢ２ ２ｇ ビタミンＢ６ ２ｇ ビタミンＢ１２ ２００mg ビタミンＥ ２０ｇ ビオチン １mg 無水カフェイン １４ｇ 上記処方ならびにショ糖１０００ｇ、エリスリトール４
００ｇ、リンゴ酸ナトリウム４０ｇおよびニッコールＨ
ＣＯ６０（商品名）５０ｇを精製水で溶解した。その
後、クエン酸にてｐＨを４．５に調整後、精製水を加
え、１０ｌ液剤（鉄濃度０．０１２５mol/l）とした。Example 4 Ammonium iron citrate 24 g Inositol 2 g Arginine 200 g Ripe ground yellow extract 560 g (converted to crude drug) Yokuinin 50 g (converted to crude drug) Ginseng 20 g (converted to crude drug) Royal jelly 100 g Taurine 400 g Calcium gluconate 100 g Magnesium aspartate 200 g Vitamin B1 6g Vitamin B2 2g Vitamin B6 2g Vitamin B12 200mg Vitamin E 20g Biotin 1mg Anhydrous caffeine 14g The above formula and sucrose 1000g, erythritol 4
00g, sodium malate 40g and Nikkor H
50 g of CO60 (trade name) was dissolved in purified water. Then, after adjusting the pH to 4.5 with citric acid, purified water was added to obtain a 10 l solution (iron concentration 0.0125 mol / l).
【００１９】 実施例５ クエン酸鉄アンモニウム ２４０mg 熟地黄エキス ２０ｇ アスパラギン酸Ｋ・Ｍｇ混合物 ２０ｇ 炭酸カルシウム １０ｇ タウリン １０ｇ ニコチン酸アミド ５ｇ ビオチン １mg ビタミンＢ２ ２００mg ビタミンＢ６ ２００mg ビタミンＣ ５ｇ ビタミンＤ３ ５０００I.U. 上記処方ならびに異性化糖８００ｇ、キシリトール２０
０ｇ、リンゴ酸１０ｇおよびクエン酸１５ｇを精製水に
溶解した。クエン酸ナトリウムでｐＨを２．０に調節
し、精製水で５ｌ液剤（鉄濃度０．０５mol/l）とし
た。Example 5 Ammonium iron citrate 240 mg Ripe ground yellow extract 20 g Aspartic acid K / Mg mixture 20 g Calcium carbonate 10 g Taurine 10 g Nicotinamide 5 g Biotin 1 mg Vitamin B2 200 mg Vitamin B6 200 mg Vitamin C 5 g Vitamin D3 5000 I.U. And 800 g of isomerized sugar, xylitol 20
0 g, malic acid 10 g and citric acid 15 g were dissolved in purified water. The pH was adjusted to 2.0 with sodium citrate and made up to 5 l with purified water (iron concentration 0.05 mol / l).
【００２０】試験例 （試験方法）実施例１のサンプルを常温で３年間放置し
た経変品の鉄の不快風味を試験したところ、６５℃で３
日間放置したものと同等の鉄風味が得られたため、風味
試験には６５℃３日間放置サンプルを用いた。Test Example (Test Method) When the sample of Example 1 was left at room temperature for 3 years to test the unpleasant taste of iron in a modified product,
Since an iron flavor equivalent to that left for a period of one day was obtained, a sample left at 65 ° C. for three days was used for the flavor test.
【００２１】比較として鉄成分のみを配合した処方（処
方１）および鉄風味改善効果が知られているピーチ香料
を配合した処方（処方２）を用い、鉄成分の経時的に増
加する不快風味が本発明により低減される効果を試験し
た。As a comparison, a formulation containing only an iron component (formulation 1) and a formulation containing a peach flavor which is known to have an effect of improving iron flavor (formulation 2) were used, and the unpleasant flavor of the iron component which increased with time was increased. The effect reduced by the present invention was tested.
【００２２】被検体として、処方１：０．００６２５mo
l/lクエン酸鉄化合物水溶液、処方２：０．００６２５m
ol/lクエン酸鉄＋０．４重量％ピーチ香料添加水溶液、
処方３：０．００６２５mol/lクエン酸鉄＋地黄エキス
（原生薬４００mg）添加水溶液、処方４：０．００６２
５mol/lクエン酸鉄＋熟地黄エキス（原生薬４００mg）
添加水溶液の４種類を用いた。各処方ともクエン酸によ
りｐＨを３．５に調節し、被験液とした。As a subject, prescription 1: 0.00625mo
l / l iron citrate compound aqueous solution, prescription 2: 0.00625m
ol / l iron citrate + 0.4 wt% peach flavored aqueous solution,
Formulation 3: 0.00625 mol / l iron citrate + ground yellow extract (crude drug 400 mg) added aqueous solution, Formulation 4: 0.0062
5mol / l iron citrate + ripened ground yellow extract (400mg of crude drug)
Four types of the aqueous solution were used. The pH of each formulation was adjusted to 3.5 with citric acid to prepare a test solution.
【００２３】試験方法としては、６５℃３日間放置後の
各被検体を専門のパネラー１０名に服用してもらい、鉄
味の程度を、５：非常に強く鉄味がするので服用するの
が難しい、４：強く鉄味がするのが服用することはでき
る、３：鉄味がするが服用することはできる、２：やや
鉄味がするが服用することはできる、１：鉄味がしな
い、の５段階評価でアンケートに答えてもらった。As a test method, each subject after standing at 65 ° C. for 3 days was taken by 10 specialized panelists, and the degree of iron taste was 5: taking a very strong iron taste. Difficult 4: Strong irony can be taken 3: Irony but can be taken 2: Somewhat irony but can be taken 1: No irony And asked them to answer the questionnaire on a five-point scale.
【００２４】結果を表１に示した。The results are shown in Table 1.
【００２５】[0025]
【表１】 [Table 1]
Claims (6)
れる生薬の少なくとも１種のエキスを配合し、ｐＨが
２．０〜４．５であることを特徴とする鉄分含有液剤。1. An iron-containing liquid formulation comprising an extract of iron and at least one extract of a crude drug selected from ground yellow and mature ground yellow, and having a pH of 2.0 to 4.5.
５〜０．０５mol/lである請求項１記載の鉄分含有液
剤。2. The iron content is 0.000 as iron content.
2. The iron-containing liquid preparation according to claim 1, wherein the amount is 5 to 0.05 mol / l.
酸鉄ナトリウム、塩化第二鉄および硫酸第一鉄から選べ
れる１種または２種以上である請求項１または２に記載
の鉄分含有液剤。3. The iron-containing liquid preparation according to claim 1, wherein the iron content is one or more selected from ammonium iron citrate, sodium iron citrate, ferric chloride and ferrous sulfate.
て、地黄および熟地黄から選ばれる生薬の少なくとも１
種のエキスを、原生薬換算量で４０〜４０００mg配合し
たことを特徴とする請求項１〜３のいずれかに記載の鉄
分含有液剤。4. An amount of at least one crude drug selected from the earthy yellow and the matured earthy yellow with respect to the iron content of 0.01 mol of iron.
The iron-containing liquid preparation according to any one of claims 1 to 3, wherein 40 to 4000 mg of a seed extract is added in terms of a crude drug.
lの鉄分を含有した液剤において、地黄および熟地黄か
ら選ばれる生薬の少なくとも１種のエキスを配合したこ
とを特徴とする鉄分含有液剤。5. An iron content of 0.0005 to 0.05 mol /
1. An iron-containing liquid preparation, characterized in that at least one extract of a crude drug selected from ground yellow and ripened ground yellow is added to the liquid preparation containing 1) iron.
Ｈを２〜４．５の範囲に調節することによる、鉄分含有
液剤の風味改善方法。6. An extract of ground yellow or mature ground yellow, wherein p
A method for improving the flavor of an iron-containing solution by adjusting H to a range of 2 to 4.5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9156403A JPH111436A (en) | 1997-06-13 | 1997-06-13 | Iron-containing liquid agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9156403A JPH111436A (en) | 1997-06-13 | 1997-06-13 | Iron-containing liquid agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH111436A true JPH111436A (en) | 1999-01-06 |
Family
ID=15626987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9156403A Withdrawn JPH111436A (en) | 1997-06-13 | 1997-06-13 | Iron-containing liquid agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH111436A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000169385A (en) * | 1998-12-10 | 2000-06-20 | Taisho Pharmaceut Co Ltd | Internal liquid pharmaceutical preparation |
| WO2003000248A1 (en) * | 2001-06-22 | 2003-01-03 | Taisho Pharmaceutical Co., Ltd. | Liquid composition |
| GB2371747B (en) * | 1999-08-31 | 2004-11-17 | Remedy Res Ltd | Metal-containing compositions, preparations and uses |
| JP2005255653A (en) * | 2004-03-15 | 2005-09-22 | Taisho Pharmaceut Co Ltd | Internal liquid medicine formulated with iron compound |
| JP2017095372A (en) * | 2015-11-19 | 2017-06-01 | 武田薬品工業株式会社 | Biotin-containing liquid formulation |
-
1997
- 1997-06-13 JP JP9156403A patent/JPH111436A/en not_active Withdrawn
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000169385A (en) * | 1998-12-10 | 2000-06-20 | Taisho Pharmaceut Co Ltd | Internal liquid pharmaceutical preparation |
| GB2371747B (en) * | 1999-08-31 | 2004-11-17 | Remedy Res Ltd | Metal-containing compositions, preparations and uses |
| US7060302B1 (en) | 1999-08-31 | 2006-06-13 | Remedy Research Limited | Metal-containing compositions, preparations and uses |
| WO2003000248A1 (en) * | 2001-06-22 | 2003-01-03 | Taisho Pharmaceutical Co., Ltd. | Liquid composition |
| JP2005255653A (en) * | 2004-03-15 | 2005-09-22 | Taisho Pharmaceut Co Ltd | Internal liquid medicine formulated with iron compound |
| JP2017095372A (en) * | 2015-11-19 | 2017-06-01 | 武田薬品工業株式会社 | Biotin-containing liquid formulation |
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