JPH10508230A - 呼吸器薬物のエアロゾル化噴霧を生成する装置及び方法 - Google Patents
呼吸器薬物のエアロゾル化噴霧を生成する装置及び方法Info
- Publication number
- JPH10508230A JPH10508230A JP51476196A JP51476196A JPH10508230A JP H10508230 A JPH10508230 A JP H10508230A JP 51476196 A JP51476196 A JP 51476196A JP 51476196 A JP51476196 A JP 51476196A JP H10508230 A JPH10508230 A JP H10508230A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- air
- patient
- flow
- membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
- A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
- A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/008—Electronic counters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
- A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
- A61J7/0418—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with electronic history memory
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
- A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0085—Inhalators using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/1075—Preparation of respiratory gases or vapours by influencing the temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
- A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
- A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
- A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/062—Desiccants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/60—General characteristics of the apparatus with identification means
- A61M2205/6045—General characteristics of the apparatus with identification means having complementary physical shapes for indexing or registration purposes
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nozzles (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.力を加えるとつぶれる壁と、直径が約0.25ミクロンから約6.0ミクロンの 孔を有し力が加えられたときに外側へ凸状構成に突出するように十分な可とう性 を有する多孔性膜で少なくとも部分的に覆われた容器の開口部と、膜の孔を通過 するときに患者の肺に吸入されうる粒子のエアロゾルを形成できることを特徴と する薬学的に活性な呼吸器薬物と担体とを含む呼吸器薬物の製剤とを備える、呼 吸器薬物製剤のエアロゾル化噴射に使用するための使い捨て容器。 2.開口部が、開口部から破壊可能なシールへ至る開放溝を形成し、該破壊可 能なシールを越えた領域が、多孔性膜で覆われた領域であり、さらに孔が、直径 が0.25ミクロンから6.0ミクロンの小末端開口部と、直径が該小末端開口 部の2倍から20倍である大末端開口部とを備える断面構成を有する、請求項1 に記載の容器。 3.多孔性膜が可とう性であり、製剤が膜を通過する際に外側へ凸状構成に突 出する、請求項1に記載の容器。 4.多孔性膜が凸状構成を有する、請求項1に記載の容器。 5.各容器が、イソプロテレノール、クロモリン、アルブテロール、及びメタ プロテレノール、テルブタリン、ピルブテロール、サルメテロールキシノトエー ト、ホルモトロール、二プロピオン酸ベクロメタゾン、トリアムシノロンアセト ニド、フルニソリド、フルチカゾン、ブデソニド、及び臭化イプラトロピウム、 及びそれらの遊離酸、塩基、塩、及び水化物、並びにペプチド非アドレナリン作 用性非コリン作用性神経伝達物質、抗コリン作用性物質、ロイコトリン阻害剤、 血管作動性腸ペプチド、タキキニン拮抗体、ブラジキニン拮抗体、エンドセリン 拮抗体、ヘパリンフロセミド、抗接着分子、サイトカインモジュレータ、生物学 的に活性なエンドヌクレアーゼ、組換えヒト(rh)DNアーゼ化合物、αアン チトリプシン、及びクロモグリグ酸二ナトリウムからなる群より選択された呼吸 器薬物を有する、相互接続された複数の請求項1に記載の使い捨て容器を備える 、使い捨てパッケージ。 6.溝を通じて直径が約0.25ミクロンから約6.0ミクロンの範囲の孔を 有する可とう性の使い捨て多孔性膜の表面の上方へ空気を引き込むこと、及び製 剤から溝を通じて引き込まれた空気の方向へ凸状構成に膜を外側に突出させるの に十分な力を用いて、薬学的に活性な呼吸器薬物と担体とを含む製剤を膜の孔を 通過させることを含む、エアロゾルを生成する方法において、該可とう性膜が、 溝内に形成された空気流の境界層を越えて外側へ突出し、該空気が、実質的に直 線状の流路を介して、突出した膜の上方から溝末端部へ引き込まれる、方法。 7.溝内の空気流を測定し吸気流量及び吸気体積を決定すること、並びに吸気 流量及び吸気体積のリアルタイム値に基づいて製剤を膜の孔を通過させるための 開始点を判定することをさらに含む、請求項6に記載の方法。 8.約0.10リットル/秒から約2.0リットル/秒の範囲の吸気流量及び 約0.15リットルから約1.5リットルの範囲の吸気体積で行われる押し出し が、実質的に同じ吸気流量及び吸気体積で反復的に開始されるように、吸入段階 、測定段階、判定段階及び輸送段階を繰り返すこと、粒子に接触させた空気を能 動的に加熱することによって、エアロゾル化粒子にエネルギーを加えること、患 者の肺に粒子を吸入させるように、ことをさらに含む、請求項7記載の方法にお いて、形成時の粒子の担体の50%以上が、患者に達する前に蒸発するような量 だけエネルギーが加えられ、空気を、患者が吸入を行う前に加熱された加熱材料 を通過させることにより能動的に加熱することによってエネルギーが加えられる 、方法。 9.空気が吸入される第1の開口部及び患者が空気を引き込むための第2の開 口部を有する溝と、作動時に製剤に物理的な力を加える機構と、溝に吸入された 空気にエネルギーを加える空気加熱装置とを備え、総重量が1kg又はそれ以下 の手持ち内蔵式装置である、薬物輸送装置。 10.大気湿度を測定し、空気加熱装置によって加えるべきエネルギーの量を 求めるために使用される情報を供給する湿度計をさらに含む、請求項9に記載の 薬物輸送装置において、製剤に物理的な力を加える機構が、ピストン及び振動装 置からなる群より選択され、さらに該製剤が、直径が0.25ミクロンから6. 0ミクロンの孔を有する多孔性膜を備える容器内に存在する、薬物輸送装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33092994A | 1994-10-28 | 1994-10-28 | |
US08/330,929 | 1994-10-28 | ||
PCT/US1995/013911 WO1996013292A1 (en) | 1994-10-28 | 1995-10-27 | Device and method of creating aerosolized mist of respiratory drug |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10508230A true JPH10508230A (ja) | 1998-08-18 |
JP3748890B2 JP3748890B2 (ja) | 2006-02-22 |
Family
ID=23291910
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51476196A Expired - Fee Related JP3748890B2 (ja) | 1994-10-28 | 1995-10-27 | 呼吸器薬物のエアロゾル化噴霧に使用するための使い捨て容器、使い捨てパッケージ、薬物輸送装置、及びエアロゾルを生成する方法 |
Country Status (5)
Country | Link |
---|---|
EP (3) | EP1486226A3 (ja) |
JP (1) | JP3748890B2 (ja) |
AU (1) | AU709572B2 (ja) |
CA (1) | CA2202884C (ja) |
WO (1) | WO1996013292A1 (ja) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003111844A (ja) * | 2001-09-18 | 2003-04-15 | Ing Erich Pfeiffer Gmbh & Co Kg | 媒質用ディスペンサー |
JP2007075259A (ja) * | 2005-09-13 | 2007-03-29 | Canon Inc | 液剤吐出装置 |
JP2011087968A (ja) * | 2000-02-11 | 2011-05-06 | Respironics Respiratory Drug Delivery (Uk) Ltd | 薬剤投与システム |
JP2012071142A (ja) * | 1999-11-17 | 2012-04-12 | Boston Scientific Scimed Inc | キャリア流体内への分子の送達のための微細加工されたデバイス |
US8256433B2 (en) | 1999-07-16 | 2012-09-04 | Aradigm Corporation | Systems and methods for effecting cessation of tobacco use |
KR101324023B1 (ko) * | 2004-09-15 | 2013-11-01 | 옵티노즈 에이에스 | 경비 투여 장치 및 비강으로의 물질 투여 방법 |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5829435A (en) * | 1997-02-24 | 1998-11-03 | Aradigm Corporation | Prefilter for prevention of clogging of a nozzle in the generation of an aerosol and prevention of administration of undesirable particles |
DE19720701A1 (de) * | 1997-05-16 | 1998-11-19 | Gsf Forschungszentrum Umwelt | Vorrichtung zur Applikation eines Medikament-Aerosols über die Lunge |
EP0919252A1 (en) * | 1997-11-25 | 1999-06-02 | The Technology Partnership Public Limited Company | Aerosol delivery method and apparatus |
US6192876B1 (en) | 1997-12-12 | 2001-02-27 | Astra Aktiebolag | Inhalation apparatus and method |
GB2343122B (en) | 1998-10-26 | 2003-01-08 | Medic Aid Ltd | Improvements in and relating to nebulisers |
US6354516B1 (en) | 1999-11-02 | 2002-03-12 | Aradigm Corporation | Pore structures for reduced pressure aerosolization |
US6584971B1 (en) | 1999-01-04 | 2003-07-01 | Medic-Aid Limited | Drug delivery apparatus |
US7654998B1 (en) | 1999-08-23 | 2010-02-02 | Aeris Therapeutics, Inc. | Tissue volume reduction |
US6610043B1 (en) | 1999-08-23 | 2003-08-26 | Bistech, Inc. | Tissue volume reduction |
WO2001019528A1 (en) | 1999-09-15 | 2001-03-22 | Aradigm Corporation | Pore structures for reduced pressure aerosolization |
US8820316B2 (en) | 2000-02-11 | 2014-09-02 | Respironics Respiratory Drug Delivery (Uk) Ltd | Drug delivery apparatus |
GB0003197D0 (en) | 2000-02-11 | 2000-04-05 | Aid Medic Ltd | Improvements in and relating to controlling drug delivery |
US7776315B2 (en) | 2000-10-31 | 2010-08-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and additional active ingredients |
DE10113366A1 (de) * | 2001-03-20 | 2002-09-26 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Endothelinantagonisten |
US6608054B2 (en) | 2001-03-20 | 2003-08-19 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics and endothelin antagonists |
US7077130B2 (en) * | 2000-12-22 | 2006-07-18 | Chrysalis Technologies Incorporated | Disposable inhaler system |
US20070122353A1 (en) | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
AU2002310085B2 (en) | 2001-05-24 | 2008-09-04 | Alexza Pharmaceuticals, Inc. | Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route |
US7766013B2 (en) | 2001-06-05 | 2010-08-03 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
US7078016B2 (en) | 2001-11-21 | 2006-07-18 | Alexza Pharmaceuticals, Inc. | Delivery of caffeine through an inhalation route |
US6759029B2 (en) | 2001-05-24 | 2004-07-06 | Alexza Molecular Delivery Corporation | Delivery of rizatriptan and zolmitriptan through an inhalation route |
US6805853B2 (en) | 2001-11-09 | 2004-10-19 | Alexza Molecular Delivery Corporation | Delivery of diazepam through an inhalation route |
JP2005503425A (ja) | 2001-05-24 | 2005-02-03 | アレックザ モレキュラー デリヴァリー コーポレイション | 所定の吸入ルートによる薬剤エステルの送出 |
US7056494B2 (en) * | 2002-09-03 | 2006-06-06 | Kos Pharmaceuticals, Inc. | Method of treating a systemic disease |
ES2594867T3 (es) | 2007-03-09 | 2016-12-23 | Alexza Pharmaceuticals, Inc. | Unidad de calentamiento para usar en un dispositivo de administración de fármaco |
US20120048963A1 (en) | 2010-08-26 | 2012-03-01 | Alexza Pharmaceuticals, Inc. | Heat Units Using a Solid Fuel Capable of Undergoing an Exothermic Metal Oxidation-Reduction Reaction Propagated without an Igniter |
GB2504076A (en) | 2012-07-16 | 2014-01-22 | Nicoventures Holdings Ltd | Electronic smoking device |
GB2528673B (en) * | 2014-07-25 | 2020-07-01 | Nicoventures Holdings Ltd | Aerosol provision system |
ES2968694T3 (es) | 2015-03-11 | 2024-05-13 | Alexza Pharmaceuticals Inc | Utilización de materiales antiestáticos en los conductos de aire para el proceso de condensación térmica de aerosol |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3812854A (en) * | 1972-10-20 | 1974-05-28 | A Michaels | Ultrasonic nebulizer |
US4090642A (en) * | 1975-08-28 | 1978-05-23 | The Gillette Company | Package and dispenser for flowable materials |
JPH02124082A (ja) * | 1988-09-08 | 1990-05-11 | R J Reynolds Tobacco Co | 電気エネルギーを使用する喫煙物品 |
WO1994027653A2 (en) * | 1993-05-21 | 1994-12-08 | Aradigm Corporation | The intrapulmonary delivery of aerosolized aqueous formulations |
JP2004290688A (ja) * | 1994-09-27 | 2004-10-21 | Aradigm Corp | エアロゾル化薬物を輸送するための動的粒径制御 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3923057A (en) * | 1974-06-20 | 1975-12-02 | Einstein Coll Med | Anesthesia delivery system |
US4621632A (en) * | 1984-11-01 | 1986-11-11 | Bear Medical Systems, Inc. | Humidifier system |
US4926852B1 (en) * | 1986-06-23 | 1995-05-23 | Univ Johns Hopkins | Medication delivery system phase one |
US5172686A (en) * | 1987-08-20 | 1992-12-22 | Anthony Jean M | Device for supplying air or medical gases in a conditioned, particularly a moistented and/or heated state to a patient |
US5394866A (en) | 1991-03-05 | 1995-03-07 | Aradigm Corporation | Automatic aerosol medication delivery system and methods |
US5450336A (en) | 1991-03-05 | 1995-09-12 | Aradigm Corporation | Method for correcting the drift offset of a transducer |
US5404871A (en) | 1991-03-05 | 1995-04-11 | Aradigm | Delivery of aerosol medications for inspiration |
WO1994009842A1 (en) * | 1992-10-28 | 1994-05-11 | Rosen Charles A | Method and devices for delivering drugs by inhalation |
US5709202A (en) | 1993-05-21 | 1998-01-20 | Aradigm Corporation | Intrapulmonary delivery of aerosolized formulations |
JP3553599B2 (ja) * | 1993-06-29 | 2004-08-11 | インジェット ディジタル エアロソルズ リミテッド | ディスペンサー |
-
1995
- 1995-10-27 AU AU40138/95A patent/AU709572B2/en not_active Ceased
- 1995-10-27 EP EP20040020817 patent/EP1486226A3/en not_active Withdrawn
- 1995-10-27 CA CA 2202884 patent/CA2202884C/en not_active Expired - Fee Related
- 1995-10-27 JP JP51476196A patent/JP3748890B2/ja not_active Expired - Fee Related
- 1995-10-27 EP EP20010126125 patent/EP1177807A3/en not_active Withdrawn
- 1995-10-27 WO PCT/US1995/013911 patent/WO1996013292A1/en not_active Application Discontinuation
- 1995-10-27 EP EP95938938A patent/EP0788387A4/en not_active Withdrawn
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3812854A (en) * | 1972-10-20 | 1974-05-28 | A Michaels | Ultrasonic nebulizer |
US4090642A (en) * | 1975-08-28 | 1978-05-23 | The Gillette Company | Package and dispenser for flowable materials |
JPH02124082A (ja) * | 1988-09-08 | 1990-05-11 | R J Reynolds Tobacco Co | 電気エネルギーを使用する喫煙物品 |
WO1994027653A2 (en) * | 1993-05-21 | 1994-12-08 | Aradigm Corporation | The intrapulmonary delivery of aerosolized aqueous formulations |
JP2004290688A (ja) * | 1994-09-27 | 2004-10-21 | Aradigm Corp | エアロゾル化薬物を輸送するための動的粒径制御 |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8256433B2 (en) | 1999-07-16 | 2012-09-04 | Aradigm Corporation | Systems and methods for effecting cessation of tobacco use |
US8381739B2 (en) | 1999-07-16 | 2013-02-26 | Aradigm Corporation | Systems and methods for effecting cessation of tobacco use |
US8689803B2 (en) | 1999-07-16 | 2014-04-08 | Aradigm Corporation | Systems and methods for effecting cessation of tobacco use |
JP2012071142A (ja) * | 1999-11-17 | 2012-04-12 | Boston Scientific Scimed Inc | キャリア流体内への分子の送達のための微細加工されたデバイス |
JP2011087968A (ja) * | 2000-02-11 | 2011-05-06 | Respironics Respiratory Drug Delivery (Uk) Ltd | 薬剤投与システム |
JP2003111844A (ja) * | 2001-09-18 | 2003-04-15 | Ing Erich Pfeiffer Gmbh & Co Kg | 媒質用ディスペンサー |
KR101324023B1 (ko) * | 2004-09-15 | 2013-11-01 | 옵티노즈 에이에스 | 경비 투여 장치 및 비강으로의 물질 투여 방법 |
KR101446507B1 (ko) * | 2004-09-15 | 2014-10-06 | 옵티노즈 에이에스 | 경비 투여 장치 및 비강으로의 물질 투여 방법 |
JP2007075259A (ja) * | 2005-09-13 | 2007-03-29 | Canon Inc | 液剤吐出装置 |
Also Published As
Publication number | Publication date |
---|---|
EP0788387A1 (en) | 1997-08-13 |
CA2202884A1 (en) | 1996-05-09 |
WO1996013292A1 (en) | 1996-05-09 |
EP0788387A4 (en) | 1998-07-08 |
EP1177807A2 (en) | 2002-02-06 |
EP1486226A2 (en) | 2004-12-15 |
AU4013895A (en) | 1996-05-23 |
EP1177807A3 (en) | 2003-10-22 |
CA2202884C (en) | 2009-01-06 |
AU709572B2 (en) | 1999-09-02 |
EP1486226A3 (en) | 2005-11-09 |
JP3748890B2 (ja) | 2006-02-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP3748890B2 (ja) | 呼吸器薬物のエアロゾル化噴霧に使用するための使い捨て容器、使い捨てパッケージ、薬物輸送装置、及びエアロゾルを生成する方法 | |
JP3596619B2 (ja) | エアロゾル化薬物を輸送するための動的粒径制御 | |
EP0769973B1 (en) | Device for intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values | |
JP3375637B2 (ja) | エアロゾル化水性製剤の肺内輸送 | |
JP3708964B2 (ja) | インシュリンのエアロゾル化製剤の製造 | |
US5934272A (en) | Device and method of creating aerosolized mist of respiratory drug | |
US5709202A (en) | Intrapulmonary delivery of aerosolized formulations | |
JPH10509607A (ja) | ペプチド薬物をエアロゾル化輸送する装置 | |
JPH11508456A (ja) | 麻酔薬をエアロゾル化する装置 | |
JP2001514940A (ja) | エアロゾル押出し機構 | |
CA2162399C (en) | Systems for the intrapulmonary delivery of aerosolized aqueous formulations | |
AU708140B2 (en) | Systems and method for drug delivery |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20040803 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20040726 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20041102 |
|
A524 | Written submission of copy of amendment under section 19 (pct) |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20041101 |
|
A72 | Notification of change in name of applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A721 Effective date: 20041101 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20050315 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20050613 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20050801 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20050915 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20051101 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20051130 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20091209 Year of fee payment: 4 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20101209 Year of fee payment: 5 |
|
LAPS | Cancellation because of no payment of annual fees |