JPH10108893A - Multi-chamber medical container for continuous mixing - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a medical container for continuous mixing capable of simply mixing and administering multiple drugs without considering the aging blend change occurring after blending. SOLUTION: Multiple solution chambers 11, 12 capable of storing multiple solutions respectively are adjacently arranged, a mixing chamber 15 having a needle passing plug 15a is disposed on the lower side of multiple solution chambers 11, 12, and a moving plug 14 capable of communicating multiple solution chambers 11, 12 and the mixing chamber 15 to each other is disposed between them. A needle is inserted into the mixing chamber 15 through the needle passing plug 15a at the time of use, and the moving plug 14 is moved to discharge multiple solutions flowing into the mixing chamber 15 from multiple solution chambers 11, 12 through the needle.

Description

【発明の詳細な説明】DETAILED DESCRIPTION OF THE INVENTION

【０００１】[0001]

【発明の属する技術分野】本発明は、溶液の形で投与さ
れる医薬で、投与時に連続して複数の溶液を混合しなが
ら投与が可能な医療容器に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a medicine to be administered in the form of a solution, and to a medical container which can be administered while continuously mixing a plurality of solutions at the time of administration.

【０００２】[0002]

【従来の技術】注射剤は経口吸収が困難な薬剤や、投与
量を厳密に調整する必要のある薬剤、経口摂取が困難な
患者に対する投与剤形として医療において重要である。
医療の場において、複数の注射剤を併用したり、配合し
て用いることはその必要性から日常的に行われることで
ある。また、注射剤は通常、溶液や乳化製剤として液状
の形態をとるが、その溶液中での安定性が悪い薬剤や、
水に対する溶解度が不十分な薬剤の場合は、用時に溶解
したり、稀釈するために、複数の容器に充填した製剤も
ある。さらに、流通においてその取扱性を考慮して軽く
て小さな包装形態が好ましい場合や、その投与時の濃度
を患者や病態に応じて調整できるようにする場合は、用
時に稀釈できる濃厚溶液の注射剤とすることもある。2. Description of the Related Art Injectables are important in medicine as a drug which is difficult to absorb orally, a drug whose dosage needs to be strictly adjusted, or a dosage form for patients who have difficulty in oral ingestion.
In a medical setting, it is necessary to use a plurality of injections in combination or in combination with each other on a daily basis because of the necessity. Injectables are usually in the form of a liquid as a solution or an emulsified formulation, but drugs with poor stability in the solution,
In the case of drugs with insufficient water solubility, some preparations are filled in multiple containers to be dissolved or diluted at the time of use. Furthermore, in the case where a light and small package form is preferable in consideration of the handling property in distribution, or when the concentration at the time of administration can be adjusted according to the patient or disease state, an injection of a concentrated solution that can be diluted at the time of use Sometimes it is.

【０００３】これらの注射剤の用時の稀釈や多種の注射
液の配合は、成分それ自身や成分同士の相互作用により
結晶析出や化学的変化を受け、好ましくない場合もあ
る。これらの注射剤同士の配合禁忌、配合不適あるいは
配合注意等の問題は、医療現場において必要な薬剤を投
与困難にするばかりでなく、薬剤の配合を行う薬剤師や
医師、看護婦等の医療従事者にとり厄介な問題である。[0003] Dilution of these injections at the time of use and blending of various types of injection solutions are not preferable in some cases because they undergo crystallization or chemical changes due to the components themselves or the interaction between the components. These incompatibilities, incompatibility, and cautions in the formulation of injections not only make it difficult to administer the necessary drugs at the medical site, but also make them difficult to administer the required drugs. This is a troublesome problem.

【０００４】これらの問題の例として、中心静脈栄養法
における糖電解質輸液とアミノ酸輸液の例がある。これ
ら輸液は、中心静脈栄養法では必須の成分であり、両者
を投与することが必要であるが、糖とアミノ酸との間の
メイラード反応により両者を混合した輸液では長期の安
定性が保てないため、用時に無菌的に混合することが行
われ、病院薬剤師の重要な職務となっている。また、中
心静脈栄養法のカロリー源として脂肪乳剤は少ない輸液
量で必要なカロリーを投与できる長所があるが、電解質
を含む輸液との配合により、乳化した脂肪油滴が経時的
に大きくなるために他の輸液と配合することができな
い。さらに、中心静脈栄養法では、ビタミンや微量元素
も必須成分となるが、ビタミンのチアミン等はアミノ酸
輸液に含まれる安定化剤により配合後、急速に分解した
り、アスコルビン酸のように微量元素製剤に含まれる銅
イオンや鉄イオンにより不安定なものがあり、これらを
配合した中心静脈栄養輸液の調整後、速やかに使用を義
務付けられるものもある。このような薬液の調整後速や
かな使用が義務付けられると、在宅治療で使用すること
は困難となるため、在宅治療が望まれるにも係わらず普
及しない一要因ともなっている。[0004] As examples of these problems, there are examples of sugar electrolyte infusion and amino acid infusion in central parenteral nutrition. These infusions are essential components in central parenteral nutrition, and it is necessary to administer both, but long-term stability cannot be maintained with infusions that mix both due to the Maillard reaction between sugar and amino acids Therefore, aseptic mixing is performed at the time of use, which is an important duty of a hospital pharmacist. In addition, fat emulsion as a source of calories in central parenteral nutrition has the advantage of being able to administer the required calories in a small infusion volume, but the emulsified fat oil droplets increase over time due to the combination with the infusion solution containing electrolytes. Cannot be combined with other infusions. Furthermore, in central parenteral nutrition, vitamins and trace elements are also essential components, but vitamins such as thiamine are rapidly degraded after being formulated with stabilizers contained in amino acid infusions, or trace element preparations such as ascorbic acid are used. Some of these are unstable due to copper ions and iron ions contained therein, and some of them are required to be used promptly after adjusting a parenteral nutritional infusion containing these. If the immediate use after the adjustment of such a drug solution is obligated, it becomes difficult to use it in home treatment, which is one factor that does not spread even though home treatment is desired.

【０００５】これらの長期間の安定性を考慮して、配合
不適の薬液を２室に分離し、使用時に簡便にこれらの溶
液を分離している隔壁を取り除き、薬液を混合して用い
る方法が開発されている。しかしながら、この方法によ
っても投与時間が長時間に及ぶ場合は、混合後の均一化
した溶液中での分解が進んだり、結晶析出が起こるなど
の問題は解決されず、この方法の適用は、長期の安定性
を保ち、配合後の変化が薬剤調製から投与までの数時間
から数日の時間内では無視できるような配合変化の場合
に限られる欠点があった。In view of these long-term stability, a method of separating unsuitable chemical solutions into two chambers, removing the partition walls separating these solutions easily at the time of use, and mixing and using the chemical solutions is known. Is being developed. However, if the administration time is prolonged even by this method, problems such as the progress of decomposition in the homogenized solution after mixing and the occurrence of crystal precipitation cannot be solved. However, there is a disadvantage that the stability after the formulation is limited and the change after formulation is negligible within a few hours to several days from preparation of the drug to administration.

【０００６】[0006]

【発明が解決しようとする課題】これらの配合後に起こ
る経時的な配合変化を考慮せずに、複数の薬剤を簡便に
混合して投与可能な投与方法の開発が望まれていた。本
発明者は、種々検討の結果、２つ以上の複数の溶液を入
れることが可能な溶液室を有し、溶液を投与のために排
出する際の操作で複数の溶液成分が連続的に混合されな
がら排出される構造を有する医療容器の構造により、２
種以上の薬液を簡便に連続して混合しながら投与できる
ことを見出した。There has been a demand for the development of an administration method which can easily mix and administer a plurality of drugs without taking into account the change over time in the composition that occurs after these formulations. As a result of various studies, the present inventor has a solution chamber in which two or more solutions can be placed, and a plurality of solution components are continuously mixed by an operation for discharging the solution for administration. The structure of the medical container having a structure that is discharged while
It has been found that it is possible to administer more than one kind of medicinal solution while mixing them simply and continuously.

【０００７】本発明は配合後に起こる経時的な配合変化
を考慮せずに、複数の薬剤を簡便に混合して投与可能な
連続混合用医療容器を提供することを目的とする。[0007] It is an object of the present invention to provide a medical container for continuous mixing which can easily mix and administer a plurality of drugs without taking into account the change in the mixing over time that occurs after the mixing.

【０００８】[0008]

【課題を解決するための手段】上記目的を達成するため
に、本発明の連続混合用医療用容器は、２つ以上の複数
の溶液をそれぞれ収納可能とする複数の溶液室を隣接し
て設けるとともに、該複数の溶液室の下部側に通針用栓
を有する１つの混合室を設け、かつ前記複数の溶液室と
混合室との間にそれぞれを互いに連通可能とする可動式
栓を設け、使用時に針を前記通針用栓を通して混合室内
に通針し前記可動式栓を動かし前記複数の溶液室から混
合室へ流入する複数の溶液を前記針を通して排出するこ
とを特徴とするものである。針を通針用栓を通して混合
室内に通針し可動式栓を動かすことで、複数の溶液室か
ら混合室へ溶液が流入して連続的に混合し、その混合溶
液が針を通して排出され、輸液セット等には排出されて
患者に投与することが可能になる。混合される時間は混
合室と輸液セット等の内容量を点滴速度等で除した時間
に限られ、この混合時間では通常の輸液セットの容量で
は短時間になり配合変化を無視することができる。In order to achieve the above object, the medical container for continuous mixing according to the present invention is provided with a plurality of solution chambers adjacent to each other capable of storing two or more solutions. A single mixing chamber having a plug for passing a needle is provided on the lower side of the plurality of solution chambers, and a movable stopper is provided between the plurality of solution chambers and the mixing chamber so that they can communicate with each other. In use, a needle is passed through the needle passing plug into the mixing chamber, and the movable stopper is moved to discharge a plurality of solutions flowing from the plurality of solution chambers into the mixing chamber through the needle. . By moving the needle through the needle into the mixing chamber through the needle plug and moving the movable stopper, the solution flows from the plurality of solution chambers into the mixing chamber and is continuously mixed, and the mixed solution is discharged through the needle and discharged. The set is discharged and can be administered to the patient. The mixing time is limited to the time obtained by dividing the contents of the mixing chamber and the infusion set by the infusion rate and the like. In this mixing time, the capacity of the normal infusion set is short, and the change in the composition can be ignored.

【０００９】前記複数の溶液室は、必要に応じて水平方
向の断面積比が変化した形状に形成されていることでも
よく、これにより溶液の混合比率を変化させることがで
きる。前記可動式栓は、直線的に好ましくは上下に垂直
に移動する栓体または回転する栓体を有することが、種
々の連通形態を実現できる点で好ましく、また開閉が自
在であるものが好ましい。前記可動式栓は、前記輸液針
の通針操作に連動して動く構造を有することが、操作を
簡単にできる点で好ましい。前記複数の溶液室は、上部
に薬剤添加用口が設けられていることが、溶液室の溶液
の混合だけでなく、他の溶液を任意に添加できる点で好
ましい。前記薬剤添加用口には、粉末製剤容器からの粉
末溶解製剤液または溶液製剤容器からの溶液製剤が添加
されることが、粉末製剤や溶液製剤を添加できる点で好
ましい。The plurality of solution chambers may be formed in a shape in which the horizontal cross-sectional area ratio is changed as required, so that the mixing ratio of the solution can be changed. It is preferable that the movable stopper has a stopper that moves linearly, preferably vertically and vertically, or a stopper that rotates, in that various communication modes can be realized, and it is preferable that the stopper can be freely opened and closed. It is preferable that the movable stopper has a structure that moves in conjunction with the needle passing operation of the infusion needle in that the operation can be simplified. It is preferable that the plurality of solution chambers are provided with a drug addition port at an upper portion in that not only mixing of the solutions in the solution chambers but also other solutions can be arbitrarily added. It is preferable that a powder-dissolved formulation liquid from a powder formulation container or a solution formulation from a solution formulation container is added to the drug addition port, since a powder formulation or a solution formulation can be added.

【００１０】[0010]

【発明の実施の形態】以下、本発明を図示の実施形態に
より具体的に説明する。図１及び図２は本発明による第
１実施形態の医療容器の構成を模式的に示した断面図で
あり、図１は医療容器の通針前の状態を示す断面図、図
２は医療容器の通針後の状態を示す断面図である。DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail with reference to the illustrated embodiments. 1 and 2 are cross-sectional views schematically showing a configuration of a medical container according to a first embodiment of the present invention. FIG. 1 is a cross-sectional view showing a state of the medical container before passing a needle, and FIG. 2 is a medical container. It is sectional drawing which shows the state after needle passing.

【００１１】これらの図において、第１実施形態の医療
容器１０は、第１の溶液を収容可能とする第１の溶液室
１１と第２の溶液を収容可能とする第２の溶液室１２と
が隔壁１３を隔て隣接して設けられ、またこれら第１及
び第２の溶液室１１，１２の下部側に通針用栓１５ａを
有する混合室１５が設けられ、かつ第１及び第２の溶液
室１１，１２と混合室１５との間にそれぞれを互いの連
通可能とする可動式栓１４が設けられ、使用時に針とし
て例えば輸液針１を通針用栓１５ａを通して混合室１５
内に通針すると同時に可動式栓１４を輸液針１の先端部
で動かして開き、第１及び第２の溶液室１１，１２から
混合室１５へ流入する複数の溶液を連続的に混合しなが
ら輸液針１を通して排出するものである。In these figures, a medical container 10 according to the first embodiment has a first solution chamber 11 capable of storing a first solution and a second solution chamber 12 capable of storing a second solution. A mixing chamber 15 having a needle plug 15a is provided below the first and second solution chambers 11 and 12, and the first and second solution chambers are provided below the first and second solution chambers 11 and 12. A movable stopper 14 is provided between the chambers 11 and 12 and the mixing chamber 15 so that they can communicate with each other. In use, for example, the infusion needle 1 is passed through the needle stopper 15a as a needle.
At the same time as the needle is passed through, the movable stopper 14 is moved and opened at the tip of the infusion needle 1 to continuously mix the plurality of solutions flowing from the first and second solution chambers 11 and 12 into the mixing chamber 15. The liquid is discharged through the infusion needle 1.

【００１２】上記第１及び第２の溶液室１１，１２は、
この実施形態では水平方向の断面積が互いに同じ程度に
なるよう形成されており、また、その容器を構成する材
質は、通常の医療分野において使用されているガラス
材、プラスチック材及びこれらを組み合わせた材質が使
用可能であるが、溶液の排出とともに変形可能な柔軟性
を有するプラスチック材が好ましく、例えば、ポリ塩化
ビニール、ポリエチレン、ポリプロピレン、ポリエチレ
ンテレフタレート、エチレン−酢酸ビニル共重合体等の
材質を使用することができる。これらの第１及び第２の
溶液室１１，１２を構成する容器は、例えば、上記の柔
軟性を有するプラスチック材の２枚のシートを重ね合わ
せて周縁を熱溶着するとともに中央部を熱溶着して隔壁
１３を設けたり、あるいは柔軟性を有するプラスチック
材からなる密封された袋の中央部を熱溶着して隔壁１３
を設けることで形成される。なお、変形の少ないガラス
材や硬質のプラスチック材あるいは柔軟性が不足する材
質を使用した場合において、溶液の排出に従って溶液室
へ空気を導入する必要があるがあるときには、例えば、
通気針を通して溶液室へ通気できる機構を備えることが
好ましい。The first and second solution chambers 11 and 12 are
In this embodiment, the cross-sectional areas in the horizontal direction are formed to be substantially equal to each other, and the material constituting the container is a glass material, a plastic material, and a combination thereof used in the ordinary medical field. Although a material can be used, a plastic material having flexibility that can be deformed with the discharge of the solution is preferable. For example, a material such as polyvinyl chloride, polyethylene, polypropylene, polyethylene terephthalate, or an ethylene-vinyl acetate copolymer is used. be able to. The containers constituting the first and second solution chambers 11 and 12 are formed, for example, by superposing two sheets of the above-mentioned plastic material having flexibility and heat-welding the periphery and heat-welding the central part. The partition 13 is provided by heat welding the central part of a sealed bag made of a flexible plastic material.
Is formed. In the case of using a glass material, a hard plastic material or a material having a lack of flexibility with less deformation, when it is necessary to introduce air into the solution chamber according to the discharge of the solution, for example,
It is preferable to provide a mechanism that can ventilate the solution chamber through the ventilating needle.

【００１３】上記可動式栓１４及び混合室１５は、第１
及び第２の溶液室１１，１２を隔てる隔壁１３の下部側
にほぼ一体に形成されている。すなわち、上部側が密閉
されて空気室１６ａに形成されその内部に栓体１７が上
下動可能に収納され、下部側が底部に通針用栓１５ａに
より閉塞された空気室１５に形成された中空筒状のケー
ス１６が、その上端部を隔壁１３の下部に接し、途中の
周面がそれぞれ第１及び第２の溶液室１１，１２内に臨
まされ、下部側が第１及び第２の溶液室１１，１２の下
方に突出するように設けられている。また、ケース１６
の第１及び第２の溶液室１１，１２内に臨まされた周面
部分には、栓体１７の上下動により開閉される連通孔１
８，１８がそれぞれ形成され、かつ混合室１５の上部に
は、栓体１７の上下動により開閉する連通孔１９が形成
されている。なお、ケース１６の周面部分の連通孔１
８，１８には、混合室１５から第１及び第２の溶液室１
１，１２への溶液の逆流を防止する逆止弁等の機構を設
けてもよい。そして、使用時に混合室１５内に通針用栓
１５ａを通して輸液針１が通針され、かつ輸液針１の先
端を栓体１７の下部に当設して、空気室１６ａ内の空気
の圧縮力に抗して栓体１７をケース１６内の上方に移動
させることにより、第１及び第２の溶液室１１，１２側
の連通孔１８，１８及び混合室１５側の連通孔１９がそ
れぞれ開くようになっている。このケース１６は、例え
ば、ポリエチレン、ポリプロピレン、ポリエチレンテレ
フタレート、ポリカーボネート、メチルペンテンポリマ
ーあるいはガラス等硬質又は適度の硬さを備えた材質が
選択可能である。栓体１７は、医療用に使用されるゴム
等の材質が使用でき、ケース１６内を円滑に移動できる
ように潤滑剤で表面処理したり、少なくとも輸液針１先
端の当接される部分が刺さらないように適度の硬さの材
料を設けたり表面処理することが好ましい。また、通針
用栓１５ａは、少なくとも輸液針１が通針できる医療用
に使用されるゴム等の材質が使用できるが、表面を種々
の材質でコーティングあるいはラミネートしたゴム栓が
使用でき、また空気室１６ａの空気の圧縮力に抗して栓
体１７を押し上げた後に摩擦力によりその位置を保持で
きることが好ましい。The movable stopper 14 and the mixing chamber 15 have a first
The second solution chambers 11 and 12 are formed substantially integrally with each other on the lower side of the partition wall 13 separating the second solution chambers 11 and 12. That is, a hollow cylindrical member formed in an air chamber 16a whose upper side is closed and formed in an air chamber 16a, in which a stopper 17 is vertically movably accommodated, and a lower side formed in an air chamber 15 closed at the bottom by a needle plug 15a. Case 16 has its upper end in contact with the lower part of the partition wall 13, the intermediate surface of which faces the first and second solution chambers 11 and 12, respectively, and the lower side is the first and second solution chambers 11 and 12. 12 is provided so as to project below. Case 16
A communication hole 1 which is opened and closed by the up and down movement of a plug 17 is provided in a peripheral surface portion facing the first and second solution chambers 11 and 12.
8 and 18 are formed respectively, and a communication hole 19 which is opened and closed by the vertical movement of the plug 17 is formed in the upper part of the mixing chamber 15. The communication hole 1 in the peripheral surface of the case 16
The first and second solution chambers 1 and 8 are provided in the mixing chamber 15 from the mixing chamber 15.
A mechanism such as a check valve for preventing the backflow of the solution to 1 and 12 may be provided. During use, the infusion needle 1 is passed through the mixing plug 15a through the needle plug 15a, and the tip of the infusion needle 1 is provided below the plug 17 to compress the air in the air chamber 16a. The stopper 17 is moved upward in the case 16 so as to open the communication holes 18 and 18 on the first and second solution chambers 11 and 12 and the communication hole 19 on the mixing chamber 15 side. It has become. For the case 16, for example, a material having rigidity or moderate hardness such as polyethylene, polypropylene, polyethylene terephthalate, polycarbonate, methylpentene polymer or glass can be selected. The stopper 17 can be made of a material such as rubber used for medical treatment, and is surface-treated with a lubricant so as to be able to move smoothly in the case 16. It is preferable to provide a material having an appropriate hardness or to perform a surface treatment so as not to cause such a problem. Further, as the needle passing stopper 15a, a material such as rubber used for medical treatment through which at least the infusion needle 1 can pass can be used, but a rubber stopper whose surface is coated or laminated with various materials can be used. After pushing up the plug 17 against the compressive force of the air in the chamber 16a, it is preferable that the position can be held by the frictional force.

【００１４】上記構成の医療容器１０によれば、第１及
び第２の溶液室１１，１２に異なる溶液を同じ液面レベ
ルに収容し、使用時に輸液針１の先端部を通針用栓１５
ａを通して混合室１５内へ通針し、さらに輸液針１を押
し上げると、その輸液針１先端が栓体１７の下部に当接
して空気室１６ａの空気の圧縮力に抗して栓体１７をケ
ース１６の上方に移動し、これにより連通孔１８，１８
及び１９がそれぞれ開き、第１の溶液室１１の溶液と第
２の溶液室１２の溶液が連通孔１８，１８から連通孔１
９を通って混合室１５へ流入して混合され、輸液針１を
通して排出される。第１及び第２の溶液室１１，１２
は、混合室１５を通して連通孔１８，１８及び１９によ
り互いに連通され、それぞれの溶液の液面が同じレベル
を保って下降するため、各溶液の排出速度はそれぞれの
溶液室１１，１２の水平方向の断面積に比例し、本第１
実施形態では同じ混合比率で排出される。このとき、容
器の材質が柔軟性を有するプラスチック材であれば、液
面上部の第１及び第２の溶液室１１，１２部分が排出さ
れた液体の容積に相当する空間だけ収縮し、また、容器
の材質が変形の少ないガラス材や硬質のプラスチック材
あるいは柔軟性が不足する材質であれば、通気機構によ
りそれぞれの溶液室１１，１２へ空気が導入される。第
１及び第２の溶液室１１，１２に収容される溶液が混合
される時間は、混合室１５と輸液セットの内容量を点滴
速度で除した時間になり、この時間は通常の輸液セット
では配合変化を無視することができる程度になり、その
ため、例えば、配合が不適な２種の注射剤を点滴で投与
する場合等においても、配合後に起こる経時的な配合変
化を考慮せずに、簡便に混合して患者に投与することが
可能になる。例えば、中心静脈栄養法で３００ｍｌ／時
間の点滴速度で、混合時間は通常の輸液セットの容量で
は数分以内となり、配合変化はほとんど無視することが
できる。また、排出は点滴で連続的に排出する場合に限
らず、注射筒で一度に排出することでもよい。この場合
は輸液の場合のように、溶液室の容量は大きなものでな
く、それぞれ２０ｍｌ以下の容量に限られ、本発明の趣
旨より混合後直ちに使用されることが望ましい。なお、
輸液針１を混合室１５から抜き取ることにより、栓体１
７が空気室１６ａの空気の圧縮力により、場合によって
は空気室１６ａ内にバネ等の弾性体を設けることにより
ケース１６の下方に移動し、これにより連通孔１８，１
８及び１９を閉じることで、途中で混合排出を中断する
ことができる。そして、溶液室の溶液を他の成分を含む
溶液に代えることも可能であり、引き続き連続混合投与
用の容器として使用することができる。また、溶液室１
１，１２から混合室１５への連通孔１８，１８は、それ
ぞれの溶液室１１，１２の液の混合比率を変化させて通
液しえるよう、連通孔１８，１８の大きさの比率を変え
て、複数の組み合わせの連通孔１８，１８を有していて
もよい。According to the medical container 10 having the above-described structure, different solutions are stored in the first and second solution chambers 11 and 12 at the same liquid level, and the tip of the infusion needle 1 is passed through the plug 15 during use.
When the infusion needle 1 is pushed up further into the mixing chamber 15 and the infusion needle 1 is further pushed up, the tip of the infusion needle 1 abuts on the lower part of the plug 17 to push the plug 17 against the compressive force of the air in the air chamber 16a. It moves above the case 16, whereby the communication holes 18, 18
And 19 are respectively opened, and the solution in the first solution chamber 11 and the solution in the second solution chamber 12 pass through the communication holes 18, 18 through the communication hole 1.
The fluid flows into the mixing chamber 15 through the mixer 9, is mixed, and is discharged through the infusion needle 1. First and second solution chambers 11, 12
Are communicated with each other through communication holes 18, 18 and 19 through the mixing chamber 15, and the liquid level of each solution is lowered while maintaining the same level, so that the discharge speed of each solution is set in the horizontal direction of each solution chamber 11, 12. Is proportional to the cross-sectional area of
In the embodiment, they are discharged at the same mixing ratio. At this time, if the material of the container is a plastic material having flexibility, the first and second solution chambers 11 and 12 above the liquid surface shrink by a space corresponding to the volume of the discharged liquid, and If the material of the container is a glass material, a hard plastic material, or a material having insufficient flexibility, air is introduced into the respective solution chambers 11 and 12 by a ventilation mechanism. The time during which the solutions accommodated in the first and second solution chambers 11 and 12 are mixed is the time obtained by dividing the contents of the mixing chamber 15 and the infusion set by the infusion rate. The change in the composition becomes negligible, so that, for example, even when two types of injections that are inappropriate to be mixed are administered by infusion, the method can be easily performed without considering the change in the composition over time that occurs after the compounding. To be administered to patients. For example, with a parenteral nutrition method at an infusion rate of 300 ml / hour, the mixing time is within a few minutes for a normal infusion set volume, and the change in formulation is almost negligible. In addition, the discharge is not limited to the case where the liquid is continuously discharged by drip, but may be discharged at a time by using a syringe. In this case, as in the case of infusion, the volume of the solution chamber is not large, but each volume is limited to 20 ml or less, and it is desirable to use immediately after mixing for the purpose of the present invention. In addition,
By withdrawing the infusion needle 1 from the mixing chamber 15, the plug 1
7 moves below the case 16 by providing an elastic body such as a spring in the air chamber 16a depending on the compressive force of the air in the air chamber 16a.
By closing 8 and 19, the mixing and discharging can be interrupted on the way. Then, the solution in the solution chamber can be replaced with a solution containing other components, and can be subsequently used as a container for continuous mixed administration. Solution chamber 1
The communication holes 18, 18 from the liquid chambers 1, 12 to the mixing chamber 15 change the size ratio of the communication holes 18, 18 so that they can be passed by changing the mixing ratio of the liquids in the respective solution chambers 11, 12. Thus, a plurality of combinations of communication holes 18 may be provided.

【００１５】本発明の第１実施形態の医療容器１０にお
いて、第１の溶液室１１に静注用総合アミノ酸輸液を収
容し、第２の溶液室１２に静注用糖電解質輸液を収容
し、上記の操作により輸液針１を通針用栓１５ａを通し
て混合室１５内へ通針し、さらに輸液針１の先端部で可
動式栓１４を動かして連通孔１８，１８，１９を開き、
それぞれの輸液を混合室１５で同じ比率で連続的に混合
しながら輸液針１から静注用高カロリー輸液として排出
することができた。In the medical container 10 according to the first embodiment of the present invention, a first solution chamber 11 contains an intravenous synthetic amino acid infusion, and a second solution chamber 12 contains an intravenous sugar electrolyte infusion. Through the above operation, the infusion needle 1 is passed through the needle plug 15a into the mixing chamber 15, and the movable stopper 14 is moved at the tip of the infusion needle 1 to open the communication holes 18, 18, 19.
The respective infusions could be discharged from the infusion needle 1 as intravenous high-calorie infusion while continuously mixing at the same ratio in the mixing chamber 15.

【００１６】図３及び図４は本発明による第２実施形態
の医療容器の構成を示した断面図であり、図３は医療容
器の通針前の状態を示す断面図、図４は医療容器の通針
後の状態を示す断面図である。第１実施形態に対応する
部分及び部材は同一の符号を記す。以下の図面も同様と
する。FIGS. 3 and 4 are cross-sectional views showing the configuration of a medical container according to a second embodiment of the present invention. FIG. 3 is a cross-sectional view showing a state before passing the medical container through needles. FIG. It is sectional drawing which shows the state after needle passing. Portions and members corresponding to the first embodiment are denoted by the same reference numerals. The same applies to the following drawings.

【００１７】この第２実施形態の医療容器２０は、第１
の溶液室２１と第２の溶液室２２とがそれぞれ独立して
形成された容器であり、それぞれの下部側が連結され、
その連結部分に第１実施形態と同様の可動用栓１４と底
部に通針用栓１５ａを有する混合室１５とが一体に設け
られている。第１の溶液室２１と第２の溶液室２２は、
第１実施形態と同様の材質からなり、それぞれの溶液室
２１，２２の水平方向の断面積が同じ程度に形成されて
いる。The medical container 20 of the second embodiment has a first
Is a container in which the solution chamber 21 and the second solution chamber 22 are independently formed, and their lower sides are connected,
A movable plug 14 similar to that of the first embodiment and a mixing chamber 15 having a needle plug 15a at the bottom are integrally provided at the connection portion. The first solution chamber 21 and the second solution chamber 22
It is made of the same material as that of the first embodiment, and the horizontal cross-sectional areas of the respective solution chambers 21 and 22 are formed to the same extent.

【００１８】この実施形態の医療容器２０では、第１実
施形態と同様の操作により第１及び第２溶液室２１，２
２に収納される異なる溶液を同じ比率で連続的に混合し
ながら輸液針１から排出し、この輸液針１から輸液セッ
トに排出し、同様に配合後に起こる経時的な配合変化を
考慮せずに、簡便に混合して患者に投与することが可能
になる。また、本発明の第２実施形態の医療容器２０に
おいて、第１の溶液室２１に静注用総合アミノ酸輸液を
収納し、第２の溶液室２２に静注用脂肪輸液を収容し、
第１実施形態と同様の操作によりそれぞれの輸液を混合
室１５で同じ比率で連続的に混合しながら輸液針１から
静注用高カロリー輸液として排出することができた。In the medical container 20 of this embodiment, the first and second solution chambers 21 and 2 are operated in the same manner as in the first embodiment.
While the different solutions stored in 2 are continuously mixed at the same ratio, the solution is discharged from the infusion needle 1 and discharged from the infusion needle 1 to the infusion set. , And can be easily mixed and administered to a patient. Further, in the medical container 20 of the second embodiment of the present invention, a first solution chamber 21 contains an intravenous comprehensive amino acid infusion, and a second solution chamber 22 contains an intravenous fat infusion.
By the same operation as in the first embodiment, each infusion could be discharged from the infusion needle 1 as intravenous high-calorie infusion while continuously mixing at the same ratio in the mixing chamber 15.

【００１９】図５及び図６は本発明による第３実施形態
の医療容器の構成を示した断面図であり、図５は医療容
器の通針前の状態を示す断面図、図６は医療容器の通針
後の状態を示す断面図である。FIGS. 5 and 6 are cross-sectional views showing the configuration of a medical container according to a third embodiment of the present invention. FIG. 5 is a cross-sectional view showing a state before passing the medical container through needles. FIG. It is sectional drawing which shows the state after needle passing.

【００２０】この第３実施形態の医療容器３０は、第１
の溶液室３１と第２の溶液室３２の横幅がそれぞれａ及
びｂで水平方向の断面積が異なる大きさに形成されてお
り、例えば、第１の溶液室３１と第２の溶液室３２の断
面積比率が１：２に形成されている。その他の構成は第
１実施形態と同様である。The medical container 30 according to the third embodiment includes a first container
The width of the solution chamber 31 and the width of the second solution chamber 32 are respectively a and b, and are formed to have different horizontal cross-sectional areas. For example, the first solution chamber 31 and the second solution chamber 32 The cross-sectional area ratio is formed to be 1: 2. Other configurations are the same as those of the first embodiment.

【００２１】この実施形態の医療容器３０では、第１の
溶液室３１と第２の溶液室３２との水平方向の断面積比
率が、例えば、１：２に形成されており、同様の操作に
より、第１及び第２の溶液室３１，３２は混合室１５を
通して互いに連通し、それぞれの溶液の液面高さが等し
くなるように排出されるため、それぞれの溶液室３１，
３２に収容された溶液を１：２の比率で連続的に混合し
ながら輸液針１から排出することが可能になる。この第
３実施形態の医療容器３０では、異なる溶液の混合比率
を所定の一定の値にして連続的に混合する場合に適して
いる。In the medical container 30 of this embodiment, the horizontal sectional area ratio between the first solution chamber 31 and the second solution chamber 32 is, for example, 1: 2. , The first and second solution chambers 31 and 32 communicate with each other through the mixing chamber 15 and are discharged so that the liquid levels of the respective solutions are equal.
It is possible to discharge the solution stored in the infusion needle 32 from the infusion needle 1 while continuously mixing the solutions in a ratio of 1: 2. The medical container 30 according to the third embodiment is suitable for a case where the mixing ratio of different solutions is set to a predetermined constant value and mixed continuously.

【００２２】図７及び図８は本発明による第４実施形態
の医療容器の構成を示した断面図であり、図７は医療容
器の通針前の状態を示す断面図、図８は医療容器の通針
後の状態を示す断面図である。FIGS. 7 and 8 are cross-sectional views showing the configuration of a medical container according to a fourth embodiment of the present invention. FIG. 7 is a cross-sectional view showing a state before passing the medical container through needles. FIG. It is sectional drawing which shows the state after needle passing.

【００２３】この第４実施形態の医療容器４０は、第１
の溶液室４１の上部側（液面から一定の深さｈ１まで）
が所定の一定の断面積に形成されその下部側（底までの
深さｈ２まで）がそれより小さい断面積に形成され、第
２の溶液室４２が一定の断面積に形成されている。その
他の構成は第１実施形態と同様である。The medical container 40 according to the fourth embodiment includes a first container
Upper side of the solution chamber 41 (from the liquid surface to a certain depth h1)
Are formed in a predetermined constant cross-sectional area, the lower side (up to the depth h2 to the bottom) is formed in a smaller cross-sectional area, and the second solution chamber 42 is formed in a constant cross-sectional area. Other configurations are the same as those of the first embodiment.

【００２４】この実施形態の医療容器４０では、第１の
溶液室４１が途中から断面積が小さく形成され、上記の
実施形態と同様の操作によりそれぞれの溶液の液面高さ
が等しくなるように排出されるため、第１及び第２の溶
液室４１，４２の溶液の混合比率を液面が上部からｈ１
に達するまで所定の値にし、その後液面がそのｈ１の上
部から底に達するまで第１の溶液室４１の溶液の比率を
小さくして連続的に混合することができる。薬剤によっ
ては早期に血中濃度を定常状態まで上げ、その後の血中
濃度を一定にしたい場合等があるが、このような場合、
従来の投与方法では、初期の薬剤の投与速度を上げるた
めに、点滴速度を上げ、その後投与速度を下げるために
点滴速度を落とす方法が採られていた。しかし、本実施
形態によれば、投与速度を調整すべき溶液の溶液室の形
状を第１溶液室４１のように途中から変えることによ
り、一定の点滴速度のもとに薬剤の投与量を容易に変え
ることが可能になる。In the medical container 40 of this embodiment, the first solution chamber 41 is formed with a small cross-sectional area from the middle, and the same operation as in the above embodiment is performed so that the liquid level of each solution becomes equal. Since the liquid is discharged, the mixing ratio of the solutions in the first and second solution chambers 41 and 42 is changed from the top to the height h1.
, And then the mixture can be continuously mixed by reducing the ratio of the solution in the first solution chamber 41 until the liquid level reaches the bottom from the top of h1. Depending on the drug, it may be necessary to raise the blood concentration to a steady state at an early stage and to keep the blood concentration constant thereafter.
In the conventional administration method, a method of increasing the infusion rate in order to increase the initial administration rate of the drug, and then decreasing the infusion rate in order to decrease the administration rate, has been adopted. However, according to the present embodiment, by changing the shape of the solution chamber of the solution for which the administration rate is to be adjusted from the middle like the first solution chamber 41, the dose of the drug can be easily controlled under a constant infusion rate. Can be changed to

【００２５】図９及び図１０は本発明による第５実施形
態の医療容器の構成を示した断面図であり、図９は医療
容器の通針前の状態を示す断面図、図１０は医療容器の
通針後の状態を示す断面図である。FIGS. 9 and 10 are cross-sectional views showing the configuration of a medical container according to a fifth embodiment of the present invention. FIG. 9 is a cross-sectional view showing a state before passing the needle through the medical container, and FIG. 10 is a medical container. It is sectional drawing which shows the state after needle passing.

【００２６】この第５実施形態の医療容器５０は、第１
の溶液室５１が上部から底部に掛けて連続的に断面積が
小さくなるように形成され、第２の溶液室５２が一定の
断面積に形成されている。その他の構成は第１実施形態
と同様である。The medical container 50 according to the fifth embodiment includes a first
Is formed so that the cross-sectional area decreases continuously from the top to the bottom, and the second solution chamber 52 is formed to have a constant cross-sectional area. Other configurations are the same as those of the first embodiment.

【００２７】この実施形態の医療容器５０では、第１の
溶液室５１が連続的に断面積が小さく第２の溶液室５２
が一定の断面積に形成され、それぞれの溶液の液面高さ
が等しくなるように排出されるため、第１の溶液の比率
を徐々に小さくして連続的に混合することができる。こ
の実施形態によれば、第４実施形態と同様に、投与速度
を調整すべき溶液の溶液室の形状を第１の溶液室５１の
ように連続的に小さくすることにより、一定の点滴速度
のもとに薬剤の投与量を徐々に少なくすることが可能に
なる。In the medical container 50 of this embodiment, the first solution chamber 51 has a continuously small cross-sectional area and the second solution chamber 52
Are formed so as to have a constant cross-sectional area, and are discharged so that the liquid levels of the respective solutions become equal. Therefore, the ratio of the first solution can be gradually reduced to enable continuous mixing. According to this embodiment, as in the fourth embodiment, the shape of the solution chamber of the solution whose administration rate is to be adjusted is continuously reduced like the first solution chamber 51, so that a constant infusion rate can be maintained. Based on this, it becomes possible to gradually reduce the dose of the drug.

【００２８】図１１及び図１２は本発明による第６実施
形態の医療容器の構成を示した断面図であり、図１１は
医療容器の通針前の状態を示す断面図、図１２は医療容
器の通針後の状態を示す断面図である。FIGS. 11 and 12 are cross-sectional views showing the configuration of a medical container according to a sixth embodiment of the present invention. FIG. 11 is a cross-sectional view showing a state before passing the medical container through needles. FIG. It is sectional drawing which shows the state after needle passing.

【００２９】この第６実施形態の医療容器６０は、第１
実施形態とほぼ同様の第１の溶液室６１と第２の溶液室
６２とを隔壁６３を隔てて隣接して設け、また第１及び
第２の溶液室６１，６２の下部側に通針用栓６５ａを有
する混合室６５を設け、かつ第１及び第２の溶液室６
１，６２と混合室６５との間にそれぞれを互いの連通可
能とする回転式栓６４を設けたものである。これら回転
式栓６４及び混合室６５は、ケース６６に一体に形成さ
れており、そのケース６６の上端部が溶液室６１，６２
と隔壁６３の下部側に設けられている。すなわち、ケー
ス６６の上部はそれぞれ第１及び第２の溶液室６１，６
２の底部内に連通する連通孔６８，６８が形成され、そ
の下部に筒状の回転栓体６７が回転可能に設けられ、そ
の下部に混合室６５が設けられている。回転栓体６７
は、外部からの手動操作等による回転で第１及び第２の
溶液室６１，６２及び混合室６５の間を開閉する３つの
連通路６７ａ，６７ｂ，６７ｃが形成されている。The medical container 60 according to the sixth embodiment includes a first container
A first solution chamber 61 and a second solution chamber 62 substantially similar to those of the embodiment are provided adjacent to each other with a partition wall 63 interposed therebetween, and a lower portion of the first and second solution chambers 61 and 62 for passing a needle therethrough. A mixing chamber 65 having a stopper 65a is provided, and the first and second solution chambers 6 are provided.
A rotary stopper 64 is provided between the mixing chambers 1 and 62 and the mixing chamber 65 so that they can communicate with each other. The rotary stopper 64 and the mixing chamber 65 are formed integrally with a case 66, and the upper end of the case 66 has solution chambers 61 and 62.
And a lower portion of the partition 63. That is, the upper part of the case 66 is provided with the first and second solution chambers 61 and 6 respectively.
Communication holes 68, 68 communicating with each other are formed in the bottom of the cylinder 2, a rotatable cylindrical stopper 67 is rotatably provided in the lower part thereof, and a mixing chamber 65 is provided in the lower part thereof. Rotating plug 67
Is formed with three communication passages 67a, 67b, 67c which open and close between the first and second solution chambers 61, 62 and the mixing chamber 65 by rotation by manual operation from the outside.

【００３０】この実施形態の医療容器６０では、輸液針
１を通針用栓６５ａを通して混合室６５内に通針し、回
転式栓６４を手動操作により回転して開くことで、第１
及び第２の溶液室６１，６２の溶液が連通孔６８，６８
及び連通路６７ａ，６７ｂ，６７ｃを通って混合室６５
に流入し連続的に混合して輸液針１を通して排出するこ
とができる。この実施形態では、例えば、点滴途中で混
合排出を中断することが容易であり、また、回転栓体６
７の形状により、途中から連通の組み合わせを変更して
単一の溶液の排出に切り換えることが可能になる。In the medical container 60 of this embodiment, the infusion needle 1 is passed through the needle plug 65a into the mixing chamber 65, and the rotary stopper 64 is rotated and opened by a manual operation, so that the first stopper is opened.
And the solutions in the second solution chambers 61 and 62 communicate with the communication holes 68 and 68.
And the mixing chamber 65 through the communication passages 67a, 67b, 67c.
And can be continuously mixed and discharged through the infusion needle 1. In this embodiment, for example, it is easy to interrupt the mixing and discharging during the drip, and the rotary plug 6
By the shape of 7, it becomes possible to change the combination of communication from the middle and switch to discharging of a single solution.

【００３１】図１３及び図１４は本発明による第７実施
形態の医療容器の構成を示した断面図であり、図１３は
医療容器の通針前の状態を示す断面図、図１４は医療容
器の通針後の状態を示す断面図である。FIGS. 13 and 14 are cross-sectional views showing the configuration of a medical container according to a seventh embodiment of the present invention. FIG. 13 is a cross-sectional view showing a state before passing the medical container through needles. FIG. It is sectional drawing which shows the state after needle passing.

【００３２】この第７実施形態の医療容器７０は、第１
実施形態と同様に隔壁７３を隔てて形成された第１の溶
液室７１及び第２の溶液室７２の上部側に、それぞれ薬
剤添加用口７４，７５が上部に突出して形成され、それ
ぞれにゴム等の材質からなる栓７６，７７が取り付けら
れ、その他の構成は第１実施形態と同様である。The medical container 70 according to the seventh embodiment includes a first container
Similarly to the embodiment, drug addition ports 74 and 75 are formed on the upper side of the first solution chamber 71 and the second solution chamber 72 formed with the partition wall 73 therebetween, and are formed to protrude upward. Plugs 76 and 77 made of the same material are attached, and the other configuration is the same as that of the first embodiment.

【００３３】この実施形態の医療容器７０では、溶液の
連続的な混合とともに第１及び第２の溶液室７１，７２
の溶液に栓７６，７７を外して薬剤添加用口７４，７５
から他の薬剤を添加することが可能になる。In the medical container 70 of this embodiment, the first and second solution chambers 71, 72 are continuously mixed with the solution.
The stoppers 76 and 77 are removed from the solution of
It is possible to add other chemicals from.

【００３４】図１５及び図１６は本発明による第７実施
形態の医療容器に粉末製剤容器を用いた構成を示した断
面図であり、図１３は医療容器と粉末製剤容器の通針前
の状態を示す断面図、図１４は医療容器と粉末製剤容器
の通針後の状態を示す断面図である。FIGS. 15 and 16 are sectional views showing a configuration using a powder preparation container as the medical container according to the seventh embodiment of the present invention. FIG. 13 shows a state before passing the medical container and the powder preparation container through a needle. FIG. 14 is a cross-sectional view showing a state after passing the medical container and the powder formulation container through the needle.

【００３５】この実施形態は、第７実施形態の医療容器
７０に粉末製剤容器８０を使用した例である。この粉末
製剤容器８０は、例えば、ガラス材やプラスチック材等
からなり粉末製剤８１を収容する容器部８０ａと、この
容器部８０ａに設けられたゴム等の栓８２を設けた口部
８０ｂと、この口部８０ｂに連接されて薬剤添加用口７
４を覆１うように形成されたカバー部８０ｃとから形成
され、かつ栓８２に貫通した両頭針の連通針８３が設け
られている。This embodiment is an example in which a powder preparation container 80 is used for the medical container 70 of the seventh embodiment. The powder formulation container 80 includes, for example, a container portion 80a made of a glass material, a plastic material, or the like and accommodating the powder formulation 81, a mouth portion 80b provided with a stopper 82 made of rubber or the like provided in the container portion 80a, The drug addition port 7 connected to the port 80b
A cover needle 80c formed so as to cover 1 and a double-ended needle 83 penetrating through the stopper 82 is provided.

【００３６】この実施形態では、粉末製剤容器８０のカ
バー部８０ｃ側を薬剤添加用口７４の上部に被せ、連通
針８３を栓７６を通して第１の溶液室７１の上部空間内
に通針し、続いて、容器全体を転倒させる等により第１
の溶液室７１の溶液を連通針８３を通して溶液室７１内
に導入して粉末製剤８１を溶解し図１６に示すように溶
液室７１に粉末製剤溶解液８４を形成する。これにより
粉末製剤溶解液８４を第１の溶液室７１の溶液に添加す
ることができる。この粉末製剤溶解液８４を添加した第
１の溶液室７１の溶液と第２の溶液室７２の連続混合に
ついては、上記実施形態と同等にできる。この実施形態
では、例えば、凍結乾燥製剤等の用時に溶解して用いる
粉末製剤を混合室１５を通さないで混合することができ
る。本実施形態において、第１の溶液室７１に静注用糖
電解質輸液を収納し、第２の溶液室７２に静注用総合ア
ミノ酸輸液を収容し、組み合わせ粉末製剤８１として粉
末製剤容器８０に静注用総合ビタミン注射剤を収納し、
使用時に粉末製剤容器８０を連通針８３を用いて第１の
溶液室７１の溶液を加えて溶解させ、この溶解液を第１
の溶液室７１に戻して混合する。その後に、上記各実施
形態と同様に可動式栓１４を開くことで、静注用総合ビ
タミン注射剤と静注用糖電解質輸液の混合溶液に静注用
総合アミノ酸輸液を連続的に混合しながら輸液針１を通
して静注用総合高カロリー・ビタミン輸液として排出す
ることができた。In this embodiment, the cover 80c of the powder preparation container 80 is placed over the drug addition port 74, and the communication needle 83 is passed through the stopper 76 into the upper space of the first solution chamber 71. Subsequently, the first container is turned over by turning over the entire container.
The solution in the solution chamber 71 is introduced into the solution chamber 71 through the communication needle 83 to dissolve the powder preparation 81, and a powder preparation solution 84 is formed in the solution chamber 71 as shown in FIG. Thereby, the powder formulation solution 84 can be added to the solution in the first solution chamber 71. The continuous mixing of the solution in the first solution chamber 71 to which the powder formulation solution 84 is added and the second solution chamber 72 can be equivalent to the above embodiment. In this embodiment, for example, a powder formulation that is dissolved and used at the time of use such as a freeze-dried formulation can be mixed without passing through the mixing chamber 15. In the present embodiment, the first solution chamber 71 accommodates an intravenous glucose electrolyte infusion, the second solution chamber 72 accommodates an intravenous comprehensive amino acid infusion, and a combined powder preparation 81 in a powder preparation container 80. Stores multi-vitamin injection for injection,
At the time of use, the powder formulation container 80 is dissolved by adding the solution in the first solution chamber 71 using the communication needle 83,
And returned to the solution chamber 71 for mixing. Thereafter, by opening the movable stopper 14 in the same manner as in the above embodiments, the intravenous synthetic amino acid infusion is continuously mixed with the mixed solution of the intravenous multivitamin injection and the intravenous sugar electrolyte infusion. Through the infusion needle 1, it could be discharged as a total intravenous high calorie and vitamin infusion.

【００３７】図１７及び図１８は本発明による第７実施
形態の医療容器に粉末製剤容器及び溶液製剤容器を用い
た構成を示した断面図であり、図１３は医療容器と粉末
製剤容器及び溶液製剤容器の通針前の状態を示す断面
図、図１４は医療容器と粉末製剤容器及び溶液製剤容器
の通針後の状態を示す断面図である。FIGS. 17 and 18 are sectional views showing a configuration using a powder preparation container and a solution preparation container in the medical container of the seventh embodiment according to the present invention, and FIG. 13 is a medical container, a powder preparation container and a solution preparation. FIG. 14 is a cross-sectional view showing a state of the preparation container before passing the needle, and FIG. 14 is a cross-sectional view showing a state of the medical container, the powder preparation container, and the solution preparation container after passing the needle.

【００３８】この実施形態は、第７実施形態の医療容器
７０と上記の粉末製剤容器８０にさらに溶液製剤容器９
０を使用した例である。この溶液製剤容器９０は、粉末
製剤容器８０と同様に容器部９１ａと口部９１ｃとカバ
ー部９１ｃが形成され、容器部９１ａ内に溶液製剤９１
が収容され、栓９２に貫通した両頭針の連通針９３が設
けられている。This embodiment is different from the medical container 70 of the seventh embodiment and the powder preparation container 80 in that the solution preparation container 9
This is an example using 0. This solution preparation container 90 has a container portion 91a, a mouth portion 91c, and a cover portion 91c formed in the same manner as the powder preparation container 80, and the solution preparation 91 is contained in the container portion 91a.
And a communication needle 93 of a double-ended needle penetrating the stopper 92 is provided.

【００３９】この実施形態では、粉末製剤溶解液８４を
第１の溶液室７１の溶液に添加することができるととも
に、同様に連通針９３を栓７７に通して第２の溶液室７
２の上部空間内に通針し、その溶液に溶液製剤９１を添
加することができる。この実施形態では、上記のような
凍結乾燥製剤等の用時に溶解して用いる粉末製剤と用時
に稀釈して用いる溶液製剤を混合室１５を通さないで混
合することができる。本実施形態において、第１の溶液
室７１に静注用糖電解質輸液を収納し、第２の溶液室２
２に静注用総合アミノ酸輸液を収容し、組み合わせ粉末
製剤８１として粉末製剤容器８０に静注用総合ビタミン
注射剤を収納し、また組み合わせ溶液製剤９１として静
注用微量元素注射剤を収納し、使用時に粉末製剤容器８
０を連通針８３を用いて第１の溶液室７１の溶液を加え
て溶解させ、この溶解液を第１の溶液室７１に戻して混
合し、さらに溶液製剤容器９１を通針針９２を用いて溶
液製剤９１を第２の溶液室７２の溶液に混合する。その
後に、上記各実施形態と同様に可動式栓１４を開くこと
で、静注用総合ビタミン注射剤と静注用糖電解質輸液の
混合溶液に静注用総合アミノ酸輸液と静注用微量元素注
射剤の混合溶液を連続的に混合しながら輸液針１を通し
て静注用総合高カロリー・ビタミン・微量元素輸液とし
て排出することができた。In this embodiment, the powder formulation solution 84 can be added to the solution in the first solution chamber 71, and the communication needle 93 is similarly passed through the stopper 77 so as to be in the second solution chamber 7.
The solution formulation 91 can be added to the solution by passing the needle through the upper space of No. 2. In this embodiment, it is possible to mix the above-mentioned lyophilized preparation or the like, which is dissolved and used at the time of use, with the solution preparation which is diluted at the time of use, without passing through the mixing chamber 15. In the present embodiment, the intravenous sugar electrolyte infusion is stored in the first solution chamber 71 and the second solution chamber 2
2, containing an intravenous synthetic amino acid infusion, storing a combined intravenous vitamin injection as a combined powder preparation 81 in a powder preparation container 80, and storing a intravenous trace element injection as a combined solution preparation 91, Powder formulation container 8 when used
0 is added to the solution in the first solution chamber 71 using the communication needle 83 to dissolve the solution, the solution is returned to the first solution chamber 71 and mixed, and the solution preparation container 91 is passed through the needle 92 using the needle 92. To mix the solution preparation 91 with the solution in the second solution chamber 72. After that, by opening the movable stopper 14 in the same manner as in the above embodiments, the mixed amino acid infusion for intravenous injection and the trace element injection for intravenous injection are added to the mixed solution of the intravenous multivitamin injection and the intravenous glucose electrolyte infusion. While the mixed solution of the preparations was continuously mixed, it could be discharged through the infusion needle 1 as a total intravenous high calorie, vitamin and trace element infusion.

【００４０】なお、上記各実施形態において、溶液室を
２つ設けた例を説明したが、少なくとも２つ以上複数設
けることもできる。また、第３〜第５実施形態において
溶液室の水平方向の断面積を変更した例を説明したが、
これらの形状に限定されず、排出時間に対応した任意の
比率で混合できる形状にしてもよい。さらに、可動式栓
として、上下に直線的に移動する栓体や回転する栓体を
説明したが、輸液針の通針により連動して開閉したり、
外部からの手動操作により開閉し、溶液室と混合室の間
を連通する可動式栓であればよい。また、輸液針１は、
混合室から溶液を排出する任意の針が使用でき、通針用
栓も混合室に臨まされて任意の場所に設けることができ
る。In each of the above embodiments, an example in which two solution chambers are provided has been described, but at least two or more solution chambers may be provided. In the third to fifth embodiments, the example in which the horizontal cross-sectional area of the solution chamber is changed has been described.
The shape is not limited to these shapes, and may be a shape that can be mixed at an arbitrary ratio corresponding to the discharge time. Furthermore, as the movable stopper, a stopper that moves linearly up and down or a rotating stopper has been described, but it is opened and closed in conjunction with the passage of an infusion needle,
Any movable stopper that can be opened and closed by an external manual operation and communicates between the solution chamber and the mixing chamber may be used. The infusion needle 1 is
Any needle that discharges the solution from the mixing chamber can be used, and a plug for passing a needle can be provided at an arbitrary location facing the mixing chamber.

【００４１】[0041]

【発明の効果】以上説明したように本発明の医療容器で
は、針を通針用栓を通して混合室内に通針し可動式栓を
動かすことで、複数の溶液室から混合室へ溶液が流入し
て連続的に混合し、その混合溶液が針を通して排出さ
れ、輸液セット等に排出されて患者に投与することが可
能になる。混合される時間は混合室と輸液セット等の内
容量を点滴速度等で除した時間に限られ、この混合時間
では通常の輸液セットの容量では短時間になり配合変化
を無視することができる。したがって、配合後に起こる
経時的な配合変化を考慮せずに、複数の薬剤を簡便に混
合して投与することができる。また、可動式栓の開閉は
自在であり、途中で混合排出の中断、さらには、他の成
分を含む溶液に代えて連続混合用容器として使用するこ
とも可能である。As described above, in the medical container according to the present invention, the solution flows from a plurality of solution chambers into the mixing chamber by moving the needle through the needle and into the mixing chamber through the stopper. And the mixed solution is discharged through a needle, discharged into an infusion set or the like, and can be administered to a patient. The mixing time is limited to the time obtained by dividing the contents of the mixing chamber and the infusion set by the infusion rate and the like. In this mixing time, the capacity of the normal infusion set is short, and the change in the composition can be ignored. Therefore, it is possible to easily mix and administer a plurality of drugs without considering the change over time in the formulation that occurs after the formulation. Further, the movable stopper can be freely opened and closed, and the mixing and discharging can be interrupted on the way, and further, it can be used as a continuous mixing container instead of a solution containing other components.

【図面の簡単な説明】[Brief description of the drawings]

【図１】本発明による第１実施形態の医療容器の通針前
の状態を示す断面図である。FIG. 1 is a cross-sectional view showing a state before passing a medical container of a medical container according to a first embodiment of the present invention.

【図２】本発明による第１実施形態の医療容器の通針後
の状態を示す断面図である。FIG. 2 is a cross-sectional view showing a state after passing the needle of the medical container of the first embodiment according to the present invention.

【図３】本発明による第２実施形態の医療容器の通針前
の状態を示す断面図である。FIG. 3 is a cross-sectional view showing a state before passing a needle of a medical container according to a second embodiment of the present invention.

【図４】本発明による第２実施形態の医療容器の通針後
の状態を示す断面図である。FIG. 4 is a cross-sectional view showing a state after passing a needle of a medical container according to a second embodiment of the present invention.

【図５】本発明による第３実施形態の医療容器の通針前
の状態を示す断面図である。FIG. 5 is a cross-sectional view showing a medical container according to a third embodiment of the present invention before needle passing.

【図６】本発明による第３実施形態の医療容器の通針後
の状態を示す断面図である。FIG. 6 is a cross-sectional view showing a state after passing a medical container of a third embodiment according to the present invention.

【図７】本発明による第４実施形態の医療容器の通針前
の状態を示す断面図である。FIG. 7 is a cross-sectional view showing a state before passing a needle of a medical container according to a fourth embodiment of the present invention.

【図８】本発明による第４実施形態の医療容器の通針後
の状態を示す断面図である。FIG. 8 is a sectional view showing a state after passing a needle of a medical container according to a fourth embodiment of the present invention.

【図９】本発明による第５実施形態の医療容器の通針前
の状態を示す断面図である。FIG. 9 is a cross-sectional view showing a state before passing a medical container of a fifth embodiment according to the present invention.

【図１０】本発明による第５実施形態の医療容器の通針
後の状態を示す断面図である。FIG. 10 is a sectional view showing a state after passing a needle of a medical container according to a fifth embodiment of the present invention.

【図１１】本発明による第６実施形態の医療容器の通針
前の状態を示す断面図である。FIG. 11 is a cross-sectional view showing a state of a medical container according to a sixth embodiment of the present invention before needle passing.

【図１２】本発明による第６実施形態の医療容器の通針
後の状態を示す断面図である。FIG. 12 is a cross-sectional view showing a state after passing a medical container of a sixth embodiment according to the present invention.

【図１３】本発明による第７実施形態の医療容器の通針
前の状態を示す断面図である。FIG. 13 is a cross-sectional view showing a medical container according to a seventh embodiment of the present invention before passing through a medical container.

【図１４】本発明による第７実施形態の医療容器の通針
後の状態を示す断面図である。FIG. 14 is a cross-sectional view showing a state after passing the medical container of the seventh embodiment according to the present invention.

【図１５】本発明による第７実施形態の医療容器に粉末
製剤容器を用いた通針前の状態を示す断面図である。FIG. 15 is a cross-sectional view showing a state before passing a needle using a powder formulation container as the medical container of the seventh embodiment according to the present invention.

【図１６】本発明による第７実施形態の医療容器に粉末
製剤容器を用いた通針後の状態を示す断面図である。FIG. 16 is a cross-sectional view showing a state after passing a needle using a powder preparation container in the medical container according to the seventh embodiment of the present invention.

【図１７】本発明による第７実施形態の医療容器に粉末
製剤容器及び溶液製剤容器を用いた通針前の状態を示す
断面図である。FIG. 17 is a cross-sectional view of a medical container according to a seventh embodiment of the present invention using a powder formulation container and a solution formulation container before needle passing.

【図１８】本発明による第７実施形態の医療容器に粉末
製剤容器及び溶液製剤容器を用いた通針後の状態を示す
断面図である。FIG. 18 is a cross-sectional view showing a state after passing a needle using a powder preparation container and a solution preparation container in the medical container according to the seventh embodiment of the present invention.

【符号の説明】[Explanation of symbols]

１ 輸液針 １０，２０，３０，４０，５０，６０，７０ 医療容器 １１，２１，３１，４１，５１，６１，７１ 第１の溶
液室 １２，２２，３２，４２，５２，６２，７２ 第２の溶
液室 １３，６３，７３ 隔壁 １４ 可動式栓 １５，６５ 混合室 １５ａ，６５ａ 通針用栓 １６，６６ ケース １７ 栓体 １８，１９，６８， 連通孔 ６４ 回転式栓 ７４，７５ 薬剤添加用口 ７６，７７ 栓 ８０ 粉末製剤容器 ８１ 粉末製剤 ８２ 栓 ８３ 連通針 ８４ 粉末製剤溶解液 ９０ 溶液製剤容器 ９１ 溶液製剤 ９２ 栓 ９３ 連通針1 Infusion needle 10, 20, 30, 40, 50, 60, 70 Medical container 11, 21, 31, 41, 51, 61, 71 First solution chamber 12, 22, 32, 42, 52, 62, 72 2 Solution chamber 13, 63, 73 Partition wall 14 Movable stopper 15, 65 Mixing chamber 15a, 65a Needle passage stopper 16, 66 Case 17 Plug body 18, 19, 68, Communication hole 64 Rotary stopper 74, 75 Drug addition Ports 76, 77 Stopper 80 Powder preparation container 81 Powder preparation 82 Stopper 83 Communication needle 84 Powder preparation solution 90 Solution preparation container 91 Solution preparation 92 Stopper 93 Communication needle

Claims (3)

【特許請求の範囲】[Claims] 【請求項１】 ２つ以上の複数の溶液をそれぞれ収納可
能とする複数の溶液室を隣接して設けるとともに、該複
数の溶液室の下部側に通針用栓を有する１つの混合室を
設け、かつ前記複数の溶液室と混合室との間にそれぞれ
を互いに連通可能とする可動式栓を設け、使用時に針を
前記通針用栓を通して混合室内に通針し前記可動式栓を
動かし前記複数の溶液室から混合室へ流入する複数の溶
液を前記針を通して排出することを特徴とする連続混合
用多室医療容器。1. A plurality of solution chambers capable of accommodating two or more solutions, respectively, are provided adjacent to each other, and one mixing chamber having a plug for passing a needle is provided below the plurality of solution chambers. A movable stopper is provided between the plurality of solution chambers and the mixing chamber so as to be able to communicate with each other, and the needle is passed through the needle-passing stopper into the mixing chamber to move the movable stopper during use. A multi-chamber medical container for continuous mixing, wherein a plurality of solutions flowing from a plurality of solution chambers to a mixing chamber are discharged through the needle. 【請求項２】 前記可動式栓は、直線的に移動する栓体
または回転する栓体を有する請求項１記載の連続混合用
多室医療容器。2. The multi-chamber medical container for continuous mixing according to claim 1, wherein the movable stopper has a stopper that moves linearly or a stopper that rotates. 【請求項３】 前記可動式栓は、前記針の通針操作に連
動して動く構造を有する請求項１記載の連続混合用多室
医療容器。3. The multi-chamber medical container for continuous mixing according to claim 1, wherein the movable stopper has a structure that moves in conjunction with a needle passing operation of the needle.