JPH0971523A - Tablet quickly disintegrating in oral cavity - Google Patents
Tablet quickly disintegrating in oral cavityInfo
- Publication number
- JPH0971523A JPH0971523A JP26458395A JP26458395A JPH0971523A JP H0971523 A JPH0971523 A JP H0971523A JP 26458395 A JP26458395 A JP 26458395A JP 26458395 A JP26458395 A JP 26458395A JP H0971523 A JPH0971523 A JP H0971523A
- Authority
- JP
- Japan
- Prior art keywords
- tablet
- low
- oral cavity
- crystalline cellulose
- cellulose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
Abstract
Description
【0001】[0001]
【発明の属する技術分野】本発明は、口腔内の唾液又は
少量の水により噛まずにただちに崩壊してそのまま又は
水にて服用できる口腔内において崩壊性の速い錠剤(以
下、速崩壊性錠剤という)の組成物および製法を提供す
る技術分野に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a rapidly disintegrating tablet in the oral cavity (hereinafter referred to as a fast disintegrating tablet) which can be taken immediately without being chewed by saliva or a small amount of water in the oral cavity and can be taken as it is or with water. The present invention relates to the technical field of providing a composition and a production method thereof.
【0002】[0002]
【従来の技術】水無しで服用できる製剤としてはチュア
ブル錠が、胃腸薬などとして市販されている。これは服
用時に水などの飲料を不要とし、必要なときにすぐに口
腔内で噛み砕いて服用できるというものである。また錠
剤型で口腔内で噛まずに速やかに崩壊して、錠剤の嚥下
を容易にする製剤は見当たらない。2. Description of the Related Art Chewable tablets are commercially available as a gastrointestinal drug and the like as a formulation which can be taken without water. This means that no drink such as water is required when taking the drug, and when necessary, it can be chewed in the oral cavity and taken immediately. In addition, there is no formulation in tablet form that disintegrates rapidly without chewing in the oral cavity and facilitates swallowing of tablets.
【0003】上述のチュアブル錠を服用する時に噛み砕
くことを必要とすることは、老人などの歯の弱い人たち
にとっては、不便である。また嚥下力の弱い患者にとっ
て口腔内で速やかに崩壊して服用できる錠剤は有用であ
る。The need to chew when taking the chewable tablets described above is inconvenient for people with weak teeth, such as the elderly. Tablets that can be rapidly disintegrated and taken in the oral cavity are useful for patients with weak swallowing power.
【0004】本発明は、かかる観点からなされたもので
あり、口腔内で唾液又は少量の水により数十秒程度で速
やかに崩壊して嚥下を容易にする錠剤を提供することを
課題とする。The present invention has been made from such a point of view, and an object of the present invention is to provide a tablet which is rapidly disintegrated by saliva or a small amount of water in the oral cavity in about several tens of seconds to facilitate swallowing.
【0005】本発明の速崩壊性錠剤を必要とする状況と
しては、水の無い場面での錠剤の服用を必要とする薬剤
で、例えば乗り物酔止め薬がある。また、従来の錠剤型
では嚥下困難な患者は錠剤を砕いて服用する必要があっ
た。本発明の速崩壊性錠剤は口腔内で速く崩壊し、嚥下
困難な患者の錠剤の服用に有用である。特に脳血管障害
などで嚥下困難な患者や寝たきりの高齢患者に速崩錠は
有用であり、薬物としては高血圧症用薬、脳循環代謝改
善薬などがある。A situation in which the rapidly disintegrating tablet of the present invention is required is a drug which requires taking the tablet in a waterless situation, for example, a motion sickness drug. Further, a patient who has difficulty swallowing with the conventional tablet type needs to crush the tablet and take it. The rapidly disintegrating tablet of the present invention disintegrates rapidly in the oral cavity and is useful for taking tablets for patients who have difficulty swallowing. In particular, quick-disintegrating tablets are useful for patients who have difficulty swallowing due to cerebrovascular disorder or bedridden elderly patients, and examples of such drugs include drugs for hypertension and drugs for improving cerebral circulation metabolism.
【0006】本発明者は、上記課題を解決するために、
錠剤の賦形剤および崩壊剤を以下の組成とした。In order to solve the above problems, the present inventor has
The tablet excipient and disintegrant had the following composition.
【0007】すなわち本発明の速崩壊性錠剤は、崩壊剤
とする低置換度ヒドロキシプロピルセルロースを1とし
た時に賦形剤として結晶セルロースを2.3から9の割
合の配合比で混合し、滑沢剤を配合・混合し、更に必要
があれば着色剤などを配合・混合し打錠することにより
錠剤を圧縮成型することを特徴とする。That is, in the rapidly disintegrating tablet of the present invention, when low-substituted hydroxypropylcellulose as a disintegrating agent is set to 1, crystalline cellulose is mixed as an excipient at a compounding ratio of 2.3 to 9, and a smooth mixture is prepared. The tablet is compression-molded by blending and mixing a lubricant, and further blending and mixing a colorant and the like and tableting if necessary.
【0008】また本発明では速崩壊性錠剤に含有させる
薬物としては、乗り物酔いの治療に有効な鎮暈および鎮
吐作用を有する薬物である塩酸メクリジンが有用であ
る。他に本発明で対象とする乗り物酔いの治療に有効な
鎮暈および鎮吐作用を有する薬物としては前述の塩酸メ
クリジン以外の具体例としては、ジメンヒドリナート、
チエルペラジン、サリチル酸ジフェンヒドラミン+ジプ
ロフィリン、プロメタジンテオクレートなどが挙げられ
る。高血圧症用薬としてはカプトプリル、シラザプリ
ル、マレイン酸エナラプリル、リシノプリルなどが挙げ
られ、脳循環代謝改善薬としてはシンナリジン、ビンポ
セチン、フマル酸ブロビンカミン、ペントキシフィリ
ン、マレイン酸シネパジド、トラピジル、塩酸ニカルジ
ピン、塩酸フルナリジン、塩酸メクロフェノキサート、
酒石酸イフェンプロジルなどが挙げられる。In the present invention, as a drug to be contained in the fast disintegrating tablet, meclizine hydrochloride, which is a drug effective for treating motion sickness and having an anti-nausea and anti-emetic action, is useful. In addition to the above-mentioned meclizine hydrochloride as a drug having an effective antispasmodic and antiemetic action for the treatment of motion sickness targeted by the present invention, dimenhydrinate,
Examples thereof include thierperazine, diphenhydramine salicylate + diprophylline, and promethazine theocrate. Drugs for hypertension include captopril, cilazapril, enalapril maleate, lisinopril, etc.As cerebral circulatory metabolism improving agents, cinnarizine, vinpocetine, brovincamin fumarate, pentoxifylline, cinepazide maleate, trapidil, nicardipine hydrochloride, flunarizine hydrochloride. , Meclofenoxate hydrochloride,
Examples include ifenprodil tartrate.
【0009】以下、本発明を説明する。The present invention will be described below.
【0010】<1>本発明の速崩壊性錠剤の製法 1)組成物 本発明では一般的に使用される下記の賦形剤、崩壊剤を
使用して速崩壊性錠剤を作ることを特徴としている。 結晶セルロース(賦形剤) (旭化成工業(株)製アビセルPH−102、粒子径1
00μm) 低置換度ヒドロキシプロピルセルロース(崩壊剤) (信越化学工業(株)製L−HPC、粒子径160μ
m、日本薬局方12局収載)<1> Method for Producing Rapidly Disintegrating Tablet of the Present Invention 1) Composition In the present invention, a rapidly disintegrating tablet is produced by using the following excipients and disintegrating agents which are generally used. There is. Crystalline cellulose (excipient) (Avicel PH-102 manufactured by Asahi Kasei Corporation, particle size 1)
00 μm) Low-substituted hydroxypropylcellulose (disintegrant) (Shin-Etsu Chemical Co., Ltd. L-HPC, particle size 160 μm)
m, listed in 12 Japanese Pharmacopoeia)
【0011】2)本発明の速崩壊性錠剤の配合割合 薬物を含有しない速崩壊性錠剤 ・ステアリン酸マグネシウム(滑沢剤:和光純薬工業
(株)製MS、粒子径70μm)1%、低置換度ヒドロ
キシプロピルセルロースと結晶セルロースの配合比を
1:2.3から1:9で配合・混合したもの各99%上
記混合物を打錠用剤とする。2) Blending ratio of the rapidly disintegrating tablet of the present invention: Fast disintegrating tablet containing no drug Magnesium stearate (lubricant: MS manufactured by Wako Pure Chemical Industries, Ltd., particle size 70 μm) 1%, low Degree of substitution Hydroxypropyl cellulose and crystalline cellulose are compounded and mixed at a compounding ratio of 1: 2.3 to 1: 9, 99% each. The above mixture is used as a tableting agent.
【0012】薬物(塩酸メクリジン)含有速崩壊性錠
剤 ・塩酸メクリジン(鎮暈・鎮吐剤:日本バルク薬品製、
分子量481.89、融点217℃(分解))10%、
ステアリン酸マグネシウム1%、低置換度ヒドロキシプ
ロピルセルロースと結晶セルロースの配合比を1:4混
合したもの89% 上記混合物を打錠用剤とする。Rapidly disintegrating tablet containing drug (meclizine hydrochloride) Meclizine hydrochloride (anxiety / antiemetic: manufactured by Nippon Bulk Chemical Co., Ltd.,
Molecular weight 481.89, melting point 217 ° C (decomposition) 10%,
Magnesium stearate 1%, low-substituted hydroxypropyl cellulose and crystalline cellulose mixed at a mixing ratio of 1: 4 89% The above mixture is used as a tableting composition.
【0013】3)本発明の速崩壊性錠剤の打錠条件 下記の条件で、錠剤を製造した。一般に成型荷重をかけ
るほど錠剤の硬度が上がり、崩壊しにくくなるとされて
いる。しかし本発明の速崩壊性錠剤は100〜300k
gfの成型荷重(以下、打錠圧という)で、硬度のある
速崩壊性錠剤を得ることができた。 装 置 :N−20E型両圧式粉末打錠機(岡田精工
(株)製)杵直径8.0mm、曲率半径10R 錠剤重量:200mg 打錠圧 :100〜300kgf3) Tableting Conditions for the Rapidly Disintegrating Tablet of the Present Invention Tablets were produced under the following conditions. Generally, it is said that the more the molding load is applied, the higher the hardness of the tablet and the more difficult it becomes to disintegrate. However, the rapidly disintegrating tablet of the present invention is 100 to 300 k
With a molding load of gf (hereinafter referred to as tableting pressure), a rapidly disintegrating tablet having hardness could be obtained. Device: N-20E double-pressure powder tableting machine (Okada Seiko Co., Ltd.), punch diameter 8.0 mm, radius of curvature 10R Tablet weight: 200 mg Tableting pressure: 100-300 kgf
【0014】<2>本発明の速崩壊性錠剤の効果を測定
するための条件 1)錠剤硬度測定 錠剤はある程度かたさ(以下、硬度と言う)がないと錠
剤の原型をとどめず、適正な打錠圧で硬度がありながら
速崩壊性の錠剤であることが必須条件である。この為に
硬度を測定した。後述する市販品素錠の測定では13〜
15Kgの硬度であった。本発明の速崩壊性の錠剤も同
様な硬度を得た。 半自動硬度計(TS−50N型、岡田精工(株)製) 圧縮破壊に要する応力を測定し、これを硬度(kg)と
する。<2> Conditions for measuring the effect of the rapidly disintegrating tablet of the present invention 1) Tablet hardness measurement Unless the tablet has a certain degree of hardness (hereinafter referred to as hardness), the tablet prototype cannot be retained and the tablet can be pressed properly. It is an essential condition that the tablet has hardness at tableting pressure but is rapidly disintegrating. For this purpose the hardness was measured. In the measurement of commercially available plain tablets described later,
The hardness was 15 kg. The rapidly disintegrating tablets of the present invention also obtained similar hardness. Semi-automatic hardness meter (TS-50N type, manufactured by Okada Seiko Co., Ltd.) The stress required for compressive fracture is measured, and this is defined as the hardness (kg).
【0015】2)錠剤の崩壊性 速崩壊性錠剤の崩壊性を下記の代用試験により測定し
た。本試験の結果は実際の口腔内での結果と相関性があ
る。本発明の速崩壊性錠剤は実施例で示すようにすべて
74秒以内で崩壊した。小型シャーレ中の水に錠剤を全
浸または半浸させる。口腔内での崩壊は、舌の動きが加
わるため、この小型シャーレーに弱い振とうを加えて崩
壊時間を測定した。 振とう器 SA−31型(ヤマトサイエンテフィック社
製)振幅距離、4cm 振とう回数:40回/分=1回/1.5秒(最小設定
値)2) Disintegration property of tablets The disintegration property of fast disintegrating tablets was measured by the following substitute test. The results of this study correlate with the actual oral results. All the rapidly disintegrating tablets of the present invention disintegrated within 74 seconds as shown in the examples. Fully or half soak the tablets in water in a small petri dish. As for the disintegration in the oral cavity, since the movement of the tongue was added, weak shaking was added to this small Petri dish to measure the disintegration time. Shaker SA-31 type (manufactured by Yamato Scientific Co., Ltd.) Amplitude distance, 4 cm Shaking frequency: 40 times / min = 1 time / 1.5 seconds (minimum setting value)
【0016】本発明の速崩壊性錠剤(重量200mg、
直径8mm)とほぼ同じ大きさの市販素錠A(重量20
0mg、直径8mm)とB(重量280mg、直径9m
mを用いて、上記の条件で試験した結果を表1に示す。
これらの市販素錠は速崩壊性錠剤と言えないことは明き
らかであり、本発明の速崩壊性錠剤は市販素錠とは大い
に異なっている。 The fast disintegrating tablet of the present invention (weight: 200 mg,
Commercial uncoated tablet A (weight 20 mm), which is almost the same size as the diameter 8 mm
0 mg, diameter 8 mm) and B (weight 280 mg, diameter 9 m)
Table 1 shows the results of tests conducted under the above conditions using m.
It is clear that these commercially available plain tablets cannot be said to be rapidly disintegrating tablets, and the rapidly disintegrating tablet of the present invention is very different from the commercially available plain tablets.
【0017】[0017]
【実施例】以下に本発明の実施例を具体的に説明する。EXAMPLES Examples of the present invention will be specifically described below.
【0018】[0018]
【実施例1】低置換度ヒドロキシプロピルセルロースと
結晶セルロースの配合比3:7(低置換度ヒドロキシプ
ロピルセルロースを1とすると1:2.3となる)。 成 分 量 結晶セルロース 69.3% 低置換度ヒドロキシプロピルセルロース 29.7% ステアリン酸マグネシウム 1.0% 上記粉末を均一に混合した後、打錠機で圧縮した。表2
に示したように良好な崩壊時間と打錠圧、硬度の関係を
得た。 [Example 1] Mixing ratio of low-substituted hydroxypropyl cellulose and crystalline cellulose 3: 7 (1: 2.3 for low-substituted hydroxypropyl cellulose). Ingredients Crystalline cellulose 69.3% Low-substituted hydroxypropylcellulose 29.7% Magnesium stearate 1.0% The above powders were uniformly mixed and then compressed with a tableting machine. Table 2
As shown in Fig. 3, a good relationship between the disintegration time, the tableting pressure and the hardness was obtained.
【0019】[0019]
【実施例2】低置換度ヒドロキシプロピルセルロースと
結晶セルロースの配合比1:3.5 成 分 量 結晶セルロース 77.0% 低置換度ヒドロキシプロピルセルロース 22.0% ステアリン酸マグネシウム 1.0% 上記粉末を均一に混合した後、打錠機で圧縮した。表3
に示したように良好な崩壊時間と打錠圧、硬度の関係を
得た。 [Example 2] Mixing ratio of low-substituted hydroxypropyl cellulose and crystalline cellulose 1: 3.5 Component amount Crystalline cellulose 77.0% Low-substituted hydroxypropyl cellulose 22.0% Magnesium stearate 1.0% The above powder Were uniformly mixed and then compressed with a tableting machine. Table 3
As shown in Fig. 3, a good relationship between the disintegration time, the tableting pressure and the hardness was obtained.
【0020】[0020]
【実施例3】低置換度ヒドロキシプロピルセルロースと
結晶セルロース配合比1:4 成 分 量 結晶セルロース 79.2% 低置換度ヒドロキシプロピルセルロース 19.8% ステアリン酸マグネシウム 1.0% 上記粉末を均一に混合した後、打錠機で圧縮した。表4
に示したように良好な崩壊時間と打錠圧、硬度の関係を
得た。 Example 3 Low-Substitution Hydroxypropyl Cellulose / Crystalline Cellulose Blending Ratio 1: 4 Content Crystalline Cellulose 79.2% Low-Substitutional Hydroxypropyl Cellulose 19.8% Magnesium Stearate 1.0% The above powder is uniformly mixed. After mixing, it was compressed with a tablet machine. Table 4
As shown in Fig. 3, a good relationship between the disintegration time, the tableting pressure and the hardness was obtained.
【0021】[0021]
【実施例4】低置換度ヒドロキシプロピルセルロースと
結晶セルロースの配合比1:8 成 分 量 結晶セルロース 88.0% 低置換度ヒドロキシプロピルセルロース 11.0% ステアリン酸マグネシウム 1.0% 上記粉末を均一に混合した後、打錠機で圧縮した。表5
に示したように良好な崩壊時間と打錠圧、硬度の関係を
得た。 [Example 4] Mixing ratio of low-substituted hydroxypropyl cellulose and crystalline cellulose 1: 8 Component amount Crystalline cellulose 88.0% Low-substituted hydroxypropyl cellulose 11.0% Magnesium stearate 1.0% The above powder was homogenized. After being mixed with, the mixture was compressed with a tableting machine. Table 5
As shown in Fig. 3, a good relationship between the disintegration time, the tableting pressure and the hardness was obtained.
【0022】[0022]
【実施例5】低置換度ヒドロキシプロピルセルロースと
結晶セルロースの配合比1:9 成 分 量 結晶セルロース 89.1% 低置換度ヒドロキシプロピルセルロース 9.9% ステアリン酸マグネシウム 1.0% 上記粉末を均一に混合した後、打錠機で圧縮した。表6
に示したように良好な崩壊時間と打錠圧、硬度の関係を
得た。 [Example 5] Mixing ratio of low-substituted hydroxypropyl cellulose and crystalline cellulose 1: 9 Component amount Crystalline cellulose 89.1% Low-substituted hydroxypropyl cellulose 9.9% Magnesium stearate 1.0% The above powder was homogenized. After being mixed with, the mixture was compressed with a tableting machine. Table 6
As shown in Fig. 3, a good relationship between the disintegration time, the tableting pressure and the hardness was obtained.
【0023】[0023]
【実施例6】 塩酸メクリジンを加えた処方。 塩酸メクリジン10%と低置換度ヒドロキシプロピルセ
ルロースと結晶セルロースの配合比3:7(低置換度ヒ
ドロキシプロピルセルロースを1とすると1:2.3と
なる)。 成 分 量 塩酸メクリジン 10.0% 結晶セルロース 62.3% 低置換度ヒドロキシプロピルセルロース 26.7% ステアリン酸マグネシウム 1.0% 上記粉末を均一に混合した後、打錠機で圧縮した。表7
に示したように良好な崩壊時間と打錠圧、硬度の関係を
得た。 Example 6 Formulation with addition of meclizine hydrochloride. Mixing ratio of meclizine hydrochloride 10%, low-substituted hydroxypropyl cellulose and crystalline cellulose 3: 7 (1: 2.3 for low-substituted hydroxypropyl cellulose). Ingredients Meclizine hydrochloride 10.0% Crystalline cellulose 62.3% Low-substituted hydroxypropylcellulose 26.7% Magnesium stearate 1.0% The above powders were uniformly mixed and then compressed with a tableting machine. Table 7
As shown in Fig. 3, a good relationship between the disintegration time, the tableting pressure and the hardness was obtained.
【0024】[0024]
【実施例7】 塩酸メクリジンを加えた処方。 塩酸メクリジン10%と低置換度ヒドロキシプロピルセ
ルロースと結晶セルロースの配合比1:4 成 分 量 塩酸メクリジン 10.0% 結晶セルロース 71.2% 低置換度ヒドロキシプロピルセルロース 17.8% ステアリン酸マグネシウム 1.0% 上記粉末を均一に混合した後、打錠機で圧縮した。表8
に示したように良好な崩壊時間と打錠圧、硬度の関係を
得た。 Example 7 Formulation with the addition of meclizine hydrochloride. Mixing ratio of meclizine hydrochloride 10%, low-substituted hydroxypropyl cellulose and crystalline cellulose 1: 4 Component amount Meclizine hydrochloride 10.0% Crystalline cellulose 71.2% Low-substituted hydroxypropyl cellulose 17.8% Magnesium stearate 1. 0% The above powders were uniformly mixed and then compressed with a tableting machine. Table 8
As shown in Fig. 3, a good relationship between the disintegration time, the tableting pressure and the hardness was obtained.
【0025】[0025]
【実施例8】 塩酸メクリジンを加えた処方。 塩酸メクリジン10%と低置換度ヒドロキシプロピルセ
ルロースと結晶セルロース配合比1:9 成分 量 塩酸メクリジン 10.0% 結晶セルロース 80.1% 低置換度ヒドロキシプロピルセルロース 8.9% ステアリン酸マグネシウム 1.0% 上記粉末を均一に混合した後、打錠機で圧縮した。表9
に示したように良好な崩壊時間と打錠圧、硬度の関係を
得た。 Example 8 Formulation with addition of meclizine hydrochloride. Meklizine hydrochloride 10%, low-substituted hydroxypropylcellulose and crystalline cellulose Blending ratio 1: 9 Component amount Meclizine hydrochloride 10.0% Crystalline cellulose 80.1% Low-substituted hydroxypropylcellulose 8.9% Magnesium stearate 1.0% The above powders were uniformly mixed and then compressed with a tableting machine. Table 9
As shown in Fig. 3, a good relationship between the disintegration time, the tableting pressure and the hardness was obtained.
【0026】[0026]
【発明の効果】本発明の速崩壊性錠剤は、小型シャーレ
による崩壊試験で崩壊時間が70秒以下で、口腔内で唾
液(少量の水)により数十秒程度で速やかに崩壊する錠
剤を提供することを可能とする。その結果、嚥下力の弱
い老人が服用する錠剤、水の無い場面での錠剤の服用を
可能にするものである。EFFECTS OF THE INVENTION The fast disintegrating tablet of the present invention provides a tablet that disintegrates in a disintegration test using a small petri dish for 70 seconds or less and rapidly disintegrates in the oral cavity with saliva (a small amount of water) in about tens of seconds. It is possible to do. As a result, it enables tablets to be taken by an elderly person having a weak swallowing power and tablets without water.
Claims (1)
ヒドロキシプロピルセルロース、滑沢剤を混合した物か
らなり、低置換度ヒドロキシプロピルセルロースと結晶
セルロースの配合比が低置換度ヒドロキシプロピルセル
ロースを1として1:2.3から1:9で配合・混合し
たものを圧縮成型することよりなる口腔内で崩壊性の速
い錠剤。1. A composition comprising a mixture of a drug, crystalline cellulose, low-substituted hydroxypropyl cellulose and a lubricant, wherein the compounding ratio of low-substituted hydroxypropyl cellulose and crystalline cellulose is 1 to 1 of low-substituted hydroxypropyl cellulose. A tablet rapidly disintegrating in the oral cavity, which is obtained by compressing and molding a mixture of 1: 2.3 to 1: 9.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP26458395A JPH0971523A (en) | 1995-09-07 | 1995-09-07 | Tablet quickly disintegrating in oral cavity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP26458395A JPH0971523A (en) | 1995-09-07 | 1995-09-07 | Tablet quickly disintegrating in oral cavity |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH0971523A true JPH0971523A (en) | 1997-03-18 |
Family
ID=17405316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP26458395A Pending JPH0971523A (en) | 1995-09-07 | 1995-09-07 | Tablet quickly disintegrating in oral cavity |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0971523A (en) |
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-
1995
- 1995-09-07 JP JP26458395A patent/JPH0971523A/en active Pending
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