JPH107506A - Inorganic antibacterial agent and its production - Google Patents
Inorganic antibacterial agent and its productionInfo
- Publication number
- JPH107506A JPH107506A JP16435696A JP16435696A JPH107506A JP H107506 A JPH107506 A JP H107506A JP 16435696 A JP16435696 A JP 16435696A JP 16435696 A JP16435696 A JP 16435696A JP H107506 A JPH107506 A JP H107506A
- Authority
- JP
- Japan
- Prior art keywords
- inorganic
- antibacterial
- mineral
- antibacterial agent
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- Pigments, Carbon Blacks, Or Wood Stains (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、無機系抗菌剤及び
その製造方法に関する。さらに詳しくは、樹脂組成物、
フィルム、包装材、繊維、ろ過材及び塗料等に用いるこ
とができ、優れた抗菌能を付与することができる無機系
抗菌剤及びその製造方法に関する。[0001] The present invention relates to an inorganic antibacterial agent and a method for producing the same. More specifically, a resin composition,
The present invention relates to an inorganic antibacterial agent which can be used for films, packaging materials, fibers, filtration materials, paints and the like, and can impart excellent antibacterial activity, and a method for producing the same.
【０００２】[0002]
【従来の技術】従来より、銀や銅などの金属やそのイオ
ンが殺菌・抗菌作用を有することは知られている。無機
系抗菌剤は、このような金属のイオンや金属粒子、金属
化合物などを無機物に担持させ、そこから徐放させるこ
とにより抗菌能を発現させるもので、無機担体としては
ゼオライトをはじめとしてアパタイト、リン酸塩、粘土
鉱物、ガラスなども用いられている。無機物質であるの
で、従来の有機系抗菌剤に比べて安全性、耐久性、耐熱
性などに優れ、また、近年、院内感染などで問題になっ
ている耐性菌を発生させることもないとされている。し
かし一方では、無機系抗菌剤を樹脂等に配合する際、担
持させた金属イオン等が溶出し、樹脂等が変色するとい
う、有機系抗菌剤にはない問題を有する。例えば金属イ
オンをゼオライトに担持させたいわゆる抗菌性ゼオライ
トは、日光、特に紫外線に露光するとそれ自体が著しく
変色するのみならず、これを配合した樹脂は経時的に褐
色に変色してしまう。この性質は金属銀を担持させたゼ
オライトについても同様で、樹脂や塗料等に配合した場
合に著しく製品価値を下げるため、大きな問題となって
いた。これを改善するものとして、酸化チタン系抗菌剤
が提案されている。これは半導体による水の光分解触媒
作用を利用したもので、光を照射することによって発生
する活性酸素によって殺菌作用が生ずるものであるが、
活性酸素には銀イオンのような強い抗菌性がなく、十分
な抗菌作用が得られなかった。2. Description of the Related Art It has been known that metals such as silver and copper and their ions have a bactericidal and antibacterial action. Inorganic antibacterial agents, such as metal ions and metal particles, metal compounds, etc. are carried on an inorganic substance, and exhibit an antibacterial activity by sustained release therefrom.As the inorganic carrier, apatite such as zeolite, Phosphates, clay minerals, glass and the like are also used. Because it is an inorganic substance, it is superior in safety, durability, heat resistance, etc. compared to conventional organic antibacterial agents, and it is also said that it does not generate resistant bacteria that have become a problem in recent hospital infections etc. ing. However, on the other hand, when an inorganic antibacterial agent is blended with a resin or the like, there is a problem that the metal ion or the like carried out elutes and the resin or the like discolors, which is not a problem with the organic antibacterial agent. For example, a so-called antibacterial zeolite in which metal ions are supported on zeolite, when exposed to sunlight, in particular, ultraviolet rays, not only discolors itself remarkably, but also a resin containing this discolors to brown over time. This property is the same for zeolites carrying metallic silver, and when blended in resins, paints, etc., the product value is significantly reduced, which has been a major problem. To improve this, an antibacterial agent based on titanium oxide has been proposed. This utilizes the catalytic action of photodecomposition of water by a semiconductor, and sterilization is caused by active oxygen generated by irradiating light.
Active oxygen did not have a strong antibacterial property like silver ions, and a sufficient antibacterial action was not obtained.
【０００３】[0003]
【発明が解決しようとする課題】したがって本発明は、
配合した樹脂や塗料等の変色を起こしにくく、高い抗菌
作用を発現する無機系抗菌剤を提供することを目的とす
る。Accordingly, the present invention provides
An object of the present invention is to provide an inorganic antibacterial agent which hardly causes discoloration of a blended resin or paint and exhibits a high antibacterial action.
【０００４】[0004]
【課題を解決するための手段】本発明者は、上記課題に
鑑み鋭意研究した結果、無機鉱物粒子を芯材として、そ
の表面に抗菌作用を有する物質を表面融合又は結合させ
て、皮膜を形成してなる複合体が、変色を起こしにくく
高い抗菌作用を有する抗菌剤となることを見い出し、こ
の知見に基づき本発明をなすに至った。すなわち本発明
は、（１）無機鉱物粒子の表面に抗菌性物質を表面融合
させるか又は結合させて被覆したことを特徴とする無機
系抗菌剤、（２）抗菌性物質が抗菌作用を有する金属又
は金属酸化物である（１）項記載の無機系抗菌剤、
（３）無機鉱物粒子が雲母粘土鉱物、層状ケイ酸塩鉱
物、シリカ鉱物、炭酸塩鉱物及び硫酸塩鉱物のいずれか
１種以上からなる（１）又は（２）項記載の無機系抗菌
剤、及び（４）回転運動による機械的混合によって、無
機鉱物粒子の表面に抗菌性物質を表面融合又は結合させ
て被覆させることを特徴とする無機系抗菌剤の製造方法
を提供するものである。Means for Solving the Problems The present inventor has conducted intensive studies in view of the above-mentioned problems, and as a result, has formed a film by using inorganic mineral particles as a core material and fusing or binding a substance having an antibacterial action to the surface thereof. It has been found that the resulting composite is an antibacterial agent that hardly causes discoloration and has a high antibacterial action, and based on this finding, has accomplished the present invention. That is, the present invention provides (1) an inorganic antibacterial agent characterized in that the surface of an inorganic mineral particle is coated with an antibacterial substance by surface fusion or bonding, and (2) a metal in which the antibacterial substance has an antibacterial action. Or the inorganic antibacterial agent according to (1), which is a metal oxide;
(3) The inorganic antibacterial agent according to (1) or (2), wherein the inorganic mineral particles comprise at least one of a mica clay mineral, a layered silicate mineral, a silica mineral, a carbonate mineral, and a sulfate mineral. And (4) a method for producing an inorganic antibacterial agent, characterized in that an antibacterial substance is surface-fused or bonded to and coated on the surface of inorganic mineral particles by mechanical mixing by rotational movement.
【０００５】[0005]
【発明の実施の形態】本発明の無機系抗菌剤の芯材とな
る無機鉱物としては、白雲母、セリサイト、イライトな
どの雲母粘土鉱物、モンモリロナイト、サポナイト、ヘ
クトライト、スチブンサイト、酸性白土などの層状ケイ
酸塩、石英、オパールなどのシリカ鉱物、炭酸カルシウ
ム、ドロマイトなどの炭酸塩鉱物、石こう、明ばん石な
どの硫酸塩鉱物などを用いることができる。これらは天
然品でも合成品でもよいが、経済性の点からは天然品を
用いることが好ましい。また、これらのいずれかを単独
で用いても、２種以上を混合して用いてもよい。無機鉱
物の平均粒径は、適宜設定することができ、特に制限は
ないが、好ましくは１００μｍ以下、より好ましくは
０．０５〜３０μｍとする。無機鉱物の粒径が大きすぎ
ると分散性が悪く、樹脂、塗料等に配合した場合、沈降
したり光線の透過を妨害したりして変色を起こす場合が
ある。また、小さすぎるときは添加量を多くしないと効
果が得がたく、抗菌作用の低下をまねく場合がある。無
機鉱物粒子の形は、球状の他、層状、板状、繊維状な
ど、どのようなものでもよい。本発明に用いる無機鉱物
の粒子の表面性状は特に制限されないが、表面が微細多
孔性のもの、平滑性のものなどが好ましい。BEST MODE FOR CARRYING OUT THE INVENTION The inorganic minerals serving as the core material of the inorganic antibacterial agent of the present invention include mica clay minerals such as muscovite, sericite and illite, montmorillonite, saponite, hectorite, stevensite, acid clay and the like. Silica minerals such as layered silicates, quartz and opal, carbonate minerals such as calcium carbonate and dolomite, and sulfate minerals such as gypsum and alunite can be used. These may be natural products or synthetic products, but it is preferable to use natural products from the viewpoint of economy. Any of these may be used alone, or two or more of them may be used in combination. The average particle size of the inorganic mineral can be appropriately set and is not particularly limited, but is preferably 100 μm or less, more preferably 0.05 to 30 μm. If the particle size of the inorganic mineral is too large, the dispersibility is poor, and when blended in a resin, a paint, or the like, discoloration may occur due to sedimentation or obstruction of light transmission. On the other hand, when the amount is too small, the effect cannot be obtained unless the added amount is increased, and the antibacterial effect may be reduced. The shape of the inorganic mineral particles may be any shape such as a layer shape, a plate shape, a fiber shape, etc., in addition to a spherical shape. The surface properties of the inorganic mineral particles used in the present invention are not particularly limited, but those having a microporous surface or a smooth surface are preferred.
【０００６】無機鉱物の表面を被覆する抗菌性物質とし
ては特に制限はなく、無機抗菌性物質ばかりでなく、そ
の他の殺菌剤として知られている防腐剤、防かび剤、消
毒薬などを用いることができるが、好ましくは無機抗菌
性物質であり、この中でも抗菌性を有する金属、金属酸
化物、金属塩などがより好ましく用いられる。これらの
中で特に銀、銅、亜鉛、酸化亜鉛、酸化チタン、アルミ
ニウム、マンガン、ニッケル、カドミウムなどの金属、
その塩化物、硝酸塩、硫酸塩などの塩、又は金属酸化物
を用いることができ、最も好ましくは銀又は銅を用い
る。この抗菌性物質は乾式で、剪断応力の印加下に薄膜
化し、無機鉱物粒子の表面に融合又は結合して皮膜を形
成し、無機鉱物粒子の表面を被覆するものである。抗菌
性物質の平均粒径は、無機鉱物粒子の粒径の１／１〜１
／６０とし、好ましくは１／６〜１／３０である。抗菌
性粒子は細かければ細かい程よい。抗菌性粒子の粒径が
大きすぎると比表面積が小さくなり、無機鉱物の粒子へ
の緻密な被覆ができなくなり、抗菌性能の低下をもたら
すことがある。本発明において無機鉱物の粒子の表面に
抗菌性粒子を被覆する。抗菌性粒子の皮膜は、無機鉱物
の粒子の表面を部分的に被覆していてもよいが、最も好
ましいのは全体を被覆しているものである。部分的被覆
の場合は表面の少なくとも６割以上覆っているのがより
好ましい。抗菌性粒子の使用量は、無機鉱物及び抗菌性
粒子の種類により異なるが、通常、無機鉱物の０．５〜
４０重量％、好ましくは１〜３０重量％である。無機系
抗菌剤の被覆層としての皮膜の厚さが０．０１〜５．０
μｍ、好ましくは０．０５〜１．０μｍとなるようにす
る。The antibacterial substance covering the surface of the inorganic mineral is not particularly limited. In addition to the inorganic antibacterial substance, other antibacterial agents such as preservatives, fungicides, disinfectants and the like are used. Among them, inorganic antibacterial substances are preferable, and among them, metals, metal oxides, metal salts and the like having antibacterial properties are more preferably used. Among these, metals such as silver, copper, zinc, zinc oxide, titanium oxide, aluminum, manganese, nickel and cadmium,
Salts such as chlorides, nitrates and sulfates, or metal oxides can be used, and silver or copper is most preferably used. This antibacterial substance is a dry type, which is formed into a thin film under the application of shear stress, and is fused or bonded to the surface of the inorganic mineral particles to form a film and coat the surface of the inorganic mineral particles. The average particle size of the antibacterial substance is 1/1 to 1 of the particle size of the inorganic mineral particles.
/ 60, preferably 1/6 to 1/30. The finer the antimicrobial particles, the better. If the particle size of the antibacterial particles is too large, the specific surface area will be small, and it will not be possible to cover the particles of the inorganic mineral densely, resulting in a decrease in antibacterial performance. In the present invention, the surface of the inorganic mineral particles is coated with antibacterial particles. The coating of the antimicrobial particles may partially cover the surface of the inorganic mineral particles, but most preferably covers the entire surface. In the case of partial coating, it is more preferable to cover at least 60% or more of the surface. The amount of the antibacterial particles used varies depending on the type of the inorganic mineral and the antibacterial particles.
It is 40% by weight, preferably 1 to 30% by weight. The thickness of the film as a coating layer of the inorganic antibacterial agent is 0.01 to 5.0.
μm, preferably 0.05 to 1.0 μm.
【０００７】本発明の無機系抗菌剤において、この抗菌
性粒子の被覆層は、表面融合又は結合によって水系に分
散させても剥離することがなくなる。したがって、例え
ば芯材に膨潤性層状ケイ酸塩を用いた場合に、芯材が水
系で膨潤しても抗菌性粒子層が剥離することがないの
で、増粘性と抗菌性をあわせ持つ無機系抗菌剤とするこ
とができるなど、芯材の特性を損なうことなく抗菌性を
付与した優れた無機系抗菌剤を得ることができる。ま
た、無機鉱物に顔料、染料などの着色剤を添加すること
により、所望する色や物性を持つ無機系抗菌剤を得るこ
とができる。In the inorganic antibacterial agent of the present invention, the coating layer of the antibacterial particles does not peel off even when dispersed in an aqueous system by surface fusion or bonding. Therefore, for example, when a swellable layered silicate is used for the core material, the antibacterial particle layer does not peel off even if the core material swells in an aqueous system. Thus, an excellent inorganic antibacterial agent imparted with antibacterial properties can be obtained without impairing the properties of the core material. Further, by adding a coloring agent such as a pigment and a dye to the inorganic mineral, an inorganic antibacterial agent having a desired color and physical properties can be obtained.
【０００８】この無機鉱物と抗菌性粒子との表面融合又
は結合は、機械的複合化処理によって形成される。本発
明方法の機械的複合化処理とは、粉体に対して装置の回
転運動による物理的な力を作用させる処理であり、例え
ば無機鉱物と導電性粒子は回転するケーシングの内壁に
遠心力で固定され、このケーシング内には円弧状のヘッ
ドを持つ静止したアームがあり、このヘッドとケーシン
グ内壁との曲率の差により両者の間にかみ込まれた粉体
層は急激に圧縮されながら強力なセン断を受けることに
より、無機系抗菌剤を製造する方法である。一般に微粉
砕機として用いられている装置を用いることができ、例
えば、高速回転式衝撃粉砕機（ピンミル、ディスクミ
ル）、摩砕式ミル、媒体攪拌型粉砕機、コスモス（商品
名、川崎重工業社製）、メカノフュージョンシステム
（商品名、ホソカワミクロン社製）、メカノミル（商品
名、岡田精工社製）、シータ・コンポーザ（商品名、徳
寿工作所社製）などがあり、特にメカノフュージョンシ
ステムが好ましく用いられる。[0008] The surface fusion or bonding of the inorganic mineral and the antibacterial particles is formed by a mechanical complexing treatment. The mechanical compounding treatment of the method of the present invention is a treatment for applying a physical force due to the rotational movement of the device to the powder, for example, the inorganic mineral and the conductive particles are centrifugally applied to the inner wall of the rotating casing. There is a stationary arm with an arc-shaped head in this casing, and the powder layer caught between the head and the inner wall of the casing due to the difference in curvature between the head and the inner wall of the casing is rapidly compressed and strong. This is a method for producing an inorganic antibacterial agent by undergoing shearing. A device generally used as a fine pulverizer can be used. For example, a high-speed rotary impact pulverizer (pin mill, disk mill), a grinding mill, a medium stirring type pulverizer, Cosmos (trade name, Kawasaki Heavy Industries, Ltd.) ), Mechano Fusion System (trade name, manufactured by Hosokawa Micron), Mechano Mill (trade name, manufactured by Okada Seiko Co., Ltd.), Theta Composer (trade name, manufactured by Tokuju Kogyo Co., Ltd.), etc. Can be
【０００９】機械的複合化による無機系抗菌剤の生成過
程は、以下のようなものと考えられる。まず、芯材とな
る無機鉱物の粒子の表面に抗菌性粒子が付着、成長し、
処理時間とともに付着率を増しながら、無機鉱物粒子の
比表面積は減少していく。そして付着率の増加が停止し
た後、芯材表面の抗菌性粒子が緻密化し、処理時間とと
もに比表面積はさらに減少する。こうして、無機鉱物粒
子と抗菌性粒子が回転するケーシングの内壁に固定さ
れ、曲率を有したヘッドを持つインナーピースとの間隙
で強力な圧縮力のもとに非常に強いセン断作用を受け、
その後スクレーパで剥離、混合されるプロセスを繰り返
される。圧縮とセン断効果が同時に作用するため、個々
の粒子が粉体層内で回転運動する傾向を持ち、粒子間相
対摩擦により粒子の融合化が促進されることにより抗菌
性粒子の緻密な被覆層が無機鉱物粒子の表面を強固に結
合した複合体が形成される。したがって、装置の回転運
動の応力条件と処理時間を変えることで無機系抗菌剤の
被覆層の微構造を変えることが可能であり、抗菌性能を
調整することができる。また、この機械的処理により昇
温するが、温度は２０〜２５０℃、好ましくは８０〜１
５０℃とする。応力条件は、少なくとも無機鉱物の破壊
限界以下となるように回転数や装置の幾何学因子、装置
内の空気の流れ等を調整する必要があり、好ましくは１
００〜３０００ｒｐｍ、さらに好ましくは１０００〜２
５００ｒｐｍで処理を行う。処理時間は、通常１分以
上、好ましくは１０〜６０分である。本発明方法は溶媒
を用いない乾式であるため、抗菌剤に溶媒が残存するこ
とがない。また、溶媒を除去するプロセスを必要とせ
ず、簡便に製造することができる。[0009] The process of producing the inorganic antibacterial agent by mechanical compounding is considered as follows. First, antibacterial particles adhere and grow on the surface of the inorganic mineral particles serving as the core material,
The specific surface area of the inorganic mineral particles decreases while the adhesion rate increases with the treatment time. Then, after the increase in the adhesion rate stops, the antibacterial particles on the surface of the core material become denser, and the specific surface area further decreases with the treatment time. In this way, the inorganic mineral particles and the antibacterial particles are fixed to the inner wall of the rotating casing and receive a very strong shearing action under a strong compressive force in the gap between the inner piece with the head having a curvature,
Thereafter, the process of peeling and mixing with a scraper is repeated. Since the compression and shearing effects act simultaneously, the individual particles tend to rotate in the powder layer, and the fusion of the particles is promoted by the relative friction between the particles, resulting in a dense coating layer of antibacterial particles. Is formed on the surface of the inorganic mineral particles. Therefore, it is possible to change the microstructure of the coating layer of the inorganic antibacterial agent by changing the stress condition and the processing time of the rotational motion of the device, and it is possible to adjust the antibacterial performance. The temperature is increased by this mechanical treatment, and the temperature is 20 to 250 ° C, preferably 80 to 1 ° C.
50 ° C. As for the stress condition, it is necessary to adjust the rotation speed, the geometrical factor of the device, the flow of air in the device, and the like so as to be at least equal to or less than the fracture limit of the inorganic mineral.
00-3000 rpm, more preferably 1000-2
Processing is performed at 500 rpm. The processing time is usually 1 minute or more, preferably 10 to 60 minutes. Since the method of the present invention is a dry method using no solvent, no solvent remains in the antibacterial agent. In addition, it can be easily manufactured without requiring a process for removing the solvent.
【００１０】[0010]
【発明の効果】本発明の無機系抗菌剤は、抗菌性物質で
被覆されているので、殺菌性物質が粒子の表面にのみ高
濃度に集中して存在し、極めて優れた抗菌作用を示す。
本発明の無機系抗菌剤は、無機鉱物粒子の表面に強固に
被覆した抗菌性粒子の被覆層が分散によっても剥離しな
いため、樹脂や塗料等に配合しても変色を引き起こしに
くく、製品価値を低下させることがない。また、無機鉱
物の増粘性等の特性を損なうことなく抗菌性が付与で
き、分散性、分散安定性にも優れている。それ故本発明
によれば、芯材の選択により、可逆的に水膨潤性を有す
る抗菌剤なども得ることができる。また、本発明の無機
系抗菌剤の製造方法は、乾式の機械処理であるため簡便
であり、水、アルコールなどの溶媒に難溶性の抗菌性物
質でも被覆して、廉価に優れた無機系抗菌剤を得ること
ができる。Since the inorganic antibacterial agent of the present invention is coated with an antibacterial substance, the bactericidal substance is concentrated only on the surface of the particles at a high concentration, and exhibits an extremely excellent antibacterial action.
The inorganic antibacterial agent of the present invention, since the coating layer of the antibacterial particles firmly coated on the surface of the inorganic mineral particles does not peel off even when dispersed, it is unlikely to cause discoloration even when blended into a resin or paint, and the product value is reduced. It does not lower. In addition, antibacterial properties can be imparted without impairing the properties such as viscosity increase of the inorganic mineral, and excellent in dispersibility and dispersion stability. Therefore, according to the present invention, an antibacterial agent or the like having reversible water swelling properties can be obtained by selecting a core material. In addition, the method for producing an inorganic antibacterial agent of the present invention is simple because it is a dry-type mechanical treatment, and is coated with an antibacterial substance that is hardly soluble in a solvent such as water or alcohol, thereby providing an inexpensive inorganic antibacterial agent. Agent can be obtained.
【００１１】[0011]
【実施例】次に、本発明を実施例に基づいてさらに詳細
に説明する。 実施例１ モンモリロナイト（クニピア、クニミネ工業社製、平均
粒径１５μｍ）９９．５重量％と銀（添川理化学社製、
ジェットミルで平均粒径０．８μｍに粉砕した）０．５
重量％をメカノフュージョンシステム（ホソカワミクロ
ン社製、ＡＭ−１５Ｆ型）で２０００ｒｐｍにて６０分
間処理し、無機系抗菌剤（平均粒径１４μｍ、銀の皮膜
の厚さ０．０５μｍ）を得た。Next, the present invention will be described in more detail with reference to examples. Example 1 99.5% by weight of montmorillonite (Kunipia, manufactured by Kunimine Industries, average particle size: 15 μm) and silver (manufactured by Soekawa Chemical Co., Ltd.)
0.5 ground by a jet mill to an average particle size of 0.8 μm)
The weight% was treated at 2000 rpm for 60 minutes with a mechanofusion system (manufactured by Hosokawa Micron, Inc., AM-15F) to obtain an inorganic antibacterial agent (average particle size: 14 μm, thickness of silver film: 0.05 μm).
【００１２】実施例２ 粒形が板状の雲母（山口雲母工業所社製、平均粒径８μ
ｍ）９９．５重量％と実施例１で用いたのと同じ銀０．
５重量％を実施例１と全く同様に処理し、無機系抗菌剤
（平均粒径８μｍ、銀の皮膜の厚さ０．０６μｍ）を得
た。Example 2 A mica having a plate-like particle shape (manufactured by Yamaguchi Mica Industrial Co., Ltd., average particle size 8 μm)
m) 99.5% by weight of the same silver as used in Example 1
5% by weight was treated exactly as in Example 1 to obtain an inorganic antibacterial agent (average particle size: 8 μm, thickness of silver film: 0.06 μm).
【００１３】実施例３ 炭酸カルシウム（日東粉化工業社製、平均粒径２μｍ）
９９．５重量％と亜鉛（添川理化学社製、ジェットミル
で平均粒径０．９μｍに粉砕した）０．５重量％を実施
例１と全く同様に処理し、無機系抗菌剤（平均粒径２μ
ｍ、亜鉛の皮膜の厚さ０．０５μｍ）を得た。Example 3 Calcium carbonate (Nitto Powder Chemical Co., Ltd., average particle size 2 μm)
99.5% by weight and 0.5% by weight of zinc (pulverized to a mean particle size of 0.9 μm by a jet mill manufactured by Soegawa Chemical Co., Ltd.) were treated in the same manner as in Example 1 to obtain an inorganic antibacterial agent (average particle size). 2μ
m, zinc film thickness 0.05 μm).
【００１４】比較例 モンモリロナイト（クニピア、クニミネ工業社製）９
９．５重量％と塩化ベンザルコニウム試薬（関東化学社
製）０．５重量％の混合物を実施例１と同様に処理して
無機質抗菌剤を得た。Comparative Example Montmorillonite (Kunipia, Kunimine Industries) 9
A mixture of 9.5% by weight and 0.5% by weight of benzalkonium chloride reagent (manufactured by Kanto Chemical Co.) was treated in the same manner as in Example 1 to obtain an inorganic antibacterial agent.
【００１５】試験例 実施例１〜３及び比較例で得た抗菌剤の抗菌力を下記の
２つの方法で試験した。その結果を表１に示した。 （１）減菌数計測法 滅菌生理食塩水５０ｍｌに実施例及び比較例で得た抗菌
剤をそれぞれ１ｇ添加し、これに試験菌（Escherichia
coli (IFO 3806）大腸菌）を接種して、初期と１時間震
盪培養をした後に生菌数計測を行い、下記式によって殺
菌率を求めた。 殺菌率（％）＝［初期生菌数−（１時間後の生菌数）／
初期生菌数］×１００ （２）ハロー法 実施例及び比較例で得た各抗菌剤を乳鉢ですりつぶした
後に、約８ｔの圧力をかけて錠剤を成型し、この錠剤を
試験菌（大腸菌）を接種した肉汁平板培地（ペプトン１
０ｇ、食塩５ｇ、肉エキス１０ｇ、寒天１５ｇを蒸留水
１リットルに溶解させた後、オートクレーブ（１２１
℃、１．１ａｔｍ）で２０分間滅菌した後、シャーレに
流し固化させたもの）の中央に埋め、２８±２℃に調整
した恒温槽に入れ、２日間培養した。培養後、ハロー
（阻止帯）を観察し、下記の基準で抗菌力を評価した。 抗菌力あり：阻止帯の形成あり 抗菌力なし：阻止帯の形成なしTest Examples The antibacterial activities of the antibacterial agents obtained in Examples 1 to 3 and Comparative Example were tested by the following two methods. The results are shown in Table 1. (1) Bacterial count measurement method 1 g of each of the antibacterial agents obtained in Examples and Comparative Examples was added to 50 ml of sterile physiological saline, and test bacteria (Escherichia) were added thereto.
coli (IFO 3806) Escherichia coli), the cells were shake-cultured at the initial stage and for 1 hour, the viable cell count was measured, and the bactericidal rate was determined by the following equation. Sterilization rate (%) = [initial viable cell count− (viable cell count after 1 hour) /
Initial viable cell count] × 100 (2) Halo method Each of the antibacterial agents obtained in Examples and Comparative Examples was ground in a mortar, and then a tablet was molded by applying a pressure of about 8 t. Plate medium (peptone 1) inoculated with
After dissolving 0 g, 5 g of salt, 10 g of meat extract, and 15 g of agar in 1 liter of distilled water, the autoclave (121
(At 25 ° C., 1.1 atm) for 20 minutes, then buried in the center of a petri dish and solidified in a petri dish, placed in a thermostat adjusted to 28 ± 2 ° C., and cultured for 2 days. After the culture, the halo (inhibition zone) was observed, and the antibacterial activity was evaluated according to the following criteria. Antibacterial activity: with formation of inhibition zone No antibacterial activity: without formation of inhibition zone
【００１６】[0016]
【表１】 [Table 1]
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.6 識別記号 庁内整理番号 ＦＩ 技術表示箇所 Ｃ０９Ｃ 1/42 ＰＡＹ Ｃ０９Ｃ 1/42 ＰＡＹ 3/06 ＰＢＳ 3/06 ＰＢＳ ──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. 6 Identification number Agency reference number FI Technical indication location C09C 1/42 PAY C09C 1/42 PAY 3/06 PBS 3/06 PBS
Claims (4)
融合させるか又は結合させて被覆したことを特徴とする
無機系抗菌剤。1. An inorganic antibacterial agent, wherein an antibacterial substance is surface-fused or bonded to the surface of an inorganic mineral particle and coated.
金属酸化物である請求項１記載の無機系抗菌剤。2. The inorganic antibacterial agent according to claim 1, wherein the antibacterial substance is a metal or a metal oxide having an antibacterial action.
酸塩鉱物、シリカ鉱物、炭酸塩鉱物及び硫酸塩鉱物のい
ずれか１種以上からなる請求項１又は２記載の無機系抗
菌剤。3. The inorganic antibacterial agent according to claim 1, wherein the inorganic mineral particles comprise at least one of a mica clay mineral, a layered silicate mineral, a silica mineral, a carbonate mineral, and a sulfate mineral.
機鉱物粒子の表面に抗菌性物質を表面融合又は結合させ
て被覆させることを特徴とする無機系抗菌剤の製造方
法。4. A method for producing an inorganic antibacterial agent, characterized in that a surface of inorganic mineral particles is fused or bonded with an antibacterial substance and coated by mechanical mixing by rotational movement.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16435696A JPH107506A (en) | 1996-06-25 | 1996-06-25 | Inorganic antibacterial agent and its production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16435696A JPH107506A (en) | 1996-06-25 | 1996-06-25 | Inorganic antibacterial agent and its production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH107506A true JPH107506A (en) | 1998-01-13 |
Family
ID=15791601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP16435696A Pending JPH107506A (en) | 1996-06-25 | 1996-06-25 | Inorganic antibacterial agent and its production |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH107506A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002114964A (en) * | 2000-10-06 | 2002-04-16 | Kunimine Industries Co Ltd | Ultraviolet-protecting agent and its manufacturing method |
| WO2009136185A1 (en) * | 2008-05-07 | 2009-11-12 | Rocktron Limited | Microbiocidal materials |
| KR101135571B1 (en) * | 2009-12-01 | 2012-04-17 | (주)에이씨티 | manufacturing method for silica powder coated by antiseptic, and composition for external skin comprising the silica powder |
| JP2012532921A (en) * | 2009-07-13 | 2012-12-20 | ディオウム，セリグネ | Fluid decontamination product and method of manufacturing the same |
| WO2015051020A1 (en) * | 2013-10-03 | 2015-04-09 | Polyone Corporation | Antimicrobial polymer concentrates and compounds |
| JP2015519433A (en) * | 2012-05-03 | 2015-07-09 | エッカルト ゲゼルシャフト ミット ベシュレンクテル ハフツングＥｃｋａｒｔ ＧｍｂＨ | Plate-like effect pigment comprising a copper-containing coating, method for producing the same, and use thereof |
| JP2015524858A (en) * | 2012-07-02 | 2015-08-27 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ | Method for producing a filled polymer material using modified filler particles |
| JP2021508345A (en) * | 2017-12-22 | 2021-03-04 | イメルテック ソシエテ パル アクシオン サンプリフィエ | Treated inorganic particulate material and methods for its preparation |
-
1996
- 1996-06-25 JP JP16435696A patent/JPH107506A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002114964A (en) * | 2000-10-06 | 2002-04-16 | Kunimine Industries Co Ltd | Ultraviolet-protecting agent and its manufacturing method |
| WO2009136185A1 (en) * | 2008-05-07 | 2009-11-12 | Rocktron Limited | Microbiocidal materials |
| JP2012532921A (en) * | 2009-07-13 | 2012-12-20 | ディオウム，セリグネ | Fluid decontamination product and method of manufacturing the same |
| KR101135571B1 (en) * | 2009-12-01 | 2012-04-17 | (주)에이씨티 | manufacturing method for silica powder coated by antiseptic, and composition for external skin comprising the silica powder |
| JP2015519433A (en) * | 2012-05-03 | 2015-07-09 | エッカルト ゲゼルシャフト ミット ベシュレンクテル ハフツングＥｃｋａｒｔ ＧｍｂＨ | Plate-like effect pigment comprising a copper-containing coating, method for producing the same, and use thereof |
| JP2015524858A (en) * | 2012-07-02 | 2015-08-27 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ | Method for producing a filled polymer material using modified filler particles |
| WO2015051020A1 (en) * | 2013-10-03 | 2015-04-09 | Polyone Corporation | Antimicrobial polymer concentrates and compounds |
| US10051867B2 (en) | 2013-10-03 | 2018-08-21 | Polyone Corporation | Antimicrobial polymer concentrates and compounds |
| JP2021508345A (en) * | 2017-12-22 | 2021-03-04 | イメルテック ソシエテ パル アクシオン サンプリフィエ | Treated inorganic particulate material and methods for its preparation |
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