JPH10509951A - 造血細胞の増殖および分化を誘導するための肝細胞増殖因子の使用 - Google Patents
造血細胞の増殖および分化を誘導するための肝細胞増殖因子の使用Info
- Publication number
- JPH10509951A JPH10509951A JP8516576A JP51657696A JPH10509951A JP H10509951 A JPH10509951 A JP H10509951A JP 8516576 A JP8516576 A JP 8516576A JP 51657696 A JP51657696 A JP 51657696A JP H10509951 A JPH10509951 A JP H10509951A
- Authority
- JP
- Japan
- Prior art keywords
- hgf
- cells
- differentiation
- hematopoietic
- growth factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1833—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 造血細胞の増殖および分化を刺激する薬物の調製のための肝細胞増殖因 子(HGF)の使用。 2. 肝細胞増殖因子が、HGFをコードしているヒト遺伝子配列またはそれ らの欠失および/または置換変異体を用いて形質転換された細胞から得られる、 請求の範囲1記載の使用。 3. 適切なキャリヤーとの混合物において、有効成分として肝細胞増殖因子 を含有する、造血細胞の増殖および分化を誘導するのに有用な医薬組成物。 4. さらに、場合により治療における連続または同時使用のための分離され た投与剤形として、有効成分としての幹細胞因子(SCF)を含有する、請求の 範囲3記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI942382A IT1271088B (it) | 1994-11-24 | 1994-11-24 | Uso di fattore di crescita degli epatociti per indurre la proliferazione e differenziazione di cellule emopoietiche |
IT94A002382 | 1994-11-24 | ||
PCT/EP1995/004589 WO1996015802A1 (en) | 1994-11-24 | 1995-11-22 | Use of the hepatocyte growth factor to induce proliferation and differentiation of hemopoietic cells |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10509951A true JPH10509951A (ja) | 1998-09-29 |
JP3874024B2 JP3874024B2 (ja) | 2007-01-31 |
Family
ID=11369904
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51657696A Expired - Fee Related JP3874024B2 (ja) | 1994-11-24 | 1995-11-22 | 造血細胞の増殖および分化を誘導するための肝細胞増殖因子の使用 |
Country Status (12)
Country | Link |
---|---|
US (1) | US5968501A (ja) |
EP (1) | EP0793503B1 (ja) |
JP (1) | JP3874024B2 (ja) |
AT (1) | ATE225183T1 (ja) |
AU (1) | AU707259B2 (ja) |
CA (1) | CA2205914C (ja) |
DE (1) | DE69528473T2 (ja) |
DK (1) | DK0793503T3 (ja) |
ES (1) | ES2183890T3 (ja) |
IT (1) | IT1271088B (ja) |
PT (1) | PT793503E (ja) |
WO (1) | WO1996015802A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006104177A (ja) * | 2004-10-08 | 2006-04-20 | Takashi Shioda | 末梢血中に、造血幹細胞を動員するための肝細胞増殖因子(hgf)の使用と、この使用を目的とした医薬品 |
JP2006522604A (ja) * | 2003-04-08 | 2006-10-05 | イエダ リサーチ アンド ディベロップメント カンパニー リミテッド | 化学誘引物質に対する増大させた感受性を有する幹細胞およびそれを産生および使用する方法 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2853551B1 (fr) | 2003-04-09 | 2006-08-04 | Lab Francais Du Fractionnement | Formulation stabilisante pour compositions d'immunoglobulines g sous forme liquide et sous forme lyophilisee |
AU2004320466A1 (en) * | 2003-06-11 | 2006-02-02 | Jan Remmereit | Nuclear reprogramming of cells for therapeutic use |
WO2005084700A1 (en) * | 2004-03-09 | 2005-09-15 | Tohoku Technoarch Co., Ltd. | An agent for promoting induction of vascular differentiation, comprising hepatocyte growth factor |
US9664671B2 (en) | 2012-07-24 | 2017-05-30 | Nissan Chemical Industries, Ltd. | Culture medium composition and method of culturing cell or tissue using thereof |
US10017805B2 (en) | 2012-08-23 | 2018-07-10 | Nissan Chemical Industries, Ltd. | Enhancing ingredients for protein production from various cells |
WO2014171486A1 (ja) * | 2013-04-17 | 2014-10-23 | 日産化学工業株式会社 | 培地組成物及び当該培地組成物を用いた赤血球の製造方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2564486B2 (ja) * | 1986-07-14 | 1996-12-18 | 修治 橋本 | 肝細胞増殖因子 |
US5763266A (en) * | 1989-06-15 | 1998-06-09 | The Regents Of The University Of Michigan | Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells |
US5362716A (en) * | 1989-12-27 | 1994-11-08 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for stimulating hematopoietic progenitors using hepatocyte growth factor and lymphokines |
EP0859009B1 (en) * | 1990-06-11 | 2005-11-30 | Toshikazu Nakamura | Recombinant human hepatocyte growth factor and method for production thereof |
ATE178354T1 (de) * | 1990-07-13 | 1999-04-15 | Snow Brand Milk Products Co Ltd | Plasmid das für die aminosäuresequenz von tcf-ii kodierende dns enthalt, transformierte zelle und produktion einer physiologisch aktiven substanz mit ihrer verwendung |
DE69230879T2 (de) * | 1991-07-26 | 2000-08-03 | Toray Industries, Inc. | Verwendung von Hepatocyten-Wachstumsfaktoren zur Herstellung eines Vermehrungssystems für Hematopoietische Stammzellen |
US5328837A (en) * | 1992-05-18 | 1994-07-12 | Genentech, Inc. | Hepatocyte growth factor protease domain variants |
US5599703A (en) * | 1993-10-28 | 1997-02-04 | The United States Of America As Represented By The Secretary Of The Navy | In vitro amplification/expansion of CD34+ stem and progenitor cells |
-
1994
- 1994-11-24 IT ITMI942382A patent/IT1271088B/it active IP Right Grant
-
1995
- 1995-11-22 AT AT95941620T patent/ATE225183T1/de active
- 1995-11-22 DK DK95941620T patent/DK0793503T3/da active
- 1995-11-22 WO PCT/EP1995/004589 patent/WO1996015802A1/en active IP Right Grant
- 1995-11-22 ES ES95941620T patent/ES2183890T3/es not_active Expired - Lifetime
- 1995-11-22 US US08/836,896 patent/US5968501A/en not_active Expired - Lifetime
- 1995-11-22 CA CA002205914A patent/CA2205914C/en not_active Expired - Fee Related
- 1995-11-22 JP JP51657696A patent/JP3874024B2/ja not_active Expired - Fee Related
- 1995-11-22 EP EP95941620A patent/EP0793503B1/en not_active Expired - Lifetime
- 1995-11-22 DE DE69528473T patent/DE69528473T2/de not_active Expired - Lifetime
- 1995-11-22 AU AU42996/96A patent/AU707259B2/en not_active Ceased
- 1995-11-22 PT PT95941620T patent/PT793503E/pt unknown
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006522604A (ja) * | 2003-04-08 | 2006-10-05 | イエダ リサーチ アンド ディベロップメント カンパニー リミテッド | 化学誘引物質に対する増大させた感受性を有する幹細胞およびそれを産生および使用する方法 |
JP2010263907A (ja) * | 2003-04-08 | 2010-11-25 | Yeda Research & Devlopment Co Ltd | 化学誘引物質に対する増大させた感受性を有する幹細胞およびそれを産生および使用する方法 |
JP2006104177A (ja) * | 2004-10-08 | 2006-04-20 | Takashi Shioda | 末梢血中に、造血幹細胞を動員するための肝細胞増殖因子(hgf)の使用と、この使用を目的とした医薬品 |
Also Published As
Publication number | Publication date |
---|---|
DK0793503T3 (da) | 2003-02-03 |
WO1996015802A1 (en) | 1996-05-30 |
EP0793503A1 (en) | 1997-09-10 |
ES2183890T3 (es) | 2003-04-01 |
ITMI942382A1 (it) | 1996-05-24 |
EP0793503B1 (en) | 2002-10-02 |
IT1271088B (it) | 1997-05-26 |
CA2205914A1 (en) | 1996-05-30 |
CA2205914C (en) | 2009-04-07 |
US5968501A (en) | 1999-10-19 |
PT793503E (pt) | 2003-02-28 |
ATE225183T1 (de) | 2002-10-15 |
JP3874024B2 (ja) | 2007-01-31 |
AU4299696A (en) | 1996-06-17 |
DE69528473T2 (de) | 2003-07-10 |
ITMI942382A0 (it) | 1994-11-24 |
AU707259B2 (en) | 1999-07-08 |
DE69528473D1 (de) | 2002-11-07 |
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