JPH1014493A - Lactose-containing food composition for baby - Google Patents
Lactose-containing food composition for babyInfo
- Publication number
- JPH1014493A JPH1014493A JP8191341A JP19134196A JPH1014493A JP H1014493 A JPH1014493 A JP H1014493A JP 8191341 A JP8191341 A JP 8191341A JP 19134196 A JP19134196 A JP 19134196A JP H1014493 A JPH1014493 A JP H1014493A
- Authority
- JP
- Japan
- Prior art keywords
- milk
- infants
- lactose
- protein
- containing food
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Dairy Products (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
【0001】[0001]
【発明の属する技術分野】本発明は、実質的に牛乳蛋白
質及び/又は牛乳蛋白質加工物を唯一の蛋白質源とする
母乳以外の乳幼児用乳糖含有食品を摂取した乳幼児の便
の色調を、母乳摂取時と同様の色調に改善する乳幼児用
乳糖含有食品組成物に関するものである。[0001] The present invention relates to a method for determining the color of stool of infants who have taken lactose-containing foods for infants other than breast milk, wherein the milk protein and / or processed milk protein is the only protein source. The present invention relates to a lactose-containing food composition for infants, which improves the color tone as in the past.
【0002】[0002]
【従来の技術】種々の理由から母乳を与えられない乳児
又は母乳が不足している乳児に対して投与する母乳代替
物として、乳蛋白質を唯一の蛋白質源とする育児用調製
粉乳が開発されている。また、乳児の発育状態、体質等
を考慮して、乳蛋白質又はその加工物を唯一の蛋白質源
とする各種乳幼児用食品等が多数開発されてきてもい
る。育児用調製粉乳以外のこれらの製品としては、生後
6か月以降の乳幼児のためのフォローアップミルク、ア
レルギー体質の乳幼児のためのペプチドミルク等を例示
することができる。2. Description of the Related Art As an alternative to breast milk to be administered to infants who are not or cannot be breastfed for various reasons, infant formulas using milk protein as the sole protein source have been developed. I have. Also, in consideration of the growth state, constitution, and the like of an infant, many foods for infants and the like using milk protein or a processed product thereof as a sole protein source have been developed. Examples of these products other than infant formula for infants include follow-up milk for babies after 6 months of age and peptide milk for babies with allergies.
【0003】しかしながら、これらの製品を改良する目
的で、乳児の発育上必要な栄養素を強化し、栄養成分組
成の母乳化が進展するにともない、これらの製品を摂取
する乳児の便が、母乳栄養児のそれと明かに相違するこ
とが指摘されてきた。即ち、乳児の栄養所要量を充足す
るために鉄分を強化し、カゼイン蛋白質と乳清蛋白質と
の比率を母乳のそれと同様に増加させた(換言すれば、
乳清蛋白質の割合を増加させた)育児用調製粉乳を哺乳
した乳児においては、便の色が緑色になる頻度が高くな
ることが知られている[ジャーナル・オブ・ペディアト
リック・ガストロエンテロロジー・アンド・ニュートリ
ッション(Journal of Pediatric Gastroenterology an
d Nutrition) 、第4巻、第771ページ、1985
年]。However, for the purpose of improving these products, the nutrients necessary for the development of infants are strengthened, and as the mother emulsification of the nutrient composition progresses, the stool of infants who take these products becomes more effective in breastfeeding. It has been pointed out that it is clearly different from that of children. That is, iron was fortified to satisfy the nutritional requirements of infants, and the ratio of casein protein to whey protein was increased similarly to that of breast milk (in other words,
It is known that the frequency of stool turns green in infants fed infant formulas (with an increased proportion of whey protein) [Journal of Pediatric Gastroenterology. And Nutrition (Journal of Pediatric Gastroenterology an
d Nutrition), vol. 4, p. 771, p. 1985
Year].
【0004】また、アレルギー体質の乳児のためのペプ
チドミルクを摂取した乳児においても同様に便の色が緑
色になる頻度が高くなることが知られている[ペディア
トリックス(Pediatrics)、第95巻、第50ページ、1
995年]。[0004] It is also known that the frequency of stool turns green similarly in infants who have taken peptide milk for infants with allergies [Pediatrics, Vol. Page 50, 1
995].
【0005】更に、最近、育児用調製粉乳の蛋白質のす
べてを適度に加水分解し、アレルギー性疾患の予防効果
が期待されるペプチドミルクが開発されたが、この製品
においても同様に便の色が緑色になる傾向が認められて
いる(食品工業、第38巻、第4号、第55ページ、1
995年)。[0005] Further, recently, peptide milk which is expected to have an effect of preventing allergic diseases by appropriately hydrolyzing all the proteins of infant formula for infant formula has been developed. Green color is observed (Food Industry, Vol. 38, No. 4, page 55, 1
995).
【0006】これらの事実は、育児用調製粉乳又はその
関連製品が種々の点で母乳の水準に未だ達していないこ
とを例証するものであり、早急な改善が望まれていた。[0006] These facts illustrate that infant formula or its related products have not yet reached the level of breast milk in various respects, and an immediate improvement was desired.
【0007】乳児の緑色便の問題を解決する方法とし
て、例えば、育児用調製粉乳にフラクトオリゴ糖を2〜
5%(重量)の割合で配合することにより緑色便を改善
する試みがなされているが(特開平3−266937号
公報)、この公開された発明によれば、2〜3%(重
量)の割合でフラクトオリゴ糖を添加した育児用調製粉
乳を摂取した乳児においても、黄色便となる割合は半数
以下(44〜50%)に過ぎず、比較対照として調査さ
れた母乳栄養児では90%以上が黄色便であることか
ら、両者間には顕著な差異のあることが開示されてい
る。[0007] As a method for solving the problem of green stool in infants, for example, fructooligosaccharides are added to infant formulas in an amount of 2 to 2%.
Attempts have been made to improve green stool by blending at a ratio of 5% (by weight) (JP-A-3-266937). However, according to the disclosed invention, 2-3% (by weight) is used. Even in infants who take infant formula containing fructooligosaccharides at a ratio, the proportion of yellow stools is only less than half (44-50%), and 90% or more of breastfeeding infants surveyed as a control. It is disclosed that there is a remarkable difference between the two because of the yellow stool.
【0008】また、腸内環境の改善により糞便臭を軽減
し、色調、硬度等の便性を改善することを目的として、
マッシュルーム抽出エキス単独、又はマッシュルーム抽
出エキスと、食物繊維及び/若しくはオリゴ糖とを含有
する腸内環境改善剤に関する発明が開示されており(特
開平5−238945号公報)、このオリゴ糖のより具
体的な実施態様として大豆オリゴ糖が例示されている。
この公開された発明においては、マッシュルーム抽出エ
キスを必須の構成要件としており、このマッシュルーム
抽出エキス単独、又はマッシュルーム抽出エキスとオリ
ゴ糖及び/若しくは食物繊維との相乗効果によって腸内
環境を清浄にし、糞便の臭気、色調、硬度等を著しく改
善するものであることが開示されている。[0008] Further, for the purpose of reducing fecal odor by improving the intestinal environment and improving the convenience such as color tone and hardness,
An invention relating to an intestinal environment improving agent containing a mushroom extract alone or a mushroom extract and dietary fiber and / or oligosaccharide has been disclosed (JP-A-5-238945). As a typical embodiment, a soybean oligosaccharide is exemplified.
In the disclosed invention, the extract of mushrooms is an essential component, and the intestinal environment is cleaned by the synergistic effect of the extract of mushrooms alone or the extract of mushrooms and oligosaccharides and / or dietary fiber, and the feces are removed. It is disclosed that the odor, the color tone, the hardness, etc. are remarkably improved.
【0009】一方、大豆オリゴ糖は、大豆から抽出した
水に可溶な糖類の総称であり、脱脂大豆から大豆蛋白質
を製造するとき、副製する大豆ホエーを出発物質として
用い、この大豆ホエーから蛋白質を除去し、脱色、脱
塩、濃縮し、大豆オリゴ糖シロップを得る。得られた大
豆オリゴ糖シロップは、固形分換算で、ショ糖39%、
スタキオース24%、果糖及びブドウ糖16%、ラフィ
ノース8%及びその他の糖質13%(分析例)からなっ
ている(農林水産省食品流通局委託事業、「飲食品用機
能性素材有効利用技術シリーズ No.2 大豆オリゴ
糖(ガラクトオリゴ糖)」、第1〜2ページ。社団法人
菓子総合技術センター、平成2年)。On the other hand, soybean oligosaccharides are a general term for water-soluble saccharides extracted from soybeans. When soybean protein is produced from defatted soybeans, soybean whey produced as a by-product is used as a starting material. The protein is removed, decolorized, desalted and concentrated to obtain a soybean oligosaccharide syrup. The obtained soybean oligosaccharide syrup has a solid content of sucrose 39%,
Consists of stachyose 24%, fructose and glucose 16%, raffinose 8% and other carbohydrates 13% (analysis example) (Contracted by the Food Distribution Bureau of the Ministry of Agriculture, Forestry and Fisheries, “Efficient Use of Functional Materials for Food and Beverage Series No. .2 soybean oligosaccharides (galacto-oligosaccharides) ", pages 1-2, Confectionery Research Institute, 1990.
【0010】このように、大豆から製造される大豆乳に
は、原料由来のオリゴ糖としてラフィノース、スタキオ
ース等が一定量含まれていることが知られている[ジャ
ーナル・オブ・デーリー・リサーチ(Journal of Dairy
Research )、第53巻、第293ページ、1986
年]。これらの商品の一部は欧米において現在も広範に
利用されているが、大豆乳を摂取した乳児においては、
ラフィノースが含まれているにもかかわらず、便は緑色
になる頻度が高くなることが報告されている[ペディア
トリックス(Pediatrics)、第95巻、第50頁、199
5年]。As described above, it is known that soybean milk produced from soybean contains a certain amount of raffinose, stachyose and the like as oligosaccharides derived from raw materials [Journal of Daily Research (Journal) of Dairy
Research), 53, 293, 1986
Year]. Some of these products are still widely used in Europe and the United States, but for infants who consume soy milk,
It has been reported that stools become green more frequently despite the presence of raffinose [Pediatrics, 95, 50, 199.
5 years].
【0011】また、母乳栄養児と人工栄養児との便の最
大の相違は、色調及び排便の回数である。母乳栄養児で
は、便の色調が黄色を示す頻度が高く、かつ1日当りの
回数も多いのに対して、人工栄養児では、便の色調が緑
色を示す頻度が高く、1日当りの回数も母乳栄養児に比
較して明かに少ないことが知られている(小児保健研
究、第43巻,第618ページ、1984年)。この緑
色便は、育児相談でも最も頻繁に問題となり、病的な状
態を示す指標ではないが、母親の関心が高い問題の一つ
である。[0011] The biggest differences between the stool of a breastfeeding infant and the artificially fed infant are the color tone and the number of defecations. In the case of breastfed infants, the color of the stool shows yellow frequently and the number of times per day is high, whereas in the case of artificially fed children, the color of the stool shows green and the number of times per day is also large. It is known that the number is clearly lower than that of nourished children (Child Health Research, Vol. 43, p. 618, 1984). This green stool is the most frequent problem in childcare consultations and is not an indicator of morbidity, but it is one of the concerns of mothers.
【0012】前記のとおり、便の色調が緑色となる現象
は、胆のうから分泌される胆汁色素であるビリルビンと
ビリベルジンとの分泌比率、並びにそれらの腸管内にお
ける酸化又は還元による直接的及び間接的な変化による
ものである。従って、腸管内容物の酸化還元に影響を及
ぼす物質(例えば、鉄等)が大量に存在する育児用調製
粉乳等を投与された乳幼児では、その便が緑色を呈する
頻度が高くなる。As described above, the phenomenon that the color of the stool becomes green is caused by the secretion ratio of bilirubin and biliverdin, which are the bile pigments secreted from the gall bladder, and their direct and indirect effects by oxidation or reduction in the intestinal tract. It is due to change. Therefore, the frequency of the stool becomes greener in infants to whom infant formula or the like in which a substance (for example, iron or the like) affecting the redox of intestinal contents is present in a large amount is administered.
【0013】更に、このように鉄が強化された育児用調
製粉乳等では、構成蛋白質に占める乳清蛋白質の割合を
増加した場合、便がより緑色を呈する傾向が増加するこ
とも知られている[ジャーナル・オブ・ペディアトリッ
ク・ガストロエンテロロジー・アンド・ニュートリッシ
ョン(Journal of Pediatric Gastroenterology andNut
rition)、第4巻、第771ページ、1985年]。[0013] Further, it is also known that in the case of infant formula or the like fortified with iron in which iron is fortified as described above, when the proportion of whey protein in the constituent proteins is increased, the stool tends to have a greener color. [Journal of Pediatric Gastroenterology and Nut
rition), Vol. 4, p. 771, 1985].
【0014】[0014]
【発明が解決しようとする課題】以上のように、従来、
母乳以外の乳幼児用食品を摂取した乳幼児の便の色調
を、母乳栄養児のそれと同等に改善する試みは成功して
おらず、乳幼児の便の色調を改善する乳幼児用食品が待
望されていた。As described above, conventionally,
Attempts to improve the stool color of infants who have taken infant foods other than breast milk to the same level as those of breastfeeding infants have not been successful, and there has been a long-awaited demand for infant foods that improve the stool color of infants.
【0015】本発明は、以上のとおりの従来技術に鑑み
てなされたものであって、従来の実質的に牛乳蛋白質及
び/又はその加工物を唯一の蛋白質源とする乳幼児用乳
糖含有食品組成物を摂取した乳幼児に認められた緑色便
がなく、乳幼児栄養にもより適当した乳幼児用乳糖含有
食品組成物を提供することを目的としている。The present invention has been made in view of the above-mentioned prior art, and is a lactose-containing food composition for infants which uses a conventional protein of substantially milk protein and / or a processed product thereof as the sole protein source. An object of the present invention is to provide a lactose-containing food composition for infants, which does not have green stool recognized by infants who have taken stomach, and is more suitable for infant nutrition.
【0016】[0016]
【課題を解決するための手段】本発明は、前記の課題を
解決するものとして、乳幼児の便の色調を母乳摂取時と
同様の色調に改善する乳幼児用乳糖含有食品組成物であ
って、乳幼児に投与し得る状態に調整した実質的に牛乳
蛋白質及び/又は牛乳蛋白質加工物を唯一の蛋白質源と
する乳幼児用乳糖含有食品に、有効成分として少なくと
も0.625%(重量)の割合で大豆オリゴ糖が含有さ
れていることを特徴とする乳幼児用乳糖含有食品組成物
を提供する。DISCLOSURE OF THE INVENTION The present invention provides a lactose-containing food composition for infants which improves the color tone of stool of infants to the same color as when breast milk is taken. A milk protein containing milk protein and / or a processed milk protein product as the sole protein source, which has been prepared so that it can be administered to a lactose-containing food for infants, at least 0.625% (by weight) as an active ingredient Provided is a lactose-containing food composition for infants, characterized by containing sugar.
【0017】また、本発明の乳幼児用乳糖含有食品組成
物においては、大豆オリゴ糖が、1.25〜2.5%
(重量)の割合で含有されていること、及び乳幼児用乳
糖含有食品が、育児用調製粉乳、ペプチド・ミルク、未
熟児用ミルク又はフォローアップミルクであることを望
ましい態様としてもいる。Further, in the lactose-containing food composition for infants of the present invention, the soybean oligosaccharide is contained in an amount of 1.25 to 2.5%.
In another preferred embodiment, the milk-containing food for infants is a milk powder for infants, peptide milk, milk for premature babies or follow-up milk.
【0018】本発明者は、乳幼児の便の色調を改善する
ための食品について鋭意研究を行った結果、大豆オリゴ
糖を、実質的に牛乳蛋白質又はその加工物を唯一の蛋白
質源とする乳幼児用乳糖含有食品組成物に配合すること
により、従来の乳幼児用食品組成物に比較して便の色調
を著しく改善し得ることを見い出した。即ち、大豆オリ
ゴ糖を配合し、実質的に牛乳蛋白質又はその加工物を唯
一の蛋白質源とする乳幼児用乳糖含有食品組成物を摂取
した乳幼児の便の色調は、直ちに黄金色ともいえる黄色
になることを見い出し、本発明を完成させた。The present inventor has conducted intensive studies on foods for improving the color of stool of infants, and as a result, it has been found that soybean oligosaccharides are used for infants containing substantially only milk protein or a processed product thereof as a sole protein source. It has been found that by adding the composition to a lactose-containing food composition, the stool color tone can be remarkably improved as compared with the conventional food composition for infants. That is, the color of the stool of an infant who ingested a lactose-containing food composition for infants containing soybean oligosaccharide and substantially using milk protein or a processed product thereof as the sole protein source immediately becomes yellow, which can be said to be golden. That is, the present invention has been completed.
【0019】[0019]
【発明の実施の形態】以下、本発明の実施の形態につい
て詳しく説明する。尚、以下の説明において、百分率の
表示は、便の色調が改善される比率を示した値を除き、
重量による値である。Embodiments of the present invention will be described below in detail. Note that, in the following description, the percentages are displayed except for the value indicating the ratio at which the color tone of the stool is improved.
It is a value by weight.
【0020】本発明において使用する乳幼児用乳糖含有
食品は、母乳代替品として乳幼児期に使用される育児用
調製粉乳、離乳期以降に使用されるフォローアップミル
ク、アレルギー性体質の乳幼児に使用されるペプチドミ
ルク、出生時の体重が標準よりも低い乳児に使用される
未熟児用ミルク等の種々のミルクの総称であり、これら
のミルクに含有される糖質の少なくとも50%が乳糖か
らなっている。The lactose-containing food for infants used in the present invention is used for infant formula used as an alternative to mother's milk in infants, follow-up milk used after weaning, and infants with allergic constitution. A generic term for various milks such as peptide milk and milk for premature babies used for infants whose birth weight is lower than the standard, and at least 50% of the carbohydrate contained in these milks is composed of lactose. .
【0021】即ち、これらの乳幼児用乳糖含有食品は、
カゼイン、乳清、これらの混合物(例えば、全脂粉乳、
脱脂粉乳等)等の乳蛋白質、これらの精製物(例えば、
乳清蛋白濃縮物等)、これらの加水分解物等の乳蛋白質
加工物又は乳蛋白質と乳蛋白質加工物との混合物を実質
的に唯一の蛋白質源としており、大豆蛋白質等の他の蛋
白質を実質的に含有していない。That is, these lactose-containing foods for infants are:
Casein, whey, mixtures thereof (eg, whole milk powder,
Milk proteins such as skim milk powder, etc., and purified products thereof (for example,
Milk protein processed products such as whey protein concentrates) and hydrolysates thereof, or a mixture of milk protein and processed milk protein is used as the substantially sole protein source, and other proteins such as soy protein are substantially used as sources. Not contained
【0022】本発明において使用する大豆オリゴ糖は、
市販品(例えば、ソーヤ・オリゴ・ジャパン社販売
等)、常法により大豆ホエーから製造されたもののいず
れにあっても使用することができる。前記のとおり大豆
オリゴ糖には、難消化性の三糖類であるラフィノース及
び四糖類のスタキオースが約32%含有されており、シ
ョ糖、ブドウ糖及び果糖が55%、その他の糖類が13
%、それぞれ含有されている。The soybean oligosaccharide used in the present invention comprises:
Any of commercially available products (for example, sold by Saoya Oligo Japan Co., Ltd.) and those manufactured from soybean whey by a conventional method can be used. As described above, soybean oligosaccharide contains about 32% of raffinose and tetrasaccharide stachyose, which are indigestible trisaccharides, 55% of sucrose, glucose and fructose, and 13% of other saccharides.
%, Respectively.
【0023】大豆オリゴ糖は、母乳中には含まれていな
いが、前記のとおり大豆乳中にオリゴ糖としてラフィノ
ース及びスタキオースが一定量含まれており、大豆乳を
ベースにした乳幼児用食品として乳児栄養上かなり長期
間の使用経験があり、前記のとおり構成糖の内容を勘案
しても乳児栄養上も全く問題がないことは明らかであ
る。また、大豆オリゴ糖は、難消化性であることから、
炭水化物としてのエネルギー効率は、乳糖に比較して低
いことが知られているが、乳幼児用乳糖含有食品に配
合、添加するうえで問題はなく、通常少なくとも0.6
25%、望ましくは1.25〜2.5%、の割合で乳幼
児用乳糖含有食品に配合、添加する。Although soybean oligosaccharide is not contained in breast milk, as described above, soybean milk contains a certain amount of raffinose and stachyose as oligosaccharides and is used as an infant food based on soymilk. It has been used for quite a long time on nutrition, and it is clear that there is no problem in infant nutrition even if the content of constituent sugars is taken into account as described above. Also, because soy oligosaccharides are indigestible,
It is known that the energy efficiency as a carbohydrate is lower than that of lactose, but there is no problem in blending and adding to lactose-containing foods for infants, and usually at least 0.6%.
25%, desirably 1.25 to 2.5% is added to and added to lactose-containing food for infants.
【0024】しかしながら、ショ糖、果糖の配合、添加
が望ましくない場合には、これらの糖類を除去して添
加、配合することもできる。この場合、前記糖組成から
明らかなとおり、これらのオリゴ糖以外の糖類を除去す
れば、これらのオリゴ糖の濃度は、約3倍になるので、
添加量又は配合量は、前記の約1/3、即ち、少なくと
も0.2%、望ましくは0.4〜0.8%、となる。However, when it is not desirable to mix and add sucrose and fructose, these sugars can be removed and added. In this case, as is clear from the saccharide composition, if saccharides other than these oligosaccharides are removed, the concentration of these oligosaccharides becomes about three times,
The amount added or blended is about 1/3 of the above, that is, at least 0.2%, preferably 0.4 to 0.8%.
【0025】本発明の乳幼児用乳糖含有食品組成物は、
実質的に牛乳蛋白質及び/又はその加工物を唯一の蛋白
質源とすること、並びに所定量の大豆オリゴ糖を配合す
ること以外は、常法により製造することができる。即
ち、乳幼児用乳糖含有食品組成物として必要な他の諸原
料とともに、所定量の大豆オリゴ糖を水に溶解し、常法
により製造することもでき、所定量の大豆オリゴ糖粉末
を乳幼児用乳糖含有食品組成物として必要な他の諸原料
粉末に常法により粉末混合することもできるので、製造
において追加又は繁雑な工程を必要とせず、極めて容易
に製造することができる。The lactose-containing food composition for infants of the present invention comprises:
It can be produced by a conventional method except that substantially the only protein source is milk protein and / or a processed product thereof, and a predetermined amount of soybean oligosaccharide is blended. That is, a predetermined amount of soybean oligosaccharide powder can be prepared by dissolving a predetermined amount of soybean oligosaccharide in water, together with other raw materials necessary for a lactose-containing food composition for infants, and a predetermined amount of soybean oligosaccharide powder. The powder can be mixed with other raw material powders necessary for the contained food composition by a conventional method, so that it can be produced very easily without requiring additional or complicated steps in production.
【0026】本発明の乳幼児用乳糖含有食品組成物は、
液状又は粉状であり、液状の製品の場合は、所定温度に
加温してそのまま乳幼児に投与することができ、粉状の
製品の場合は所定温度の温水に所定濃度で溶解し(得ら
れた液が調乳液である)、乳幼児に投与することがで
き、従来の乳幼児用食品組成物の投与方法と何ら変わり
なく投与し得る。The lactose-containing food composition for infants of the present invention comprises:
It is liquid or powdery, and in the case of a liquid product, it can be heated to a predetermined temperature and administered to infants as it is. In the case of a powdery product, it can be dissolved at a predetermined concentration in warm water at a predetermined temperature (obtained. The liquid composition is a milky lotion), and can be administered to infants, and can be administered in the same manner as conventional administration methods of infant food compositions.
【0027】次に試験例を示して本発明の作用効果を詳
しく説明する。Next, the operation and effect of the present invention will be described in detail with reference to test examples.
【0028】試験例 この試験は、牛乳蛋白質又はその加工物が唯一の蛋白質
源であり、乳糖を主たる糖質とする各種乳幼児用乳糖含
有食品に対する大豆オリゴ糖の添加量が、乳幼児の便の
色調に与える影響を調べるために行った。Test Example In this test, milk protein or its processed product was the only protein source, and the amount of soybean oligosaccharide added to various lactose-containing foods for infants containing lactose as the main sugar was determined by the color tone of infant stool. Was conducted to investigate the effect on
【0029】1)試料の調製 表1に示す割合(表1の大豆オリゴ糖添加量200〜2
500mg/100mlの欄)で大豆オリゴ糖(ソーヤ
・オリゴ・ジャパン社販売)を添加したことを除き、実
施例1乃至実施例4及び参考例と同一の方法により製造
した育児用調製粉乳、ペプチドミルク、未熟児用ミル
ク、フォローアップミルク及び乳糖無添加ミルク(対
照)を調製した。1) Preparation of Samples The ratios shown in Table 1 (the amount of soybean oligosaccharide added in Table 1 was 200 to 2)
Except that soybean oligosaccharide (Soya Oligo Japan Co., Ltd.) was added at 500 mg / 100 ml column, infant formula and milk powder produced by the same method as in Examples 1 to 4 and Reference Example. And milk for premature babies, follow-up milk and milk without lactose (control) were prepared.
【0030】一方、大豆オリゴ糖を添加しないことを除
き、実施例1乃至実施例4及び参考例と同一の方法によ
り製造した育児用調製粉乳、ペプチドミルク、未熟児用
ミルク、フォローアップミルク及び乳糖無添加ミルクを
調製し、対照試料とした(表1の大豆オリゴ糖添加量0
mg/100mlの欄)。On the other hand, except that no soybean oligosaccharide is added, infant formula, peptide milk, premature infant milk, follow-up milk and lactose prepared by the same method as in Examples 1 to 4 and Reference Example. A non-added milk was prepared and used as a control sample (soybean oligosaccharide addition amount 0 in Table 1).
mg / 100 ml column).
【0031】2)試験方法 各試料を所定の濃度で溶解して調乳し、各群30人の乳
幼児に継続的に哺乳又は摂取させ、試験開始3日後から
3日間の便を採取し、その色調を男女5人が肉眼で観察
し、便の色調が黄色を示した乳幼児の人数を確認して大
豆オリゴ糖の添加効果を試験した。2) Test Method Each sample was dissolved at a predetermined concentration to prepare a milk, and 30 infants in each group were continuously fed or ingested. Three days after the start of the test, stool was collected for 3 days. The color tone was visually observed by five men and women, and the number of infants whose stool color tone was yellow was confirmed to test the effect of adding soybean oligosaccharide.
【0032】尚、各群の乳幼児の構成は、男女15人、
育児用調製粉乳について2〜4か月齢、ペプチドミルク
について2〜4か月齢、未熟児用ミルクについて2〜4
か月齢、フォローアップミルクについて6〜8か月齢、
乳糖無添加ミルクについて2〜4か月齢である。In addition, the composition of the infants in each group is 15 men and women,
2-4 months old for infant formula, 2-4 months for peptide milk, 2-4 months for premature infant milk
6 months old, 6-8 months old for follow-up milk,
2-4 months old for milk without lactose.
【0033】3)試験結果 この試験の結果は、表1に示すとおりである。表1から
明らかなとおり、大豆オリゴ糖による便の色調改善効果
は、乳幼児用乳糖含有食品組成物の種類によって若干相
違するが、対照(乳糖無添加ミルク)を除き、摂取又は
哺乳可能な状態の食品(調乳液)に大豆オリゴ糖が少な
くとも625mg/100ml(0.625%)の割合
で添加された試料では、乳幼児の便の色調が黄色に改善
される比率が50%以上に増加し、大豆オリゴ糖が12
50mg/100ml(1.25%)の割合で添加され
た試料では、乳幼児の便の色調が黄色に改善される比率
が60〜80%に、大豆オリゴ糖が2500mg/10
0ml(2.5%)の割合で添加された試料では、乳幼
児の便の色調が黄色に改善される比率が70〜90%
に、それぞれ増加することが認められた。3) Test results The results of this test are as shown in Table 1. As is evident from Table 1, the effect of improving the color tone of stool by soybean oligosaccharides slightly differs depending on the type of lactose-containing food composition for infants, except for the control (milk without added lactose). In the sample in which the soybean oligosaccharide was added to the food (milk preparation) at a rate of at least 625 mg / 100 ml (0.625%), the ratio of improving the color tone of infant stool to yellow increased to 50% or more, 12 oligosaccharides
In the sample added at a rate of 50 mg / 100 ml (1.25%), the ratio of improving the color tone of infant stool to yellow is 60 to 80%, and the content of soybean oligosaccharide is 2500 mg / 10
In the sample added at a rate of 0 ml (2.5%), the rate at which the color of stool of infants is improved to yellow is 70 to 90%.
It was found that each increased.
【0034】しかしながら、牛乳蛋白質又はその加工物
を唯一の蛋白質源とするが、乳糖を含有しない乳糖無添
加ミルクの場合は、大豆オリゴ糖の添加量の如何にかか
わらず、乳幼児の便の色調が黄色に改善される比率の増
加が認められなかった。However, milk protein or a processed product thereof is used as the sole protein source. However, in the case of lactose-free milk containing no lactose, the color of the stool of infants and infants is independent of the amount of added soybean oligosaccharide. No increase in the percentage improved to yellow was noted.
【0035】このことは、本発明の乳幼児用乳糖含有食
品による乳幼児の便の色調改善効果が、大豆オリゴ糖単
独の効果として達成されるものではなく、乳幼児用乳糖
含有食品が牛乳蛋白質又はその加工物を唯一の蛋白質源
とし、かつ乳糖を主たる糖質とする各種乳幼児用乳糖含
有食品であることを必須の要件とすることを示す結果で
あった。また、このことは大豆オリゴ糖が含まれている
にもかかわらず、牛乳蛋白質及び乳糖を全く含有しない
大豆乳では、これを哺乳した乳児の便が緑色になる頻度
が高くなる前記の報告[ペディアトリックス(Pediatric
s)、第95巻、第50頁、1995年]とも一致してい
るのである。This means that the effect of improving the color tone of infant stool by the lactose-containing food for infants of the present invention is not achieved as the effect of soybean oligosaccharide alone, but that the lactose-containing food for infants is milk protein or processed protein thereof. The results show that the essential requirement is that the lactose-containing foods for infants and infants have lactose as the sole protein source and lactose as the main sugar. In addition, this fact suggests that in spite of containing soybean oligosaccharide, soymilk containing no milk protein or lactose has a higher frequency of stool of infants who feed it with green color [pedia] Trix (Pediatric
s), Vol. 95, p. 50, 1995].
【0036】以上の結果から、牛乳蛋白質又はその加工
物を唯一の蛋白質源とし、かつ乳糖を含有する乳幼児用
乳糖含有食品では、わずか0.625%の大豆オリゴ糖
の添加により50%以上の乳幼児の便の色調が改善され
ることが明らかであり、従来の技術では達成できなかっ
た顕著な効果である。From the above results, in the case of lactose-containing food for infants containing milk protein or a processed product thereof as the sole protein source and containing lactose, only 0.625% of soybean oligosaccharide is added, and 50% or more of infants are added. It is clear that the color of the stool is improved, a remarkable effect that cannot be achieved by the conventional technology.
【0037】尚、大豆オリゴ糖の添加量が2.5%を超
える試料についても同様に試験を行ったが、2.5%の
割合で添加された試料と比較して、顕著な便の色調の改
善は認められなかった。また、乳幼児用乳糖含有食品の
種類及び製造法を変更して試験したが、ほぼ同様な結果
が得られた。The same test was carried out for a sample containing more than 2.5% of the soybean oligosaccharide, but the color tone of the stool was remarkable as compared with the sample added at a ratio of 2.5%. No improvement was observed. In addition, tests were conducted by changing the type and production method of lactose-containing foods for infants, and almost the same results were obtained.
【0038】[0038]
【表1】 参考例 市販カゼイン(日本プロテイン社製)13.5kg、調
整脂肪(日本油脂社製)20.8kg、可溶性多糖類
(昭和産業社製)59.0kg、ビタミン混合物(田辺
製薬社製)23g、ミネラル混合物(富田製薬社製)5
50g及び大豆オリゴ糖(ソーヤ・オリゴ・ジャパン社
販売)6.1kgを、水200lに添加し、標準化し、
調乳液を均質化し、121℃で2秒間殺菌し、次いで殺
菌した調乳液を濃縮し、噴霧乾燥し、粉末状の乳糖無添
加ミルク約97kgを得た。[Table 1] Reference example 13.5 kg of commercially available casein (manufactured by Nippon Protein), 20.8 kg of adjusted fat (manufactured by Nippon Oil & Fats), 59.0 kg of soluble polysaccharide (manufactured by Showa Sangyo), 23 g of vitamin mixture (manufactured by Tanabe Seiyaku), mineral Mixture (Tomita Pharmaceutical) 5
50 g and 6.1 kg of soybean oligosaccharide (sold by Saoya Oligo Japan) are added to 200 l of water, standardized,
The milk preparation was homogenized and sterilized at 121 ° C. for 2 seconds, and then the sterilized milk preparation was concentrated and spray-dried to obtain about 97 kg of powdery lactose-free milk.
【0039】次に実施例を示して本発明を更に詳しく説
明するが、本発明は以下の例に限定されるものではな
い。Next, the present invention will be described in more detail with reference to examples, but the present invention is not limited to the following examples.
【0040】[0040]
実施例1 市販の乳清粉末(ドモ社製)4.3kgを水道水38.
7lに溶解し、1規定の水酸化ナトリウムによりpHを
8.0に調整し、市販のトリプシン(ノボノルディスク
バイオインダストリー社製)17.2gを添加し、37
℃で12時間加水分解し、のち80℃で10分間加熱し
て酵素を失活させ、室温に冷却し、連続遠心分離により
沈殿物を除去し、透明な上清液を得た。得られた上清液
を30%に濃縮し、噴霧乾燥し、分解度約50%の粉末
状乳清蛋白質加水分解物約3.6kgを得た。Example 1 4.3 kg of commercially available whey powder (manufactured by Domo) was added to tap water.
The solution was dissolved in 7 L, the pH was adjusted to 8.0 with 1 N sodium hydroxide, and 17.2 g of commercially available trypsin (manufactured by Novo Nordisk Bioindustry) was added.
The enzyme was inactivated by heating at 80 ° C for 10 minutes, cooled to room temperature, and the precipitate was removed by continuous centrifugation to obtain a clear supernatant liquid. The obtained supernatant was concentrated to 30% and spray-dried to obtain about 3.6 kg of a powdery whey protein hydrolyzate having a decomposition degree of about 50%.
【0041】原料乳200kgに、前記加水分解物3.
6kg、脱塩乳清粉末(ドモ社製)2.8kg、調整脂
肪(日本油脂社製)25.65kg、乳糖(メグレ社
製)39.6kg、ビタミン混合物(田辺製薬社製)2
2g、ミネラル混合物(富田製薬社製)550g及び大
豆オリゴ糖(ソーヤ・オリゴ・ジャパン社販売)4.5
kgを添加し、標準化し、調乳液を均質化し、121℃
で2秒間殺菌し、次いで殺菌した調乳液を濃縮し、噴霧
乾燥し、育児用調製粉乳約90kgを得た。The above hydrolyzate was added to 200 kg of raw milk.
6 kg, desalted whey powder (manufactured by Domo) 2.8 kg, adjusted fat (manufactured by NOF Corporation) 25.65 kg, lactose (manufactured by Megre) 39.6 kg, vitamin mixture (manufactured by Tanabe Seiyaku) 2
2 g, 550 g of a mineral mixture (manufactured by Tomita Pharmaceutical Co., Ltd.) and 4.5 of soybean oligosaccharides (sold by Saoya Oligo Japan)
kg, standardize, homogenize the formula,
And then sterilized milk concentrate was concentrated and spray-dried to obtain about 90 kg of infant formula powder.
【0042】この育児用調製粉乳の13%調乳液100
mlには、625mgの大豆オリゴ糖が含有されてお
り、この調乳液を生後1〜5か月の乳児に哺乳させ、試
験例と同一の方法により試験した結果、便の色調は2日
以内に黄色乃至黄緑色に改善された。A 13% formula of the infant formula 100
Each ml contains 625 mg of soybean oligosaccharide, and this milk preparation is fed to an infant of 1 to 5 months of age, and tested according to the same method as in the test example. Improved from yellow to yellow-green.
【0043】実施例2 市販乳清粉末(ドモ社製)47kgを水道水450lに
溶解し、1規定の水酸化ナトリウムでpHを8.0に調
整し、市販のトリプシン(ノボノルディスクバイオイン
ダストリー社製)190gを添加し、37℃で12時間
加水分解し、のち80℃で10分間加熱して酵素を失活
させ、室温に冷却し、連続遠心分離により沈殿物を除去
し、透明な上清液を得た。得られた上清液を30%に濃
縮し、噴霧乾燥し、分解度約50%の乳清蛋白質加水分
解物約40kgを得た。Example 2 47 kg of commercial whey powder (manufactured by Domo) was dissolved in 450 liters of tap water, the pH was adjusted to 8.0 with 1N sodium hydroxide, and commercially available trypsin (Novo Nordisk Bioindustry) 190 g), hydrolyze at 37 ° C. for 12 hours, heat at 80 ° C. for 10 minutes to inactivate the enzyme, cool to room temperature, remove the precipitate by continuous centrifugation, and remove the clear supernatant. A liquid was obtained. The obtained supernatant was concentrated to 30% and spray-dried to obtain about 40 kg of a whey protein hydrolyzate having a decomposition degree of about 50%.
【0044】市販カゼイン(日本プロテイン社製)10
kgを、10%の水酸化ナトリウム溶液でpH7.3に
調整した温水に溶解し、18%濃度のカゼイン溶液を調
製し、常法により加熱殺菌し、室温に放冷し、10%水
酸化ナトリウムでpHを9.0に調整し、市販のパパイ
ン(天野製薬社製)100gとパンクレアチンF(天野
製薬社製)100gを添加し、45℃で16時間加水分
解し、90℃で10分間加熱して酵素を失活させ、室温
に冷却し、セライト瀘過により沈殿物を除去し、透明な
瀘過液を濃縮し、噴霧乾燥し、カゼイン加水分解物約7
kgを得た。Commercial casein (manufactured by Nippon Protein Co., Ltd.) 10
kg was dissolved in warm water adjusted to pH 7.3 with a 10% sodium hydroxide solution to prepare an 18% concentration casein solution, sterilized by heating by a conventional method, allowed to cool to room temperature, and cooled to 10% sodium hydroxide. PH was adjusted to 9.0, and 100 g of commercially available papain (manufactured by Amano Pharmaceutical Co.) and 100 g of pancreatin F (manufactured by Amano Pharmaceutical Co.) were added. The mixture was hydrolyzed at 45 ° C. for 16 hours, and heated at 90 ° C. for 10 minutes. To inactivate the enzyme, cool to room temperature, remove the precipitate by filtration through celite, concentrate the clear filtrate, spray dry and remove about 7 parts of casein hydrolyzate.
kg.
【0045】前記乳清蛋白質加水分解物40kg、カゼ
イン加水分解物7kg、精製乳糖(メグレ社製)36.
3kg及び可溶性多糖類(昭和産業社製)11.5kg
を精製水300lに溶解し、調整脂肪(日本油脂社製)
40kg、ビタミン混合物(田辺製薬社製)35g、ミ
ネラル混合物(富田製薬社製)920g及び大豆オリゴ
糖(ソーヤ・オリゴ・ジャパン社販売)14kgを混合
溶解し、均質化し、120℃で2秒間殺菌し、濃縮し、
噴霧乾燥し、粉末状のペプチドミルク約145kgを得
た。40 kg of the whey protein hydrolyzate, 7 kg of casein hydrolyzate, and purified lactose (from Megre)
3 kg and soluble polysaccharide (Showa Sangyo Co., Ltd.) 11.5 kg
Is dissolved in 300 liters of purified water and adjusted fat (manufactured by NOF Corporation)
40 kg, 35 g of a vitamin mixture (manufactured by Tanabe Seiyaku Co., Ltd.), 920 g of a mineral mixture (manufactured by Tomita Pharmaceutical Co., Ltd.) and 14 kg of soybean oligosaccharide (sold by Saoya Oligo Japan) are dissolved and homogenized, and sterilized at 120 ° C. for 2 seconds. , Concentrate,
By spray drying, about 145 kg of powdered peptide milk was obtained.
【0046】このペプチドミルクに含まれる乳蛋白質は
全てが酵素分解されており、13%調乳液100ml当
り1250mgの大豆オリゴ糖が含有されていた。All of the milk proteins contained in the peptide milk were enzymatically degraded, and contained 1250 mg of soybean oligosaccharide per 100 ml of 13% milk preparation.
【0047】この調乳液を生後1〜5か月の乳児に哺乳
させ、試験例と同一の方法により試験した結果、便の色
調は2日以内に黄色乃至黄緑色に改善された。The milk preparation was fed to an infant of 1 to 5 months of age and tested by the same method as in the test example. As a result, the color of the stool was improved from yellow to yellowish green within 2 days.
【0048】実施例3 原料乳200kgに、脱塩乳清粉末(ドモ社製)7.5
kg、市販カゼイン(日本プロテイン社製)2.1k
g、調整脂肪(日本油脂社製)12.5kg、乳糖(メ
グレ社製)27.8kg、可溶性多糖類(昭和産業社
製)7.0kg、ビタミン混合物(田辺製薬社製)22
g、ミネラル混合物(富田製薬社製)840g及び大豆
オリゴ糖(ソーヤ・オリゴ・ジャパン社販売)9.7k
gを添加し、標準化し、調乳液を均質化し、121℃で
2秒間殺菌し、次いで殺菌した調乳液を濃縮し、噴霧乾
燥し、粉末状の未熟児用ミルク約90kgを得た。Example 3 Desalted whey powder (manufactured by Domo) 7.5 in 200 kg of raw milk
kg, commercially available casein (Nippon Protein Co., Ltd.) 2.1 k
g, adjusted fat (Nippon Oil & Fats Co., Ltd.) 12.5 kg, lactose (Megure Co., Ltd.) 27.8 kg, soluble polysaccharide (Showa Sangyo Co., Ltd.) 7.0 kg, vitamin mixture (Tanabe Seiyaku Co., Ltd.) 22
g, mineral mixture (manufactured by Tomita Pharmaceutical Co., Ltd.) 840 g and soybean oligosaccharide (sold by Saoya Oligo Japan) 9.7 k
g, standardized, homogenized the formula, sterilized at 121 ° C. for 2 seconds, and then concentrated and spray-dried to obtain about 90 kg of powdered premature infant milk.
【0049】この未熟児用ミルクの14%調乳液100
ml当り1500mgの大豆オリゴ糖が含有されてい
た。この調乳液を体重1500〜2400gの未熟児に
哺乳させ、試験例と同一の方法により試験した結果、便
の色調は2日以内に黄色乃至は黄緑色に改善された。A 14% milk preparation 100 of this premature infant milk
It contained 1500 mg of soy oligosaccharide per ml. This milk preparation was fed to a premature infant weighing 1500 to 2400 g and tested in the same manner as in the test example. As a result, the color of the stool was improved to yellow or yellowish green within 2 days.
【0050】実施例4 原料乳200kgに、脱塩乳清粉末(ドモ社製)7.5
kg、市販カゼイン(日本プロテイン社製)2.1k
g、調整脂肪(日本油脂社製)12.5kg、乳糖(メ
グレ社製)27.8kg、可溶性多糖類(昭和産業社
製)10.0kg、ビタミン混合物(田辺製薬社製)2
2g、ミネラル混合物(富田製薬社製)840g及び大
豆オリゴ糖(ソーヤ・オリゴ・ジャパン社販売)6.5
kgを添加し、標準化し、調乳液を均質化し、121℃
で2秒間殺菌し、次いで殺菌した調乳液を濃縮し、噴霧
乾燥し、粉末状のフォローアップミルク約90kgを得
た。Example 4 Desalted whey powder (manufactured by Domo) 7.5 in 200 kg of raw milk
kg, commercially available casein (Nippon Protein Co., Ltd.) 2.1 k
g, adjusted fat (manufactured by NOF Corporation) 12.5 kg, lactose (manufactured by Megre) 27.8 kg, soluble polysaccharide (manufactured by Showa Sangyo) 10.0 kg, vitamin mixture (manufactured by Tanabe Seiyaku) 2
2 g, 840 g of a mineral mixture (manufactured by Tomita Pharmaceutical Co., Ltd.) and 6.5 of soybean oligosaccharide (sold by Saoya Oligo Japan)
kg, standardize, homogenize the formula,
For 2 seconds, and then the pasteurized liquid was concentrated and spray-dried to obtain about 90 kg of powdery follow-up milk.
【0051】このフォローアップミルクの14%調乳液
100ml当り1000mgの大豆オリゴ糖が含有され
ていた。この調乳液を生後6〜10か月の乳児に哺乳さ
せ、試験例と同一の方法により試験した結果、便の色調
が2日以内に黄色に改善された。The follow-up milk contained 1000 mg of soybean oligosaccharide per 100 ml of 14% milk preparation. This milk preparation was fed to a 6 to 10 month old infant and tested by the same method as in the test example. As a result, the color of the stool was improved to yellow within 2 days.
【0052】[0052]
【発明の効果】以上詳しく説明したとおり、本発明は、
乳幼児に投与し得る状態に調整した実質的に牛乳蛋白質
及び/又は牛乳蛋白質加工物を唯一の蛋白質源とする乳
幼児用乳糖含有食品に、有効成分として少なくとも0.
625%(重量)の割合で大豆オリゴ糖が含有されてい
る乳幼児用乳糖含有食品組成物であり、本発明によって
次のとおりの効果が奏せられる。 1)本発明の乳幼児用乳糖含有食品組成物を哺乳又は摂
取した乳幼児の便の色調は、母乳栄養児のそれと同様の
黄色便になるため、母親の育児不安を解消することが可
能である。 2)本発明の乳幼児用乳糖含有食品組成物は、乳幼児の
発育に何ら支障がない。 3)本発明の乳幼児用乳糖含有食品組成物は、追加又は
複雑な工程を必要とせず、従来の製造法と同様に、容易
に製造することができる。As described in detail above, the present invention provides:
A lactose-containing food for infants containing substantially only milk protein and / or processed milk protein prepared in a state ready for administration to infants, containing at least 0.1% as an active ingredient.
It is a lactose-containing food composition for infants containing soybean oligosaccharide at a ratio of 625% (weight). The present invention has the following effects. 1) Since the color tone of the stool of the infant who has fed or ingested the lactose-containing food composition for infants of the present invention becomes yellow stool similar to that of the breastfeeding infant, it is possible to eliminate the mother's anxiety about child care. 2) The lactose-containing food composition for infants of the present invention does not hinder the growth of infants at all. 3) The lactose-containing food composition for infants of the present invention does not require additional or complicated steps, and can be easily produced as in the conventional production method.
Claims (3)
色調に改善する乳幼児用乳糖含有食品組成物であって、
乳幼児に投与し得る状態に調整した実質的に牛乳蛋白質
及び/又は牛乳蛋白質加工物を唯一の蛋白質源とする乳
幼児用乳糖含有食品に、有効成分として少なくとも0.
625%(重量)の割合で大豆オリゴ糖が含有されてい
ることを特徴とする乳幼児用乳糖含有食品組成物。1. A lactose-containing food composition for infants, which improves the color tone of infant stool to the same color tone as when breast milk is taken,
A lactose-containing food for infants containing substantially only milk protein and / or processed milk protein prepared in a state ready for administration to infants, containing at least 0.1% as an active ingredient.
A lactose-containing food composition for infants, which comprises 625% (by weight) of soybean oligosaccharide.
(重量)の割合で含有されている請求項1の乳幼児用乳
糖含有食品組成物。2. The soybean oligosaccharide is 1.25-2.5%
The lactose-containing food composition for infants according to claim 1, which is contained in a ratio of (weight).
チドミルク、未熟児用ミルク又はフォローアップミルク
である請求項1又は請求項2の乳幼児用乳糖含有食品組
成物。3. The lactose-containing food composition for infants according to claim 1, wherein the infant food is infant formula, peptide milk, premature infant milk or follow-up milk.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8191341A JPH1014493A (en) | 1996-07-02 | 1996-07-02 | Lactose-containing food composition for baby |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8191341A JPH1014493A (en) | 1996-07-02 | 1996-07-02 | Lactose-containing food composition for baby |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH1014493A true JPH1014493A (en) | 1998-01-20 |
Family
ID=16272960
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8191341A Pending JPH1014493A (en) | 1996-07-02 | 1996-07-02 | Lactose-containing food composition for baby |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH1014493A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0853890A4 (en) * | 1995-09-29 | 1999-01-20 | Morinaga Milk Industry Co Ltd | Lactose-containing food composition for infants |
JP2007097465A (en) * | 2005-10-04 | 2007-04-19 | Calpis Co Ltd | Peptide-containing food and drink reduced in bitter taste and astringency, and method for producing the same |
JP2007320946A (en) * | 2006-06-05 | 2007-12-13 | Advance Co Ltd | Composition for ameliorating intestinal flora |
-
1996
- 1996-07-02 JP JP8191341A patent/JPH1014493A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0853890A4 (en) * | 1995-09-29 | 1999-01-20 | Morinaga Milk Industry Co Ltd | Lactose-containing food composition for infants |
JP2007097465A (en) * | 2005-10-04 | 2007-04-19 | Calpis Co Ltd | Peptide-containing food and drink reduced in bitter taste and astringency, and method for producing the same |
JP2007320946A (en) * | 2006-06-05 | 2007-12-13 | Advance Co Ltd | Composition for ameliorating intestinal flora |
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