JPH0966033A - Leaching liquid suction device and its drawing method - Google Patents
Leaching liquid suction device and its drawing methodInfo
- Publication number
- JPH0966033A JPH0966033A JP7226587A JP22658795A JPH0966033A JP H0966033 A JPH0966033 A JP H0966033A JP 7226587 A JP7226587 A JP 7226587A JP 22658795 A JP22658795 A JP 22658795A JP H0966033 A JPH0966033 A JP H0966033A
- Authority
- JP
- Japan
- Prior art keywords
- suction
- cell
- suction port
- exudate
- leachate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Abstract
Description
【発明の詳細な説明】Detailed Description of the Invention
【０００１】[0001]
【発明の属する技術分野】本発明は、生体表面から微量
の間質液である浸出液を採取する浸出液吸引装置及びそ
の採取方法に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a leachate suction device for collecting a small amount of exudate, which is an interstitial fluid, from a surface of a living body, and a method for collecting the same.
【０００２】[0002]
【従来の技術】従来、生体内のグルコース濃度、乳酸、
尿素窒素などの化学物質濃度の連続測定は、一般的に採
血して測定していた。これらは、固定化酵素膜電極を備
えたバイオセンサを用いてその濃度を測定するもので、
バイオセンサが微小な寸法で良いため微量なサンプル量
で高感度に測定できる特徴をもっている。したがって、
これらの測定装置、測定方法は医療、診断や生化学の分
野、たとえば血液、尿などに含まれる有機成分濃度の測
定による病気の診断に利用できる。しかし、採血に伴う
患者の苦痛や医療側の労力が必要で、感染、失血などの
肉体的、精神的苦痛を取り除くことができない問題があ
った。2. Description of the Related Art Conventionally, in vivo glucose concentration, lactic acid,
The continuous measurement of the concentration of chemical substances such as urea nitrogen was generally performed by collecting blood. These measure the concentration using a biosensor equipped with an immobilized enzyme membrane electrode,
The biosensor has a feature that it can measure with high sensitivity with a small amount of sample because it requires a small size. Therefore,
These measuring devices and measuring methods can be used in the fields of medical care, diagnosis and biochemistry, for example, in the diagnosis of diseases by measuring the concentration of organic components contained in blood, urine and the like. However, there is a problem in that the patient's pain associated with blood collection and labor on the medical side are required, and physical and mental pain such as infection and blood loss cannot be eliminated.
【０００３】最近、これらの問題を解決する方法とし
て、局部的に皮膚の角質層を除去し、その部分から血液
の代わりに間質液を抽出し、この浸出液をセンサで体内
の成分濃度を測定する方法が開発された。この方法の一
つが特開平４−３４１２４１号公報に開示されている。Recently, as a method for solving these problems, the stratum corneum of the skin is locally removed, interstitial fluid is extracted from the portion instead of blood, and the concentration of the in-vivo component is measured by a sensor using this exudate. The way to do was developed. One of these methods is disclosed in Japanese Patent Application Laid-Open No. 4-341241.
【０００４】図４は従来の浸出液吸引装置の一例を示す
断面図である。この浸出液吸引装置は図４に示すように
一端に吸引口２１を有し、他端に開口部２４をもつ吸引
セル本体２０と、開口部２４に嵌合され枠２３で固定さ
れるメッシュ部２２とで構成されている。そして、間質
液を採取するときは、まず、メッシュ部２２を角質層を
剥離した皮膚面に接触させ吸引セル本体２０の端部を密
着させ、吸引口２１から排気し内部の空間部を減圧し、
間質液である浸出液を吸引し採取していた。FIG. 4 is a sectional view showing an example of a conventional leachate suction device. As shown in FIG. 4, this leachate suction device has a suction cell body 20 having a suction port 21 at one end and an opening 24 at the other end, and a mesh part 22 fitted in the opening 24 and fixed by a frame 23. It consists of and. When collecting the interstitial fluid, first, the mesh portion 22 is brought into contact with the skin surface from which the stratum corneum has been peeled off, the end portion of the suction cell main body 20 is brought into close contact, the gas is exhausted from the suction port 21, and the internal space is depressurized. Then
The exudate, which is interstitial fluid, was aspirated and collected.
【０００５】[0005]
【発明が解決しようとする課題】上述した従来の浸出液
吸引装置では、浸出液はメッシュ部２２を介して吸引さ
れるので、メッシュ部２２の細穴に浸出液が充満してし
まうと吸引経路が閉鎖されることになり、円滑に連続し
て浸出させることができなくなってくる。その結果、所
要浸出液を得るには時間が多大に必要となり、浸出液の
採取効率が劣るという問題があった。In the above-described conventional leachate suction device, the leachate is sucked through the mesh portion 22, so that when the fine holes in the mesh portion 22 are filled with the leachate, the suction path is closed. As a result, it will not be possible to leach smoothly and continuously. As a result, it takes a lot of time to obtain the required leachate, and there is a problem that the efficiency of collecting leachate is poor.
【０００６】例えば、吸引口２１を約０．５気圧に減圧
したとすると、最初は皮膚面も０．５気圧に減圧される
ので、浸出液が皮膚面から吸引される。しかしながら徐
々に浸出液が吸引されメッシュ部２２に充填し、しか
も、皮膚面は柔らかいので盛り上がりメッシュ部２２に
倣って張り付いてしまう。この結果、吸引口２１から常
に減圧吸引しても、吸引系が閉鎖されてしまい、排気抵
抗が増大する。皮膚面の圧力は上昇して１気圧に近い値
になってしまうため、皮膚面からの浸出液の浸出が極端
に遅くなる。また、吸引セル本体２０の皮膚面との間で
シール不良が発生しリークして、浸出液中に気泡が混入
し、見かけ上の採取量は増えるが希釈して計測する場合
希釈比が不均一になる問題があった。採取時間が決まっ
ている血糖値負荷試験や日内変動を計測する場合など時
間が不足したり、気泡の影響で酵素反応が一定せず、浸
出液の量も不足して測定精度を悪くしてしまう問題があ
った。For example, if the suction port 21 is depressurized to about 0.5 atmospheric pressure, the skin surface is also depressurized to 0.5 atmospheric pressure at first, so that the exudate is sucked from the skin surface. However, the exudate is gradually sucked and filled in the mesh portion 22, and since the skin surface is soft, it sticks following the rising mesh portion 22. As a result, the suction system is closed even if vacuum suction is always performed from the suction port 21, and the exhaust resistance increases. Since the pressure on the skin surface rises to a value close to 1 atm, the leaching of the exudate from the skin surface becomes extremely slow. In addition, a sealing failure occurs between the suction cell body 20 and the skin surface, causing leakage, and air bubbles are mixed in the exudate, resulting in an increase in the apparent collection amount, but when the dilution is measured, the dilution ratio becomes uneven. There was a problem. Problems such as lack of time when measuring a blood glucose load test with a fixed collection time or measurement of diurnal fluctuation, enzyme reaction not being constant due to the effect of bubbles, and the amount of exudate being insufficient, resulting in poor measurement accuracy was there.
【０００７】本発明の目的は、血糖値など生化学物質濃
度の測定精度に悪影響を与えることなく効率よく吸引し
浸出液を採取できる浸出液吸引装置およびその採取方法
を提供することにある。It is an object of the present invention to provide a leachate suction device and a leachate collection method capable of efficiently sucking leachate without adversely affecting the measurement accuracy of biochemical substance concentration such as blood glucose level.
【０００８】[0008]
【課題を解決するための手段】本発明の第１の特徴は、
生体表面から浸出液を浸出させるために吸引減圧する第
１の吸引口を一端に有し、他端に前記生体表面に面する
第１の開口部を持つ外部吸引セルと、この外部吸引セル
の該第１の開口部に内装され、前記浸出液を抽出させる
ために吸引減圧する第２の吸引口を一端に有し、他端に
前記生体表面に面する第２の開口部に嵌合され、前記生
体表面に直接接触し複数の抽出口を具備する抽出板部材
とからなる内部吸引セルと、前記外部吸引セルに対し、
この内部吸引セルを上下に摺動できる可変手段とを備え
る浸出液吸引装置である。The first feature of the present invention is to:
An external suction cell having a first suction port for sucking and decompressing the exudate from the surface of the living body at one end and having a first opening at the other end facing the surface of the living body; The first opening has a second suction port at one end that is suctioned and decompressed in order to extract the exudate, and the other end is fitted into the second opening facing the living body surface. An internal suction cell consisting of an extraction plate member that is in direct contact with the living body surface and has a plurality of extraction ports, and the external suction cell,
The leachate suction device is provided with a variable means capable of sliding the internal suction cell up and down.
【０００９】また、前記抽出板部材は、枠で固定される
メッシュ状部材であるか、金属あるいは樹脂板に複数の
貫通孔を形成した多孔板部材であるか、多孔質板部材で
あるか、複数の抽出孔を形成してある多針板部材である
か、中心より放射状に外方に伸びる複数の流路溝とこれ
ら流路溝内に配置され前記生体表面に直接接触する面に
貫通する複数の前記抽出口を有する板部材と、前記流路
溝を覆い複数のトンネル状の流路を形成すると共に、前
記第２の吸引口と通じる流路をもつ補強板部材とで構成
されていることを特徴としている。Further, whether the extraction plate member is a mesh member fixed by a frame, a perforated plate member having a plurality of through holes formed in a metal or resin plate, or a porous plate member, It is a multi-needle plate member having a plurality of extraction holes formed therein, or a plurality of flow channel grooves extending radially outward from the center and penetrating a surface which is arranged in these flow channel grooves and which is in direct contact with the surface of the living body. It is composed of a plate member having a plurality of extraction ports, and a reinforcing plate member that covers the flow channel groove to form a plurality of tunnel-shaped flow channels and has a flow channel that communicates with the second suction port. It is characterized by that.
【００１０】さらに、前記第２の吸引口部材の外周と前
記外部吸引セルとは、シール部材で支持されていること
を特徴としている。Further, the outer periphery of the second suction port member and the external suction cell are supported by a seal member.
【００１１】本発明の第２の特徴は浸出液吸引装置の浸
出液採取方法において、前記第１の吸引口を吸引するス
テップと、該第１の吸引口の吸引減圧を一定期間行い前
記外部吸引セル内を減圧保持するステップと、該第１の
吸引口の吸引減圧を保持あるいは中断している間に前記
内部吸引セルを前記生体表面に押しあてるステップと、
前記第２の吸引口を吸引し前記内部吸引セル内を減圧す
るステップと、該第２の吸引口の減圧を一定期間行い浸
出液を抽出するステップと、前記内部吸引セルを前記生
体表面から分離させるように上昇させるステップを少な
くとも１回含むことを特徴としている。A second feature of the present invention is, in the leachate collecting method of the leachate suction device, a step of sucking the first suction port, and a suction depressurization of the first suction port for a certain period of time in the external suction cell. Holding a reduced pressure, and pressing the internal suction cell against the living body surface while holding or interrupting the suction reduced pressure of the first suction port,
A step of sucking the second suction port to reduce the pressure inside the internal suction cell; a step of reducing the pressure of the second suction port for a certain period of time to extract a leachate; and separating the internal suction cell from the surface of the living body. Thus, it is characterized by including at least one step of raising.
【００１２】また、前記第１の吸引口の吸引減圧を一定
期間行い、前記外部吸引セル内を減圧保持するステップ
の次に、前記第１の吸引口からガスを供給、あるいはリ
ークさせてほぼ大気圧に戻すステップを含むことを特徴
としている。[0012] In addition, after the step of holding the reduced pressure inside the external suction cell by performing suction decompression of the first suction port for a certain period of time, gas is supplied or leaked from the first suction port to cause a large amount. It is characterized by including a step of returning to atmospheric pressure.
【００１３】[0013]
【発明の実施の形態】次に本発明について、図面を参照
して説明する。DESCRIPTION OF THE PREFERRED EMBODIMENTS Next, the present invention will be described with reference to the drawings.
【００１４】図１（ａ）〜（ｂ）は本発明の浸出液吸引
装置の第一の実施の形態を示す断面図（ａ）ならびに動
作を説明するためのタイミングチャート（ｂ）である。
この浸出液吸引装置は、図１（ａ）に示すように、外部
吸引セル１に第１の吸引口２と、第１の開口部３が設け
られてあり、その第１の開口部３内には内部吸引セル４
が内装されている。1 (a) and 1 (b) are a sectional view (a) and a timing chart (b) for explaining the operation of the first embodiment of the exudate suction device of the present invention.
As shown in FIG. 1A, this exudate suction device is provided with a first suction port 2 and a first opening 3 in an external suction cell 1, and inside the first opening 3. Is the internal suction cell 4
Is decorated.
【００１５】さらに、この内部吸引セル４の一端の第２
の開口部６には生体表面に直接接触するメッシュ部７が
隙間無く嵌合され、他端には第２の吸引口５が設けられ
ている。メッシュ部７はナイロン製メッシュを枠８に支
持させたものである。Further, a second end of one end of the internal suction cell 4 is
A mesh portion 7 that directly contacts the surface of the living body is fitted into the opening portion 6 with no gap, and the second suction port 5 is provided at the other end. The mesh part 7 is made by supporting a nylon mesh on the frame 8.
【００１６】また第２の吸引口５の外周は外部吸引セル
１にシール部材で支持されている。ここではシリコーン
製Ｏリング９を使用してあり、外部吸引セル１に対し内
部吸引セル４は自由に上下の摺動がマニュアルで出来る
構造になっている。The outer periphery of the second suction port 5 is supported by the external suction cell 1 by a seal member. Here, a silicone O-ring 9 is used, and the internal suction cell 4 can freely slide up and down with respect to the external suction cell 1 manually.
【００１７】また、第１の吸引口２と第２の吸引口５に
はそれぞれ第１，第２の開閉弁１０，１１が設けられ、
独立して減圧吸引、減圧中断、開放、閉鎖などが出来る
ようにしている。Further, the first suction port 2 and the second suction port 5 are provided with first and second on-off valves 10 and 11, respectively.
It is possible to perform vacuum suction, vacuum suspension, opening, and closing independently.
【００１８】このような構造の浸出液吸引装置を、まず
角質層を除去した皮膚面に載置する。そして第２の開閉
弁１１を閉じたまま内部吸引セル４を上昇させておき第
１の開閉弁１０を設け、第１の吸引口２から減圧吸引す
る。The exudate suction device having such a structure is first placed on the skin surface from which the stratum corneum has been removed. Then, the internal suction cell 4 is raised while the second opening / closing valve 11 is closed, the first opening / closing valve 10 is provided, and vacuum suction is performed from the first suction port 2.
【００１９】例えば０．５気圧程度に減圧すると、第１
の開口部３と皮膚面との空間は０．５気圧に保持され
る。浸出液の浸出速度は通常健常被験者では０．２μｌ
／ｍｉｎ／ｃｍ2 程度であるので、１０μｌが所要量
で、１．５ｃｍの直径の外部吸引セル１であれば１０ｍ
ｉｎ以下で所要量に達する。For example, if the pressure is reduced to about 0.5 atm, the first
The space between the opening 3 and the skin surface is maintained at 0.5 atm. The leaching rate of the exudate is usually 0.2 μl in healthy subjects.
/ Min / so cm is about 2, 10 [mu] l is in the required amount, if external suction cell 1 of 1.5cm diameter 10m
The required amount is reached within in.
【００２０】次に、第１の開閉弁１０を閉じ、外部吸引
セル１の吸引減圧を中断した後、静かに内部吸引セル４
を下降させ、皮膚面にメッシュ部７を押しあてる。この
時浸出液はメッシュ部７に浸透される。Next, after closing the first on-off valve 10 and interrupting the suction decompression of the external suction cell 1, the internal suction cell 4 is gently placed.
Down and press the mesh portion 7 against the skin surface. At this time, the exudate permeates the mesh portion 7.
【００２１】次に第２の開閉弁１１を開け、第２の吸引
口５から浸出液を抽出させる。浸出液は予めメッシュ部
７に浸透しているので、吸引圧は外部吸引セル１の圧力
と同等、或いは若干負圧に保てば、その時間は２ｍｉｎ
程で完了する。この時、第１の開閉弁１０を開放し大気
を導入してもいいしＮ2 などのガスを導入しても良い。Next, the second on-off valve 11 is opened and the exudate is extracted from the second suction port 5. Since the exudate has already permeated into the mesh part 7, if the suction pressure is kept equal to the pressure of the external suction cell 1 or slightly negative, the time is 2 min.
Complete in about. At this time, the first on-off valve 10 may be opened to introduce the atmosphere, or a gas such as N 2 may be introduced.
【００２２】完全に抽出し終わったら第２の開閉弁１１
を閉じ、内部吸引セル４を上昇させる。このような過程
を基本として、浸出液の浸出、浸出液の抽出を繰り返す
ことによって、間欠的で、連続した浸出液の化学濃度成
分を計測するための浸出液を得ることができる。When the extraction is completed, the second on-off valve 11
Is closed and the internal suction cell 4 is raised. By repeating the leaching of the leachate and the extraction of the leachate on the basis of such a process, it is possible to obtain an leachate for measuring the chemical concentration component of the leachate which is intermittent and continuous.
【００２３】外部吸引セル１で減圧吸引している時、皮
膚面は盛り上がり内部吸引セル４の第２の開口部６内に
嵌合したメッシュ部７に軽く接触する。この時は第２の
開口部６はまだ吸引減圧をしていないので、外部吸引セ
ル１内の皮膚面全体が０．５気圧に保たれたままで、皮
膚面がメッシュ部７に張り付くことはない。外部吸引セ
ル１による吸引を妨げることにはならず、浸出液の浸出
は継続されることになる。逆に、皮膚面が盛り上がり過
ぎると皮下出血を発生させる場合があるが、メッシュ部
７で押さえていることによって出血を抑圧していること
になっている。When vacuum suction is performed by the external suction cell 1, the skin surface rises and contacts the mesh portion 7 fitted in the second opening 6 of the internal suction cell 4 lightly. At this time, since the second opening 6 has not yet been depressurized by suction, the entire skin surface in the external suction cell 1 is kept at 0.5 atmospheric pressure, and the skin surface does not stick to the mesh portion 7. . The suction by the external suction cell 1 is not hindered, and the leaching of the exudate is continued. On the contrary, if the skin surface rises too much, subcutaneous bleeding may occur, but the bleeding is supposed to be suppressed by pressing with the mesh portion 7.
【００２４】外部吸引セル１の第１の開口部３の内径
は、内部吸引セル４の外径に対して自由に可動できる範
囲であればよく、例えば１ｍｍ程度のクリアランスを持
っていれば十分であり、マニュアルで容易に動かすこと
が出来る。また、外部吸引セル１で減圧吸引している時
の、メッシュ部７のストロークは上述の理由から１ｍｍ
程度が適当であった。The inner diameter of the first opening 3 of the external suction cell 1 may be within a range in which it can be freely moved with respect to the outer diameter of the internal suction cell 4, for example, a clearance of about 1 mm is sufficient. Yes, it can be easily moved manually. Further, the stroke of the mesh portion 7 during vacuum suction by the external suction cell 1 is 1 mm due to the above reason.
The degree was appropriate.
【００２５】このような浸出液吸引装置は、まず浸出液
の吸引と抽出を別々のステップで実施することにより、
常に、一定の浸出速度で浸出液を浸出できるようになる
ことである。従って、外部吸引セル１と皮膚面間では確
実に減圧吸引が保持され、リークするような事故は発生
しない。In such a leachate suction device, first, leachate suction and extraction are performed in separate steps,
It is always possible to leach the leachate at a constant leach rate. Therefore, the vacuum suction is reliably held between the external suction cell 1 and the skin surface, and no accident such as leakage occurs.
【００２６】浸出液を希釈して、一定の割合の希釈比で
計測する場合でも採取時間が短縮され、安定で、精度の
高い計測が出来るようになる。従来、皮膚面からの浸出
液の吸引及び抽出を、ナイロンメッシュを介して同時に
おこなっていたときのように流路を浸出液や皮膚の盛り
上がりによって遮断されるようなことが無くなる。浸出
液の採取効率が向上し、患者の肉体的、精神的負担が軽
減される計測が可能になる利点を有する。Even when the leachate is diluted and measured at a fixed dilution ratio, the sampling time is shortened, and stable and highly accurate measurement can be performed. Conventionally, the flow path is not blocked by the exudate or the swelling of the skin unlike the case where the exudate is suctioned and extracted from the skin surface at the same time through the nylon mesh. There is an advantage that the efficiency of collecting the exudate is improved and the measurement that reduces the physical and mental burden on the patient becomes possible.
【００２７】図２は本発明の浸出液吸引装置の第２の実
施の形態を示す断面図である。この浸出液吸引装置は、
図３に示すように、前述の実施の形態におけるメッシュ
部７の代わりに、中心より放射状あるいは同心円状に外
方に伸びる複数の流路溝１５と、これら流路溝１５内に
配置される面に貫通する複数の抽出口１６を有するステ
ンレス製スペーサ１７と、流路溝１５を覆い複数のトン
ネル状の流路を形成すると共に、第２の吸引口５と通じ
る流路口１９をもつ補強板１８とで浸出液抽出板部材を
設けたことである。それ以外は前述の実施の形態と同じ
である。FIG. 2 is a sectional view showing a second embodiment of the exudate suction device of the present invention. This leachate suction device
As shown in FIG. 3, instead of the mesh portion 7 in the above-described embodiment, a plurality of flow channel grooves 15 extending outward from the center in a radial or concentric manner, and surfaces arranged in these flow channel grooves 15. A spacer 17 made of stainless steel having a plurality of extraction ports 16 penetrating therethrough, a plurality of tunnel-shaped channels covering the channel groove 15, and a reinforcing plate 18 having a channel port 19 communicating with the second suction port 5. That is, the leachate extraction plate member is provided by and. Other than that is the same as the above-mentioned embodiment.
【００２８】このような構造の浸出液吸引装置は、前述
の実施の形態に示した効果は同様に得られる他、スペー
サ１７の厚さを０．１ｍｍ程度の薄い寸法に出来るの
で、第２の開口部６の浸出液の滞留容積が２０μｌ以下
に少なくできる。前述の実施例のメッシュ部７では１０
０μｌ程と大きい容積を持っていたのに対し、格段に少
なくそれだけ浸出液の回収率が上がると言う利点があ
る。In the leachate suction device having such a structure, in addition to the same effects as those of the above-described embodiment, the thickness of the spacer 17 can be made as thin as about 0.1 mm. The retention volume of the exudate in the part 6 can be reduced to 20 μl or less. In the mesh unit 7 of the above-described embodiment, 10
While it has a large volume of about 0 μl, it has an advantage that the recovery rate of the leachate is significantly increased, which is much less.
【００２９】なお、図１のメッシュ部７および図２のス
ペーサ１７の材質は、ナイロンメッシュとステンレスに
限定して説明したが、これに限らず同様な性能の材料、
例えばニッケル、高分子材料、射出成形材料でも良い。
いずれにしても、抽出口１６、流路溝１５などの形成は
比較的量産しやすいので低価格で実現できる。Although the material of the mesh portion 7 of FIG. 1 and the spacer 17 of FIG. 2 is limited to nylon mesh and stainless steel, the material is not limited to nylon mesh and has the same performance.
For example, nickel, a polymer material, or an injection molding material may be used.
In any case, the formation of the extraction port 16, the flow path groove 15, etc. is relatively easy to mass-produce, so that it can be realized at a low price.
【００３０】また、この様な浸出液抽出板部材は他の構
造のものでも使用することができる。例えば、単なる金
属あるいは樹脂板に直径０．１ｍｍ以下の微細貫通孔を
複数個設けた多孔板、厚さ０．１ｍｍ程で不織布や多孔
質に焼結したセラミックのような材料を用いた多孔質薄
板のような抽出板部材でも同様な効果が得られる。Further, such a leachate extraction plate member can be used with another structure. For example, a mere metal or resin plate having a plurality of fine through holes with a diameter of 0.1 mm or less, a porous plate made of a material such as a nonwoven fabric or a porous sintered ceramic having a thickness of about 0.1 mm. The same effect can be obtained with an extraction plate member such as a thin plate.
【００３１】さらに、長さおよび直径が０．１ｍｍ以下
の微細針と貫通口とを多数形成した多針板のような抽出
板部材でも同様な結果が得られる他、角質層を除去しな
くとも皮膚面から浸出液を効率的に採取することが出来
る。Furthermore, similar results can be obtained with an extraction plate member such as a multi-needle plate having a large number of fine needles having a length and a diameter of 0.1 mm or less and through holes, and the stratum corneum is not removed. The exudate can be efficiently collected from the skin surface.
【００３２】[0032]
【発明の効果】以上説明したように本発明は、外部吸引
セルに内部吸引セルを内装させた二重構造吸引セルで、
外部吸引セルで浸出液を吸引、内部吸引セルで浸出液を
抽出させるステップを交互に実施することにより、浸出
させた浸出液抽出部材内の浸出液を吸引口側に効率より
送液する事が出来、減圧吸引中、常に一定の浸出速度で
浸出液を採取出来るという効果がある。また、浸出液の
生体内成分濃度を連続して計測する場合、短時間で且
つ、精度良く浸出液の成分濃度を測定することが出来る
ような効果がある。As described above, the present invention is a dual structure suction cell in which an internal suction cell is incorporated in an external suction cell,
By alternately performing the steps of sucking the exudate in the external suction cell and extracting the exudate in the internal suction cell, the exudate in the exuded exudate extraction member can be efficiently delivered to the suction port side, and vacuum suction is performed. Medium, there is an effect that the leachate can always be collected at a constant leach rate. Further, when the in vivo component concentration of the exudate is continuously measured, there is an effect that the component concentration of the exudate can be accurately measured in a short time.
【００３３】なお、本発明の実施の形態においては外部
吸引セルおよび内部吸引セルは円形状としたが、これに
限定されることなく、矩形形状など他の形状でも良い。Although the external suction cell and the internal suction cell are circular in the embodiment of the present invention, the shape is not limited to this, and other shapes such as a rectangular shape may be used.
【図１】本発明の浸出液吸引装置の第１の実施例を示す
断面図（ａ）および動作を説明するためのタイミングチ
ャート（ｂ）である。FIG. 1 is a sectional view (a) showing a first embodiment of a leachate suction device of the present invention and a timing chart (b) for explaining the operation.
【図２】本発明の浸出液吸引装置の第２の実施例を示す
断面図である。FIG. 2 is a sectional view showing a second embodiment of the exudate suction device of the present invention.
【図３】図２の浸出液吸引装置の浸出液抽出部材の一例
を示す平面図である。FIG. 3 is a plan view showing an example of a leachate extraction member of the leachate suction device of FIG.
【図４】従来の浸出液吸引装置の一例を示す断面図であ
る。FIG. 4 is a sectional view showing an example of a conventional leachate suction device.
１ 外部吸引セル ２ 第１の吸引口 ３ 第１の開口部 ４ 内部吸引セル ５ 第２の吸引口 ６ 第２の開口部 ７，２２ メッシュ部 ８，２３ 枠 ９ Ｏリング １０ 第１の開閉弁 １１ 第２の開閉弁 １５ 流路溝 １６ 抽出口 １７ スペーサ １８ 補強板 １９ 流路口 ２０ 吸引セル本体 ２１ 吸引口 ２４ 開口部 1 External Suction Cell 2 First Suction Port 3 First Opening Port 4 Internal Suction Cell 5 Second Suction Port 6 Second Opening Port 7,22 Mesh Part 8,23 Frame 9 O-Ring 10 First Open / Close Valve 11 Second on-off valve 15 Flow channel 16 Extraction port 17 Spacer 18 Reinforcing plate 19 Flow port 20 Suction cell body 21 Suction port 24 Opening
Claims (9)
吸引減圧する第１の吸引口を一端に有し、他端に前記生
体表面に面する第１の開口部を有する外部吸引セルと、
この外部吸引セルの前記第１の開口部に内装され、前記
浸出液を抽出させるために吸引減圧する第２の吸引口を
一端に有し、他端に前記生体表面に面する第２の開口部
に嵌合され、前記生体表面に直接接触し複数の抽出口を
具備する抽出板部材とで構成される内部吸引セルと、前
記外部吸引セルに対し、この内部吸引セルを上下に摺動
する可変手段とを備えることを特徴とする浸出液吸引装
置。1. An external suction cell having at one end a first suction port for sucking and depressurizing the exudate from the surface of the living body, and at the other end having a first opening facing the surface of the living body.
A second opening portion, which is internally provided in the first opening portion of the external suction cell and has a second suction port for sucking and reducing the pressure for extracting the exudate at one end and facing the living body surface at the other end. Which is fitted to the living body surface and which directly contacts the surface of the living body and comprises an extraction plate member having a plurality of extraction ports, and a variable that slides the internal suction cell up and down with respect to the external suction cell. And a means for sucking the exudate.
シュ状部材であることを特徴とする請求項１記載の浸出
液吸引装置。2. The exudate suction device according to claim 1, wherein the extraction plate member is a mesh member fixed by a frame.
に複数の貫通孔を形成した多孔板部材であることを特徴
とする請求項１記載の浸出液吸引装置。3. The leachate suction device according to claim 1, wherein the extraction plate member is a perforated plate member having a plurality of through holes formed in a metal or resin plate.
ことを特徴とする請求項１記載の浸出液吸引装置。4. The leachate suction device according to claim 1, wherein the extraction plate member is a porous plate member.
してある多針板部材であることを特徴とする請求項１記
載の浸出液吸引装置。5. The exudate suction device according to claim 1, wherein the extraction plate member is a multi-needle plate member having a plurality of extraction holes formed therein.
方に伸びる複数の流路溝とこれら流路溝内に配置され前
記生体表面に直接接触する面に貫通する複数の前記抽出
口を有する板部材と、前記流路溝を覆い複数のトンネル
状の流路を形成すると共に、前記第２の吸引口と通じる
流路をもつ補強板部材とで構成されていることを特徴と
する請求項１記載の浸出液吸引装置。6. The extraction plate member includes a plurality of flow channel grooves extending radially outward from a center and a plurality of the extraction ports penetrating a surface arranged in the flow channel grooves and directly contacting the surface of the living body. And a reinforcing plate member having a flow path communicating with the second suction port while forming a plurality of tunnel-shaped flow paths that cover the flow path groove. Item 1. The leachate suction device according to item 1.
吸引セルとは、シール部材で支持されていることを特徴
とする請求項１記載の浸出液吸引装置。7. The exudate suction device according to claim 1, wherein an outer periphery of the second suction port member and the external suction cell are supported by a seal member.
採取方法において、前記第１の吸引口を吸引するステッ
プと、該第１の吸引口の吸引減圧を一定期間行い前記外
部吸引セル内を減圧保持するステップと、該第１の吸引
口の吸引減圧を保持あるいは中断している間に前記内部
吸引セルを前記生体表面に押しあてるステップと、前記
第２の吸引口を吸引し前記内部吸引セル内を減圧するス
テップと、該第２の吸引口の減圧を一定期間行い浸出液
を抽出するステップと、前記内部吸引セルを前記生体表
面から分離させるように上昇させるステップを少なくと
も１回含むことを特徴とする浸出液採取方法。8. The method for collecting leachate in the leachate suction device according to claim 1, wherein the step of sucking the first suction port and the suction depressurization of the first suction port are performed for a certain period of time to set the inside of the external suction cell. Depressurizing and holding, pressing the internal suction cell against the surface of the living body while holding or interrupting the suction depressurization of the first suction port, and sucking the second suction port to suck the internal suction. Depressurizing the inside of the cell, depressurizing the second suction port for a certain period of time to extract the exudate, and raising the internal suction cell to separate it from the surface of the living body at least once. Characteristic leachate collection method.
行い、前記外部吸引セル内を減圧保持するステップの次
に、前記第１の吸引口からガスを供給、あるいはリーク
させてほぼ大気圧に戻すステップを含むことを特徴とす
る請求項８記載の浸出液採取方法。9. The step of performing vacuum decompression of the first suction port for a certain period of time to hold the decompression inside the external suction cell, and then supplying or leaking gas from the first suction port to substantially increase the pressure. The method for collecting leachate according to claim 8, further comprising the step of returning to atmospheric pressure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7226587A JP2713264B2 (en) | 1995-09-04 | 1995-09-04 | Leachate suction device and its collection method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7226587A JP2713264B2 (en) | 1995-09-04 | 1995-09-04 | Leachate suction device and its collection method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0966033A true JPH0966033A (en) | 1997-03-11 |
| JP2713264B2 JP2713264B2 (en) | 1998-02-16 |
Family
ID=16847522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7226587A Expired - Lifetime JP2713264B2 (en) | 1995-09-04 | 1995-09-04 | Leachate suction device and its collection method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2713264B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2006077750A1 (en) * | 2005-01-19 | 2008-06-19 | シスメックス株式会社 | Analytical apparatus and analyte extraction cartridge |
-
1995
- 1995-09-04 JP JP7226587A patent/JP2713264B2/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2006077750A1 (en) * | 2005-01-19 | 2008-06-19 | シスメックス株式会社 | Analytical apparatus and analyte extraction cartridge |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2713264B2 (en) | 1998-02-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11660030B2 (en) | Syringe-based fluid diversion mechanism for bodily fluid sampling | |
| JP2985816B2 (en) | Liquid sampling device | |
| EP1112718B1 (en) | Assembly for providing an opening in the skin of a patient by means of a lancet | |
| US10265007B2 (en) | Fluid diversion mechanism for bodily-fluid sampling | |
| DE60110785D1 (en) | DEVICE FOR PERFORMING DIAGNOSTIC TESTS OF THE BLOOD | |
| US20130116599A1 (en) | Fluid diversion mechanism for bodily-fluid sampling | |
| RU2002128734A (en) | METHOD AND DEVICE FOR TAKING SAMPLES AND ANALYSIS OF INTERSTITIAL FLUID AND WHOLE BLOOD SAMPLES | |
| JP2718408B2 (en) | Leachate suction device | |
| JPH1085203A (en) | Method and device for collecting sucked exudate | |
| JP2713264B2 (en) | Leachate suction device and its collection method | |
| JP2636800B2 (en) | Leachate collection device and collection method | |
| CN217566069U (en) | Tissue fluid detection device and system | |
| JPH0756001Y2 (en) | Suction leachate acquisition device | |
| JP2023172799A (en) | Leaching solution sampling device | |
| AU764905B2 (en) | Method and apparatus for obtaining blood for diagnostic tests | |
| JPH0614728Y2 (en) | Suction leachate sampling device | |
| JPH04317643A (en) | Collecting device of sucking and leaching liquid | |
| JPH04253850A (en) | Suction exudate sampler |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 19970930 |