JPH10152169A - Medicine packaging container - Google Patents
Medicine packaging containerInfo
- Publication number
- JPH10152169A JPH10152169A JP8309195A JP30919596A JPH10152169A JP H10152169 A JPH10152169 A JP H10152169A JP 8309195 A JP8309195 A JP 8309195A JP 30919596 A JP30919596 A JP 30919596A JP H10152169 A JPH10152169 A JP H10152169A
- Authority
- JP
- Japan
- Prior art keywords
- polypropylene
- aluminum foil
- polyethylene
- sheet
- heat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004806 packaging method and process Methods 0.000 title description 8
- 239000003814 drug Substances 0.000 title description 3
- 229940079593 drug Drugs 0.000 title 1
- -1 polypropylene Polymers 0.000 claims abstract description 58
- 239000004743 Polypropylene Substances 0.000 claims abstract description 35
- 229920001155 polypropylene Polymers 0.000 claims abstract description 33
- 239000004698 Polyethylene Substances 0.000 claims abstract description 27
- 229920000573 polyethylene Polymers 0.000 claims abstract description 25
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229910052782 aluminium Inorganic materials 0.000 claims abstract description 22
- 239000011888 foil Substances 0.000 claims abstract description 22
- 239000004711 α-olefin Substances 0.000 claims abstract description 15
- 229920000089 Cyclic olefin copolymer Polymers 0.000 claims abstract description 12
- 239000000155 melt Substances 0.000 claims abstract description 10
- 239000000853 adhesive Substances 0.000 claims abstract description 8
- 230000001070 adhesive effect Effects 0.000 claims abstract description 8
- 238000007789 sealing Methods 0.000 claims abstract description 8
- 238000002844 melting Methods 0.000 claims abstract description 6
- 230000008018 melting Effects 0.000 claims abstract description 6
- 238000009512 pharmaceutical packaging Methods 0.000 claims description 7
- 239000012803 melt mixture Substances 0.000 claims description 4
- 238000003856 thermoforming Methods 0.000 claims description 3
- 238000010030 laminating Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 abstract description 18
- 238000000034 method Methods 0.000 abstract description 5
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract description 4
- 239000005977 Ethylene Substances 0.000 abstract description 4
- 238000002156 mixing Methods 0.000 abstract description 3
- 229920000915 polyvinyl chloride Polymers 0.000 description 6
- 239000004800 polyvinyl chloride Substances 0.000 description 6
- 229920005989 resin Polymers 0.000 description 5
- 239000011347 resin Substances 0.000 description 5
- 229920001577 copolymer Polymers 0.000 description 3
- 229920001903 high density polyethylene Polymers 0.000 description 3
- 239000004700 high-density polyethylene Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 3
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 3
- 239000011342 resin composition Substances 0.000 description 3
- VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical compound CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 description 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 229920001684 low density polyethylene Polymers 0.000 description 2
- 239000004702 low-density polyethylene Substances 0.000 description 2
- 229920001179 medium density polyethylene Polymers 0.000 description 2
- 239000004701 medium-density polyethylene Substances 0.000 description 2
- 239000005022 packaging material Substances 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 229920000098 polyolefin Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- LIKMAJRDDDTEIG-UHFFFAOYSA-N 1-hexene Chemical compound CCCCC=C LIKMAJRDDDTEIG-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 1
- 229920010126 Linear Low Density Polyethylene (LLDPE) Polymers 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 229920001328 Polyvinylidene chloride Polymers 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 239000004708 Very-low-density polyethylene Substances 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000002216 antistatic agent Substances 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 229920005679 linear ultra low density polyethylene Polymers 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 description 1
- 239000002667 nucleating agent Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000005033 polyvinylidene chloride Substances 0.000 description 1
- 229920001384 propylene homopolymer Polymers 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 229920005604 random copolymer Polymers 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 229920001866 very low density polyethylene Polymers 0.000 description 1
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、医薬品包装の各種
包装形態、中でも一般にＰＴＰと称される固形剤包装用
として好ましく用いられる医薬品包装容器に関するもの
である。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to various packaging forms for pharmaceuticals, and more particularly to a pharmaceutical packaging container preferably used for packaging solid preparations generally called PTP.
【０００２】[0002]
【従来の技術】固形医薬品の包装用材料として用いられ
ているＰＴＰ包装用シートには、従来、ポリ塩化ビニル
(以下、ＰＶＣと略記する)が広く用いられている。この
ＰＶＣシートは、成形加工性、透明性、耐衝撃性などＰ
ＴＰ包装に必要な特性をほぼ満足する優れたシートであ
るが防湿特性が充分でない。このため、高い防湿性を必
要とする製剤に対してはＰＴＰ包装を行なった後、更に
アルミ箔を含むラミネートフィルムなどを用いてピロー
包装を行うか、あるいはＰＶＣシートにポリ塩化ビニリ
デンをコーティングした複合シートを用いることにより
防湿性の向上をはかっている。しかしながら、このよう
な方法では工程数が増え、包材のコスト上昇が大きく好
ましくない。2. Description of the Related Art PTP packaging sheets used as packaging materials for solid pharmaceuticals have conventionally used polyvinyl chloride.
(Hereinafter, abbreviated as PVC) is widely used. This PVC sheet has P processing properties such as moldability, transparency, and impact resistance.
It is an excellent sheet that almost satisfies the characteristics required for TP packaging, but has insufficient moisture-proof properties. For this reason, for preparations requiring high moisture resistance, PTP packaging is performed, and then pillow packaging is performed using a laminated film containing aluminum foil, or a PVC sheet coated with polyvinylidene chloride is used. By using a sheet, the moisture-proof property is improved. However, in such a method, the number of steps is increased, and the cost of the packaging material is undesirably increased.
【０００３】また、近年、環境汚染の防止、防湿性向上
等の見地からＰＶＣに代わりポリプロピレンからなるシ
ートが使用されつつある。しかしながら、ポリプロピレ
ンはアルミ箔とヒートシール後のシートのカールが極め
て大きいという工業上大きな問題がある。すなわち、ポ
リプロピレンは、ＰＶＣと比較して線膨張率が大きい
為、アルミ箔をヒートシールした後の収縮が大きく、そ
の為製品がアルミ箔と反対側にカールして商品価値を損
ねたり、自動包装ライン上での集積不能等のトラブルが
発生するというような問題がある。[0003] In recent years, a sheet made of polypropylene has been used instead of PVC from the viewpoint of preventing environmental pollution and improving moisture resistance. However, polypropylene has a major industrial problem that the curl of the sheet after heat sealing with the aluminum foil is extremely large. In other words, polypropylene has a higher coefficient of linear expansion than PVC, and therefore has a large shrinkage after heat-sealing the aluminum foil, so that the product curls to the opposite side of the aluminum foil and impairs commercial value, or automatic packaging. There is a problem that troubles such as inability to integrate on a line occur.
【０００４】このため、カールを改良する為の検討がポ
リプロピレン多層シートにおいて行われている。例え
ば、外層に高剛性の高結晶性ポリプロピレンを使用し、
剛性改良によりカールを改良する方法（特開平５−６４
８６４号公報）等である。しかしながら、これらは多層
シートでの改良方法であり、製造面・コスト面で有利な
単層シートにおいてカールの少ないものは未だ開発され
ていない。[0004] For this reason, studies for improving curl have been made in polypropylene multilayer sheets. For example, using high rigidity highly crystalline polypropylene for the outer layer,
Method for improving curl by improving rigidity (Japanese Patent Laid-Open No. 5-64)
No. 864). However, these methods are an improvement method for a multilayer sheet, and a single-layer sheet having less curl in terms of production and cost has not yet been developed.
【０００５】[0005]
【発明が解決しようとする課題】本発明の目的はアルミ
箔とのヒートシール後のカールが抑制された医薬品包装
容器を提供することにある。本発明者は種々検討を行っ
た結果、特定の熱成形性に優れたポリプロピレン系樹脂
組成物よりなる単層シートに、特定の接着剤を積層した
アルミ箔を所定の条件下でヒートシールすることにより
前記の課題を解決し得るとの知見を得て本発明を完成す
るに至った。SUMMARY OF THE INVENTION An object of the present invention is to provide a pharmaceutical packaging container in which curling after heat sealing with aluminum foil is suppressed. As a result of various studies, the present inventor has found that a single-layer sheet made of a polypropylene resin composition excellent in specific thermoformability is heat-sealed under a predetermined condition with an aluminum foil laminated with a specific adhesive. As a result, the present inventors have found that the above-mentioned problems can be solved, and have completed the present invention.
【０００６】[0006]
【課題を解決するための手段】すなわち、本発明は組成
物全量に対してポリプロピレン８５〜５０重量％と、ポ
リプロピレンとの常温での屈折率差が０．０２５以下で
あり、かつＪＩＳ Ｋ７１９９に従ってキャピラリーレ
オメータにより２５０℃、剪断速度１２１.６sec-1にお
いて測定した溶融粘度(ρEP)がポリプロピレンの溶融粘
度(ρPP)に対する粘度比(ρEP/ρPP)０.０５〜１.０で
あるポリエチレン及びエチレン−α−オレフィン共重合
体からなる溶融混合物１５〜５０重量％とを配合してな
るシートを熱成形し、その後特定の接着剤を用いてアル
ミ箔を特定の温度範囲でヒートシールしてなる医薬品包
装容器を提供するものである。That is, the present invention relates to a polymer having a refractive index difference of 85 to 50% by weight with respect to the total amount of the composition, which is not more than 0.025 at room temperature, and a capillary according to JIS K7199. Polyethylene having a melt viscosity (ρ EP ) measured by a rheometer at 250 ° C. and a shear rate of 121.6 sec −1 with a viscosity ratio (ρ EP / ρ PP ) to the melt viscosity (ρ PP ) of polypropylene of 0.05 to 1.0. And a molten mixture comprising 15 to 50% by weight of a ethylene-α-olefin copolymer, and then heat-sealing the aluminum foil in a specific temperature range using a specific adhesive. The present invention provides a pharmaceutical packaging container.
【０００７】[0007]
（ポリプロピレン）本発明の樹脂組成物に用いられるポ
リプロピレンの種類としては、例えばプロピレンのホモ
ポリマー、プロピレンとエチレンやα−オレフィンとの
ブロックコポリマー、ランダムコポリマーなどの公知の
ポリプロピレン及びこれらの混合物が挙げられる。特に
高度の防湿性、透明性、剛性が必要な場合は、プロピレ
ンのホモポリマーが好ましい。また、これらの樹脂は２
種以上を併用してもよい。(Polypropylene) Examples of the type of polypropylene used in the resin composition of the present invention include known polypropylenes such as propylene homopolymers, block copolymers of propylene and ethylene or α-olefins, and random copolymers, and mixtures thereof. . In particular, when high moisture resistance, transparency and rigidity are required, a homopolymer of propylene is preferred. These resins are 2
More than one species may be used in combination.
【０００８】ポリプロピレンはフィルム、シート等の押
出成形性の良好なものが好ましい。このような樹脂とし
ては、ＭＦＲ(ＪＩＳ Ｋ ７２１０、条件１４)が０.１
〜１０ｇ／１０minであるのが好ましく、より好ましく
は０．５〜８ｇ／１０minであり、最も好ましくは１〜
５ｇ／１０minである。ＭＦＲが前記の値より小さい
と、押出しシートの表面外観が悪くなる傾向があり好ま
しくない。一方、ＭＦＲが前記の値より大きいとシート
押出し加工性が不安定となり好ましくない。As the polypropylene, those having good extrusion moldability, such as films and sheets, are preferable. Such a resin has an MFR (JIS K 7210, condition 14) of 0.1.
It is preferably 10 to 10 g / 10 min, more preferably 0.5 to 8 g / 10 min, and most preferably 1 to 10 g / 10 min.
It is 5 g / 10 min. If the MFR is smaller than the above-mentioned value, the surface appearance of the extruded sheet tends to deteriorate, which is not preferable. On the other hand, if the MFR is larger than the above value, the sheet extrusion processability becomes unstable, which is not preferable.
【０００９】ポリプロピレンの配合量は組成物全量に対
して、８５〜５０重量％、好ましくは８０〜５５重量
％、より好ましくは７５〜６０重量％である。ポリプロ
ピレンの配合量が前記の範囲より多いと、フィルムを真
空・圧空成形する場合の二次加工性など、成形性の改良
が充分でない。また、ポリプロピレンの配合量が前記の
範囲より少ないとポリプロピレンの優れた特性である耐
熱性が得られない。The amount of the polypropylene is from 85 to 50% by weight, preferably from 80 to 55% by weight, more preferably from 75 to 60% by weight, based on the total amount of the composition. If the blending amount of the polypropylene is larger than the above range, the moldability is not sufficiently improved, such as the secondary workability in the case of vacuum / pressure forming the film. On the other hand, if the amount of the polypropylene is less than the above range, heat resistance, which is an excellent property of polypropylene, cannot be obtained.
【００１０】（ポリエチレン）ポリエチレンとしては、
例えば高密度ポリエチレン(ＨＤＰＥ)、中密度ポリエチ
レン(ＭＤＰＥ)、低密度ポリエチレン(ＬＤＰＥ)、直鎖
状低密度ポリエチレン(ＬＬＤＰＥ)、超低密度ポリエチ
レン(ＶＬＤＰＥ)等をいずれも用いることができる。高
い防湿性が必要な場合は、ポリエチレンとして防湿性に
優れた高密度ポリエチレンを用いるのが好ましい。(Polyethylene) As polyethylene,
For example, any of high-density polyethylene (HDPE), medium-density polyethylene (MDPE), low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), and ultra-low-density polyethylene (VLDPE) can be used. When high moisture resistance is required, it is preferable to use high density polyethylene having excellent moisture resistance as polyethylene.
【００１１】（エチレン−α−オレフィン共重合体）エ
チレン−α−オレフィン共重合体としては、エチレンと
α−オレフィン、例えばプロピレン，ブテン−１，ヘキ
セン−１，オクテン−１などとの共重合体である。中で
もエチレン−プロピレン共重合体（ＥＰＲ）が好まし
い。(Ethylene-α-olefin copolymer) Examples of the ethylene-α-olefin copolymer include copolymers of ethylene with α-olefins such as propylene, butene-1, hexene-1, and octene-1. It is. Among them, ethylene-propylene copolymer (EPR) is preferable.
【００１２】また、ＪＩＳ Ｋ ７１９９に従って前記条
件にて測定したポリエチレン及びエチレン−α−オレフ
ィン共重合体の溶融混合物の溶融粘度(ρEP)と主成分で
あるポリプロピレンの溶融粘度(ρPP)との粘度比(ρEP/
ρPP)は０.０５〜１.０であり、好ましくは０．１〜
０．８、より好ましくは０．２〜０．７である。この粘
度比が前記の範囲より小さいと樹脂が充分均一に混合で
きずフィルムなどの成形が困難となる。一方、前記の範
囲を越えると成形の可能な温度幅が充分に拡大せず好ま
しくない。The melt viscosity (ρ EP ) of the melt mixture of polyethylene and ethylene-α-olefin copolymer and the melt viscosity (ρ PP ) of the main component polypropylene measured under the above conditions according to JIS K 7199 are described. Viscosity ratio (ρ EP /
ρ PP ) is 0.05 to 1.0, preferably 0.1 to 1.0.
0.8, more preferably 0.2 to 0.7. If the viscosity ratio is smaller than the above range, the resin cannot be mixed sufficiently uniformly, and it becomes difficult to form a film or the like. On the other hand, if it exceeds the above range, the temperature range in which molding can be performed is not sufficiently widened, which is not preferable.
【００１３】また、ポリエチレンはＭＦＲ(ＪＩＳ Ｋ
７２１０、条件４)が２〜４０ｇ／１０minであるのが好
ましく、より好ましくは４〜４０ｇ／min、最も好まし
くは５〜２０ｇ／minである。ポリエチレンのＭＦＲが
前記の範囲より小さいと押出しシートの表面外観が悪く
なる傾向があり好ましくない。一方、前記の範囲より大
きいとシートの押出し加工性が不安定になり、更に物性
低下を招く。[0013] Polyethylene is MFR (JIS K).
7210, Condition 4) is preferably 2 to 40 g / 10 min, more preferably 4 to 40 g / min, and most preferably 5 to 20 g / min. If the MFR of the polyethylene is smaller than the above range, the surface appearance of the extruded sheet tends to deteriorate, which is not preferable. On the other hand, if it is larger than the above range, the extrudability of the sheet becomes unstable, and the physical properties are further reduced.
【００１４】また、エチレン−α−オレフィン共重合体
はムーニー粘度（ＪＩＳ Ｋ ６３００、ＭＬ1+4 １０
０℃）が１〜８０であるのが好ましく、より好ましくは
５〜４０、最も好ましくは８〜２０である。ムニー粘度
が前記の範囲より小さいとシートの押出し加工性が不安
定になり物性低下を招く。一方、前記の範囲より大きい
とポリエチレンとの溶融混合物の粘度が高くなりすぎる
ので好ましくない。The ethylene-α-olefin copolymer has a Mooney viscosity (JIS K 6300, ML 1 + 4 10
0 ° C.) is preferably 1 to 80, more preferably 5 to 40, and most preferably 8 to 20. If the Mooney viscosity is less than the above range, the extrudability of the sheet becomes unstable and physical properties are reduced. On the other hand, if it is larger than the above range, the viscosity of the molten mixture with polyethylene becomes too high, which is not preferable.
【００１５】ポリエチレン及びエチレン−α−オレフィ
ン共重合体の溶融混合物の配合量は、前記ポリプロピレ
ンの配合量に対応し、組成物全量に対して１５〜５０重
量％、好ましくは２０〜４５重量％、より好ましくは２
５〜４０重量％である。The amount of the molten mixture of polyethylene and ethylene-α-olefin copolymer corresponds to the amount of the polypropylene, and is 15 to 50% by weight, preferably 20 to 45% by weight, based on the total amount of the composition. More preferably 2
5 to 40% by weight.
【００１６】また、ポリエチレン及びエチレン−α−オ
レフィン共重合体の溶融混合物とポリプロピレンとの常
温での屈折率差は０．０２５以下であり、好ましくは
０．０２０以下、より好ましくは０．０１５以下であ
る。屈折率差が前記範囲より大きいと透明性において良
好なものが得られない。The difference in refractive index between the molten mixture of polyethylene and ethylene-α-olefin copolymer and polypropylene at room temperature is 0.025 or less, preferably 0.020 or less, more preferably 0.015 or less. It is. If the difference in refractive index is larger than the above range, good transparency cannot be obtained.
【００１７】本発明の組成物では、溶融粘度比が特定範
囲にあるポリプロピレンと、ポリエチレン及びエチレン
−α−オレフィン共重合体の溶融混合物とを所定量配合
することにより、加熱時のシートの粘弾性挙動を広範囲
の温度にわたり精密に制御することが可能となった。そ
の結果、熱成形時の成形加工性、すなわち成形可能な温
度幅が約６℃以上と飛躍的に拡大した。また、ポリプロ
ピレンと、ポリエチレン及びエチレン−α−オレフィン
共重合体の溶融混合物との屈折率差を少なくすることに
より透明性の更なる改良が可能となった。In the composition of the present invention, a predetermined amount of a polypropylene having a melt viscosity ratio in a specific range and a melt mixture of polyethylene and an ethylene-α-olefin copolymer are blended to obtain a viscoelastic property of the sheet when heated. The behavior can be precisely controlled over a wide range of temperatures. As a result, the moldability at the time of thermoforming, that is, the moldable temperature range was dramatically increased to about 6 ° C. or more. Further, the transparency can be further improved by reducing the difference in refractive index between polypropylene and a molten mixture of polyethylene and ethylene-α-olefin copolymer.
【００１８】本発明の組成物には、さらに必要に応じて
基本的性質を損なわず、衛生上許容される範囲において
添加剤、例えば染顔料、安定剤、可塑剤、帯電防止剤、
紫外線吸収剤、酸化防止剤、滑剤、造核剤、充填剤など
を添加してもよい。The composition of the present invention may further contain, if necessary, additives such as dyes and pigments, stabilizers, plasticizers, antistatic agents without impairing the basic properties and within hygiene-acceptable ranges.
UV absorbers, antioxidants, lubricants, nucleating agents, fillers, and the like may be added.
【００１９】（アルミ箔）アルミ箔としては、特に限定
されるものではないが、硬質アルミ箔が好適に用いられ
る。また、アルミ箔はシートに接着可能な接着剤が積層
されたものであり、接着剤としては、ポリエチレンと接
着可能なものが使用可能である。特に変性ポリエチレン
が好適に用いられる。変性ポリエチレンとしては、例え
ばアクリル酸、メタクリル酸、マレイン酸、イタコン
酸、アクリル酸メチル、アクリル酸エチル、メタクリル
酸メチル、無水マレイン酸、アリールマレイン酸イミ
ド、アルキルマレイン酸イミド等の不飽和有機酸または
その誘導体により変性されたポリエチレンが挙げられ
る。(Aluminum Foil) The aluminum foil is not particularly limited, but a hard aluminum foil is preferably used. Further, the aluminum foil is formed by laminating an adhesive capable of adhering to the sheet, and an adhesive capable of adhering to polyethylene can be used as the adhesive. Particularly, modified polyethylene is preferably used. Examples of the modified polyethylene include unsaturated organic acids such as acrylic acid, methacrylic acid, maleic acid, itaconic acid, methyl acrylate, ethyl acrylate, methyl methacrylate, maleic anhydride, arylmaleimide, and alkylmaleimide. Examples include polyethylene modified with its derivatives.
【００２０】また、カールを抑制するためには低温での
ヒートシールが好ましく、ポリエチレンの融点以上であ
って、ポリプロピレンの融点以下であることが好まし
い。実際の温度としては１００〜１６０℃、好ましくは
１１０〜１５０℃、更に好ましくは１２０〜１４０℃で
ある。ポリプロピレンを溶融させることなくアルミ箔と
シートの接着が可能となり、成形品のカールの抑制につ
ながる。Further, in order to suppress curling, heat sealing at a low temperature is preferable, and it is preferable that the temperature is higher than the melting point of polyethylene and lower than the melting point of polypropylene. The actual temperature is 100 to 160 ° C, preferably 110 to 150 ° C, and more preferably 120 to 140 ° C. Adhesion between the aluminum foil and the sheet becomes possible without melting the polypropylene, which leads to suppression of curling of the molded product.
【００２１】[0021]
【実施例】つぎに本発明を実施例に基づきさらに具体的
に説明する。実施例及び比較例において用いた各成分を
以下に示す。また、アルミ箔としては硬質アルミ箔２０
μmに無水マレイン酸変性ポリエチレン５μmを塗布した
ものを使用した。なお、溶融粘度はキャピログラフ１Ｃ
［(株)東洋精機製作所］により、２５０℃，剪断速度１
２１.６sec-1で、長さ１０ｍｍ、直径１ｍｍのキャピラ
リーを使用して測定を行った。ＭＦＲの測定はポリプロ
ピレンについてはＪＩＳ Ｋ 7210、条件１４、ポリエチ
レンについてはＪＩＳ Ｋ 7210、条件４で行った。。ム
ニー粘度の測定は、ＪＩＳ Ｋ 6300（ＭＬ1+4 １００
℃）で行った。また、屈折率（ｎD）については、デジ
タル屈折率計ＲＸ−２０００（（株）アタゴ製）によ
り、シート状態での２３℃の屈折率の測定を行った。ま
た、ポリエチレンとエチレン−α−オレフィン共重合体
成分を充分にドライブレンドした後、２軸混練機により
高剪断のもとで樹脂温度２５０℃にて溶融混練すること
により微分散させ、実質上相溶させたものをペレット化
し、溶融混合物（ＥＰ−１〜４）を作製した。EXAMPLES Next, the present invention will be described more specifically based on examples. The components used in the examples and comparative examples are shown below. As the aluminum foil, a hard aluminum foil 20
One coated with 5 μm of maleic anhydride-modified polyethylene on μm was used. The melt viscosity was measured using Capillograph 1C.
[Toyo Seiki Seisakusho], 250 ° C, shear rate 1
The measurement was performed at 21.6 sec -1 using a capillary having a length of 10 mm and a diameter of 1 mm. The MFR was measured according to JIS K 7210, condition 14 for polypropylene, and according to JIS K 7210, condition 4 for polyethylene. . The measurement of Mooney viscosity is performed according to JIS K 6300 (ML 1 + 4 100
C). The refractive index (n D ) was measured at 23 ° C. in a sheet state using a digital refractometer RX-2000 (manufactured by Atago Co., Ltd.). Further, after the polyethylene and the ethylene-α-olefin copolymer component are sufficiently dry-blended, they are finely dispersed by melt-kneading at a resin temperature of 250 ° C. under high shear by a biaxial kneader to substantially disperse the phase. The melted product was pelletized to prepare a molten mixture (EP-1 to EP-4).
【００２２】（ポリプロピレン） ・ＰＰ（ρPP=５５３Ｐa・s、ＭＦＲ＝２.３、ｎD=１．
５０２） ＨＴ−６００４［チッソ(株)製］ （ポリエチレン） ・ＨＤＰＥ−１（ρPE=１９２Ｐa・s、ＭＦＲ＝２０、ｎ
D=１．５２８） Ｆ６２００Ｖ［日本ポリオレフィン(株)製］ ・ＨＤＰＥ−２（ρPE=５１３Ｐa・s、ＭＦＲ＝５.０、
ｎD=１．５３２） ５０５０ＦＤ［日本ポリオレフィン(株)製］ （エチレン−α−オレフィン共重合体） ・ＥＰＲ（ρEPR=６７１Ｐa・s、ＭＬ1+4(100℃)＝１
０、ｎD=１．４９０） ＥＰ９１２Ｐ［日本合成ゴム(株)製］ （溶融混合物） ・ＥＰ−１（ρEP=２４７Ｐa・s、ｎD=１．５２０） ＨＤＰＥ−１：ＥＰＲ＝８０重量％：２０重量％ ・ＥＰ−２（ρEP=４８４Ｐa・s、ｎD=１．５１４） ＨＤＰＥ−２：ＥＰＲ＝６０重量％：４０重量％(Polypropylene) PP (ρ PP = 553 Pa · s, MFR = 2.3, n D = 1.
502) HT-6004 [manufactured by Chisso Corporation] (polyethylene) HDPE-1 (ρ PE = 192 Pa · s, MFR = 20, n
D = 1.528) F6200V [manufactured by Nippon Polyolefin Co., Ltd.] HDPE-2 (ρ PE = 513 Pa · s, MFR = 5.0,
n D = 1.532) 5050FD [Nippon Polyolefin Co., Ltd.] (ethylene -α- olefin copolymer) · EPR (ρ EPR = 671Pa · s, ML 1 + 4 (100 ℃) = 1
0, n D = 1.490) EP912P [manufactured by Nippon Synthetic Rubber Co., Ltd.] (melt mixture) EP-1 (ρ EP = 247 Pa · s, n D = 1.520) HDPE-1: EPR = 80 weight %: 20% by weight ・ EP-2 (ρ EP = 484 Pa · s, n D = 1.514) HDPE-2: EPR = 60% by weight: 40% by weight
【００２３】［実施例１〜８及び比較例１〜３］各成分
を充分にドライブレンドした後、２軸混練機を用いて樹
脂温度２５０℃にて融混練し、熱成形用樹脂組成物を得
た。[Examples 1 to 8 and Comparative Examples 1 to 3] The components were sufficiently dry-blended and then melt-kneaded at a resin temperature of 250 ° C. using a biaxial kneader to obtain a thermoforming resin composition. Obtained.
【００２４】シート： 厚さ０.３ｍｍのＴ−ダイ押出
しシート（冷却ロール温度；６０℃）を使用した。Sheet: A 0.3 mm thick T-die extruded sheet (cooling roll temperature; 60 ° C.) was used.
【００２５】成形性： 圧空方式成形機［ＦＢＰ−Ｍ
２；シーケーディ(株)製］を用いて一定圧力下（５kgf/
cm2）、１２０〜１６０℃にて熱板温度を１℃単位で上
昇させ、試料シートを成形品（直径；１０ｍｍ、高さ；
４.５ｍｍ、Ｒ；１.５ｍｍ）とした。得られた成形品の
全体の厚みが均一である温度を成形可能温度とし、その
温度幅を求めた。Formability: Compressed air molding machine [FBP-M
2; manufactured by CK Corporation] under a constant pressure (5 kgf /
cm 2 ), the temperature of the hot plate is increased by 1 ° C. at 120 to 160 ° C., and the sample sheet is molded (diameter; 10 mm, height;
4.5 mm, R; 1.5 mm). The temperature at which the entire thickness of the obtained molded article was uniform was defined as the moldable temperature, and the temperature range was determined.
【００２６】透明性： ＨＡＺＥ測定にはＡＳＴＭ−Ｄ
１００３を用いた。Transparency: ASTM-D for HAZE measurement
1003 was used.
【００２７】カール： 良好な成形性を示す条件で成形
し、内容物を充填せずにアルミ箔とヒートシールし、１
３０℃でスリッターを入れた後、幅；３７ｍｍ、長さ；
９４ｍｍ、コーナーＲ；５ｍｍに打ち抜いた成形品をフ
ラットな面に置き、打ち抜き１０分後の成形品のソリを
測定した。１０個の成形品について、各成形品の四隅を
測定し平均値で評価を行った。配合組成及び各測定値の
結果を表１〜２に示す。Curl: Molded under conditions showing good moldability, heat-sealed with aluminum foil without filling the contents,
After inserting a slitter at 30 ° C., width; 37 mm, length;
A molded product punched out at 94 mm, corner R; 5 mm was placed on a flat surface, and the warpage of the molded product 10 minutes after punching was measured. Four corners of each molded product were measured for 10 molded products, and evaluated by an average value. Tables 1 and 2 show the composition and the results of the measured values.
【００２８】[0028]
【表１】 [Table 1]
【００２９】[0029]
【表２】 [Table 2]
【００３０】[0030]
【発明の効果】本発明の医薬品包装容器は、容器成形時
の熱成形性、特に真空成形性、圧空成形性に優れてお
り、アルミ箔とのヒートシール後のソリが非常に少なく
医薬品包装容器として好ましい。Industrial Applicability The pharmaceutical packaging container of the present invention is excellent in thermoformability at the time of molding the container, particularly excellent in vacuum moldability and air pressure moldability, and has very little warping after heat sealing with aluminum foil. Is preferred.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.6 識別記号 ＦＩ // Ｃ０８Ｌ 23/06 Ｃ０８Ｌ 23/08 23/08 23/12 23/12 Ａ６１Ｊ 1/00 ３７０Ｚ ──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. 6 Identification symbol FI // C08L 23/06 C08L 23/08 23/08 23/12 23/12 A61J 1/00 370Z
Claims (4)
リプロピレンとの常温での屈折率差が０．０２５以下で
あり、かつＪＩＳ Ｋ ７１９９に従ってキャピラリーレ
オメータにより２５０℃、剪断速度１２１.６sec-1にお
いて測定した溶融粘度(ρEP)がポリプロピレンの溶融粘
度(ρPP)に対する粘度比(ρEP/ρPP)０.０５〜１.０で
あるポリエチレン及びエチレン−α−オレフィン共重合
体からなる溶融混合物１５〜５０重量％とを配合してな
るシートを熱成形し、その後アルミ箔をヒートシールし
てなる医薬品包装容器。1. A difference in refractive index between 85 to 50% by weight of polypropylene and polypropylene at room temperature is 0.025 or less, and measured at 250 ° C. and a shear rate of 121.6 sec −1 by a capillary rheometer according to JIS K 7199. Melt mixture 15 comprising a polyethylene and an ethylene-α-olefin copolymer having a melt viscosity (ρ EP ) of 0.05 to 1.0 with a viscosity ratio (ρ EP / ρ PP ) to the melt viscosity (ρ PP ) of polypropylene.医 薬 品 50% by weight, followed by thermoforming a sheet, followed by heat sealing the aluminum foil.
ル可能な接着剤を積層したアルミ箔である請求項１記載
の医薬品包装容器。2. The pharmaceutical packaging container according to claim 1, wherein the aluminum foil is an aluminum foil obtained by laminating a heat-sealable adhesive on polyethylene.
る請求項２記載の医薬品包装容器。3. The pharmaceutical packaging container according to claim 2, wherein the laminated adhesive is a modified polyethylene.
融点の５℃以下の温度でヒートシールしてなる請求項
１、２又は３記載の医薬品包装容器。4. The pharmaceutical packaging container according to claim 1, wherein the sheet and the aluminum foil are heat-sealed at a temperature of 5 ° C. or less of the melting point of polypropylene.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8309195A JPH10152169A (en) | 1996-11-20 | 1996-11-20 | Medicine packaging container |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8309195A JPH10152169A (en) | 1996-11-20 | 1996-11-20 | Medicine packaging container |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH10152169A true JPH10152169A (en) | 1998-06-09 |
Family
ID=17990078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8309195A Pending JPH10152169A (en) | 1996-11-20 | 1996-11-20 | Medicine packaging container |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH10152169A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009107701A (en) * | 2007-10-31 | 2009-05-21 | Toppan Printing Co Ltd | Packaging container |
| JP2014034637A (en) * | 2012-08-09 | 2014-02-24 | Sumitomo Chemical Co Ltd | Polyolefin resin composition for vapor-deposition film and polyolefin film for vapor-deposition comprising the composition |
| WO2016159233A1 (en) * | 2015-03-31 | 2016-10-06 | 大日本印刷株式会社 | Packaging material for cell, process for producing same, and cell |
-
1996
- 1996-11-20 JP JP8309195A patent/JPH10152169A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009107701A (en) * | 2007-10-31 | 2009-05-21 | Toppan Printing Co Ltd | Packaging container |
| JP2014034637A (en) * | 2012-08-09 | 2014-02-24 | Sumitomo Chemical Co Ltd | Polyolefin resin composition for vapor-deposition film and polyolefin film for vapor-deposition comprising the composition |
| WO2016159233A1 (en) * | 2015-03-31 | 2016-10-06 | 大日本印刷株式会社 | Packaging material for cell, process for producing same, and cell |
| JPWO2016159233A1 (en) * | 2015-03-31 | 2018-01-25 | 大日本印刷株式会社 | Battery packaging material, manufacturing method thereof, and battery |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH09131838A (en) | Multiple layer polypropylene based packaging film and its application | |
| JP2007520586A (en) | Resin composition and laminate thereof | |
| JP4642499B2 (en) | Polyolefin resin composition and packaging film | |
| US5902848A (en) | Polypropylene films suitable for packaging | |
| JP3132373B2 (en) | Multilayer film | |
| JP2000079663A (en) | Easy unsealable laminated film, lid material and container | |
| JPH10152169A (en) | Medicine packaging container | |
| JPH10235815A (en) | Polyethylene-based multilayered film | |
| JP3291969B2 (en) | Polyethylene-based unstretched film, laminated film and bag | |
| JPS5851822B2 (en) | Crystalline polypropylene stretched composite film | |
| JP4692818B2 (en) | Co-extrusion laminated film and laminate film and packaging container using the same | |
| JP3360532B2 (en) | Thermoforming resin composition and sheet | |
| JPS6141749B2 (en) | ||
| JPH1085307A (en) | Medicinal package container | |
| JP3270386B2 (en) | Surface conductive polyolefin sheet | |
| JPH10237239A (en) | Resin composition for thermoforming and sheet made therefrom | |
| JP2008162163A (en) | Polypropylene based resin laminated film | |
| JP3737547B2 (en) | Thermoplastic resin composition and use thereof | |
| JPH11170454A (en) | Polypropylene sheet | |
| JP4011422B2 (en) | Hollow container | |
| JP2004035711A (en) | Heat-sealing film, and laminate using the same | |
| JPH0532834A (en) | Resin film or sheet excellent in heat sealability | |
| JP2018131564A (en) | Adhesive for sealant and easily peelable film | |
| JP7071060B2 (en) | Polyethylene film | |
| JP2002019054A (en) | Polypropylene laminated sheet |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20060602 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20060721 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20061205 |