JPH10265369A - Liquid agent for internal use having improved taste - Google Patents
Liquid agent for internal use having improved tasteInfo
- Publication number
- JPH10265369A JPH10265369A JP9071812A JP7181297A JPH10265369A JP H10265369 A JPH10265369 A JP H10265369A JP 9071812 A JP9071812 A JP 9071812A JP 7181297 A JP7181297 A JP 7181297A JP H10265369 A JPH10265369 A JP H10265369A
- Authority
- JP
- Japan
- Prior art keywords
- flavor
- acid
- sugar alcohol
- oral liquid
- liquid preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 29
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 81
- 239000000796 flavoring agent Substances 0.000 claims abstract description 45
- 235000019634 flavors Nutrition 0.000 claims abstract description 45
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims abstract description 28
- 150000005846 sugar alcohols Chemical class 0.000 claims abstract description 25
- 229960002685 biotin Drugs 0.000 claims abstract description 14
- 235000020958 biotin Nutrition 0.000 claims abstract description 14
- 239000011616 biotin Substances 0.000 claims abstract description 14
- 239000004386 Erythritol Substances 0.000 claims abstract description 10
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims abstract description 10
- 235000019414 erythritol Nutrition 0.000 claims abstract description 10
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims abstract description 10
- 229940009714 erythritol Drugs 0.000 claims abstract description 10
- 239000000845 maltitol Substances 0.000 claims abstract description 9
- 235000010449 maltitol Nutrition 0.000 claims abstract description 9
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims abstract description 9
- 229940035436 maltitol Drugs 0.000 claims abstract description 9
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 claims abstract description 8
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims abstract description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims abstract description 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 4
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000001630 malic acid Substances 0.000 claims abstract description 4
- 235000011090 malic acid Nutrition 0.000 claims abstract description 4
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000000600 sorbitol Substances 0.000 claims abstract description 4
- 235000010356 sorbitol Nutrition 0.000 claims abstract description 4
- 239000000811 xylitol Substances 0.000 claims abstract description 4
- 235000010447 xylitol Nutrition 0.000 claims abstract description 4
- 229960002675 xylitol Drugs 0.000 claims abstract description 4
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 3
- PVXPPJIGRGXGCY-DJHAAKORSA-N 6-O-alpha-D-glucopyranosyl-alpha-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](O)(CO)O1 PVXPPJIGRGXGCY-DJHAAKORSA-N 0.000 claims abstract description 3
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 3
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 3
- 229960002920 sorbitol Drugs 0.000 claims abstract description 3
- 244000228451 Stevia rebaudiana Species 0.000 claims abstract 2
- 235000015165 citric acid Nutrition 0.000 claims description 26
- 238000002360 preparation method Methods 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 16
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 9
- 235000013399 edible fruits Nutrition 0.000 claims description 8
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 4
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 3
- 235000011054 acetic acid Nutrition 0.000 claims description 3
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
- 239000001361 adipic acid Substances 0.000 claims description 2
- 235000011037 adipic acid Nutrition 0.000 claims description 2
- 235000003704 aspartic acid Nutrition 0.000 claims description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 2
- 239000008369 fruit flavor Substances 0.000 claims description 2
- 239000001530 fumaric acid Substances 0.000 claims description 2
- 235000011087 fumaric acid Nutrition 0.000 claims description 2
- 239000000174 gluconic acid Substances 0.000 claims description 2
- 235000012208 gluconic acid Nutrition 0.000 claims description 2
- 239000004310 lactic acid Substances 0.000 claims description 2
- 235000014655 lactic acid Nutrition 0.000 claims description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 2
- 239000011976 maleic acid Substances 0.000 claims description 2
- 235000019629 palatability Nutrition 0.000 claims description 2
- 239000011975 tartaric acid Substances 0.000 claims description 2
- 235000002906 tartaric acid Nutrition 0.000 claims description 2
- 239000000892 thaumatin Substances 0.000 claims description 2
- 235000010436 thaumatin Nutrition 0.000 claims description 2
- 235000000346 sugar Nutrition 0.000 abstract description 27
- 235000003599 food sweetener Nutrition 0.000 abstract description 6
- 239000003765 sweetening agent Substances 0.000 abstract description 6
- 238000013329 compounding Methods 0.000 abstract description 3
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 18
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 17
- 239000003205 fragrance Substances 0.000 description 16
- 239000004227 calcium gluconate Substances 0.000 description 14
- 229960004494 calcium gluconate Drugs 0.000 description 14
- 235000013927 calcium gluconate Nutrition 0.000 description 14
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 239000008213 purified water Substances 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 230000000052 comparative effect Effects 0.000 description 11
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 10
- 229960001948 caffeine Drugs 0.000 description 9
- 229960003080 taurine Drugs 0.000 description 9
- JXXCENBLGFBQJM-UHFFFAOYSA-N (3-carboxy-2-hydroxypropyl)-trimethylazanium;chloride Chemical compound [Cl-].C[N+](C)(C)CC(O)CC(O)=O JXXCENBLGFBQJM-UHFFFAOYSA-N 0.000 description 8
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 8
- 229960000367 inositol Drugs 0.000 description 8
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 8
- 235000005152 nicotinamide Nutrition 0.000 description 8
- 239000011570 nicotinamide Substances 0.000 description 8
- 239000002304 perfume Substances 0.000 description 8
- 229940089782 pyridoxine hydrochloride 5 mg Drugs 0.000 description 8
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 8
- UIERGBJEBXXIGO-UHFFFAOYSA-N thiamine mononitrate Chemical compound [O-][N+]([O-])=O.CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N UIERGBJEBXXIGO-UHFFFAOYSA-N 0.000 description 8
- AEDORKVKMIVLBW-BLDDREHASA-N 3-oxo-3-[[(2r,3s,4s,5r,6r)-3,4,5-trihydroxy-6-[[5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]methoxy]oxan-2-yl]methoxy]propanoic acid Chemical compound OCC1=C(O)C(C)=NC=C1CO[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](COC(=O)CC(O)=O)O1 AEDORKVKMIVLBW-BLDDREHASA-N 0.000 description 7
- 229960003966 nicotinamide Drugs 0.000 description 7
- 241000544066 Stevia Species 0.000 description 6
- 229940100688 oral solution Drugs 0.000 description 6
- -1 L-aspartic acid magnesium potassium potassium Chemical compound 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HFWPXARYYXLTQE-UHFFFAOYSA-N [Mg].[K].[K] Chemical compound [Mg].[K].[K] HFWPXARYYXLTQE-UHFFFAOYSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 239000004301 calcium benzoate Substances 0.000 description 3
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- HZQXCUSDXIKLGS-UHFFFAOYSA-L calcium;dibenzoate;trihydrate Chemical compound O.O.O.[Ca+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 HZQXCUSDXIKLGS-UHFFFAOYSA-L 0.000 description 3
- 239000003002 pH adjusting agent Substances 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
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- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
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- 150000007522 mineralic acids Chemical class 0.000 description 2
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- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 1
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- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
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- 230000000694 effects Effects 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229960004452 methionine Drugs 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000011772 phylloquinone Substances 0.000 description 1
- MBWXNTAXLNYFJB-LKUDQCMESA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCCC(C)CCCC(C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-LKUDQCMESA-N 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229940109850 royal jelly Drugs 0.000 description 1
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 description 1
- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 description 1
- WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 229960002898 threonine Drugs 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、風味が改善された
内服液剤に関する。TECHNICAL FIELD The present invention relates to an oral liquid preparation having an improved flavor.
【０００２】[0002]
【従来の技術】内服液剤中の有効成分、特にビオチンは
還元糖（例えば砂糖）の存在下では不安定であることか
ら、内服液剤に配合する甘味剤としては糖アルコールが
好ましい場合がある。しかし、甘味剤として糖アルコー
ルを配合すると、一般的に内服したとき、砂糖と比較し
て水っぽく風味が劣り、美味感がなかった。2. Description of the Related Art Since an active ingredient in an oral solution, particularly biotin, is unstable in the presence of a reducing sugar (for example, sugar), a sugar alcohol may be preferable as a sweetener to be incorporated in the oral solution. However, when sugar alcohol was added as a sweetener, the taste was inferior to sugar and generally less delicious when taken orally.
【０００３】現在まで糖アルコールを配合した液剤にお
いて、香料で風味を砂糖並に改善する方法は知られてい
なかった。[0003] Until now, there has been no known method for improving the flavor to the same level as that of sugar by using a flavor in a liquid preparation containing a sugar alcohol.
【０００４】[0004]
【発明が解決しようとする課題】本発明は、糖アルコー
ルを配合した内服液剤の風味を改善することを目的とす
る。また、本発明は、ビオチンなど、還元糖の存在下で
はその安定性に問題がある有効成分が配合されても風味
が損なわれない内服液剤を提供することである。SUMMARY OF THE INVENTION An object of the present invention is to improve the flavor of an oral solution containing a sugar alcohol. Another object of the present invention is to provide a liquid medicine for oral administration that does not impair the flavor even when an active ingredient having a problem in stability in the presence of a reducing sugar such as biotin is incorporated.
【０００５】[0005]
【課題を解決するための手段】本発明者らは鋭意研究し
た結果、糖アルコールを配合した液剤に、ミックスフル
ーツ系香料を配合すると、通常糖アルコールを配合した
液剤と比較して、液剤の風味が大幅に改善され、甘味剤
として従来繁用される砂糖を用いた液剤の風味とほぼ同
等であることを見いだし本発明を完成した。すなわち、
本発明は、ミックスフルーツ系香料を配合することを特
徴とする糖アルコール配合内服液剤である。また、他の
本発明は、ミックスフルーツ系香料を配合することを特
徴とする糖アルコール含有内服液剤の嗜好性向上方法で
ある。Means for Solving the Problems As a result of diligent studies, the present inventors have found that when a mixed fruit-based flavor is added to a liquid preparation containing a sugar alcohol, the flavor of the liquid preparation is usually higher than that of a liquid preparation containing a sugar alcohol. Has been greatly improved, and it has been found that the flavor is almost the same as that of a liquid preparation using sugar, which is conventionally used as a sweetener, to complete the present invention. That is,
The present invention is a sugar alcohol-containing oral liquid, which comprises a mixed fruit-based flavor. Another aspect of the present invention is a method for improving the palatability of a sugar alcohol-containing oral solution, which comprises mixing a mixed fruit-based flavor.
【０００６】[0006]
【発明の実施の形態】本発明において、ミックスフルー
ツ系香料とはピーチ様、グレープ様、ライチ様、アプリ
コット様、ストロベリー様香料からなる群より選ばれる
１種又は２種以上であって、その配合量は内服液剤全量
に対して０.０５〜０.５Ｗ／Ｖ％であり、好ましくは
０.０５〜０.２Ｗ／Ｖ％である。更に好ましくは、香料
中の香気成分は５〜５０Ｗ／Ｖ％である。糖アルコール
とはエリスリトール、マルチトール、ソルビトール及び
キシリトールからなる群より選ばれる１種又は２種以上
であって、その配合量は内服液剤全体の５〜５０Ｗ／Ｖ
％が好ましい。BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, the mixed fruit-based flavor is one or more selected from the group consisting of peach-like, grape-like, lychee-like, apricot-like, and strawberry-like flavors. The amount is from 0.05 to 0.5 W / V%, preferably from 0.05 to 0.2 W / V%, based on the total amount of the oral solution. More preferably, the fragrance component in the fragrance is 5 to 50 W / V%. The sugar alcohol is one or more selected from the group consisting of erythritol, maltitol, sorbitol and xylitol, and the compounding amount thereof is 5 to 50 W / V of the whole oral liquid preparation.
% Is preferred.
【０００７】本発明において、ミックスフルーツ系香料
の配合量は、糖アルコール１重量部に対して０.００４
５〜０.０４５重量部が好ましい。In the present invention, the mixing amount of the mixed fruit-based flavor is 0.004 per 1 part by weight of the sugar alcohol.
5 to 0.045 parts by weight are preferred.
【０００８】本発明の内服液剤は、ｐＨ２〜６の範囲が
好ましい。更に好ましくはｐＨ２.５〜４.０である。[0008] The oral solution of the present invention preferably has a pH of 2 to 6. More preferably, the pH is 2.5 to 4.0.
【０００９】本発明の内服液剤は、有機酸、無機酸を同
時に配合すると風味の点でより好ましい。その場合の有
機酸としてはクエン酸、リンゴ酸、酒石酸、コハク酸、
乳酸、酢酸、マレイン酸、グルコン酸、アスパラギン
酸、アジピン酸、グルタミン酸、フマル酸、酢酸、無機
酸としてはリン酸、塩酸などをあげることができるが、
特に好ましいものとしてクエン酸、リンゴ酸をあげるこ
とができる。それらは１種又は２種以上で用いられる。The oral liquid preparation of the present invention is more preferably mixed with an organic acid and an inorganic acid from the viewpoint of flavor. In this case, the organic acids include citric acid, malic acid, tartaric acid, succinic acid,
Lactic acid, acetic acid, maleic acid, gluconic acid, aspartic acid, adipic acid, glutamic acid, fumaric acid, acetic acid, examples of inorganic acids include phosphoric acid and hydrochloric acid,
Particularly preferred are citric acid and malic acid. They are used alone or in combination of two or more.
【００１０】また、服用感の改善のために更に甘味剤を
加えることもできる。甘味剤としては、トレハロース、
パラチノース、マルチトール、ソルビトール、パラチニ
ット、エリスリトール、キシリトール、ステビア、ソー
マチンなどが挙げられる。[0010] Further, a sweetener can be further added to improve the feeling of taking. As sweeteners, trehalose,
Palatinose, maltitol, sorbitol, palatinit, erythritol, xylitol, stevia, thaumatin and the like.
【００１１】本発明の内服液剤には、上記成分の他、通
常液剤に用いることの可能な成分、例えばタウリン、各
種ビタミン（ビタミンＢ1、ビタミンＢ2、ビタミン
Ｂ3、ビタミンＢ5、ビタミンＢ6、ビタミンＢ12、ビタ
ミンＡ、ビタミンＣ、ビタミンＤ2、ビタミンＤ3、ビタ
ミンＥ、ビタミンＰ、ビタミンＫ1、ビオチン、ビタミ
ンＦ、ビタミンＵなど）もしくはビタミン誘導体、アミ
ノ酸（Ｌ−アスパラギン酸、Ｌ−アルギニン、Ｌ−トリ
プトファン、Ｌ−リジン、Ｌ−スレオニン、Ｌ−メチオ
ニンなど）、ミネラル（カルシウム、マグネシウム、
鉄、カリウムなど）、生薬（ムイラプアマ、ニンジン、
ジオウ、トウチュウカソウなど）、カフェイン、ローヤ
ルゼリー、多価アルコール（プロピレングリコールな
ど）、保存剤などを本発明の効果を損なわない範囲で配
合することができる。[0011] The oral liquid preparation of the present invention contains, in addition to the above-mentioned components, components which can be usually used in liquid preparations, for example, taurine, various vitamins (vitamin B 1 , vitamin B 2 , vitamin B 3 , vitamin B 5 , vitamin B 5) 6, vitamin B 12, vitamin A, vitamin C, vitamin D 2, vitamin D 3, vitamin E, vitamin P, vitamin K 1, biotin, vitamin F, vitamin U, etc.) or vitamin derivative, an amino acid (L- aspartic acid, L-arginine, L-tryptophan, L-lysine, L-threonine, L-methionine and the like, minerals (calcium, magnesium,
Iron, potassium, etc.), crude drugs (muirapuama, carrots,
Jio, Eucalyptus and the like), caffeine, royal jelly, polyhydric alcohols (such as propylene glycol), preservatives and the like can be blended within a range that does not impair the effects of the present invention.
【００１２】本発明の内服液剤は常法により製造するこ
とができる。The oral liquid preparation of the present invention can be produced by a conventional method.
【００１３】[0013]
【発明の効果】本発明により、糖アルコール配合内服液
剤の風味を改善させることが可能となった。また、ビオ
チンなど、還元糖の存在下ではその安定性に問題がある
有効成分が配合されても風味が損なわれない内服液剤を
提供することができた。According to the present invention, it has become possible to improve the flavor of a liquid preparation containing a sugar alcohol. In addition, it was possible to provide a liquid medicine for internal use in which the flavor was not impaired even when an active ingredient having a problem in stability in the presence of reducing sugar such as biotin was added.
【００１４】[0014]
【実施例】以下、実施例及び試験例を挙げて本発明を更
に詳細に説明する。なお、各実施例及び比較例におい
て、香料ａ、ｂ、ｃ及びｄとはそれぞれ次の組成からな
るものを示す。The present invention will be described below in more detail with reference to examples and test examples. In each of the examples and comparative examples, the fragrances a, b, c, and d each have the following composition.
【００１５】香料ａ；ライチ様香料、アプリコット様香
料、ピーチ様香料及びグレープ様香料の混合物 １０
％、精製水及びエタノール ９０％ 香料ｂ；ストロベリー様香料及びグレープ様香料の混合
物 １０％、精製水及びエタノール ９０％ 香料ｃ；ヨーグルト様香料、シトラス様香料及びバニラ
様香料の混合物 １０％、精製水及びエタノール ９０
％ 香料ｄ；ウメ様香料、シソ様香料、ワイン様香料及びブ
ランディ様香料の混合物 １０％、精製水及びエタノー
ル ９０％。Perfume a; mixture of lychee-like fragrance, apricot-like fragrance, peach-like fragrance and grape-like fragrance 10
%, Purified water and ethanol 90% fragrance b; mixture of strawberry-like fragrance and grape-like fragrance 10%, purified water and ethanol 90% fragrance c; mixture of yogurt-like fragrance, citrus-like fragrance and vanilla-like fragrance 10%, purified water And ethanol 90
Perfume d; 10% mixture of ume-like, perilla-like, wine-like and brandy-like flavors, 90% purified water and ethanol.
【００１６】実施例１ ビタミンＢ１硝酸塩 ５ｍｇ 塩酸ピリドキシン ５ｍｇ ニコチン酸アミド ２０ｍｇ イノシトール ５０ｍｇ タウリン ２０００ｍｇ 無水カフェイン ５０ｍｇ ｄｌ−塩化カルニチン ５０ｍｇ ビオチン ０.２ｍｇ Ｌ−アスハ゜ラキ゛ン酸マク゛ネシウム・カリウム ２００ｍｇ グルコン酸カルシウム ２００ｍｇ 安息香酸ナトリウム ７０ｍｇ 香料ａ １００ｍｇ マルチトール ３０００ｍｇ エリスリトール ８０００ｍｇ ステビア ２５ｍｇ クエン酸（ｐＨ調節剤） 適量 精製水 全１００ｍｌ クエン酸を除く上記各成分を混合溶解し、クエン酸でｐ
Ｈ３に調節後８０℃３０分滅菌した。Example 1 Vitamin B1 nitrate 5mg Pyridoxine hydrochloride 5mg Nicotinamide 20mg Inositol 50mg Taurine 2000mg Anhydrous caffeine 50mg dl-Carnitine chloride 50mg Biotin 0.2mg L-aspartic acid magnesium potassium potassium 200mg calcium gluconate 200mg calcium gluconate 200mg Perfume a 100mg Maltitol 3000mg Erythritol 8000mg Stevia 25mg Citric acid (pH regulator) Appropriate amount Purified water Total 100ml Mix and dissolve each of the above components except citric acid and add p with citric acid
After adjusting to H3, the mixture was sterilized at 80 ° C. for 30 minutes.
【００１７】実施例２ ビタミンＢ１硝酸塩 ５ｍｇ 塩酸ピリドキシン ５ｍｇ ニコチン酸アミド ２０ｍｇ イノシトール ５０ｍｇ タウリン ２０００ｍｇ 無水カフェイン ５０ｍｇ ｄｌ−塩化カルニチン ５０ｍｇ ビオチン ０.２ｍｇ Ｌ−アスハ゜ラキ゛ン酸マク゛ネシウム・カリウム ２００ｍｇ グルコン酸カルシウム ２００ｍｇ 安息香酸ナトリウム ７０ｍｇ 香料ｂ １００ｍｇ マルチトール ３０００ｍｇ エリスリトール ８０００ｍｇ ステビア ２５ｍｇ クエン酸（ｐＨ調節剤） 適量 精製水 全１００ｍｌ。Example 2 Vitamin B1 nitrate 5 mg Pyridoxine hydrochloride 5 mg Nicotinic acid amide 20 mg Inositol 50 mg Taurine 2000 mg Anhydrous caffeine 50 mg dl-Carnitine chloride 50 mg Biotin 0.2 mg L-aspartic acid magnesium potassium potassium 200 mg Calcium benzoate 200 mg calcium gluconate 200 mg calcium gluconate Perfume b 100 mg Maltitol 3000 mg Erythritol 8000 mg Stevia 25 mg Citric acid (pH regulator) Appropriate amount Purified water 100 ml in total.
【００１８】クエン酸を除く上記各成分を混合溶解し、
クエン酸でｐＨ３に調節後８０℃３０分滅菌した。The above components except citric acid are mixed and dissolved,
After adjusting to pH 3 with citric acid, the mixture was sterilized at 80 ° C. for 30 minutes.
【００１９】比較例１ ビタミンＢ１硝酸塩 ５ｍｇ 塩酸ピリドキシン ５ｍｇ ニコチン酸アミド ２０ｍｇ イノシトール ５０ｍｇ タウリン ２０００ｍｇ 無水カフェイン ５０ｍｇ ｄｌ−塩化カルニチン ５０ｍｇ ビオチン ０.２ｍｇ Ｌ−アスハ゜ラキ゛ン酸マク゛ネシウム・カリウム ２００ｍｇ グルコン酸カルシウム ２００ｍｇ 安息香酸ナトリウム ７０ｍｇ 砂糖 １５０００ｍｇ クエン酸（ｐＨ調節剤） 適量 精製水 全１００ｍｌ。COMPARATIVE EXAMPLE 1 Vitamin B1 nitrate 5 mg Pyridoxine hydrochloride 5 mg Nicotinamide 20 mg Inositol 50 mg Taurine 2000 mg Anhydrous caffeine 50 mg dl-Carnitine chloride 50 mg Biotin 0.2 mg L-aspartic acid magnesium potassium potassium 200 mg calcium gluconate 200 mg calcium gluconate 200 mg Sugar 15000mg Citric acid (pH adjuster) Appropriate amount Purified water 100ml in total.
【００２０】クエン酸を除く上記各成分を混合溶解し、
クエン酸でｐＨ３に調節後８０℃３０分滅菌した。The above components except for citric acid are mixed and dissolved,
After adjusting to pH 3 with citric acid, the mixture was sterilized at 80 ° C. for 30 minutes.
【００２１】比較例２ ビタミンＢ１硝酸塩 ５ｍｇ 塩酸ピリドキシン ５ｍｇ ニコチン酸アミド ２０ｍｇ イノシトール ５０ｍｇ タウリン ２０００ｍｇ 無水カフェイン ５０ｍｇ ｄｌ−塩化カルニチン ５０ｍｇ ビオチン ０.２ｍｇ Ｌ−アスハ゜ラキ゛ン酸マク゛ネシウム・カリウム ２００ｍｇ グルコン酸カルシウム ２００ｍｇ 安息香酸ナトリウム ７０ｍｇ マルチトール ３０００ｍｇ エリスリトール ８０００ｍｇ ステビア ２５ｍｇ クエン酸（ｐＨ調節剤） 適量 精製水 全１００ｍｌ。COMPARATIVE EXAMPLE 2 Vitamin B1 nitrate 5 mg Pyridoxine hydrochloride 5 mg Nicotinamide 20 mg Inositol 50 mg Taurine 2000 mg Anhydrous caffeine 50 mg dl-Carnitine chloride 50 mg Biotin 0.2 mg L-aspartic acid magnesium potassium potassium 200 mg calcium gluconate 200 mg calcium gluconate 200 mg Maltitol 3000 mg Erythritol 8000 mg Stevia 25 mg Citric acid (pH regulator) qs Purified water 100 ml in total.
【００２２】クエン酸を除く上記各成分を混合溶解し、
クエン酸でｐＨ３に調節後８０℃３０分滅菌した。The above components except for citric acid are mixed and dissolved,
After adjusting to pH 3 with citric acid, the mixture was sterilized at 80 ° C. for 30 minutes.
【００２３】比較例３ ビタミンＢ１硝酸塩 ５ｍｇ 塩酸ピリドキシン ５ｍｇ ニコチン酸アミド ２０ｍｇ イノシトール ５０ｍｇ タウリン ２０００ｍｇ 無水カフェイン ５０ｍｇ ｄｌ−塩化カルニチン ５０ｍｇ ビオチン ０.２ｍｇ Ｌ-アスハ゜ラキ゛ン酸マク゛ネシウム・カリウム ２００ｍｇ グルコン酸カルシウム ２００ｍｇ 安息香酸ナトリウム ７０ｍｇ 香料ｃ １００ｍｇ マルチトール ３０００ｍｇ エリスリトール ８０００ｍｇ ステビア ２５ｍｇ クエン酸（ｐＨ調節剤） 適量 精製水 全１００ｍｌ。Comparative Example 3 Vitamin B1 Nitrate 5 mg Pyridoxine Hydrochloride 5 mg Nicotinamide 20 mg Inositol 50 mg Taurine 2000 mg Anhydrous Caffeine 50 mg dl-Carnitine Chloride 50 mg Biotin 0.2 mg L-Asperakidionate Potassium Magnesium Potassium 200 mg Calcium Gluconate 200 mg Calcium Gluconate 200 mg Perfume c 100 mg Maltitol 3000 mg Erythritol 8000 mg Stevia 25 mg Citric acid (pH regulator) Appropriate amount Purified water 100 ml in total.
【００２４】クエン酸を除く上記各成分を混合溶解し、
クエン酸でｐＨ３に調節後８０℃３０分滅菌した。The above components except for citric acid are mixed and dissolved,
After adjusting to pH 3 with citric acid, the mixture was sterilized at 80 ° C. for 30 minutes.
【００２５】比較例４ ビタミンＢ１硝酸塩 ５ｍｇ 塩酸ピリドキシン ５ｍｇ ニコチン酸アミド ２０ｍｇ イノシトール ５０ｍｇ タウリン ２０００ｍｇ 無水カフェイン ５０ｍｇ ｄｌ−塩化カルニチン ５０ｍｇ ビオチン ０.２ｍｇ Ｌ-アスハ゜ラキ゛ン酸マク゛ネシウム・カリウム ２００ｍｇ グルコン酸カルシウム ２００ｍｇ 安息香酸ナトリウム ７０ｍｇ 香料ｄ １００ｍｇ マルチトール ３０００ｍｇ エリスリトール ８０００ｍｇ ステビア ２５ｍｇ クエン酸（ｐＨ調節剤） 適量 精製水 全１００ｍｌ。Comparative Example 4 Vitamin B1 Nitrate 5 mg Pyridoxine Hydrochloride 5 mg Nicotinamide 20 mg Inositol 50 mg Taurine 2000 mg Anhydrous Caffeine 50 mg dl-Carnitine Chloride 50 mg Biotin 0.2 mg L-Asparaduccinate Magnesium Potassium Magnesium 200 mg Calcium Gluconate 200 mg Calcium Benzoate 200 mg Perfume d 100 mg Maltitol 3000 mg Erythritol 8000 mg Stevia 25 mg Citric acid (pH regulator) Appropriate amount Purified water 100 ml in total.
【００２６】クエン酸を除く上記各成分を混合溶解し、
クエン酸でｐＨ３に調節後８０℃３０分滅菌した。The above components except for citric acid are mixed and dissolved.
After adjusting to pH 3 with citric acid, the mixture was sterilized at 80 ° C. for 30 minutes.
【００２７】比較例５ ビタミンＢ１硝酸塩 ５ｍｇ 塩酸ピリドキシン ５ｍｇ ニコチン酸アミド ２０ｍｇ イノシトール ５０ｍｇ タウリン ２０００ｍｇ 無水カフェイン ５０ｍｇ ｄｌ−塩化カルニチン ５０ｍｇ ビオチン ０.２ｍｇ Ｌ-アスハ゜ラキ゛ン酸マク゛ネシウム・カリウム ２００ｍｇ グルコン酸カルシウム ２００ｍｇ 安息香酸ナトリウム ７０ｍｇ 香料ｃ １００ｍｇ 砂糖 １５０００ｍｇ クエン酸（ｐＨ調節剤） 適量 精製水 全１００ｍｌ 上記各成分を混合溶解し、クエン酸でｐＨ３に調節後８
０℃３０分滅菌した。Comparative Example 5 Vitamin B1 Nitrate 5 mg Pyridoxine Hydrochloride 5 mg Nicotinamide 20 mg Inositol 50 mg Taurine 2000 mg Anhydrous Caffeine 50 mg dl-Carnitine Chloride 50 mg Biotin 0.2 mg L-Asperakidionate Potassium Magnesium Potassium 200 mg Calcium Gluconate 200 mg Calcium Gluconate 200 mg Perfume c 100mg Sugar 15000mg Citric acid (pH adjuster) Appropriate amount Purified water Total 100ml Mix and dissolve each of the above components, adjust to pH 3 with citric acid, then 8
Sterilized at 0 ° C. for 30 minutes.
【００２８】比較例６ ビタミンＢ１硝酸塩 ５ｍｇ 塩酸ピリドキシン ５ｍｇ ニコチン酸アミド ２０ｍｇ イノシトール ５０ｍｇ タウリン ２０００ｍｇ 無水カフェイン ５０ｍｇ ｄｌ−塩化カルニチン ５０ｍｇ ビオチン ０.２ｍｇ Ｌ-アスハ゜ラキ゛ン酸マク゛ネシウム・カリウム ２００ｍｇ グルコン酸カルシウム ２００ｍｇ 安息香酸ナトリウム ７０ｍｇ 香料ｄ １００ｍｇ 砂糖 １５０００ｍｇ クエン酸（ｐＨ調節剤） 適量 精製水 全１００ｍｌ クエン酸を除く上記各成分を混合溶解し、クエン酸でｐ
Ｈ３に調節後８０℃３０分滅菌した。Comparative Example 6 Vitamin B1 Nitrate 5 mg Pyridoxine Hydrochloride 5 mg Nicotinamide 20 mg Inositol 50 mg Taurine 2000 mg Anhydrous Caffeine 50 mg dl-Carnitine Chloride 50 mg Biotin 0.2 mg L-Asparaduccinate Potassium Magnesium Potassium 200 mg Calcium Gluconate 200 mg Calcium Benzoate 200 mg Perfume d 100mg Sugar 15000mg Citric acid (pH adjuster) Appropriate amount Purified water Total 100ml Mix and dissolve each of the above components except citric acid, p with citric acid
After adjusting to H3, the mixture was sterilized at 80 ° C. for 30 minutes.
【００２９】試験例 試験方法は、下記実施例及び比較例で製造した試験溶液
を２０人のパネラーにそれぞれ２０ｍｌ飲ませ、砂糖と
比較した風味改善（砂糖風味）の強度を下記の基準にて
評価させた。Test Example The test method was such that 20 ml of the test solutions prepared in the following Examples and Comparative Examples were respectively drunk by 20 panelists, and the strength of flavor improvement (sugar flavor) compared with sugar was evaluated according to the following criteria. I let it.
【００３０】 砂糖風味を全く感じない ０点 砂糖風味を僅かに感じる １点 砂糖風味を弱く感じる ２点 砂糖風味を感じる ３点 砂糖風味を強く感じる ４点 砂糖風味をかなり強く感じる ５点 砂糖風味を非常に強く感じる ６点。No sugar flavor is felt 0 point Sugar flavor is slightly felt 1 point Sugar flavor is weakened 2 points Sugar flavor is felt 3 points Sugar flavor is strongly felt 4 points Sugar flavor is felt strongly 5 points Sugar flavor is felt 5 points Very strong 6 points.
【００３１】結果を表１に示した。The results are shown in Table 1.
【００３２】[0032]
【表１】 [Table 1]
【００３３】比較例１、２より糖アルコールのみの配合
では砂糖風味度数がかなり劣っている。また，比較例
５、６より香料ｃ、ｄで砂糖が配合されていれば砂糖風
味度数は高いが、比較例３、４では香料ｃ、ｄで糖アル
コールが配合されていれば砂糖風味度数が低く、水っぽ
く、風味が劣り美味感がなかった。しかし、実施例１，
２は糖アルコールを配合し、ミックスフルーツ系香料
ａ、ｂを用いることにより砂糖風味度数が高くなり、糖
アルコールを使用しても砂糖と同程度となり、服用しや
すさが大幅に改善するとともに、向上することがわかっ
た。Compared with Comparative Examples 1 and 2, the sugar flavor degree was considerably inferior when the sugar alcohol was used alone. In addition, the sugar flavor degree is higher when the sugars are blended with the fragrances c and d than in Comparative Examples 5 and 6, but in Comparative Examples 3 and 4, the sugar flavor degree is higher when the sugar alcohol is blended with the fragrances c and d. It was low, watery, inferior in flavor, and had no taste. However, in Example 1,
2 mixes sugar alcohol and increases the sugar flavor frequency by using mixed fruit flavors a and b. Even when sugar alcohol is used, the sugar flavor level is almost the same as sugar, and the ease of taking is greatly improved, It was found to improve.
Claims (11)
を特徴とする糖アルコール含有内服液剤。1. A sugar alcohol-containing oral liquid, which comprises a mixed fruit-based flavor.
料、グレープ様香料、ライチ様香料、アプリコット様香
料及びストロベリー様香料からなる群より選ばれる１種
又は２種以上を配合した請求項１記載の内服液剤。2. The internal medicine according to claim 1, wherein the mixed fruit-based flavor contains one or more selected from the group consisting of a peach-like flavor, a grape-like flavor, a lychee-like flavor, an apricot-like flavor, and a strawberry-like flavor. Liquid.
チトール、ソルビトール及びキシリトールからなる群よ
り選ばれる１種又は２種以上である請求項１又は２記載
の内服液剤。3. The oral liquid preparation according to claim 1, wherein the sugar alcohol is one or more selected from the group consisting of erythritol, maltitol, sorbitol, and xylitol.
求項１又は２記載の内服液剤。4. The oral liquid preparation according to claim 1, wherein the sugar alcohol is erythritol.
スフルーツ系香料が０.００４５〜０.０４５重量部であ
る請求項１〜４のいずれかに記載の内服液剤。5. The oral liquid preparation according to claim 1, wherein the mixed fruit flavor is 0.0045 to 0.045 parts by weight per 1 part by weight of the sugar alcohol.
のいずれかに記載の内服液剤。6. The method according to claim 1, wherein the pH is in the range of 2 to 6.
The oral liquid preparation according to any one of the above.
少なくとも１種を配合した請求項１〜６のいずれかに記
載の内服液剤。7. The oral liquid preparation according to claim 1, further comprising at least one of trehalose and palatinose.
とも１種を配合した請求項１〜７のいずれかに記載の内
服液剤。8. The oral liquid preparation according to claim 1, further comprising at least one of stevia and thaumatin.
酸、乳酸、酢酸、マレイン酸、グルコン酸、アスパラギ
ン酸、アジピン酸及びフマル酸からなる群より選ばれる
１種又は２種以上を配合することを特徴とする請求項１
〜８のいずれかに記載の内服液剤。9. A composition comprising one or more selected from the group consisting of citric acid, malic acid, tartaric acid, succinic acid, lactic acid, acetic acid, maleic acid, gluconic acid, aspartic acid, adipic acid and fumaric acid. Claim 1 characterized by the following:
The oral liquid preparation according to any one of Items 1 to 8.
とする請求項１〜９のいずれかに記載の内服液剤。10. The oral liquid preparation according to claim 1, further comprising biotin.
とを特徴とする糖アルコール含有内服液剤の嗜好性向上
方法。11. A method for improving the palatability of a sugar alcohol-containing oral liquid preparation, comprising mixing a mixed fruit-based flavor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9071812A JPH10265369A (en) | 1997-03-25 | 1997-03-25 | Liquid agent for internal use having improved taste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9071812A JPH10265369A (en) | 1997-03-25 | 1997-03-25 | Liquid agent for internal use having improved taste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH10265369A true JPH10265369A (en) | 1998-10-06 |
Family
ID=13471361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9071812A Pending JPH10265369A (en) | 1997-03-25 | 1997-03-25 | Liquid agent for internal use having improved taste |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH10265369A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004043475A (en) * | 2002-07-08 | 2004-02-12 | Sankyo Co Ltd | Oral cephalosporin preparation |
| JP2006345810A (en) * | 2005-06-17 | 2006-12-28 | Taisho Pharmaceut Co Ltd | Beverage containing high-sweetness sweetener |
| WO2007116915A1 (en) * | 2006-04-04 | 2007-10-18 | Kobayashi Pharmaceutical Co., Ltd. | Liquid drug preparation for oral administration packaged in a container having discharge unit |
| US8150881B2 (en) | 2000-10-17 | 2012-04-03 | Mekiki Co., Ltd. | Human relationships registering system and device for registering human relationships, program for registering human relationships, and medium storing human relationships registering program and readable by computer |
| US8409643B2 (en) | 2005-09-02 | 2013-04-02 | Kraft Foods Group Brands Llc | Methods for the application of ingredients to the inside of a straw |
-
1997
- 1997-03-25 JP JP9071812A patent/JPH10265369A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8150881B2 (en) | 2000-10-17 | 2012-04-03 | Mekiki Co., Ltd. | Human relationships registering system and device for registering human relationships, program for registering human relationships, and medium storing human relationships registering program and readable by computer |
| JP2004043475A (en) * | 2002-07-08 | 2004-02-12 | Sankyo Co Ltd | Oral cephalosporin preparation |
| JP4526247B2 (en) * | 2002-07-08 | 2010-08-18 | 第一三共株式会社 | Oral cephalosporins |
| JP2006345810A (en) * | 2005-06-17 | 2006-12-28 | Taisho Pharmaceut Co Ltd | Beverage containing high-sweetness sweetener |
| JP4548836B2 (en) * | 2005-06-17 | 2010-09-22 | 大正製薬株式会社 | High-intensity sweetener-containing beverage |
| US8409643B2 (en) | 2005-09-02 | 2013-04-02 | Kraft Foods Group Brands Llc | Methods for the application of ingredients to the inside of a straw |
| WO2007116915A1 (en) * | 2006-04-04 | 2007-10-18 | Kobayashi Pharmaceutical Co., Ltd. | Liquid drug preparation for oral administration packaged in a container having discharge unit |
| JP2007275197A (en) * | 2006-04-04 | 2007-10-25 | Kobayashi Pharmaceut Co Ltd | Liquid medicinal preparation for oral administration which is stored in container equipped with discharging device |
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