JPH0975723A - Harmful matter adsorbing and removing agent - Google Patents
Harmful matter adsorbing and removing agentInfo
- Publication number
- JPH0975723A JPH0975723A JP7184483A JP18448395A JPH0975723A JP H0975723 A JPH0975723 A JP H0975723A JP 7184483 A JP7184483 A JP 7184483A JP 18448395 A JP18448395 A JP 18448395A JP H0975723 A JPH0975723 A JP H0975723A
- Authority
- JP
- Japan
- Prior art keywords
- activated carbon
- food
- digestive system
- processed
- adsorption
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Fodder In General (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- General Preparation And Processing Of Foods (AREA)
- Jellies, Jams, And Syrups (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、食品等に付着もし
くは含有されるまたは消化器系内に存在する有害物質の
吸着除去剤に関する。TECHNICAL FIELD The present invention relates to an adsorbent / removal agent for harmful substances attached to or contained in foods or present in the digestive system.
【０００２】[0002]
【従来の技術】活性炭は、比表面積が大きく高い吸着能
を示し、代表的な吸着剤として各種用途に使用されてい
る。しかし、活性炭をゲル状物質または固形食品中に分
散させた有害物質の吸着除去剤を、直接食品等に接触さ
せるまたは直接消化器系内に投与する態様で利用した例
は見当たらない。2. Description of the Related Art Activated carbon has a large specific surface area and high adsorption capacity, and is used as a typical adsorbent for various purposes. However, there is no example in which an adsorbent / removal agent for harmful substances in which activated carbon is dispersed in a gelled substance or a solid food is used in a mode of being brought into direct contact with food or directly administered into the digestive system.
【０００３】[0003]
【発明が解決しようとする課題】本発明者らは、後述す
るように、微粒子活性炭の存在下における植物細胞の培
養試験において、活性炭の細胞への移動、取り込みは起
こらないものの、活性炭が核になって細胞集塊が形成さ
れることを確認した。このことは、消化器系内におい
て、個々の細胞内には微粒子活性炭は取り込まれない
が、細胞がコロニーを形成する際に細胞間隙物質内に取
り込まれ易く、細胞コロニーから微粒子活性炭を分離す
ることが困難となることを示唆するものである。また、
動物細胞では、細胞膜外層の蛋白または糖蛋白に微粒子
活性炭が吸着されることも知られている。したがって、
微粒子活性炭を有害物質の吸着除去剤として直接消化器
系内に投与した場合、これを完全に消化器系外に排出さ
せることが極めて難しいと考えられる。DISCLOSURE OF THE INVENTION As will be described later, the present inventors have found that in the test of culturing plant cells in the presence of fine particle activated carbon, the activated carbon does not migrate to the cells but is taken up by the nucleus. It was confirmed that cell aggregates were formed. This means that in the digestive system, fine particle activated carbon is not incorporated into individual cells, but it is easily incorporated into interstitial substances when cells form colonies, and fine particle activated carbon is separated from cell colonies. Suggest that it will be difficult. Also,
It is also known that in animal cells, fine particle activated carbon is adsorbed on the protein or glycoprotein of the outer layer of the cell membrane. Therefore,
When particulate activated carbon is directly administered into the digestive system as an adsorbent / removal agent for harmful substances, it is considered extremely difficult to completely discharge the activated carbon out of the digestive system.
【０００４】本発明者らは、直接消化器系内に投与可能
な有害物質の吸着除去剤について鋭意研究を重ねた結
果、微粒子活性炭を生理学的に許容されるゲル状物質ま
たは固形食品中に分散含有させたものが、種々の有害物
質に対し極めて高い吸着能を有し、しかも、これらが消
化器系内に直接投与された場合、細胞膜外層の蛋白また
は糖蛋白に吸着されることなく容易に消化器系外に排出
されうることを知り、本発明を完成した。The inventors of the present invention have conducted extensive studies as to an adsorption remover for harmful substances which can be directly administered into the digestive system, and as a result, dispersed fine particle activated carbon in a physiologically acceptable gel-like substance or solid food. The contained substances have extremely high adsorption ability for various harmful substances, and when they are directly administered into the digestive system, they are easily adsorbed to the protein or glycoprotein in the outer layer of the cell membrane. The inventors have completed the present invention, knowing that they can be discharged outside the digestive system.
【０００５】本発明の目的は、直接食品等に接触させま
たは直接消化器系内に投与することにより、食品等に付
着もしくは含有されるまたは消化器系内に存在する有害
物質を極めて高率に吸着除去しうる有害物質の吸着除去
剤を提供することにある。An object of the present invention is to bring extremely high rates of harmful substances attached to or contained in foods or present in the digestive system by directly contacting with foods or administering directly into the digestive system. An object is to provide an adsorption / removal agent for harmful substances that can be adsorbed and removed.
【０００６】[0006]
【課題を解決するための手段】本発明は、粒径５μｍ〜
１０ｍｍの活性炭を生理学的に許容されるゲル状分散媒
中に０．０２〜９０重量％分散させてなる有害物質の吸
着除去剤に関する。The present invention has a particle size of 5 .mu.m.
The present invention relates to a harmful substance adsorption / removal agent in which 10 mm of activated carbon is dispersed in a physiologically acceptable gel-like dispersion medium in an amount of 0.02 to 90% by weight.
【０００７】本発明の有害物質の吸着除去剤は、微粒子
活性炭をゲル状分散媒中に均一に分散させた分散系から
なるので、活性炭単独で使用するよりも吸着剤全体とし
ての有効吸着面積が増加し吸着能が増大して、有害物質
を極めて高率に吸着除去することができる。Since the toxic substance adsorption / removal agent of the present invention comprises a dispersion system in which fine particle activated carbon is uniformly dispersed in a gel dispersion medium, the effective adsorption area of the entire adsorbent is larger than that of the activated carbon alone. As a result, the adsorptive capacity increases and harmful substances can be adsorbed and removed at an extremely high rate.
【０００８】また、本発明の有害物質の吸着除去剤は、
微粒子活性炭を生理学的に許容されるゲル状物質に分散
含有させているので、消化器系内に直接投与することが
でき、食品等に混入されて消化器系内に摂取された有害
物質を消化器系内において簡便に吸着除去することがで
きる。しかも、消化器系内の有害物質を吸着除去した後
の吸着剤は、極めて速やかに容易に消化器系外に排出さ
れうるものである。Further, the adsorbent / removal agent for harmful substances of the present invention is
Since fine particle activated carbon is dispersed and contained in a physiologically acceptable gel-like substance, it can be directly administered into the digestive system and digests harmful substances that are mixed into foods and ingested into the digestive system. It can be easily adsorbed and removed in the system. Moreover, the adsorbent after the harmful substances in the digestive system have been adsorbed and removed can be discharged to the outside of the digestive system very quickly and easily.
【０００９】また、本発明の有害物質の吸着除去剤は、
食品等に混合接触させて食品等に含まれる有害物質を吸
着除去することもできる。この場合、活性炭を単独で使
用した場合に比べ、有害物質を吸着除去後の吸着剤を食
品から簡単に短時間で分離することができる。さらに、
誤って吸着剤が分離されずに食品等に混入して消化器系
内に摂取されたとしても、上述のように迅速に消化器系
外に排出されるので安全である。The adsorption remover for harmful substances of the present invention is
It is also possible to adsorb and remove harmful substances contained in foods by mixing and contacting them with foods. In this case, as compared with the case where the activated carbon is used alone, the adsorbent after the harmful substances are adsorbed and removed can be easily separated from the food in a short time. further,
Even if the adsorbent is accidentally mixed into food or the like without being separated and ingested into the digestive system, it is safely discharged as described above because it is promptly discharged.
【００１０】本発明の有害物質の吸着除去剤は、上述の
ように消化器系内に直接投与して利用するほか、加工食
品等に混合して利用することもできる。また、本発明の
有害物質の吸着除去剤と同様の効果は、加工食品等に活
性炭を直接混入することによっても得られる。The harmful substance adsorption / removal agent of the present invention can be used by directly administering it into the digestive system as described above, or by mixing it with a processed food or the like. Further, the same effect as the harmful substance adsorption / removal agent of the present invention can also be obtained by directly mixing activated carbon into the processed food or the like.
【００１１】本発明の有害物質の吸着除去剤は、人体に
有害な物質の吸着除去剤としてヒトに対して利用できる
ほか、飼養動物に対しても利用することができる。すな
わち、本発明の吸着除去剤を用いて飼料を処理し、また
は本発明の吸着除去剤を直接もしくは飼料に混合するこ
とにより飼養動物に投与して利用できる。The harmful substance adsorption / removal agent of the present invention can be used not only for humans as an adsorption / removal agent for substances harmful to the human body, but also for domestic animals. That is, it can be used by treating a feed with the adsorption / removal agent of the present invention, or by administering the adsorption / removal agent of the present invention directly or by mixing it with a feed to a fed animal.
【００１２】[0012]
【発明の実施の形態】本発明の一つは、粒径５μｍ〜１
０ｍｍの活性炭を生理学的に許容されるゲル状分散媒中
に０．０２〜９０重量％分散させてなる有害物質の吸着
除去剤である。BEST MODE FOR CARRYING OUT THE INVENTION One of the present inventions has a particle size of 5 μm to 1 μm.
It is an adsorbent / removal agent for harmful substances obtained by dispersing 0 to 90% by weight of activated carbon of 0 mm in a physiologically acceptable gel-like dispersion medium.
【００１３】本発明の有害物質の吸着除去剤において使
用する活性炭の粒径は、５μｍ〜１０ｍｍがよい。活性
炭の粒径が５μｍ未満では取り扱いが困難になり、１０
ｍｍを超えると活性炭の単位重量当たりの吸着能が低下
する。The particle size of the activated carbon used in the harmful substance adsorption / removal agent of the present invention is preferably 5 μm to 10 mm. If the particle size of the activated carbon is less than 5 μm, it becomes difficult to handle, and 10
If it exceeds mm, the adsorption capacity of the activated carbon per unit weight decreases.
【００１４】また、分散媒中への活性炭の混合量は０．
０２〜９０重量％がよい。活性炭の混合量が０．０２重
量％未満では吸着効果が低く、９０重量％を超えるとゲ
ル状分散倍中に分散させることが困難になる。The amount of activated carbon mixed in the dispersion medium is 0.
It is preferably from 02 to 90% by weight. If the amount of activated carbon mixed is less than 0.02% by weight, the adsorption effect is low, and if it exceeds 90% by weight, it becomes difficult to disperse it in a gel dispersion.
【００１５】本発明の有害物質の吸着除去剤において使
用する生理学的に許容されるゲル状分散媒としては、消
化器系内に投与しても無害なゲル状物質、たとえば高分
子ポリカルボン酸の二価金属塩が挙げられる。高分子ポ
リカルボン酸の二価金属塩としては、アルギン酸、ペク
チン酸、カルボキシメチルセルロース、カルボキシメチ
ルキチン、スチレン−マレイン酸共重合体、スチレン−
マレイン酸半アルキルエステル共重合体、エチレン−ア
クリル酸共重合体、ポリアクリル酸、ポリメタクリル
酸、アクリル酸−メタクリル酸共重合体、アクリル酸−
マレイン酸共重合体、アクリル酸−マレイン酸半アルキ
ルエステル共重合体等、側鎖にカルボキシル基を有する
高分子化合物のカルシウム、マグネシウム、鉄、銅塩等
が挙げられる。As the physiologically acceptable gel-like dispersion medium used in the harmful substance adsorption / removal agent of the present invention, a gel-like substance such as a high molecular weight polycarboxylic acid which is harmless when administered into the digestive system is used. A divalent metal salt is mentioned. Examples of the divalent metal salt of high molecular weight polycarboxylic acid include alginic acid, pectic acid, carboxymethyl cellulose, carboxymethyl chitin, styrene-maleic acid copolymer, styrene-
Maleic acid half alkyl ester copolymer, ethylene-acrylic acid copolymer, polyacrylic acid, polymethacrylic acid, acrylic acid-methacrylic acid copolymer, acrylic acid-
Examples thereof include calcium, magnesium, iron and copper salts of polymer compounds having a carboxyl group in the side chain, such as maleic acid copolymers and acrylic acid-maleic acid half alkyl ester copolymers.
【００１６】高分子ポリカルボン酸の二価金属塩を用い
た吸着除去剤は、高分子ポリカルボン酸のアルカリ金属
塩またはアンモニウム塩と活性炭の懸濁液を二価金属塩
水溶液中に滴下することにより得られる。上記懸濁液の
高分子ポリカルボン酸のアルカリ金属塩またはアンモニ
ウム塩の濃度は０．０１〜５モルがよく、下限未満では
活性炭を分散するしっかりしたゲルが得られず、上限を
超えると活性炭をとりまく高分子ポリカルボン酸塩が多
く、被吸着物の吸着体内部への進入が阻害され吸着能が
著しく低下する。また、二価金属塩水溶液の濃度は０．
０５〜５モルがよく、下限未満では架橋率が少なく吸着
体の強度が弱くなり、上限を超える架橋率が大きくなり
吸着体の孔径が極めて小さくなり、被吸着体が吸着体内
部へ進入しにくくなる。As the adsorption remover using a divalent metal salt of a high molecular weight polycarboxylic acid, a suspension of an alkali metal salt or ammonium salt of a high molecular weight polycarboxylic acid and activated carbon is dropped into an aqueous solution of a divalent metal salt. Is obtained by The concentration of the alkali metal salt or ammonium salt of the high-molecular polycarboxylic acid in the above suspension is preferably 0.01 to 5 mol. Below the lower limit, a solid gel that disperses activated carbon cannot be obtained, and above the upper limit, activated carbon is removed. Since there are many high molecular weight polycarboxylic acid salts, the invasion of the substance to be adsorbed into the adsorbent is hindered and the adsorbability is significantly reduced. Further, the concentration of the divalent metal salt aqueous solution is 0.
The amount is preferably from 05 to 5 mol, and if it is less than the lower limit, the cross-linking rate is small and the strength of the adsorbent becomes weak, and if it exceeds the upper limit, the cross-linking rate becomes large and the pore size of the adsorbent becomes extremely small, so that the adsorbent hardly penetrates into the adsorbent Become.
【００１７】また、本発明においては、生理学的に許容
されるゲル状分散媒として、豆腐、ゼリー、コンニャ
ク、寒天、エゴまたはトコロテン等のゲル状食品、キト
サンシュウ酸塩ゲル等を用いることもできる。これらの
分散媒を用いた吸着除去剤は、それぞれのゲル状食品の
製造過程でゲル形成前に活性炭を適宜添加し分散させる
ことにより得られる。Further, in the present invention, gel food such as tofu, jelly, konjak, agar, ego or tocorotene, chitosan oxalate gel and the like can be used as the physiologically acceptable gel dispersion medium. . The adsorption-removing agent using these dispersion media can be obtained by appropriately adding and dispersing activated carbon before gel formation in the production process of each gel food.
【００１８】本発明の有害物質の吸着除去剤は、食品も
しくは飼料に含有されるまたは消化器系内に摂取された
食品添加物、飼料添加物、農薬類、自然毒、アレルゲ
ン、重金属、毒性の強い有機化合物等を吸着除去するの
に用いることができる。食品添加物としては、サッカリ
ンおよびその塩類、グリチルリチン酸二カリウム、グリ
チルリチン酸三カリウム、アセト酢酸エチル等の甘味
料、三二酸化鉄、食用赤色３号、４０号、１０２号、１
０４号、１０５号、１０６号、食用黄色４号、５号、食
用緑色３号、食用青色１号、２号、二酸化チタン等の着
色料、安息香酸、オルトフェニルフェノール、ソルビン
酸、デヒドロ酢酸、プロピオン酸およびそれらの塩類、
ジフェニル、チアベンダゾール、パラオキシ安息香酸エ
ステル類等の保存料、プロピレングリコール等の品質保
持剤、アルギン酸プロピレングリコール、カルボキシメ
チルセルロースカリウム、カルボキシメチルセルロース
ナトリウム、デンプングリコール酸ナトリウム、デンプ
ンリン酸エステルナトリウム、メチルセルロース、ポリ
アクリル酸ナトリウム等の増粘剤・安定剤・ゲル化剤・
糊料、ｄｌ−αトコフェロール、ニリソルビン酸および
そのナトリウム塩、グアヤク脂、クエン酸イソプロピ
ル、ジブチルヒドロキシトルエン、ノルジヒドログアヤ
レチック酸、ブチルヒドロキシアニソール、没食子酸プ
ロピル、エチレンジアミン四酢酸カルシウム二ナトリウ
ム、エチレンジアミン四酢酸二ナトリウム等の酸化防止
剤、亜硝酸ナトリウム、硝酸カリウム、硝酸ナトリウ
ム、硫酸第一鉄、リン酸塩等の発色剤、過酸化水素、次
亜塩素酸、次亜塩素酸ナトリウム等の殺菌剤、亜硫酸お
よびその塩類等の漂白剤、オルトフェニルフェノールお
よびその塩類、ジフェニル、チアベンダゾール等の防カ
ビ・防ばい剤、女性ホルモン等のホルモン等が挙げられ
る。農薬類としては、ＭＥＰ、ダイアジノン、ＰＡＰ、
ＩＢＰ、ＥＤＤＰ、ＤＤＶＰ、ＤＥＰ、マラソン、ＥＰ
Ｎ等の有機リン、クロロサロニル、クロルピクリン、Ｄ
−Ｄ、ピラゾレート、ＰＣＮＢ、フラサイド、ＤＣＩ
Ｐ、プロシミドン等の有機塩素、ＢＰＭＣ、ＭＴＭＣ、
ＸＭＣ、ＭＣＣ、ＭＩＰＣ等のカーバメート、臭化メチ
ル等の有機臭素、チオファネートメチル等のベンゾイミ
ダゾール、ベンチオカーブ等のチオカーバメイト、ＣＮ
Ｐ等のジフェニルエーテル、塩素酸塩等の塩素、キャプ
タン等のフタルイミド、マンネブ等のジチオカルバメー
ト、パラコート等のビピリジウム、クロメトキシニル等
のジフェニルエーテル、ＤＣＰＡ等の酸アミド、無機銅
等の銅、セトキシジム、イソプロチオラン、プロベナゾ
ール、ダイムロン、ナプロアニリド等の殺菌剤、殺虫
剤、除草剤等が挙げられる。自然毒としては、じゃがい
もの新芽に含まれるソラニン、アルカロイド、青酸配糖
体等が挙げられる。アレルゲンとしては、アレルギーよ
う食中毒の原因であり肉等の腐敗により生成するヒスタ
ミン等が挙げられる。重金属としては、水銀、鉛、六角
クロム、カドミウム、セレン、ヒ素、銅、鉄、亜鉛等が
挙げられる。また、毒性の強い有機化合物としては、リ
ン化物、塩化物、ベンゼン等が挙げられる。The harmful substance adsorption / removal agent of the present invention is a food additive, feed additive, pesticide, natural poison, allergen, heavy metal, or toxic substance contained in food or feed or ingested in the digestive system. It can be used to adsorb and remove strong organic compounds and the like. As food additives, saccharin and salts thereof, dipotassium glycyrrhizinate, tripotassium glycyrrhizinate, sweeteners such as ethyl acetoacetate, iron sesquioxide, food red 3, 40, 102, 1
Nos. 04, 105, 106, food yellows 4, 5, food greens 3, food blues 1, 2, colorants such as titanium dioxide, benzoic acid, orthophenylphenol, sorbic acid, dehydroacetic acid, Propionic acid and salts thereof,
Preservatives such as diphenyl, thiabendazole, paraoxybenzoic acid esters, quality preservatives such as propylene glycol, propylene glycol alginate, potassium carboxymethyl cellulose, sodium carboxymethyl cellulose, sodium starch glycolate, sodium starch phosphate, methyl cellulose, polyacrylic acid Thickeners / stabilizers / gelling agents such as sodium
Paste, dl-α tocopherol, nilysorbic acid and its sodium salt, guaiac butter, isopropyl citrate, dibutylhydroxytoluene, nordihydroguaiaretic acid, butylhydroxyanisole, propyl gallate, calcium disodium ethylenediaminetetraacetate, ethylenediaminetetraacetic acid. Antioxidants such as disodium acetate, sodium nitrite, potassium nitrate, sodium nitrate, ferrous sulfate, coloring agents such as phosphate, hydrogen peroxide, hypochlorous acid, disinfectant such as sodium hypochlorite, Examples thereof include bleaching agents such as sulfurous acid and salts thereof, orthophenylphenol and salts thereof, antifungal and antifungal agents such as diphenyl and thiabendazole, and hormones such as female hormones. Pesticides include MEP, diazinon, PAP,
IBP, EDDP, DDVP, DEP, marathon, EP
Organic phosphorus such as N, chlorosalonyl, chloropicrin, D
-D, pyrazolate, PCNB, flacide, DCI
P, organic chlorine such as procymidone, BPMC, MTMC,
Carbamate such as XMC, MCC, MIPC, organic bromine such as methyl bromide, benzimidazole such as thiophanate methyl, thiocarbamate such as bench iocarb, CN
Diphenyl ether such as P, chlorine such as chlorate, phthalimide such as captan, dithiocarbamate such as manneb, bipyridium such as paraquat, diphenyl ether such as clomethoxynil, acid amide such as DCPA, copper such as inorganic copper, setoxydim, isoprothiolane, probenazole , Dymuron, naproanilide and the like, insecticides, herbicides and the like. Examples of natural poisons include solanine, alkaloids and hydrocyanic acid glycosides contained in shoots of potatoes. Examples of the allergen include histamine, which is a cause of food poisoning such as allergy and is produced by decay of meat and the like. Examples of heavy metals include mercury, lead, hexagonal chromium, cadmium, selenium, arsenic, copper, iron and zinc. Examples of highly toxic organic compounds include phosphides, chlorides and benzene.
【００１９】また、本発明の有害物質の吸着除去剤は、
消化器系内に摂取された余剰栄養素を吸着除去するのに
も使用することができる。後述するように、本発明の吸
着除去剤は、細胞培養試験において培地中の栄養源を吸
着することにより細胞増殖を抑制する働きがあり、食品
等と一緒にまたは食前もしくは食後に摂取することによ
り食物等の代謝を抑制し抗肥満剤等としても利用するこ
とができる。The adsorbent / removal agent for harmful substances of the present invention is
It can also be used to adsorb and remove excess nutrients ingested in the digestive system. As described below, the adsorption-removing agent of the present invention has a function of suppressing cell growth by adsorbing a nutrient source in a medium in a cell culture test, and can be taken with foods or before or after eating. It can also be used as an antiobesity agent or the like by suppressing the metabolism of food and the like.
【００２０】さらに、本発明の有害物質の吸着除去剤
は、飲酒後消化器系内に生成するアルコールの中間代謝
物であるアセトアルデヒド等を吸着除去するのに用いる
ことができる。すなわち、哺乳動物におけるアルコール
（エチルアルコール）代謝は段階的に進行して中間代謝
物としてアセトアルデヒドを生成し、アセトアルデヒド
はついで酢酸とアセチル−ＣｏＡに酸化される。これら
のアルコール代謝において、アセトアルデヒドの濃度が
高くなると悪心、嘔吐、顔面紅潮、心拍増加、拍動性頭
痛、皮膚温上昇、最低血圧低下等の症状（アセトアルデ
ヒド症状）が起こる。したがって、飲酒の際またはその
前後に本発明の吸着剤を摂取し消化器系内に生成するア
セトアルデヒドを吸着除去することによって、これらの
アセトアルデヒド症状を予防または治療することができ
る。また、メタノール等の誤用による中毒症状もそのア
ルコールの中間代謝物に起因するものであるが、これら
のアチドーシスの治療にも利用することができる。Further, the harmful substance adsorption / removal agent of the present invention can be used to adsorb and remove acetaldehyde and the like which are intermediate metabolites of alcohol produced in the digestive system after drinking. That is, alcohol (ethyl alcohol) metabolism in mammals proceeds stepwise to produce acetaldehyde as an intermediate metabolite, which is then oxidized to acetic acid and acetyl-CoA. In these alcohol metabolisms, when the concentration of acetaldehyde increases, symptoms such as nausea, vomiting, hot flush, increased heartbeat, pulsatile headache, elevated skin temperature, and decreased minimum blood pressure (acetaldehyde symptoms) occur. Therefore, these acetaldehyde symptoms can be prevented or treated by ingesting the adsorbent of the present invention during or before drinking alcohol to adsorb and remove acetaldehyde generated in the digestive system. In addition, the poisoning symptom due to the misuse of methanol and the like is also caused by the intermediate metabolite of the alcohol, but it can be used for the treatment of these atidosis.
【００２１】本発明の他の一つは、上記有害物質の吸着
除去剤を０．０１〜６０重量％混入した加工食品または
飼料である。Another aspect of the present invention is a processed food or feed containing 0.01 to 60% by weight of the adsorbent / removal agent for harmful substances.
【００２２】本発明の有害物質の吸着除去剤の加工食品
等への混合量を０．０１〜６０重量％としたのは、０．
０１重量％未満では十分な吸着能が得られず、６０％を
超えると食品等としての風合いや食感が得られず異物感
がひどくなるからである。The mixing amount of the harmful substance adsorption-removing agent of the present invention with processed foods is 0.01 to 60% by weight.
This is because if it is less than 01% by weight, a sufficient adsorption ability cannot be obtained, and if it exceeds 60%, the texture and texture of a food or the like cannot be obtained and the feeling of foreign matter becomes severe.
【００２３】吸着除去剤を混入する加工食品としては、
ヨーグルト、チーズ等の乳製品、かまぼこ、ちくわ、は
んぺん、さつま揚げ、なると、つみれ等の水産練り製
品、でんぶ等の魚介類加工品、ソーセージ、フランクフ
ルト、レバーペースト等の食肉加工品、豆腐、焼き豆
腐、生揚げ、油揚げ、がんもどき、おから、凍り豆腐、
湯葉等の豆製品、ピューレ等の野菜加工品、マッシュポ
テト、くず、はるさめ、こんにゃく、しらたき等の芋加
工品、もち、白玉、白飯、麩、ビーフン、マカロニ、ス
パゲッティ、そうめん、そば、うどん、中華めん、食パ
ン、乾パン、アンパン等の穀物の加工品、ジャム等の甘
味類、バター、マーガリン、マヨネーズ、ドレッシング
等の油脂類、あめ、らくがん、せんべい、あられ、カス
テラ、ようかん、もなか、まんじゅう、大福もち、だん
ご、ういろう、チョコレート、ビスケット、クッキー、
ドーナツ、ケーキ、パイ、アイスクリーム、プリン、ゼ
リー、ババロア等の菓子類等が挙げられる。As a processed food containing an adsorbent / removal agent,
Yogurt, dairy products such as cheese, kamaboko, chikuwa, hanpen, fried fried fish, when it comes to fish paste products such as tsumire, processed seafood products such as starch, processed meat products such as sausage, Frankfurt, liver paste, tofu, baked tofu, fried, Deep-fried tofu, ganmodoki, okara, frozen tofu,
Bean products such as yuba, processed vegetables such as purees, mashed potatoes, litter, processed products of potatoes such as harusame, konjac, shirataki, mochi, white balls, white rice, fu, beef noodles, macaroni, spaghetti, somen, soba, udon, Chinese noodles, Processed grain products such as loaf, dried bread, and anpan, sweets such as jam, butter, margarine, mayonnaise, oils and fats such as dressings, candy, luck cancer, rice cracker, hail, castella, yokan, honey, manju, daifuku rice cake, dumpling , Uiro, chocolate, biscuits, cookies,
Examples include confectionery such as donuts, cakes, pies, ice cream, puddings, jellies and bavarois.
【００２４】本発明のさらに他の一つは、粒径５μｍ〜
０．５ｍｍの活性炭を０．０１〜６０重量％混入した加
工食品または飼料である。Still another aspect of the present invention is that the particle size is 5 μm
It is a processed food or feed containing 0.01 to 60% by weight of 0.5 mm activated carbon.
【００２５】活性炭の粒径が５μｍ未満では取り扱いが
困難になり、０．５ｍｍを超えると食品等としての風合
いや食感が得られず異物感がひどくなる。また、活性炭
の加工食品等への混合量が制限されるのは、前記本発明
の加工食品等における制限と同様の理由によるものであ
る。また、活性炭を混入する加工食品としては、前記加
工食品と同様のものが挙げられる。If the particle size of the activated carbon is less than 5 μm, it becomes difficult to handle, and if it exceeds 0.5 mm, the texture and texture of foods and the like cannot be obtained, and the feeling of foreign matter becomes awful. Further, the reason why the amount of activated carbon mixed in the processed food or the like is limited is the same as the restriction in the processed food or the like of the present invention. The processed food containing activated carbon may be the same as the above processed food.
【００２６】[0026]
［実施例１］ 活性炭入りコンニャクの製造 精粉１６ｇと粒径約１５μｍの活性炭４ｇとをよく混
ぜ、３０℃の温水７５０ｍｌに固まりができないように
少量ずつ加え、撹拌しながら強火で約５分間加熱した。
気泡がぶつぶつ吹き出すようになったのち中火にして７
〜８分間撹拌を続け、その後４０℃程度まで冷却した。
乳鉢でよくすり潰したＣａＯを４０℃の温湯５０ｍｌに
溶かしたものをこれに加え、全体を手早くこね、型箱に
入れて指でよく押さえ内部の空気を抜いて均質にした。
型箱ごと熱湯中に入れて約５分間加熱し、型箱から取り
出してさらに２５分間加熱を続けて完全に凝固させた。
できあがった活性炭入りコンニャクを流水にさらしてあ
く抜きをし、約１ｍｍ３ に細切し、実験試料とした。[Example 1] Production of konjak containing activated carbon 16 g of refined powder and 4 g of activated carbon having a particle size of about 15 µm were mixed well, added little by little to 750 ml of warm water at 30 ° C so as not to clump, and heated for 5 minutes with high heat with stirring. did.
After the air bubbles began to blow out, set it to medium heat 7
The stirring was continued for 8 minutes, and then cooled to about 40 ° C.
What melted CaO well ground in a mortar in 50 ml of hot water at 40 ° C was added to this, and the whole was quickly kneaded, put in a mold box and well pressed with fingers to remove air inside to homogenize.
The whole mold box was put in boiling water and heated for about 5 minutes, taken out from the mold box and further heated for 25 minutes to be completely solidified.
The resulting konjak containing activated carbon was exposed to running water, punched out, and cut into pieces of about 1 mm 3 to obtain experimental samples.
【００２７】［実施例２］ 活性炭入りアルギン酸カルシウムゲルボールの製造 アルギン酸ナトリウム２ｇと粒径約１５μｍの活性炭３
ｇとをよく混合し、撹拌下水８００ｍｌ中に少量ずつ添
加し、さらに水を加えて全量を１０００ｍｌとした。さ
らに２４時間撹拌し、０．３％活性炭入りのアルギン酸
ナトリウム溶液を調製した。別に塩化カルシウム１１．
１ｇを蒸留水８００ｍｌ中に溶かし、さらに蒸留水を加
えて重量を１０００ｍｌとし、１．１１％塩化カルシウ
ム溶液を調製した。Example 2 Production of calcium alginate gel balls containing activated carbon 2 g of sodium alginate and activated carbon 3 having a particle size of about 15 μm
g and well mixed, and added little by little to 800 ml of water with stirring, and water was further added to make the total amount 1000 ml. The mixture was further stirred for 24 hours to prepare a sodium alginate solution containing 0.3% activated carbon. Separately calcium chloride 11.
1 g was dissolved in 800 ml of distilled water, and distilled water was added to make the weight 1000 ml to prepare a 1.11% calcium chloride solution.
【００２８】次に、０．３％活性炭入りのアルギン酸ナ
トリウム溶液を５０ｍｌのビューレットに注入し、１．
１１％塩化カルシウム溶液５００ｍｌ中に１適づつ滴下
し、活性炭入りアルギン酸カルシウムゲルボールの粗製
品を得た。得られたゲルボールを集め、５ｌの容器に入
れ、イオン交換水を流しつつ、１０時間処理して未反応
物および副生成物を除去して、活性炭入りアルギン酸カ
ルシウムゲルボールを得た。Next, a sodium alginate solution containing 0.3% activated carbon was poured into 50 ml of burette, and 1.
One drop was added dropwise to 500 ml of 11% calcium chloride solution to obtain a crude product of calcium alginate gel balls containing activated carbon. The obtained gel balls were collected, placed in a 5 liter container, and treated with ion-exchanged water for 10 hours to remove unreacted substances and by-products to obtain activated carbon-containing calcium alginate gel balls.
【００２９】［実施例３］ 活性炭入り食パンの製造 強力粉４００ｇ、粒径約１５μｍの活性炭４ｇ、バター
１５ｇ、スキムミルク８ｇ、砂糖１０ｇ、塩７ｇおよび
ドライイースト４ｇを用い、ナショナル自動ホームベー
カリー（松下電器産業株式会社製 ＳＤ−ＢＴ６）によ
り４時間１５分かけて製パンした。得られた活性炭入り
食パンを食したところ、風味と食感は活性炭を入れない
場合と比較して全く同じであった。Example 3 Production of Bread Containing Activated Carbon Using 400 g of strong flour, 4 g of activated carbon having a particle size of about 15 μm, 15 g of butter, 8 g of skim milk, 10 g of sugar, 7 g of salt and 4 g of dry yeast, National Automatic Home Bakery (Matsushita Electric Industrial Co., Ltd.) Bread was made for 4 hours and 15 minutes by SD-BT6) manufactured by the company. When the obtained bread containing activated carbon was eaten, the flavor and texture were exactly the same as when the activated carbon was not added.
【００３０】［実施例４］ 種々の活性炭粒子の植物細胞への吸着性試験 モデル植物細胞としてＣａｔｈａｒａｎｔｈｕｓ ｒｏ
ｓｃｕｓ（ニチニチソウ）の培養細胞を用い、培地１０
０ｍｌを含む５００ｍｌ三角フラスコで、回転振盪培養
（１２０ｒｐｍ）による細胞培養を行った。培地はＭｕ
ｒａｓｈｉｎｇｅ Ｓｋｏｏｇ（ＭＳ）培地にＳｕｃｒ
ｏｓｅ（蔗糖）３０ｇ／ｌと植物生長調節物質である
２，４−Ｄ０．５ｍｇ／ｌを添加したものを用いた。粒
径の大きい活性炭（粒径約５ｍｍ）、粒径の小さい活性
炭（粒径約１５μｍ）、実施例１で製造した活性炭入り
コンニャクおよび実施例３で製造した活性炭入り食パン
をそれぞれ培地に１．０％（Ｗ／Ｖ）になるように添加
した。細胞の増殖量は、Ｐａｃｋｅｄ ｃｅｌｌ ｖｏ
ｌｕｍｅ（圧縮細胞量法、「植物細胞組織培養 実際・
応用・展望 第一版」原田宏他編集、第５５頁、１９９
３年）により行った。[Example 4] Adsorption test of various activated carbon particles to plant cells Catharanthus ro was used as a model plant cell.
Using culture cells of scus (Pinus periwinkle), medium 10
Cell culture was performed by rotary shaking culture (120 rpm) in a 500 ml Erlenmeyer flask containing 0 ml. The medium is Mu
Sucr in rushinge Skoog (MS) medium
30 g / l of ose (sucrose) and 0.5 mg / l of 2,4-D which is a plant growth regulator were used. Activated carbon having a large particle size (particle size of about 5 mm), activated carbon having a small particle size (particle size of about 15 μm), konjak containing activated carbon produced in Example 1 and bread containing activated carbon produced in Example 3 were respectively added to the medium at 1.0. % (W / V). The amount of cells grown was determined by packed cell vo
lume (compressed cell mass method, “plant cell tissue culture
Application / Prospect, 1st edition ”edited by Hiroshi Harada et al., P. 55, 199
3 years).
【００３１】植物細胞は通常、単細胞の状態よりも数十
から数千の細胞で構成される細胞集塊の状態で数多く存
在する。培養１４日目の細胞について顕微鏡観察を行っ
た結果、粒径の大きい活性炭および粒径の小さい活性炭
を添加したものは、ともに活性炭が核になり細胞集塊を
形成したものが一部認められた。これに対し、本発明の
活性炭入りコンニャクおよび活性炭入り食パンを添加し
たものではほとんど認められなかった。The plant cells usually exist in a large number in the state of a cell mass composed of tens to thousands of cells rather than a single cell. As a result of microscopic observation of the cells on the 14th day of culture, in some of the cells to which the activated carbon having a large particle size and the activated carbon having a small particle size were added, both of which activated carbon became a nucleus and formed a cell aggregate were partially observed. . On the other hand, it was hardly observed in the case of adding the konjak containing activated carbon and the bread containing activated carbon of the present invention.
【００３２】また、いずれの場合も、細胞内部への活性
炭の移動、吸収は認められなかった。 細胞の増殖につ
いて見てみると、活性炭を添加した場合、いずれのタイ
プにおいても、細胞の増殖が約３０％阻害されていた。
この現象は培地中の栄養源が活性炭に吸着し、栄養源が
不足したために生じたものと考察される。Further, in any case, migration or absorption of activated carbon into the cells was not observed. As for the cell growth, when activated carbon was added, cell growth was inhibited by about 30% in all types.
It is considered that this phenomenon occurred because the nutrient source in the medium was adsorbed on the activated carbon and the nutrient source was insufficient.
【００３３】［実施例５］ 着色料（食用赤色１０4号（フロキシン））の吸着除去
試験 食品添加物着色料は食品の美化または天然色の色彩模倣
を目的に使用されているが、合成タール系色素で現在使
用が認められているものは赤色１０４号等の水溶性酸性
色素のみであり、その使用も制限されている。[Example 5] Adsorption / removal test of colorant (Edible Red No. 104 (phloxine)) A food additive colorant is used for the purpose of beautifying foods or imitating the color of natural colors. The only dyes currently approved for use are water-soluble acidic dyes such as Red No. 104, and their use is also limited.
【００３４】ソーセージ２０ｇを細かく砕き、実施例１
で製造した活性炭入りコンニャク０．５ｇと水１００ｍ
ｌを加え１０分間撹拌し吸着処理を行なった。５倍用の
温湯を加え溶解した後、遠心分離し、上澄液を試験溶液
とした。これを、「目で見る食品衛生検査法」春田三佐
夫他編集、中央法規出版、第１４６〜１４９頁に記載の
方法に準じて処理し、濾紙クロマトグラフィーにより判
定した。20 g of sausage was finely crushed, and Example 1 was used.
0.5g Konjac with activated carbon and water 100m
1 was added and stirred for 10 minutes for adsorption treatment. After adding 5 times warm water for dissolution, the mixture was centrifuged and the supernatant was used as a test solution. This was treated according to the method described in "Visual Inspection of Food Hygiene" by Misao Haruta et al., Central Law Publishing, pages 146-149, and judged by filter paper chromatography.
【００３５】活性炭入りコンニャクを加えない以外は同
じ条件で処理したコントロールでは食用赤色１０４号が
検出されたのに対し、活性炭入りコンニャクを混入した
場合では検出されなかった。Food red No. 104 was detected in the control treated under the same conditions except that konjak containing activated carbon was not added, whereas it was not detected in the case where konjak containing activated carbon was mixed.
【００３６】［実施例６］ 保存料（オルトフェニルフェノール（ＯＰＰ））の吸着
除去試験 オルトフェニルフェノールはチャンベンダゾール（ＴＢ
Ｚ）と同様発ガン性や催奇形成が認められる。この保存
料はカビ類、各種の好気性および嫌気性菌に対して発育
阻止作用があり、広範囲の加工食品に使用されている。Example 6 Adsorption / removal test of preservative (orthophenylphenol (OPP)) Orthophenylphenol was chanbendazole (TB).
Carcinogenicity and teratogenicity are observed as in Z). This preservative has a growth inhibitory action against molds and various aerobic and anaerobic bacteria, and is used in a wide variety of processed foods.
【００３７】オレンジを細切りした試料５０ｇをビーカ
ーに採取し、水を約１００ｍｌ加え、さらに実施例２で
製造した活性炭入りアルギン酸カルシウムゲルボール１
ｇを加え、１０分間撹拌し混和した。これを「目で見る
食品衛生検査法」春田三佐夫他編集、中央法規出版、第
１４２〜１４３頁に記載の方法に準じて処理し、ガスク
ロマトグラフィーによりオルトフェニルフェノール濃度
を定量した。50 g of a finely sliced orange sample was collected in a beaker, about 100 ml of water was added, and the activated carbon-containing calcium alginate gel ball 1 produced in Example 2 was further added.
g was added, and the mixture was stirred for 10 minutes and mixed. This was processed according to the method described in "Visual Inspection of Food Hygiene" by Misao Haruta et al., Central Law Publishing, pages 142-143, and the orthophenylphenol concentration was determined by gas chromatography.
【００３８】活性炭入りアルギン酸カルシウムゲルボー
ルを加えない以外は同じ条件で処理したコントロールで
は、１０．０５ｐｐｍのオルトフェニルフェノールが検
出されたのに対し、活性炭入りアルギン酸カルシウムゲ
ルボールを混入した場合では、定量限界（０．０１ｐｐ
ｍ）以下であった。In the control treated under the same conditions except that the calcium alginate gel ball containing activated carbon was not added, 10.05 ppm of orthophenylphenol was detected, while the amount of calcium alginate gel ball containing activated carbon was mixed in the control. Limit (0.01pp
m).
【００３９】［実施例７］ 酸化防止剤（ジブチルヒドロキシトルエン（ＢＨＴ））
の吸着除去試験 酸化防止剤は油脂の酸敗を防ぐことの他に、風味の損失
の防止、酸化により劣化する食品の栄養価の保持、水産
加工品の日焼けの防止、色素の褐色防止等の効果があ
り、多種類の食品に使用されている。Example 7 Antioxidant (dibutylhydroxytoluene (BHT))
Adsorption removal test of antioxidants, in addition to preventing rancidity of fats and oils, it also prevents flavor loss, retains the nutritional value of foods that are deteriorated by oxidation, prevents sunburn of processed marine products, and prevents browning of pigments. It is used in many kinds of foods.
【００４０】チューインガム５ｇ、ＮａＣｌ５０ｇ、ピ
ロガロール０．２ｇ、水２００ｍｌ、沸騰石および実施
例２で製造した活性炭入りアルギン酸カルシウム１ｇを
５００ｍｌのナス型フラスコに入れ、還流冷却器付の連
続抽出器に接続し、連続抽出した。これを「目で見る食
品衛生検査法」春田三佐夫他編集、中央法規出版、第１
５８〜１５９頁に記載の方法に準じて処理し、ガスクロ
マトグラフィーによりジブチルヒドロキシトルエン濃度
を定量した。5 g of chewing gum, 50 g of NaCl, 0.2 g of pyrogallol, 200 ml of water, 1 g of calcium alginate containing boiling stone and the activated carbon prepared in Example 2 were put in a 500 ml eggplant-shaped flask and connected to a continuous extractor equipped with a reflux condenser. , Extracted continuously. Edited by "Visual Inspection of Food Hygiene" by Misao Haruta and others, Central Law Publishing, No. 1
The treatment was carried out according to the method described on pages 58 to 159, and the concentration of dibutylhydroxytoluene was quantified by gas chromatography.
【００４１】活性炭入りアルギン酸カルシウムゲルボー
ルを加えない以外は同じ条件で処理したコントロールで
は、０．３５ｇ／ｋｇのジブチルヒドロキシトルエンが
検出されたのに対し、活性炭入りアルギン酸カルシウム
ゲルボールを混入した場合では、定量限界（０．０１ｇ
／ｋｇ）以下であった。In the control treated under the same conditions except that the calcium alginate gel ball containing activated carbon was not added, 0.35 g / kg of dibutylhydroxytoluene was detected, whereas the calcium alginate gel ball containing activated carbon was mixed in the control. , Limit of quantification (0.01g
/ Kg) or less.
【００４２】［実施例８］ 殺菌料（過酸化水素）の吸着除去試験 過酸化水素は強力な酸化作用、殺菌力を有するが、マウ
スへの経口投与で十二指腸に微弱ながらがんの発生が認
められて以来使用が制限され、現在はカズノコのみに使
用されている。[Example 8] Adsorption / removal test of bactericidal agent (hydrogen peroxide) Hydrogen peroxide has a strong oxidative action and bactericidal activity, but when it is orally administered to mice, the occurrence of cancer is recognized in the duodenum, although it is weak. Its use has been limited since then, and is currently used only for Kazunoko.
【００４３】細切りしたカズノコ約５ｇを採り、磨砕用
カップに入れ、浸出用液４０ｍｌを加え、外側から氷冷
しながら３分間激しくかき混ぜた後、実施例１で製造し
た活性炭入りコンニャク０．３ｇを加え５分間さらに混
合した。シリコーンを０．１ｍｌ加えて生成した気泡を
除去し、水を加えて５０ｍｌとした後よくかき混ぜろ過
した。ろ液は最初の５ｍｌを捨て、そのまま試験溶液と
した。これを、「目で見る食品衛生検査法」春田三佐夫
他編集、中央法規出版、第１４４〜１４５頁に記載の方
法に準じて処理し、酸素電位測定により過酸化水素濃度
を定量した。Approximately 5 g of shredded cabbage was placed in a grinding cup, 40 ml of the leaching solution was added, and the mixture was vigorously stirred for 3 minutes while cooling with ice from the outside, and then 0.3 g of the konjak containing activated carbon produced in Example 1 Was added and further mixed for 5 minutes. The generated air bubbles were removed by adding 0.1 ml of silicone, water was added to make 50 ml, and the mixture was thoroughly stirred and filtered. The first 5 ml of the filtrate was discarded and used as the test solution as it was. This was processed according to the method described in "Visual Inspection of Food Hygiene" by Misao Haruta et al., Central Law Publishing, pages 144-145, and the hydrogen peroxide concentration was quantified by oxygen potential measurement.
【００４４】活性炭入りコンニャクを加えない以外は同
じ条件で処理したコントロールでは、０．８５ｐｐｍの
オルトフェニルフェノールが検出されたのに対し、活性
炭入りコンニャクを混入した場合では、定量限界（０．
０１ｐｐｍ）以下であった。In the control treated under the same conditions except that the konjak containing activated carbon was not added, 0.85 ppm of orthophenylphenol was detected, while the quantification limit (0.
01 ppm) or less.
【００４５】［実施例９］ 漂白剤（亜硫酸）の吸着除去実験 亜硫酸およびその塩類は漂白効果以外に、保存、酸化防
止などの効果を有するため、多くの食品に添加物として
使用されており、各食品別に二酸化硫黄の残存量として
規制されている。[Example 9] Adsorption and removal experiment of bleaching agent (sulfurous acid) Sulfurous acid and its salts are used as an additive in many foods because they have effects such as storage and antioxidant in addition to the bleaching effect. Each food item is regulated as the residual amount of sulfur dioxide.
【００４６】細切りしたかんぴょう０．２ｇを採り、実
施例１で製造した活性炭入りコンニャク０．２ｇと蒸留
水２０ｍｌとを加え１０分間撹拌混和し試料とした。こ
れを、「目で見る食品衛生検査法」春田三佐夫他編集、
中央法規出版、第１５０〜１５１頁に記載の方法に準じ
て処理し、改良ランキン法により亜硫酸濃度を定量し
た。0.2 g of finely sliced Kanpyo was taken, 0.2 g of konjak containing activated carbon produced in Example 1 and 20 ml of distilled water were added, and the mixture was stirred and mixed for 10 minutes to prepare a sample. This was edited by Misao Haruta et al., "Food Hygiene Inspection Act by Eye,"
The treatment was carried out according to the method described on pages 150 to 151 of Chuo Hokoku Shuppan, and the sulfite concentration was quantified by the modified Rankine method.
【００４７】活性炭入りコンニャクを加えない以外は同
じ条件で処理したコントロールでは、２００ｐｐｍの亜
硫酸が検出されたのに対し、活性炭入りコンニャクを混
入した場合では、定量限界（１６０ｐｐｍ）以下であっ
た。In the control treated under the same conditions except that the konjak containing activated carbon was not added, 200 ppm of sulfurous acid was detected, while the quantification limit (160 ppm) was not exceeded when konjak containing activated carbon was mixed.
【００４８】［実施例１０］ 女性ホルモン（エストラジオール）の吸着除去実験 エストラジオールを混餌投与した雄牛肉２５ｇを採取
し、水を加えて全量を５０ｇとした。これに実施例１で
製造した活性炭入りコンニャク７ｇを加え、３０分間撹
拌後５０００ｒｐｍで遠心分離し、上澄み液を試料とし
た。これを、ＲＩＡ（Ｒａｄｉｏｉｍｍｕｎｏａｓｓａ
ｙ）放射免疫測定法（「臨床検査法提要」改訂第３０版
金井正光編著 金原出版株式会社 第８１８頁）に従
い、エストラジオール測定キット（エストラジオール＝
抗体キット；日本ＤＰＣ製）を用いてエストラジオール
濃度を測定した。Example 10 Adsorption and Removal Experiment of Female Hormone (Estradiol) 25 g of beef to which estradiol was administered as a diet was collected, and water was added to bring the total amount to 50 g. To this, 7 g of konjak containing activated carbon produced in Example 1 was added, stirred for 30 minutes and then centrifuged at 5000 rpm, and the supernatant was used as a sample. This is the RIA (Radioimmunoassa
y) According to the radioimmunoassay method ("Clinical test method requirement", revised 30th edition, edited by Masamitsu Kanai, Kinhara Publishing Co., Ltd., p. 818), an estradiol measurement kit (estradiol =
The estradiol concentration was measured using an antibody kit (manufactured by Japan DPC).
【００４９】活性炭入りコンニャクを加えない以外は同
じ条件で処理したコントロールでは、３００ｐｇ／ｍｌ
のエストラジオールが検出されたのに対し、活性炭入り
食パンを混入した場合では、定量限界（５ｐｇ／ｍｌ）
以下であった。In the control treated under the same conditions except that konjac containing activated carbon was not added, 300 pg / ml was used.
Of estradiol was detected, whereas the limit of quantification (5 pg / ml) was observed when bread containing activated carbon was mixed.
It was below.
【００５０】［実施例１１］ 有機リン剤（ダイアジノン）の吸着除去試験 有機リン剤は、現在殺虫剤として３５種類、殺菌剤とし
て３種類、除草剤として８種類が登録されており、低残
留性、低毒性ということで広く利用されている。[Example 11] Adsorption / removal test of organophosphorus agent (diazinon) 35 kinds of organophosphorus agents, 3 kinds of fungicides, and 8 kinds of herbicides are currently registered, and they have low residual property. It is widely used due to its low toxicity.
【００５１】細片リンゴ２０ｇをアセトン１００ｍｌ中
に入れ、高速ホモジナイザーで５分間混和した。これ
に、実施例２で製造した活性炭入りアルギン酸カルシウ
ムゲルボール１ｇを加え５分間撹拌混和した。次に桐山
製漏斗（ろ過助剤５ｍｍ）でろ過し、さらに３０％含水
アセトン１００ｍｌで同様に抽出ろ過した。得られたろ
液を、「目で見る食品衛生検査法」春田三佐夫他編集、
中央法規出版、第９４〜９５頁に記載の方法に準じて処
理し、ガスクロマトグラフィーによりダイアジノン濃度
を定量した。20 g of apple pieces was put in 100 ml of acetone and mixed by a high speed homogenizer for 5 minutes. To this, 1 g of calcium alginate gel balls containing activated carbon produced in Example 2 was added and mixed with stirring for 5 minutes. Then, the mixture was filtered with a funnel made by Kiriyama (filter aid 5 mm), and then similarly extracted and filtered with 100 ml of 30% hydrous acetone. The resulting filtrate was edited by Misao Haruta et al., "Food Hygiene Inspection Method by Eye",
The treatment was performed according to the method described in Central Law Publication, pages 94 to 95, and the diazinon concentration was quantified by gas chromatography.
【００５２】活性炭入りアルギン酸カルシウムゲルボー
ルを加えない以外は同じ条件で処理したコントロールで
は、０．０１ｐｐｍのダイアジノンが検出されたのに対
し、活性炭入りアルギン酸カルシウムゲルボールを混入
した場合では、検出限界（１０ｐｐｂ）以下であった。In the control treated under the same conditions except that the calcium alginate gel ball containing activated carbon was not added, 0.01 ppm of diazinon was detected, whereas the calcium alginate gel ball containing activated carbon was mixed in the detection limit ( It was 10 ppb) or less.
【００５３】［実施例１２］ 有機塩素剤（クロロサロニル（ＴＰＮ））の吸着除去試
験 有機塩素剤は毒性、残留性の点で問題となり、現在はほ
とんど使用禁止となったが、クロロサロニル（ＴＰ
Ｎ）、ＰＣＮＢ、フタルイミド系、クロルベンジレート
類等は現在も殺菌剤、殺ダニ剤として使用されている。Example 12 Adsorption / removal test of organochlorine agent (chlorosalonyl (TPN)) The organochlorine agent became a problem in terms of toxicity and persistence, and it is almost prohibited to use it at present.
N), PCNB, phthalimides, chlorobenzilates and the like are still used as fungicides and acaricides.
【００５４】細片キュウリ２０ｇをアセトン１００ｍｌ
中に加え、高速ホモジナイザーで５分間混和した後、実
施例２で製造した活性炭入りアルギン酸カルシウムゲル
ボール１ｇを加え１０分間撹拌混入した。得られた抽出
液を、「目で見る食品衛生検査法」春田三佐夫他編集、
中央法規出版、第９６〜９９頁に記載の方法に準じて処
理し、ガスクロマトグラフィーによりクロロサロニル濃
度を定量した。20 g of cucumber strips and 100 ml of acetone
The mixture was added to the inside and mixed with a high-speed homogenizer for 5 minutes, and then 1 g of the calcium alginate gel balls containing activated carbon produced in Example 2 was added and stirred for 10 minutes. The resulting extract was edited by Misao Haruta et al., “Visual Food Hygiene Inspection Method,”
The treatment was carried out according to the method described in Central Law Publication, pages 96 to 99, and the chlorosalonil concentration was quantified by gas chromatography.
【００５５】活性炭入りアルギン酸カルシウムゲルボー
ルを加えない以外は同じ条件で処理したコントロールで
は、２．０１９ｐｐｍのクロロサロニルが検出されたの
に対し、活性炭入りアルギン酸カルシウムゲルボールを
混入した場合では、定量限界（０．００１ｐｐｍ）以下
であった。In the control treated under the same conditions except that the calcium alginate gel ball containing activated carbon was not added, 2.019 ppm of chlorosalonil was detected, whereas the limit of quantification was found when the calcium alginate gel ball containing activated carbon was mixed ( It was 0.001 ppm) or less.
【００５６】［実施例１３］ カーバメート剤の吸着除去試験 カーバメイト剤は、殺虫剤として１１種類、除草剤とし
て８種類登録されており、低毒性、低残留性ということ
で有機リン剤とともに殺虫剤として多く利用されてい
る。Example 13 Carbamate Adsorption Removal Test 11 kinds of carbamate agents are registered as insecticides and 8 kinds of herbicides are registered, and they are used as insecticides together with organophosphorus agents because of their low toxicity and low residue. Many are used.
【００５７】細片トマト２０ｇをアセトン１００ｍｌ中
に加え、高速ホモジナイザーで５分間混和した後、実施
例１で製造した活性炭入りコンニャク１ｇを加え１０分
間撹拌混入した。得られた抽出液を、「目で見る食品衛
生検査法」春田三佐夫他編集、中央法規出版、第１０２
〜１０３頁に記載の方法に準じて処理し、ガスクロマト
グラフィーによりカーバメート剤濃度を定量した。20 g of the stripped tomato was added to 100 ml of acetone and mixed for 5 minutes with a high-speed homogenizer, then 1 g of konjak containing activated carbon produced in Example 1 was added and stirred for 10 minutes. The extract obtained was edited by "The Visual Inspection Method of Food Hygiene" by Misao Haruta et al., Central Law Publishing, No. 102
The treatment was carried out according to the method described on page 103 and the carbamate agent concentration was quantified by gas chromatography.
【００５８】活性炭入りコンニャクを加えない以外は同
じ条件で処理したコントロールでは、０．８５０ｐｐｍ
のカーバメート剤が検出されたのに対し、活性炭入りコ
ンニャクを混入した場合では、定量限界（０．００１ｐ
ｐｍ）以下であった。In the control treated under the same conditions except that konjak containing activated carbon was not added, 0.850 ppm
Carbamate agent was detected, whereas the quantification limit (0.001 p
pm) or less.
【００５９】［実施例１４］ 自然毒（ソラニン）の吸着除去試験 ソラニンはジャガイモの新芽部分に存在するアルカロイ
ド配糖体である。ＬＤ５０はウサギ経口で０．４５ｇ／
ｋｇであり、ヒトの場合０．２〜０．4ｇで中毒を起こ
す。Example 14 Adsorption and Removal Test of Natural Toxin (Solanine) Solanine is an alkaloid glycoside existing in the sprout portion of potato. LD50 is 0.45 g / orally in rabbit
In humans, 0.2 to 0.4 g causes poisoning.
【００６０】細片したジャガイモ５ｇをメタノール３０
ｍｌ中に入れ５分間ホモジナイズした後、実施例２で製
造した活性炭入りアルギン酸カルシウムゲルボール０．
５ｇを加え５分間撹拌した。得られた抽出液を、「目で
見る食品衛生検査法」春田三佐夫他編集、中央法規出
版、第８２〜８３頁に記載の方法に準じて処理し、液体
クロマトグラフィーによりソラニン濃度を定量した。5 g of the potatoes that had been cut into pieces was added to 30 parts of methanol.
After homogenizing for 5 minutes, the activated carbon-containing calcium alginate gel balls prepared in Example 2 were added.
5 g was added and stirred for 5 minutes. The obtained extract was treated according to the method described in "Visual Inspection of Food Hygiene" by Misao Haruta et al., Central Law Publication, pages 82-83, and the solanine concentration was quantified by liquid chromatography. .
【００６１】上記の操作で活性炭入りアルギン酸カルシ
ウムゲルボールを加えない以外は全て同一条件で処理し
たコントロールでは、８０ｐｐｍのソラニンが検出され
たのに対し、活性炭入りアルギン酸カルシウムゲルボー
ルを混入した場合では、検出限界（０．００１ｐｐｍ）
以下であった。In the control which was treated under the same conditions except that the calcium alginate gel ball containing activated carbon was not added in the above operation, 80 ppm of solanine was detected, whereas in the case where calcium alginate gel ball containing activated carbon was mixed, Detection limit (0.001ppm)
It was below.
【００６２】［実施例１５］ ヒスタミンの吸着除去試験 アレルギーよう食中毒の原因となりやすいサバ、アジ、
サンマ等の赤身の魚類は、筋肉中の遊離のヒスチジン含
有量が高い。これらの魚肉がヒスチジンデカルボキシラ
ーゼ活性が強くヒスタミナーゼ活性が弱い細菌によって
汚染されるとヒスタミンが蓄積される。[Example 15] Adsorption / removal test of histamine Mackerel, horse mackerel, and horse mackerel
Red fish such as saury have a high content of free histidine in muscle. When these fish meats are contaminated with bacteria having high histidine decarboxylase activity and weak histaminease activity, histamine is accumulated.
【００６３】サバの筋肉１０ｇに水１５ｍｌを加えて５
分間ホモジナイズした。さらに実施例２で製造した活性
炭入りアルギン酸カルシウムゲルボール１ｇを入れ、１
０分間撹拌し混和した。得られた水溶液を、「目で見る
食品衛生検査法」春田三佐夫他編集、中央法規出版、第
１３４〜１３５頁に記載の方法に準じて処理し、液体ク
ロマトグラフィーによりヒスタミン濃度を定量した。15 ml of water was added to 10 g of mackerel muscle to obtain 5
Homogenized for minutes. Furthermore, 1 g of the calcium alginate gel ball containing activated carbon produced in Example 2 was added, and 1
Stir for 0 minutes and mix. The obtained aqueous solution was treated according to the method described in "Visual Food Hygiene Inspection Method" edited by Misao Haruta et al., Central Law Publication, pages 134-135, and histamine concentration was quantified by liquid chromatography.
【００６４】活性炭入りアルギン酸カルシウムゲルボー
ルを加えない以外は同じ条件で処理したコントロールで
は、２８０ｍｇ／１００ｇのヒスタミンが検出されたの
に対し、活性炭入りアルギン酸カルシウムゲルボールを
混入した場合では、定量限界（２．５ｍｇ／１００ｇ）
以下であった。While 280 mg / 100 g of histamine was detected in the control treated under the same conditions except that the calcium alginate gel ball containing activated carbon was not added, the quantification limit ( 2.5 mg / 100 g)
It was below.
【００６５】［実施例１６］ カドミウムの吸着除去実験 カドミウムは、自然界に広く分布し、工業的にも大量に
利用され、それに伴う環境汚染や、食品を介しての人体
へのカドミウム汚染が問題視されている。カドミウムは
経口により大量摂取をした場合には急性胃腸障害が、微
量の摂取による慢性中毒では腎障害が生ずる。日本人の
カドミウムの１日摂取量は、おおよそ３０〜６０μｇで
あり、その３０〜４０％は米からであると推定されてい
る。[Example 16] Cadmium adsorption / removal experiment Cadmium is widely distributed in nature and is industrially used in large quantities, and environmental pollution associated therewith and cadmium contamination of the human body through foodstuffs are problematic. Has been done. Cadmium causes acute gastrointestinal damage when ingested in large amounts, and renal damage in chronic poisoning caused by ingestion of a small amount. It is estimated that the daily intake of cadmium in Japanese is approximately 30 to 60 μg, of which 30 to 40% is from rice.
【００６６】細粉玄米１０ｇと実施例１で製造した活性
炭入りコンニャク３ｇを反応器にとり、蒸留水４０ｍｌ
を加え、さらに硫酸を加えた後、徐々に加熱した。分解
液が淡黄色透明になったら冷却し、さらに蒸留水を加え
て全量を１００ｍｌとし、試験溶液とした。これを、
「目で見る食品衛生検査法」春田三佐夫他編集、中央法
規出版、第１２６〜１２７頁に記載の方法に準じて処理
し、原子吸光光度法によりカドミウムを定量した。10 g of fine brown rice and 3 g of konjak containing activated carbon prepared in Example 1 were placed in a reactor, and 40 ml of distilled water was used.
Was further added, and sulfuric acid was further added, and then gradually heated. When the decomposed liquid became pale yellow and transparent, it was cooled, and distilled water was further added to bring the total amount to 100 ml to prepare a test solution. this,
"Visual food hygiene inspection method" was processed according to the method described by Misao Haruta et al., Central Law Publishing, pages 126-127, and cadmium was quantified by atomic absorption spectrophotometry.
【００６７】活性炭入りコンニャクを加えない以外は同
じ条件で処理したコントロールでは、０．５ｐｐｍの亜
硫酸が検出されたのに対し、活性炭入りコンニャクを混
入した場合では、定量限界（０．０２ｐｐｍ）以下であ
った。In the control treated under the same conditions except that konjak containing activated carbon was not added, 0.5 ppm of sulfurous acid was detected, whereas in the case where konjak containing activated carbon was mixed, it was below the quantification limit (0.02 ppm). there were.
【００６８】［実施例１７］ ジエチレングリコール（ＤＥＧ）の吸着除去試験 ジエチレングリコール（ＤＥＧ）は、自動車用不凍液、
ブレーキ油配合剤、セロハン柔軟剤、ゴム・油脂等の溶
剤等として使用されており、その毒性はヒトの場合経口
でＬＤ５０１０００ｍｇ／ｋｇとされている。昭和６０
年食品添加物として使用が許可されていないジエチリン
グリコールがワインのコクと甘みを増すことを目的に外
国産ワインに混和されわが国へも輸入されていることが
判明し問題となった。[Example 17] Adsorption removal test of diethylene glycol (DEG) Diethylene glycol (DEG) was used as an antifreeze solution for automobiles.
It is used as a compounding agent for brake oil, a softener for cellophane, a solvent for rubber and fats and oils, and its toxicity is LD50 1000 mg / kg orally in humans. Showa 60
It became a problem that it was found that dietiline glycol, which is not allowed to be used as a food additive in the year, is mixed with foreign wine and imported to Japan for the purpose of increasing the richness and sweetness of wine.
【００６９】ジエチレングリコールを１００μｇ／ｍｌ
となるようにメタノールに溶かし、溶液１００ｇを調製
した。この溶液４０ｇを採取し、実施例１で製造した活
性炭入りコンニャク３ｇと１０分間撹拌混和してジエチ
レングリコールを吸着した。得られた抽出液を4５℃で
濃縮した後水を加えて１０ｍｌに調製した。これを、
「目で見る食品衛生検査法」春田三佐夫他編集、中央法
規出版、第１１４〜１１５頁に記載の方法に準じて処理
し、ガスクロマトグラフィーによりジエチレングリコー
ル濃度を定量したところ、ジエチレングリコール濃度は
検出限界（１０ｐｐｍ）以下であった。100 μg / ml of diethylene glycol
Was dissolved in methanol so that 100 g of the solution was prepared. 40 g of this solution was collected and mixed with 3 g of konjak containing activated carbon produced in Example 1 for 10 minutes with stirring to adsorb diethylene glycol. The obtained extract was concentrated at 45 ° C. and water was added to adjust the volume to 10 ml. this,
"Food hygiene inspection method by eye," edited according to the method described by Misao Haruta et al., Central Law Publishing, pages 114-115, and the diethylene glycol concentration was quantified by gas chromatography. It was (10 ppm) or less.
【００７０】［実施例１８］ アセトアルデヒドの吸着除去試験 成人男性２０ 名につき、１０名が飲酒直前に実施例１
で製造した活性炭入りコンニャク１０ｇを食し、他の１
０名は食さずに、２時間で１人平均５００ｍｌのアルコ
ール飲料（日本酒、アルコール含有率１６％）を摂取し
た。Example 18 Acetaldehyde Adsorption Removal Test For every 20 adult males, 10 were tested immediately before drinking Example 1
Eat 10 g of konjak with activated carbon manufactured in
0 people took an average of 500 ml of alcoholic beverage (sake, alcohol content rate 16%) per person in 2 hours without eating.
【００７１】飲酒後各人の体調を観察したところ、飲酒
前に活性炭入りコンニャクを食さない群１０人中、吐き
気を催したまたは気分が悪くなった人は、飲酒直後で６
人、１２時間後で８人であったのに対し、飲酒前に活性
炭入りコンニャクを食した群１０人中、吐き気を催した
または気分が悪くなった人は、飲酒直後で０人、１２時
間後で０人であった。After observing the physical condition of each person after drinking alcohol, among the 10 persons who did not eat konjak with activated carbon before drinking alcohol, those who had nausea or felt sick were 6 immediately after drinking alcohol.
The number was 8 after 12 hours, whereas in the group of 10 who ate konjak with activated charcoal before drinking, those who had nausea or felt sick were 0 and 12 hours immediately after drinking. There were 0 people later.
【００７２】[0072]
【発明の効果】本発明の有害物質の吸着除去剤は、微粒
子活性炭をゲル状分散媒中に均一に分散させた分散系か
らなるので吸着能が高く、有害物質を極めて高率に吸着
除去することができる。The adsorbent / removal agent for harmful substances of the present invention comprises a dispersion system in which finely divided activated carbon is uniformly dispersed in a gel-like dispersion medium, and therefore has a high adsorbing ability and adsorbs and removes harmful substances at an extremely high rate. be able to.
【００７３】また、本発明の有害物質の吸着除去剤は、
微粒子活性炭を生理学的に許容されるゲル状物質に分散
含有させているので、食品等に接触させまたは直接消化
器系内に投与することにより、食品等に付着もしくは含
有されるまたは消化器系内に存在する有害物質を簡便に
吸着除去することができる。The toxic substance adsorption / removal agent of the present invention is
Since fine particle activated carbon is dispersed and contained in a physiologically acceptable gel-like substance, it can be attached to or contained in foods, etc. or in the digestive system by contacting it with food or directly administering it into the digestive system. It is possible to easily remove the harmful substances present in the.
【００７４】本発明の有害物質の吸着除去剤を加工食品
等に混合し、または加工食品等に活性炭を直接混入する
ことによっても同様の効果も得られる。Similar effects can be obtained by mixing the adsorbent / removal agent for harmful substances of the present invention with processed foods or directly mixing activated carbon with the processed foods.
【００７５】本発明の有害物質の吸着除去剤は上記の優
れた効果を奏するので、食品等に付着もしくは含有され
るまたは消化器系内に存在する食品添加物、飼料添加
物、農薬類、自然毒、アレルゲン、重金属または毒性の
強い有機化合物等の吸着除去、消化器系内に存在する余
剰栄養素の吸着除去、アルコール摂取後消化器系内に生
成するアルコールの中間代謝物の吸着除去等に用いた場
合特に有用である。Since the toxic substance adsorption / removal agent of the present invention exhibits the above-mentioned excellent effects, it is attached to or contained in food or the like, or is present in the digestive system, food additives, feed additives, agricultural chemicals, natural substances. Used for adsorption / removal of poisons, allergens, heavy metals or highly toxic organic compounds, adsorption / removal of excess nutrients existing in the digestive system, adsorption / removal of intermediate metabolites of alcohol produced in the digestive system after alcohol intake It is especially useful if
【００７６】[0076]
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.6 識別記号 庁内整理番号 ＦＩ 技術表示箇所 Ａ６１Ｋ 47/32 Ａ６１Ｋ 47/32 Ｆ 47/36 47/36 Ｆ ─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. 6 Identification code Office reference number FI Technical display location A61K 47/32 A61K 47/32 F 47/36 47/36 F
Claims (11)
的に許容されるゲル状分散媒中に０．０２〜９０重量％
分散させてなる有害物質の吸着除去剤。1. Activated carbon having a particle size of 5 μm to 10 mm in a physiologically acceptable gel dispersion medium in an amount of 0.02 to 90% by weight.
Adsorption remover for harmful substances that are dispersed.
が高分子ポリカルボン酸の二価金属塩である請求項１記
載の有害物質の吸着除去剤。2. The harmful substance adsorption / removal agent according to claim 1, wherein the physiologically acceptable gel dispersion medium is a divalent metal salt of a high-molecular polycarboxylic acid.
がカルシウム塩である請求項２記載の有害物質の吸着除
去剤。3. The adsorptive remover for harmful substances according to claim 2, wherein the divalent metal salt of the polymer polycarboxylic acid is a calcium salt.
がアルギン酸カルシウムである請求項２記載の有害物質
の吸着除去剤。4. The adsorptive remover for harmful substances according to claim 2, wherein the divalent metal salt of the polymer polycarboxylic acid is calcium alginate.
が豆腐、ゼリー、コンニャク、寒天、エゴ、トコロテン
またはキトサンシュウ酸塩ゲルである請求項１記載の有
害物質の吸着除去剤。5. The adsorptive remover for harmful substances according to claim 1, wherein the physiologically acceptable gel dispersion medium is tofu, jelly, konjak, agar, ego, tocorotene or chitosan oxalate gel.
もしくは含有されるまたは消化器系内に摂取された食品
添加物、飼料添加物、農薬類、自然毒、アレルゲン、重
金属または毒性の強い有機化合物である請求項１〜５記
載の有害物質の吸着除去剤。6. A food additive, feed additive, pesticide, natural poison, allergen, heavy metal or highly toxic organic compound in which the harmful substance is attached to or contained in food or feed or ingested in digestive system. The adsorptive remover for harmful substances according to claims 1 to 5.
余剰栄養素である請求項１〜５記載の有害物質の吸着除
去剤。7. The toxic substance adsorption / removal agent according to claim 1, wherein the toxic substance is a surplus nutrient ingested in the digestive system.
系内に生成するアルコールの中間代謝物である請求項１
〜５記載の有害物質の吸着除去剤。8. The toxic substance is an intermediate metabolite of alcohol produced in the digestive system after ingesting alcohol.
5) Adsorbent / removal agent for harmful substances according to 5).
剤を０．０１〜６０重量％混入した加工食品または飼
料。9. A processed food or feed containing 0.01 to 60% by weight of the harmful substance adsorption-removing agent according to any one of claims 1 to 8.
０．０２〜６０重量％混入した加工食品または飼料。10. A processed food or feed containing 0.02 to 60% by weight of activated carbon having a particle size of 5 μm to 0.5 mm.
品、食肉加工品、豆製品、野菜加工品、芋加工品、穀物
加工品、甘味類、油脂類または菓子類である請求項９ま
たは１０記載の加工食品。11. A dairy product, a fish paste product, a processed seafood product, a processed meat product, a bean product, a processed vegetable product, a processed potato product, a processed grain product, a sweetener, an oil or fat, or a confectionery product. Processed food as described.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7184483A JPH0975723A (en) | 1995-07-20 | 1995-07-20 | Harmful matter adsorbing and removing agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7184483A JPH0975723A (en) | 1995-07-20 | 1995-07-20 | Harmful matter adsorbing and removing agent |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004168782A Division JP2005015482A (en) | 2004-06-07 | 2004-06-07 | Hazardous substance absorbing and removing agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0975723A true JPH0975723A (en) | 1997-03-25 |
Family
ID=16153971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7184483A Pending JPH0975723A (en) | 1995-07-20 | 1995-07-20 | Harmful matter adsorbing and removing agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0975723A (en) |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20000050513A (en) * | 1999-01-11 | 2000-08-05 | 박동래 | Aaaaa |
| FR2799652A1 (en) * | 1999-10-13 | 2001-04-20 | Serge Schlee | Antidote for chemical or biological toxins comprises a colloidal solution of micronized or pulverized activated vegetable carbon, fructose or laevulose and sterile mineral water |
| US6759049B2 (en) * | 2000-02-28 | 2004-07-06 | Medecine Information Formation S.A. | Pharmaceutical or dietetic mushroom-based compositions |
| WO2005120458A1 (en) * | 2004-06-07 | 2005-12-22 | Kureha Corporation | Dry-form composition for oral ingestion and gel-form composition for oral ingestion of type prepared at time of use |
| JP2006273772A (en) * | 2005-03-30 | 2006-10-12 | Japan Organo Co Ltd | Orally administered drug and method for producing the same |
| JP2006333751A (en) * | 2005-06-01 | 2006-12-14 | Ina Food Ind Co Ltd | Potassium absorption inhibitor for food and food containing the same |
| JP2012136484A (en) * | 2010-12-27 | 2012-07-19 | Api Co Ltd | Intestinal harmful substance adsorbent, and method for producing the same |
| JP2013502509A (en) * | 2010-11-11 | 2013-01-24 | エンパイア テクノロジー ディベロップメント エルエルシー | Control of environmental pollution |
| WO2014038630A1 (en) * | 2012-09-07 | 2014-03-13 | 株式会社キミカ | Cesium-excreting agent, poisonous metal-excreting agent, food or beverage, feed, and medicinal product |
| JP2014237001A (en) * | 2009-03-26 | 2014-12-18 | テイコク ファーマ ユーエスエー インコーポレーテッド | Medication disposal system |
| JPWO2013073614A1 (en) * | 2011-11-15 | 2015-04-02 | 株式会社日本触媒 | Water-absorbing agent composition, production method thereof, and storage and inventory method thereof |
| JP2015167900A (en) * | 2014-03-06 | 2015-09-28 | 富士シリシア化学株式会社 | Arsenic removing agent, and arsenic removing method |
| CN107125543A (en) * | 2017-05-29 | 2017-09-05 | 南京大方生物工程有限公司 | Mould detoxifying agent and preparation method thereof and feed addictive |
| CN107986581A (en) * | 2017-12-29 | 2018-05-04 | 杭州中艺生态环境工程有限公司 | Plant water purifying ecological floating bed device and its impurity absorption preparation |
| WO2021014861A1 (en) * | 2019-07-23 | 2021-01-28 | デクセリアルズ株式会社 | Harmful-to-health substance removing agent and health food |
| CN116173920A (en) * | 2022-12-29 | 2023-05-30 | 唐山师范学院 | Efficient adsorbent C@SA@CMC and preparation method and application thereof |
-
1995
- 1995-07-20 JP JP7184483A patent/JPH0975723A/en active Pending
Cited By (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20000050513A (en) * | 1999-01-11 | 2000-08-05 | 박동래 | Aaaaa |
| FR2799652A1 (en) * | 1999-10-13 | 2001-04-20 | Serge Schlee | Antidote for chemical or biological toxins comprises a colloidal solution of micronized or pulverized activated vegetable carbon, fructose or laevulose and sterile mineral water |
| US6759049B2 (en) * | 2000-02-28 | 2004-07-06 | Medecine Information Formation S.A. | Pharmaceutical or dietetic mushroom-based compositions |
| WO2005120458A1 (en) * | 2004-06-07 | 2005-12-22 | Kureha Corporation | Dry-form composition for oral ingestion and gel-form composition for oral ingestion of type prepared at time of use |
| TWI421032B (en) * | 2004-06-07 | 2014-01-01 | Kureha Corp | Dry composition for oral uptake, and in-use-preparing gel composition for oral uptake |
| US9161557B2 (en) | 2004-06-07 | 2015-10-20 | Kureha Corporation | Dry composition for oral ingestion and gel composition prepared just before use for oral ingestion |
| JP5537762B2 (en) * | 2004-06-07 | 2014-07-02 | 株式会社クレハ | Composition for oral intake prepared in dry form and composition for oral intake gel |
| JP2006273772A (en) * | 2005-03-30 | 2006-10-12 | Japan Organo Co Ltd | Orally administered drug and method for producing the same |
| JP2006333751A (en) * | 2005-06-01 | 2006-12-14 | Ina Food Ind Co Ltd | Potassium absorption inhibitor for food and food containing the same |
| JP2014237001A (en) * | 2009-03-26 | 2014-12-18 | テイコク ファーマ ユーエスエー インコーポレーテッド | Medication disposal system |
| JP2013502509A (en) * | 2010-11-11 | 2013-01-24 | エンパイア テクノロジー ディベロップメント エルエルシー | Control of environmental pollution |
| JP2012136484A (en) * | 2010-12-27 | 2012-07-19 | Api Co Ltd | Intestinal harmful substance adsorbent, and method for producing the same |
| JPWO2013073614A1 (en) * | 2011-11-15 | 2015-04-02 | 株式会社日本触媒 | Water-absorbing agent composition, production method thereof, and storage and inventory method thereof |
| JP2018047467A (en) * | 2011-11-15 | 2018-03-29 | 株式会社日本触媒 | Absorbent composition and method for producing the same, and storage of the same and stock method |
| US10363339B2 (en) | 2011-11-15 | 2019-07-30 | Nippon Shokubai Co., Ltd. | Water absorbent agent composition and method for producing same, as well as storage and stocking method for same |
| WO2014038630A1 (en) * | 2012-09-07 | 2014-03-13 | 株式会社キミカ | Cesium-excreting agent, poisonous metal-excreting agent, food or beverage, feed, and medicinal product |
| JP2015167900A (en) * | 2014-03-06 | 2015-09-28 | 富士シリシア化学株式会社 | Arsenic removing agent, and arsenic removing method |
| CN107125543A (en) * | 2017-05-29 | 2017-09-05 | 南京大方生物工程有限公司 | Mould detoxifying agent and preparation method thereof and feed addictive |
| CN107125543B (en) * | 2017-05-29 | 2020-07-28 | 南京大方生物工程有限公司 | Mold detoxicant, preparation method thereof and feed additive |
| CN107986581A (en) * | 2017-12-29 | 2018-05-04 | 杭州中艺生态环境工程有限公司 | Plant water purifying ecological floating bed device and its impurity absorption preparation |
| CN107986581B (en) * | 2017-12-29 | 2023-12-29 | 杭州中艺生态环境工程有限公司 | Plant water purifying ecology Floating bed device its impurity adsorbing body preparation method |
| WO2021014861A1 (en) * | 2019-07-23 | 2021-01-28 | デクセリアルズ株式会社 | Harmful-to-health substance removing agent and health food |
| JP2021016844A (en) * | 2019-07-23 | 2021-02-15 | デクセリアルズ株式会社 | Health-hazard removing agent and health food |
| CN114096163A (en) * | 2019-07-23 | 2022-02-25 | 迪睿合株式会社 | Health harmful substance remover and health food |
| CN116173920A (en) * | 2022-12-29 | 2023-05-30 | 唐山师范学院 | Efficient adsorbent C@SA@CMC and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6299867B1 (en) | Adsorbent | |
| JPH0975723A (en) | Harmful matter adsorbing and removing agent | |
| EP2852294B1 (en) | Compositions and methods for increasing the stability of food product additives | |
| US20090104251A1 (en) | Heat stable microcapsules and methods for making and using the same | |
| Carcea et al. | Nutritional characterization of traditional and improved dihé, alimentary blue-green algae from the lake Chad region in Africa | |
| JP4358957B2 (en) | Agent for scavenging or reducing free radicals or active oxygen | |
| CN107105693A (en) | For the method for the stability for increasing the composition comprising the aliphatic acid of how unsaturated Ω 6 | |
| US20050217596A1 (en) | Novel health food and drink containing marine algae | |
| CN108601372A (en) | The effective anti-oxidant compositions of collaboration for pet | |
| WO2009054841A2 (en) | Heat stable microcapsules and methods for making and using the same | |
| US20050101482A1 (en) | Novel adsorbent | |
| JP2001128643A (en) | Soft capsule enclosing mastic oil solution | |
| KR100810868B1 (en) | Microencapsulation processing method of omaga-3 fatty acid, method for making the food and food | |
| Sturza et al. | Use of sea buckthorn fruits in the pastry manufacturing | |
| JP2005015482A (en) | Hazardous substance absorbing and removing agent | |
| Adjei-Duodu | Physical, chemical and functional properties of tiger nuts (Cyperus esculentus) selected from Ghana, Cameroon and UK market (Spain) | |
| JP3815882B2 (en) | Foods and drinks containing processed sesame seeds | |
| KR20110072772A (en) | Fractionation of kimchi and preparation method thereof | |
| KR20150064521A (en) | Fermented composition comprising bamboo salt and rhynchosia nulubilis | |
| KR101933043B1 (en) | Method for Manufacturing Soy Sauce Marinated Crab Containing Allium hookeri | |
| EP1729598A1 (en) | Composition; use of a composition and a method for treating obesity | |
| Ajani et al. | Free Polyphenol Contents, Antioxidant Activity and Inhibition of Enzymes Linked with Type-2-Diabetes of Bread Produced from Cocoa Powder Flavoured Improved Variety Cassava-Wheat Composite Flours: doi. org/10.26538/tjnpr/v6i2. 10 | |
| CN108208492A (en) | A kind of ginger coconut water edible bamboo charcoal paste powder beverage and preparation method thereof | |
| JP2005198502A (en) | Admixture for food | |
| JPH08140592A (en) | Deodorization, functional food material or its composition and functional food |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20040406 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20040607 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20040721 |
|
| A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20040820 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20070621 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20070626 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070723 |