JPH1087410A - Composition for sterilization and disinfection - Google Patents
Composition for sterilization and disinfectionInfo
- Publication number
- JPH1087410A JPH1087410A JP26510196A JP26510196A JPH1087410A JP H1087410 A JPH1087410 A JP H1087410A JP 26510196 A JP26510196 A JP 26510196A JP 26510196 A JP26510196 A JP 26510196A JP H1087410 A JPH1087410 A JP H1087410A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- disinfection
- skin
- bacteria
- disinfectant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
Description
【０００１】[0001]
【産業上の技術分野】本発明は殺菌作用を有し、かつ皮
膚保護作用を有する殺菌消毒用組成物に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a disinfecting composition having a bactericidal action and a skin protecting action.
【０００２】[0002]
【背景技術】近年、モダシン、アジセフ、メイセリンな
どの第３世代セフェム系の抗生物質を多量に投与した場
合、その抗生物質に対し耐性を有するようになった細菌
の出現が問題化している。著名な例では、抵抗力が低下
している人体に対し敗血症等を誘発し、最悪の場合致命
的な影響を及ぼすメチシリン耐性黄色ブドウ球菌（Meth
icillin Resistant Staphylococcus aureus：以下ＭＲ
ＳＡと略称する）による院内感染が大きな社会問題とな
っている。BACKGROUND ART In recent years, when a large amount of third generation cephem antibiotics such as modacin, azisef, and meserin are administered, the emergence of bacteria that have become resistant to the antibiotics has become a problem. A prominent example is methicillin-resistant Staphylococcus aureus (Meth), which induces sepsis and the like in a worst case human body with reduced resistance.
icillin Resistant Staphylococcus aureus: MR
No. SA) is a major social problem.
【０００３】そこでこのＭＲＳＡに対する対応措置とし
て、病院においては室内設備を主に消毒用アルコールで
殺菌する処理が施されている。また一般にはアルコール
水溶液等の殺菌剤を不織紙等に含浸させたウェットティ
ッシュや、便座クリーナティッシュ等が市販されてい
る。[0003] As a countermeasure against this MRSA, in hospitals, a treatment for sterilizing indoor facilities mainly with disinfecting alcohol is performed. Generally, a wet tissue in which non-woven paper or the like is impregnated with a bactericide such as an aqueous alcohol solution, a toilet seat cleaner tissue, and the like are commercially available.
【０００４】エチルアルコール、イソプロピルアルコー
ル等を用いた殺菌消毒剤は、被消毒部を強力に殺菌する
ことができるが、これらのアルコール類は常温下または
体温で徐々に蒸散するため、アルコールが被消毒部から
蒸散した後は殺菌力がなくなる。そのためこの被消毒部
に細菌が再付着すると細菌の増殖を防ぐ事ができず、い
わゆる殺菌力が殆ど持続しないという欠点がある。A disinfectant using ethyl alcohol, isopropyl alcohol or the like can strongly disinfect a portion to be disinfected. However, since these alcohols gradually evaporate at normal temperature or body temperature, the alcohol is disinfected. After transpiration from the part, the sterilizing power is lost. Therefore, if the bacteria re-adhere to the disinfected part, the growth of the bacteria cannot be prevented, and there is a drawback that the so-called bactericidal power is hardly maintained.
【０００５】さらに、エチルアルコール、イソプロピル
アルコール等の殺菌消毒剤を皮膚の消毒等に使用する
際、これらのアルコール類の脱水力により、皮膚のかさ
つき、柔軟性の欠如を起こす、いわゆる手荒れ、肌荒れ
の原因となり、特に病院等でＭＲＳＡに対処する措置と
して連続的に長期に亙って使用する際には、その使用後
に保湿剤などを塗布して皮膚を保護する必要がある。Further, when a disinfectant such as ethyl alcohol and isopropyl alcohol is used for disinfecting skin, etc., the dehydration power of these alcohols causes the skin to become bulky and lack flexibility, so-called rough hands and rough skin. When used for a long time continuously as a measure against MRSA in a hospital or the like, it is necessary to protect the skin by applying a moisturizer or the like after the use.
【０００６】[0006]
【発明の開示】本発明者は、上記の如き問題点を解決す
べく鋭意研究を行ったところ、強い殺菌性とその持続性
を発揮し、かつ皮膚のかさつき、柔軟性の欠如を生起す
ることのない殺菌消毒用組成物の開発に成功した。DISCLOSURE OF THE INVENTION The present inventors have made intensive studies to solve the above-mentioned problems, and found that they exhibit strong bactericidal properties and long-lasting properties, and cause bulkiness and lack of flexibility of the skin. Successfully developed a sterile-free disinfectant composition.
【０００７】すなわち、本発明は、アルコール媒体中に
下記（ａ）〜（ｄ）の各物質を有効成分として含有する
ことを特徴とする殺菌消毒用組成物を提供するものであ
る。 （ａ） 塩化ベンザルコニウム （ｂ） プロピレングリコール （ｃ） グリセロール （ｄ） トリエタノールアミンThat is, the present invention provides a composition for disinfection and disinfection characterized by containing the following substances (a) to (d) as active ingredients in an alcohol medium. (A) benzalkonium chloride (b) propylene glycol (c) glycerol (d) triethanolamine
【０００８】本発明に係る殺菌消毒用組成物は、被消毒
部の強い殺菌性とその持続性を有し、被消毒部が皮膚で
ある場合においては、皮膚のかさつき防止、柔軟性の維
持に効果的であるという格別の特長を有する。以下、本
発明を詳細に説明する。[0008] The composition for disinfection and disinfection according to the present invention has a strong disinfecting property of the part to be disinfected and its persistence. When the part to be disinfected is skin, it is effective for preventing bulkiness of the skin and maintaining flexibility. It has the special feature of being effective. Hereinafter, the present invention will be described in detail.
【０００９】本発明におけるアルコール媒体中の塩化ベ
ンザルコニウムの含有量は０.１〜１.０％好ましくは
０.１〜０.５％、プロピレングリコールの含有量は１.
０〜２.０％、グリセロールの含有量は０.１〜１．0
％、トリエタノールアミンの含有量は０.１〜０.５％好
ましくは０.１５〜０.２％がより好適であり、これらの
使用範囲において、対象となる被消毒部の特性を考慮
し、その使用時の状況に応じてそれぞれの含量を適宜設
定し使用する。また、アルコール媒体としては、エチル
アルコール又はイソプロピルアルコールが好ましく、そ
の７０〜９０％溶液として用いられる。さらに、殺菌消
毒剤に通常添加されている界面活性剤、香料等の添加剤
を適宜加えて使用することも可能である。In the present invention, the content of benzalkonium chloride in the alcohol medium is 0.1 to 1.0%, preferably 0.1 to 0.5%, and the content of propylene glycol is 1.0.
0-2.0%, glycerol content 0.1-1.0.
%, And the content of triethanolamine is preferably 0.1 to 0.5%, more preferably 0.15 to 0.2%. In these usage ranges, the characteristics of the target disinfected part are taken into consideration. Each content is appropriately set and used according to the situation at the time of use. Further, as the alcohol medium, ethyl alcohol or isopropyl alcohol is preferable, and a 70-90% solution thereof is used. Further, it is also possible to appropriately add additives such as a surfactant and a fragrance which are usually added to the germicidal disinfectant.
【００１０】本発明に係る殺菌消毒用組成物は、被消毒
部において強力な殺菌作用とその持続性を発揮し、さら
に皮膚の保護作用を発揮する、その作用は、被消毒部に
おいて塩化ベンザルコニウムとアルコールとの協奏作用
により殺菌効果を発揮しアルコール媒体が常温下又は体
温等で経時的に蒸散したとしても、この蒸散によりプロ
ピレングリコール、グリセロール、トリエタノールアミ
ン及び塩化ベンザルコニウムが濃縮され、被消毒部に被
膜となって残ることによって、持続的な殺菌力と皮膚保
護作用を発揮するものである。このような本発明の殺菌
消毒用組成物の有する格別の作用効果は、（ａ）成分〜
（ｄ）成分の単独あるいは単に２〜３の成分からなる組
成物によっては得ることのできないものであり、（ａ）
成分〜（ｄ）成分がアルコール媒体中に適度の量割合に
配合されることによって奏されるものである。The composition for disinfecting and disinfecting according to the present invention exerts a strong disinfecting action and its persistence in the disinfected part and further exerts a protective action on the skin. Even if the alcohol medium exerts a bactericidal effect by the concerted action of aluminum and alcohol and evaporates over time at room temperature or body temperature, propylene glycol, glycerol, triethanolamine and benzalkonium chloride are concentrated by this evaporation, By remaining as a film on the part to be disinfected, it exerts a continuous bactericidal effect and a skin protection effect. The special effects of the composition for sterilization and disinfection of the present invention are as follows:
(D) cannot be obtained by a single component or a composition consisting of only two or three components;
This is achieved by mixing the components (d) and (d) in an appropriate amount in the alcohol medium.
【００１１】すなわち、本発明者は、本発明の目的とす
る被消毒部の殺菌効果とその持続性及び皮膚保護作用を
単なる成分の混合ではなく、無数に存在する構成成分の
混合比と夫々の濃度の条件の中から目的を達成する組み
合わせ及び各成分の至適濃度幅を、多くの実験により見
い出したものである。That is, the inventor of the present invention has proposed not only the mixing of the components but also the mixing ratio of the innumerable components and the bactericidal effect of the portion to be disinfected, its persistence and the skin protection effect. The combination which achieves the object and the optimum concentration range of each component among the concentration conditions have been found through many experiments.
【００１２】そして本発明に係る殺菌消毒用組成物は、
スプレー法、浸布での擦拭または浸漬法などにより適用
することが可能であり、下記（１）〜（５）に挙げる広
範な分野で利用される。 （１）皮膚の消毒用 （２）実験器具等の消毒用 （３）衣服等の消毒用 （４）病院等の院内設備の消毒用 （５）公共施設での消毒用The composition for sterilization according to the present invention comprises:
It can be applied by a spray method, wiping with a dipping cloth or a dipping method, and is used in a wide range of fields described in the following (1) to (5). (1) For disinfection of skin (2) For disinfection of laboratory equipment, etc. (3) For disinfection of clothes, etc. (4) For disinfection of hospital facilities, etc. (5) For disinfection in public facilities
【００１３】このように本発明の殺菌消毒剤を用いて被
消毒部を殺菌消毒することにより、確実な殺菌はもとよ
り、その持続する殺菌効果により再付着した菌の殺菌を
可能とし、加えて皮膚に用いた場合における皮膚保護作
用により使用者の長期または連続使用を可能とし、社会
問題化しているＭＲＳＡによる院内感染の蔓延防止等に
も極めて有効である。次に、本発明の技術的内容を明ら
かにするため、実施例によりさらに具体的に説明する。
尚、以下の実施例は本発明を何ら限定するものではな
い。[0013] As described above, the disinfected part is disinfected by the disinfectant of the present invention, so that not only reliable disinfection but also disinfection of re-adhered bacteria due to its continuous disinfection effect can be achieved. The skin protection effect in the case of using it enables long-term or continuous use of the user, and is extremely effective in preventing spread of hospital-acquired infections due to MRSA, which has become a social problem. Next, in order to clarify the technical contents of the present invention, the present invention will be described more specifically with reference to examples.
Note that the following examples do not limit the present invention in any way.
【００１４】[0014]
［実施例１］ 殺菌消毒液の調製 殺菌消毒液―１ エチルアルコール７００mlに塩化ベンザルコニウム２.
５ｇを加えて溶解し、その後プロピレングリコール１５
ml、グリセロール５.０ml、及びトリエタノールアミン
１.８mlを加えて溶かし、蒸留水を加えて全量を１.０リ
ットルとした。[Example 1] Preparation of disinfectant solution Disinfectant solution-1 Benzalkonium chloride in 700 ml of ethyl alcohol 2.
5 g was added and dissolved, and then propylene glycol 15
ml, 5.0 ml of glycerol and 1.8 ml of triethanolamine were added and dissolved, and distilled water was added to make a total volume of 1.0 liter.
【００１５】 殺菌消毒液―２ エチルアルコール８００mlに塩化ベンザルコニウム１.
５ｇを加えて溶解し、その後プロピレングリコール１５
ml、グリセロール５.０ml、トリエタノールアミン１.５
ml、及びレモンエッセンス（香料）９mlを加えて溶か
し、蒸留水を加えて全量を１.０リットルとした。Bactericidal disinfectant-2 Benzalkonium chloride in 800 ml of ethyl alcohol 1.
5 g was added and dissolved, and then propylene glycol 15
ml, glycerol 5.0 ml, triethanolamine 1.5
Then, 9 ml of lemon essence (perfume) was added and dissolved, and distilled water was added to make the total volume 1.0 liter.
【００１６】［実施例２］ 殺菌力の評価試験 本実施例では細菌としてＭＲＳＡ、Pseudomonus aerugi
nosa、Serratia marcescens、Escherichia coliを用い
その殺菌力を下記の操作により評価した。 直径２cmのアルミ円板５枚を洗浄、乾燥させ、夫々
の細菌浮遊液（細菌濃度として約１.５億個／ml）に浸
した後自然乾燥させ菌付着アルミ板を作製した。 （対照１）上記で作製した菌付着アルミ板をその
ままチオグリコレ−ト寒天倍地に接触させ、ふ卵器内３
７℃で２４時間培養し、殺菌剤を使用しない場合の菌の
発育度を調べた。[Example 2] Evaluation test of bactericidal activity In this example, MRSA, Pseudomonus aerugi were used as bacteria.
Nosa, Serratia marcescens, and Escherichia coli were used to evaluate the bactericidal activity by the following operation. Five aluminum discs having a diameter of 2 cm were washed, dried, immersed in the respective bacterial suspensions (bacterial concentration: about 150 million cells / ml), and then naturally dried to prepare bacterial-attached aluminum plates. (Control 1) The aluminum plate adhered to the bacterium prepared above was brought into contact with thioglycolate agar as it was, and placed in an incubator.
After culturing at 7 ° C. for 24 hours, the growth of the bacterium when no fungicide was used was examined.
【００１７】 上記で作製した夫々の菌付着アルミ
板を実施例１で調製した夫々の殺菌消毒液に２秒間浸
し、自然乾燥させた後チオグリコレ−ト寒天倍地に接触
させ、ふ卵器内３７℃で２４時間培養し、殺菌消毒液で
２秒間殺菌消毒した場合の菌の発育度を調べた。 上記で作製した夫々の菌付着アルミ板を実施例１
で調製した夫々の殺菌消毒液に３０秒間浸し、自然乾燥
させた後チオグリコレ−ト寒天倍地に接触させ、ふ卵器
内３７℃で２４時間培養し、殺菌消毒液で３０秒間殺菌
消毒した場合の菌の発育度を調べた。[0017] Each of the bacteria-adhered aluminum plates prepared above was immersed in each of the disinfectant solutions prepared in Example 1 for 2 seconds, allowed to dry naturally, and then contacted with thioglycolate agar medium, and placed in an incubator at 37 ° C. For 24 hours and sterilized with a disinfectant solution for 2 seconds to examine the growth of the bacteria. Each of the bacteria-adhered aluminum plates prepared above was used in Example 1.
After immersing for 30 seconds in each of the disinfectants prepared in the above, air-drying, contacting with thioglycolate agar medium, culturing at 37 ° C. for 24 hours in an incubator, and disinfecting with the disinfectants for 30 seconds. The growth of the fungus was examined.
【００１８】 上記で作製した夫々の菌付着アルミ
板を実施例１で調製した夫々の殺菌消毒液に６０秒間浸
し、自然乾燥させた後チオグリコレ−ト寒天倍地に接触
させ、ふ卵器内３７℃で２４時間培養し、殺菌消毒液で
６０秒間殺菌消毒した場合の菌の発育度を調べた。 （対照２） 上記で作製した夫々の菌付着アルミ板
を７０％エチルアルコール溶液に２秒間浸し、自然乾燥
させた後チオグリコレ−ト寒天倍地に接触させ、ふ卵器
内３７℃で２４時間培養し、７０％エチルアルコ−ル溶
液で２秒間殺菌消毒した場合の菌の発育度を調べた。Each of the aluminum plates adhered to the bacteria prepared as described above was immersed in each of the disinfecting solutions prepared in Example 1 for 60 seconds, allowed to dry naturally, and then contacted with thioglycolate agar medium at 37 ° C. in an incubator. For 24 hours and sterilized with a disinfectant solution for 60 seconds to examine the growth rate of the bacteria. (Control 2) Each of the aluminum plates adhered to the bacteria prepared above was immersed in a 70% ethyl alcohol solution for 2 seconds, air-dried, then contacted with thioglycolate agar medium, and cultured at 37 ° C. for 24 hours in an incubator. And the degree of growth of the bacteria when sterilized with a 70% ethyl alcohol solution for 2 seconds was examined.
【００１９】上記、、、及びで行った試験の
結果を表−１ａ(殺菌消毒液−１)、表―１ｂ(殺菌消毒
液−２)に示す。各表に示す通り、(対照１)、すなわ
ち殺菌消毒液を使用しなかった場合には菌の発育が認め
られた。これに対し、、及び、すなわち実施例１
で調製した及びの殺菌消毒液を使用した場合には殺
菌消毒液への浸し時間及び菌の種類に関係なく菌の発育
が認められず、(対照２)で行った培養結果、すなわち
従来多く殺菌消毒剤として用いられている７０％エチル
アルコール溶液を使用した場合と少なくとも同等の強い
殺菌力のあることが確認された。The results of the tests performed above, and are shown in Table 1a (sterilizing solution-1) and Table-1b (sterilizing solution-2). As shown in each table, (Control 1), that is, when the sterilizing solution was not used, the growth of bacteria was observed. On the other hand, and, namely, the first embodiment
When the germicidal disinfectant prepared in and above was used, no growth of bacteria was observed irrespective of the time of immersion in the germicidal disinfectant and the type of bacterium. It was confirmed that it had at least the same strong bactericidal activity as when a 70% ethyl alcohol solution used as a disinfectant was used.
【００２０】[0020]
【表１】 [Table 1]
【００２１】［実施例３］ 持続性試験 本実施例では細菌としてＭＲＳＡを用いその殺菌力の持
続性を下記の操作にて評価した。 実施例１で調製した殺菌消毒液―１に直径２cmのア
ルミ円板３枚を夫々１０秒間浸した。 上記で殺菌消毒液―１に浸したアルミ円板を３０
分間放置した後、実施例２で用いたＭＲＳＡ浮遊液に浸
し、そのままチオグリコレ−ト寒天倍地に接触させ、ふ
卵器内３７℃で２４時間培養し、殺菌消毒液使用３０分
後の殺菌効果を菌の発育度で調べた。Example 3 Persistence Test In this example, MRSA was used as a bacterium, and the bactericidal activity of the bacterium was evaluated for persistence by the following procedure. Three aluminum disks each having a diameter of 2 cm were immersed in the disinfectant solution-1 prepared in Example 1 for 10 seconds. The aluminum disk immersed in the disinfectant solution-1
After standing for a few minutes, the plate was immersed in the MRSA suspension used in Example 2, and allowed to come into contact with thioglycolate agar medium as it was, and cultured at 37 ° C. for 24 hours in an incubator. The degree of growth of the fungus was examined.
【００２２】 上記で殺菌消毒液―１に浸したアル
ミ円板を３時間放置した後、実施例２で用いたＭＲＳＡ
浮遊液に浸し、そのままチオグリコレ−ト寒天倍地に接
触させ、ふ卵器内３７℃で２４時間培養し、殺菌消毒液
使用３時間後の殺菌効果を菌の発育度で調べた。 上記で殺菌消毒液―１に浸したアルミ円板を６時
間放置した後、実施例２で用いたＭＲＳＡ浮遊液に浸
し、そのままチオグリコレ−ト寒天倍地に接触させ、ふ
卵器内３７℃で２４時間培養し、殺菌消毒液使用６時間
後の殺菌効果を菌の発育度で調べた。After leaving the aluminum disk immersed in the disinfectant / disinfectant solution 1 for 3 hours as described above, the MRSA used in Example 2 was used.
The cells were immersed in the suspension, and were directly contacted with thioglycolate agar medium, cultured in an incubator at 37 ° C. for 24 hours, and the bactericidal effect 3 hours after using the germicidal disinfectant was examined by the growth rate of the bacteria. After leaving the aluminum disk immersed in the disinfectant-1 as described above for 6 hours, it was immersed in the MRSA suspension used in Example 2, and was allowed to come into contact with the thioglycolate agar medium as it was. After culturing for a period of time, the bactericidal effect 6 hours after using the germicidal disinfectant was examined by the growth rate of the bacteria.
【００２３】 ７０％エチルアルコール溶液に浸した
アルミ円板を３０分間放置した後、実施例２で用いたＭ
ＲＳＡ浮遊液に浸し、そのままチオグリコレ−ト寒天倍
地に接触させ、ふ卵器内３７℃で２４時間培養し、７０
％エチルアルコール溶液使用30分後の殺菌効果を菌の発
育度で調べた。 ７０％エチルアルコール溶液に浸したアルミ円板を
３時間放置した後、実施例２で用いたＭＲＳＡ浮遊液に
浸し、そのままチオグリコレ−ト寒天倍地に接触させ、
ふ卵器内３７℃で２４時間培養し、７０％エチルアルコ
ール溶液使用３時間後の殺菌効果を菌の発育度で調べ
た。 ７０％エチルアルコール溶液に浸したアルミ円板を
６時間放置した後、実施例２で用いたＭＲＳＡ浮遊液に
浸し、そのままチオグリコレ−ト寒天倍地に接触させ、
ふ卵器内３７℃で２４時間培養し、７０％エチルアルコ
ール溶液使用６時間後の殺菌効果を菌の発育度で調べ
た。After leaving the aluminum disk immersed in a 70% ethyl alcohol solution for 30 minutes, the M disk used in Example 2 was used.
It was immersed in the RSA suspension, contacted directly with thioglycolate agar medium, and cultured in an incubator at 37 ° C for 24 hours.
The bactericidal effect 30 minutes after the use of the% ethyl alcohol solution was examined by the growth rate of the bacteria. After leaving the aluminum disk immersed in the 70% ethyl alcohol solution for 3 hours, it was immersed in the MRSA suspension used in Example 2, and allowed to come into contact with thioglycolate agar medium as it was,
The cells were cultured in an incubator at 37 ° C. for 24 hours, and the bactericidal effect 3 hours after using a 70% ethyl alcohol solution was examined based on the growth rate of the bacteria. After leaving the aluminum disk immersed in a 70% ethyl alcohol solution for 6 hours, it was immersed in the MRSA suspension used in Example 2, and allowed to come into contact with the thioglycolate agar medium as it was,
The cells were cultured at 37 ° C. for 24 hours in an incubator, and the bactericidal effect after 6 hours of using a 70% ethyl alcohol solution was examined based on the growth of the bacteria.
【００２４】上記、、、、及びで行った培
養結果を表−２に示す。表−２に示す通り、、及び
、すなわち殺菌消毒液を使用した場合には使用６時間
後においても菌の発育が認められず殺菌力の持続性が確
認された。これに対し、、及び、すなわち７０％
エチルアルコール溶液を使用した場合には僅か使用３０
分後であっても菌の発育が認められ、一般に消毒剤とし
て用いられている７０％エチルアルコール溶液を使用し
た場合では殺菌力の持続性に乏しいことが確認された。Table 2 shows the results of the cultivation performed above,, and. As shown in Table 2, that is, when the disinfectant solution was used, the growth of the bacteria was not observed even after 6 hours of use, and the persistence of the disinfecting power was confirmed. On the other hand, and, ie, 70%
Use only 30 when using ethyl alcohol solution
Even after a minute, the growth of the bacterium was observed, and it was confirmed that the bactericidal activity was not persistent when a 70% ethyl alcohol solution generally used as a disinfectant was used.
【００２５】[0025]
【表２】 [Table 2]
【００２６】［実施例４］ 皮膚保護効果の評価試験 本実施例においては、ボランティア４２名を２つの群に
分け、第Ｉ群を実施例１にて調製した殺菌消毒液―１使
用群、第II群を既存の市販品（丸石製薬株式会社：ウエ
ルパス）使用群とし、皮膚保護効果試験を行った。Example 4 Evaluation Test of Skin Protective Effect In this example, 42 volunteers were divided into two groups, and Group I was a group using the disinfectant and disinfectant-1 prepared in Example 1, Group II was used as a group using an existing commercial product (Maruishi Pharmaceutical Co., Ltd .: Wellpass), and a skin protection effect test was performed.
【００２７】第Ｉ群、第II群ともに１日６回夫々実施例
１にて調製した殺菌消毒液―１または既存の市販品に両
手を浸し自然乾燥を行う作業を連続２ヶ月間行い、掌表
面を肉眼で観察し表−３に示す基準で皮膚表面形態の分
類を行い、皮膚のカサつき度、もしくは肌荒れ度を試験
した。その結果を表−４に示す。In both groups I and II, the hands were immersed in the disinfectant solution-1 prepared in Example 1 or an existing commercially available product and air-dried six times a day for two consecutive months. The surface was observed with the naked eye, and the skin surface morphology was classified based on the criteria shown in Table 3, and the degree of roughness of the skin or the degree of skin roughness was tested. Table 4 shows the results.
【００２８】[0028]
【表３】 [Table 3]
【００２９】表−４に示す通り、第II群に比べて第Ｉ群
の皮膚は評価Ａ、Ｂすなわち表面が滑らかできめ細かい
状態もしくは表面はやや滑らかな状態が多く、本発明に
よる殺菌消毒剤が皮膚保護効果を持ち合わせていること
が確認された。As shown in Table 4, the skin of Group I had more evaluation A and B, that is, the surface was smooth and fine, or the surface was slightly smoother than that of Group II. It was confirmed that it had a skin protection effect.
【００３０】[0030]
【表４】 [Table 4]
Claims (1)
の物質を有効成分として含有することを特徴とする殺菌
消毒用組成物。 （ａ） 塩化ベンザルコニウム （ｂ） プロピレングリコール （ｃ） グリセロール （ｄ） トリエタノールアミン(1) The following (a) to (d) are contained in an alcohol medium.
A composition for disinfecting and disinfecting, comprising the substance as an active ingredient. (A) benzalkonium chloride (b) propylene glycol (c) glycerol (d) triethanolamine
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26510196A JPH1087410A (en) | 1996-09-17 | 1996-09-17 | Composition for sterilization and disinfection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26510196A JPH1087410A (en) | 1996-09-17 | 1996-09-17 | Composition for sterilization and disinfection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH1087410A true JPH1087410A (en) | 1998-04-07 |
Family
ID=17412629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP26510196A Pending JPH1087410A (en) | 1996-09-17 | 1996-09-17 | Composition for sterilization and disinfection |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH1087410A (en) |
Cited By (9)
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|---|---|---|---|---|
| WO2002023990A1 (en) * | 2000-09-20 | 2002-03-28 | Lonza Ag | Disinfectant |
| WO2003059062A1 (en) * | 2002-01-18 | 2003-07-24 | Lonza Ag | Virucidal disinfectant |
| KR20040003657A (en) * | 2002-07-03 | 2004-01-13 | 유경진 | a composition of sterilant-cleaner for external use and manufacturing method of the same |
| KR100425943B1 (en) * | 2000-11-30 | 2004-04-03 | 구본길 | Germicide with the skin care of lotion type |
| WO2008133717A2 (en) * | 2006-11-07 | 2008-11-06 | The Dial Corporation | Method of controlling the transmission of community-acquired-methicillin-resistant staphylococcus aureus, and preventing or reducing infections caused by the same |
| WO2010061764A1 (en) * | 2008-11-27 | 2010-06-03 | ユニ・チャーム株式会社 | Chemical liquid for alcohol sterilization sheet and alcohol sterilization sheet containing same |
| US8034844B2 (en) | 2006-05-30 | 2011-10-11 | The Dial Corporation | Compositions having a high antiviral efficacy |
| US8337872B2 (en) | 2006-06-02 | 2012-12-25 | The Dial Corporation | Method of inhibiting the transmission of influenza virus |
| AU2011265527B2 (en) * | 2002-01-18 | 2013-01-17 | Lonza Ag | Virucidal disinfectant |
-
1996
- 1996-09-17 JP JP26510196A patent/JPH1087410A/en active Pending
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6939840B2 (en) | 2000-09-20 | 2005-09-06 | Lonza Ag | Disinfectant |
| JP2013028632A (en) * | 2000-09-20 | 2013-02-07 | Lonza Ag | Disinfectant |
| AU2002221601B2 (en) * | 2000-09-20 | 2006-08-17 | Lonza Ag | Disinfectant |
| JP2004509138A (en) * | 2000-09-20 | 2004-03-25 | ロンザ ア−ゲ− | disinfectant |
| WO2002023990A1 (en) * | 2000-09-20 | 2002-03-28 | Lonza Ag | Disinfectant |
| EP1671541A1 (en) * | 2000-09-20 | 2006-06-21 | Lonza Ag | Disinfectant |
| KR100425943B1 (en) * | 2000-11-30 | 2004-04-03 | 구본길 | Germicide with the skin care of lotion type |
| JP2005514427A (en) * | 2002-01-18 | 2005-05-19 | ロンザ ア−ゲ− | Viralicide |
| JP4647912B2 (en) * | 2002-01-18 | 2011-03-09 | ロンザ アーゲー | Viralicide |
| US8221733B2 (en) | 2002-01-18 | 2012-07-17 | Lonza Ag | Virucidal disinfectant |
| AU2011265527B2 (en) * | 2002-01-18 | 2013-01-17 | Lonza Ag | Virucidal disinfectant |
| WO2003059062A1 (en) * | 2002-01-18 | 2003-07-24 | Lonza Ag | Virucidal disinfectant |
| KR20040003657A (en) * | 2002-07-03 | 2004-01-13 | 유경진 | a composition of sterilant-cleaner for external use and manufacturing method of the same |
| US8034844B2 (en) | 2006-05-30 | 2011-10-11 | The Dial Corporation | Compositions having a high antiviral efficacy |
| US8337872B2 (en) | 2006-06-02 | 2012-12-25 | The Dial Corporation | Method of inhibiting the transmission of influenza virus |
| WO2008133717A2 (en) * | 2006-11-07 | 2008-11-06 | The Dial Corporation | Method of controlling the transmission of community-acquired-methicillin-resistant staphylococcus aureus, and preventing or reducing infections caused by the same |
| WO2008133717A3 (en) * | 2006-11-07 | 2009-12-03 | The Dial Corporation | Method of preventing infections caused by community acquired methicillin-resistant staphylococcus aureus |
| WO2010061764A1 (en) * | 2008-11-27 | 2010-06-03 | ユニ・チャーム株式会社 | Chemical liquid for alcohol sterilization sheet and alcohol sterilization sheet containing same |
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