JPH09508410A - 乱用防止錠剤 - Google Patents
乱用防止錠剤Info
- Publication number
- JPH09508410A JPH09508410A JP7520437A JP52043795A JPH09508410A JP H09508410 A JPH09508410 A JP H09508410A JP 7520437 A JP7520437 A JP 7520437A JP 52043795 A JP52043795 A JP 52043795A JP H09508410 A JPH09508410 A JP H09508410A
- Authority
- JP
- Japan
- Prior art keywords
- tablet
- gelling agent
- drug
- gelling
- tablet according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 230000002265 prevention Effects 0.000 title description 2
- 229940079593 drug Drugs 0.000 claims abstract description 55
- 239000003814 drug Substances 0.000 claims abstract description 55
- 239000003349 gelling agent Substances 0.000 claims abstract description 53
- 229940035676 analgesics Drugs 0.000 claims abstract description 8
- 239000000730 antalgic agent Substances 0.000 claims abstract description 8
- 239000002249 anxiolytic agent Substances 0.000 claims abstract description 8
- 230000000949 anxiolytic effect Effects 0.000 claims abstract description 8
- 229940005530 anxiolytics Drugs 0.000 claims abstract description 8
- 239000003326 hypnotic agent Substances 0.000 claims abstract description 7
- 230000000147 hypnotic effect Effects 0.000 claims abstract description 7
- GBBSUAFBMRNDJC-MRXNPFEDSA-N (5R)-zopiclone Chemical compound C1CN(C)CCN1C(=O)O[C@@H]1C2=NC=CN=C2C(=O)N1C1=CC=C(Cl)C=N1 GBBSUAFBMRNDJC-MRXNPFEDSA-N 0.000 claims description 34
- 229960000820 zopiclone Drugs 0.000 claims description 34
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 25
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 25
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 25
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 22
- 238000000576 coating method Methods 0.000 claims description 21
- 239000011248 coating agent Substances 0.000 claims description 16
- 235000010980 cellulose Nutrition 0.000 claims description 10
- 229920002678 cellulose Polymers 0.000 claims description 10
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 239000001913 cellulose Substances 0.000 claims description 8
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 claims description 7
- 229960003529 diazepam Drugs 0.000 claims description 7
- 229920001285 xanthan gum Polymers 0.000 claims description 7
- XADCESSVHJOZHK-UHFFFAOYSA-N Meperidine Chemical compound C=1C=CC=CC=1C1(C(=O)OCC)CCN(C)CC1 XADCESSVHJOZHK-UHFFFAOYSA-N 0.000 claims description 6
- SEQDDYPDSLOBDC-UHFFFAOYSA-N Temazepam Chemical compound N=1C(O)C(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 SEQDDYPDSLOBDC-UHFFFAOYSA-N 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 229960000482 pethidine Drugs 0.000 claims description 6
- 229960003188 temazepam Drugs 0.000 claims description 6
- ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 claims description 6
- 229960001475 zolpidem Drugs 0.000 claims description 6
- 229960004126 codeine Drugs 0.000 claims description 5
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims description 5
- 229920000609 methyl cellulose Polymers 0.000 claims description 5
- 235000010981 methylcellulose Nutrition 0.000 claims description 5
- 239000001923 methylcellulose Substances 0.000 claims description 5
- CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 claims description 4
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 claims description 4
- 229960002695 phenobarbital Drugs 0.000 claims description 4
- 229960002036 phenytoin Drugs 0.000 claims description 4
- 235000010493 xanthan gum Nutrition 0.000 claims description 4
- 239000000230 xanthan gum Substances 0.000 claims description 4
- 229940082509 xanthan gum Drugs 0.000 claims description 4
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 3
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 claims description 3
- 240000008886 Ceratonia siliqua Species 0.000 claims description 3
- 235000013912 Ceratonia siliqua Nutrition 0.000 claims description 3
- 244000303965 Cyamopsis psoralioides Species 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- 235000010443 alginic acid Nutrition 0.000 claims description 3
- 229920000615 alginic acid Polymers 0.000 claims description 3
- 239000000783 alginic acid Substances 0.000 claims description 3
- 229960001126 alginic acid Drugs 0.000 claims description 3
- 150000004781 alginic acids Chemical class 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 239000004584 polyacrylic acid Substances 0.000 claims description 3
- 235000010413 sodium alginate Nutrition 0.000 claims description 3
- 239000000661 sodium alginate Substances 0.000 claims description 3
- 229940005550 sodium alginate Drugs 0.000 claims description 3
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 2
- 235000014698 Brassica juncea var multisecta Nutrition 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- 244000275904 brauner Senf Species 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 235000001727 glucose Nutrition 0.000 claims description 2
- 238000007911 parenteral administration Methods 0.000 abstract description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 164
- 239000003826 tablet Substances 0.000 description 132
- 235000019359 magnesium stearate Nutrition 0.000 description 82
- 239000010410 layer Substances 0.000 description 64
- 239000008187 granular material Substances 0.000 description 48
- 239000000203 mixture Substances 0.000 description 36
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 34
- 229940075614 colloidal silicon dioxide Drugs 0.000 description 33
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 28
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 27
- 229960001375 lactose Drugs 0.000 description 27
- 239000008101 lactose Substances 0.000 description 27
- 239000000843 powder Substances 0.000 description 26
- 239000004615 ingredient Substances 0.000 description 23
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 22
- 235000019700 dicalcium phosphate Nutrition 0.000 description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 19
- 239000002245 particle Substances 0.000 description 16
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 14
- 229940016286 microcrystalline cellulose Drugs 0.000 description 14
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 14
- 239000008108 microcrystalline cellulose Substances 0.000 description 14
- 239000008109 sodium starch glycolate Substances 0.000 description 14
- 229920003109 sodium starch glycolate Polymers 0.000 description 14
- 229940079832 sodium starch glycolate Drugs 0.000 description 14
- 238000007906 compression Methods 0.000 description 13
- 230000006835 compression Effects 0.000 description 13
- 229920002261 Corn starch Polymers 0.000 description 12
- 239000008120 corn starch Substances 0.000 description 12
- 229940099112 cornstarch Drugs 0.000 description 12
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 229920003081 Povidone K 30 Polymers 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- 229920002785 Croscarmellose sodium Polymers 0.000 description 9
- 229960001681 croscarmellose sodium Drugs 0.000 description 9
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 9
- 238000002156 mixing Methods 0.000 description 9
- 229920002472 Starch Polymers 0.000 description 8
- 235000019698 starch Nutrition 0.000 description 8
- 239000008367 deionised water Substances 0.000 description 7
- 229910021641 deionized water Inorganic materials 0.000 description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 229940032147 starch Drugs 0.000 description 6
- 239000008107 starch Substances 0.000 description 6
- -1 Includes dazepam Chemical compound 0.000 description 5
- 229920001223 polyethylene glycol Polymers 0.000 description 5
- 238000003825 pressing Methods 0.000 description 5
- 239000002356 single layer Substances 0.000 description 5
- 238000005303 weighing Methods 0.000 description 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 4
- 238000013268 sustained release Methods 0.000 description 4
- 239000012730 sustained-release form Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000003086 colorant Substances 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- DKSZLDSPXIWGFO-BLOJGBSASA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;phosphoric acid;hydrate Chemical compound O.OP(O)(O)=O.OP(O)(O)=O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC DKSZLDSPXIWGFO-BLOJGBSASA-N 0.000 description 2
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- VIROVYVQCGLCII-UHFFFAOYSA-N amobarbital Chemical compound CC(C)CCC1(CC)C(=O)NC(=O)NC1=O VIROVYVQCGLCII-UHFFFAOYSA-N 0.000 description 2
- 229940049706 benzodiazepine Drugs 0.000 description 2
- 229960004415 codeine phosphate Drugs 0.000 description 2
- 239000012792 core layer Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 229920006158 high molecular weight polymer Polymers 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 229960001797 methadone Drugs 0.000 description 2
- 229960005189 methadone hydrochloride Drugs 0.000 description 2
- FJQXCDYVZAHXNS-UHFFFAOYSA-N methadone hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 FJQXCDYVZAHXNS-UHFFFAOYSA-N 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- WRLGYAWRGXKSKG-UHFFFAOYSA-M phenobarbital sodium Chemical compound [Na+].C=1C=CC=CC=1C1(CC)C(=O)NC([O-])=NC1=O WRLGYAWRGXKSKG-UHFFFAOYSA-M 0.000 description 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 2
- 229920001592 potato starch Polymers 0.000 description 2
- 229940069328 povidone Drugs 0.000 description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 description 2
- 235000011152 sodium sulphate Nutrition 0.000 description 2
- KNXVOGGZOFOROK-UHFFFAOYSA-N trimagnesium;dioxido(oxo)silane;hydroxy-oxido-oxosilane Chemical compound [Mg+2].[Mg+2].[Mg+2].O[Si]([O-])=O.O[Si]([O-])=O.[O-][Si]([O-])=O.[O-][Si]([O-])=O KNXVOGGZOFOROK-UHFFFAOYSA-N 0.000 description 2
- DIWRORZWFLOCLC-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-HNNXBMFYSA-N 0.000 description 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 1
- ZSLUVFAKFWKJRC-IGMARMGPSA-N 232Th Chemical compound [232Th] ZSLUVFAKFWKJRC-IGMARMGPSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- PCLITLDOTJTVDJ-UHFFFAOYSA-N Chlormethiazole Chemical compound CC=1N=CSC=1CCCl PCLITLDOTJTVDJ-UHFFFAOYSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 229920001800 Shellac Polymers 0.000 description 1
- 240000006394 Sorghum bicolor Species 0.000 description 1
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
- 240000001058 Sterculia urens Species 0.000 description 1
- 235000015125 Sterculia urens Nutrition 0.000 description 1
- 229910052776 Thorium Inorganic materials 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- VEUACKUBDLVUAC-UHFFFAOYSA-N [Na].[Ca] Chemical compound [Na].[Ca] VEUACKUBDLVUAC-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000004847 absorption spectroscopy Methods 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 1
- 229960001301 amobarbital Drugs 0.000 description 1
- 229960004977 anhydrous lactose Drugs 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 229940125717 barbiturate Drugs 0.000 description 1
- 150000001557 benzodiazepines Chemical class 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 229960003874 butobarbital Drugs 0.000 description 1
- STDBAQMTJLUMFW-UHFFFAOYSA-N butobarbital Chemical compound CCCCC1(CC)C(=O)NC(=O)NC1=O STDBAQMTJLUMFW-UHFFFAOYSA-N 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- 229960004414 clomethiazole Drugs 0.000 description 1
- 239000008119 colloidal silica Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 229960000913 crospovidone Drugs 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000012738 dissolution medium Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- FYSNRPHRLRVCSW-UHFFFAOYSA-N dodecasodium;tetraborate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]B([O-])[O-].[O-]B([O-])[O-].[O-]B([O-])[O-].[O-]B([O-])[O-] FYSNRPHRLRVCSW-UHFFFAOYSA-N 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 229960003528 flurazepam Drugs 0.000 description 1
- SAADBVWGJQAEFS-UHFFFAOYSA-N flurazepam Chemical compound N=1CC(=O)N(CCN(CC)CC)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1F SAADBVWGJQAEFS-UHFFFAOYSA-N 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229960003019 loprazolam Drugs 0.000 description 1
- UTEFBSAVJNEPTR-RGEXLXHISA-N loprazolam Chemical compound C1CN(C)CCN1\C=C/1C(=O)N2C3=CC=C([N+]([O-])=O)C=C3C(C=3C(=CC=CC=3)Cl)=NCC2=N\1 UTEFBSAVJNEPTR-RGEXLXHISA-N 0.000 description 1
- 229960004391 lorazepam Drugs 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 229960001454 nitrazepam Drugs 0.000 description 1
- KJONHKAYOJNZEC-UHFFFAOYSA-N nitrazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1 KJONHKAYOJNZEC-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229960004535 oxazepam Drugs 0.000 description 1
- ADIMAYPTOBDMTL-UHFFFAOYSA-N oxazepam Chemical compound C12=CC(Cl)=CC=C2NC(=O)C(O)N=C1C1=CC=CC=C1 ADIMAYPTOBDMTL-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229960002790 phenytoin sodium Drugs 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 125000005498 phthalate group Chemical class 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920001289 polyvinyl ether Polymers 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920003124 powdered cellulose Polymers 0.000 description 1
- 235000019814 powdered cellulose Nutrition 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- FJPYVLNWWICYDW-UHFFFAOYSA-M sodium;5,5-diphenylimidazolidin-1-ide-2,4-dione Chemical compound [Na+].O=C1[N-]C(=O)NC1(C=1C=CC=CC=1)C1=CC=CC=C1 FJPYVLNWWICYDW-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.薬物及びゲル化剤が錠剤の別々の層に含まれていることを特徴とする1種又 はそれ以上の薬物及び1種又はそれ以上のゲル化剤を含む2層又はそれ以上の層 を含む錠剤。 2.ゲル化剤が約4,000cp〜約100,000cpの範囲内の粘度を有す る請求の範囲第1項に記載の錠剤。 3.ゲル化剤が約10,000cp〜約100,000cpの範囲内の粘度を有 する請求の範囲第2項に記載の錠剤。 4.ゲル化層におけるゲル化剤の重量による割合が約20〜約60%である請求 の範囲第1〜3項のいずれかに記載の錠剤。 5.ゲル化層におけるゲル化剤の重量による割合が約30〜約50%である請求 の範囲第4項に記載の錠剤。 6.錠剤中のゲル化層の合計量が約50〜約80重量%である請求の範囲第1〜 5項のいずれかに記載の錠剤。 7.ゲル化剤が修飾セルロース、アルギン酸ナトリウム、アルギン酸、トラガカ ント、ポリアクリル酸、ならびにキサンタン、グアー、ローカストビーン及びカ ラヤガムから選ばれる請求の範囲第1〜6項のいずれかに記載の錠剤。 8.ゲル化剤がヒドロキシプロピルメチルセルロース、カルボキシメチルセルロ ース、メチルセルロース及びキサンタンガムから選ばれる請求の範囲第7項に記 載の錠剤。 9.ゲル化剤がヒドロキシプロピルメチルセルロースである請求の範囲第8項に 記載の錠剤。 10.薬物が鎮痛薬、催眠薬及び抗不安薬から選ばれる請求の範囲第1 〜9項のいずれかに記載の錠剤。 11.薬物がゾピクロン、テマゼパム、ジアゼパム、ゾルピデム、コデイン、メ サドン、ペチジン、フェニトイン及びフェノバルビトンから選ばれる請求の範囲 第10項に記載の錠剤。 12.薬物がゾピクロンである請求の範囲第11項に記載の錠剤。 13.2層を有し、そのうちの1層が薬物を含み、他の層がゲル化剤を含む請求 の範囲第1〜12項のいずれかに記載の錠剤。 14.1層が薬物ゾピクロンを含み、他の層がゲル化剤を含む2層錠剤。 15.ゲル化剤がヒドロキシプロピルメチルセルロースである請求の範囲第14 項に記載の2層錠剤。 16.コーティングも含む請求の範囲第1〜15項のいずれかに記載の錠剤。 17.活性層及びゲル化層が実質的に色及び外観において同一である請求の範囲 第1〜16項のいずれかに記載の錠剤。 18.別々の活性層及びゲル化層を形成し、次いで適した錠剤形成機で層を合わ せ、場合により続いて従来のコーティング法を用いてコーティングを適用するこ とを含む請求の範囲第1項に記載の錠剤の製造法。 19.鎮痛薬、催眠薬又は抗不安薬を必要とする患者に、請求の範囲第1項に記 載の錠剤内に含まれる該薬物を投与することを含む、該患者の処置の方法。 20.実質的に前文において記載されている通りの請求の範囲第1項に記載の錠 剤の製造法。 21.実質的に実施例に言及して前文に記載されている通りの錠剤。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9401894A GB9401894D0 (en) | 1994-02-01 | 1994-02-01 | New compositions of matter |
GB9401894.2 | 1994-02-01 | ||
PCT/GB1995/000137 WO1995020947A1 (en) | 1994-02-01 | 1995-01-24 | Abuse resistant tablets |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH09508410A true JPH09508410A (ja) | 1997-08-26 |
Family
ID=10749671
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7520437A Ceased JPH09508410A (ja) | 1994-02-01 | 1995-01-24 | 乱用防止錠剤 |
Country Status (20)
Country | Link |
---|---|
US (1) | US6309668B1 (ja) |
EP (1) | EP0742711B1 (ja) |
JP (1) | JPH09508410A (ja) |
AT (1) | ATE177630T1 (ja) |
AU (1) | AU696005B2 (ja) |
CA (1) | CA2182508C (ja) |
CZ (1) | CZ291980B6 (ja) |
DE (1) | DE69508385T2 (ja) |
DK (1) | DK0742711T3 (ja) |
ES (1) | ES2132626T3 (ja) |
FI (1) | FI963025A (ja) |
GB (1) | GB9401894D0 (ja) |
GR (1) | GR3029734T3 (ja) |
HU (1) | HU223144B1 (ja) |
IL (1) | IL112501A (ja) |
NO (1) | NO313267B1 (ja) |
NZ (1) | NZ278643A (ja) |
PL (1) | PL178572B1 (ja) |
WO (1) | WO1995020947A1 (ja) |
ZA (1) | ZA95800B (ja) |
Cited By (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002531499A (ja) * | 1998-12-04 | 2002-09-24 | サノフィ−サンテラボ | ゾルピデムまたはその塩からなる制御放出剤形 |
JP2005534664A (ja) * | 2002-06-17 | 2005-11-17 | グリューネンタ−ル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 乱用が防止された製剤 |
JP2006500426A (ja) * | 2002-07-05 | 2006-01-05 | コルジェジウム ファーマシューティカル | オピオイドおよび他の薬物に関する乱用抑止性の薬学的組成物 |
JP2006502192A (ja) * | 2002-09-23 | 2006-01-19 | ベリオン インコーポレイテッド | 乱用抵抗性の医薬組成物 |
JP2006506374A (ja) * | 2002-10-25 | 2006-02-23 | グリューネンタ−ル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 乱用が防止された製剤 |
JP2008529990A (ja) * | 2005-02-08 | 2008-08-07 | フラメル・テクノロジー | 誤用防止用の微小粒子状経口薬物形態 |
JP2010536770A (ja) * | 2007-08-13 | 2010-12-02 | アビューズ ディタレント ファーマスティカル エルエルシー | 乱用抵抗性医薬組成物、その使用方法および作製方法 |
JP2012512139A (ja) * | 2008-12-16 | 2012-05-31 | ラボファーム インコーポレイテッド | 誤用を防止する放出制御製剤 |
US8722086B2 (en) | 2007-03-07 | 2014-05-13 | Gruenenthal Gmbh | Dosage form with impeded abuse |
JP2015500264A (ja) * | 2011-12-06 | 2015-01-05 | エティファルムEthypharm | 注射による誤用に対処可能な錠剤 |
US9161917B2 (en) | 2008-05-09 | 2015-10-20 | Grünenthal GmbH | Process for the preparation of a solid dosage form, in particular a tablet, for pharmaceutical use and process for the preparation of a precursor for a solid dosage form, in particular a tablet |
US9629807B2 (en) | 2003-08-06 | 2017-04-25 | Grünenthal GmbH | Abuse-proofed dosage form |
US9636303B2 (en) | 2010-09-02 | 2017-05-02 | Gruenenthal Gmbh | Tamper resistant dosage form comprising an anionic polymer |
US9655853B2 (en) | 2012-02-28 | 2017-05-23 | Grünenthal GmbH | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
US9675610B2 (en) | 2002-06-17 | 2017-06-13 | Grünenthal GmbH | Abuse-proofed dosage form |
US9737490B2 (en) | 2013-05-29 | 2017-08-22 | Grünenthal GmbH | Tamper resistant dosage form with bimodal release profile |
US9750701B2 (en) | 2008-01-25 | 2017-09-05 | Grünenthal GmbH | Pharmaceutical dosage form |
US9855263B2 (en) | 2015-04-24 | 2018-01-02 | Grünenthal GmbH | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
US9872835B2 (en) | 2014-05-26 | 2018-01-23 | Grünenthal GmbH | Multiparticles safeguarded against ethanolic dose-dumping |
US9913814B2 (en) | 2014-05-12 | 2018-03-13 | Grünenthal GmbH | Tamper resistant immediate release capsule formulation comprising tapentadol |
US9925146B2 (en) | 2009-07-22 | 2018-03-27 | Grünenthal GmbH | Oxidation-stabilized tamper-resistant dosage form |
US10058548B2 (en) | 2003-08-06 | 2018-08-28 | Grünenthal GmbH | Abuse-proofed dosage form |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
US10080721B2 (en) | 2009-07-22 | 2018-09-25 | Gruenenthal Gmbh | Hot-melt extruded pharmaceutical dosage form |
US10130591B2 (en) | 2003-08-06 | 2018-11-20 | Grünenthal GmbH | Abuse-proofed dosage form |
US10154966B2 (en) | 2013-05-29 | 2018-12-18 | Grünenthal GmbH | Tamper-resistant dosage form containing one or more particles |
US10201502B2 (en) | 2011-07-29 | 2019-02-12 | Gruenenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
US10300141B2 (en) | 2010-09-02 | 2019-05-28 | Grünenthal GmbH | Tamper resistant dosage form comprising inorganic salt |
US10335373B2 (en) | 2012-04-18 | 2019-07-02 | Grunenthal Gmbh | Tamper resistant and dose-dumping resistant pharmaceutical dosage form |
US10449547B2 (en) | 2013-11-26 | 2019-10-22 | Grünenthal GmbH | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
US10624862B2 (en) | 2013-07-12 | 2020-04-21 | Grünenthal GmbH | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
JP2020090464A (ja) * | 2018-12-06 | 2020-06-11 | 日本ケミファ株式会社 | ゾピクロン、その光学異性体又はこれらの塩の何れかを有効成分として含有する錠剤 |
US10695297B2 (en) | 2011-07-29 | 2020-06-30 | Grünenthal GmbH | Tamper-resistant tablet providing immediate drug release |
US10729658B2 (en) | 2005-02-04 | 2020-08-04 | Grünenthal GmbH | Process for the production of an abuse-proofed dosage form |
US10842750B2 (en) | 2015-09-10 | 2020-11-24 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
US11224576B2 (en) | 2003-12-24 | 2022-01-18 | Grünenthal GmbH | Process for the production of an abuse-proofed dosage form |
US11844865B2 (en) | 2004-07-01 | 2023-12-19 | Grünenthal GmbH | Abuse-proofed oral dosage form |
Families Citing this family (128)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9803240D0 (sv) * | 1998-09-24 | 1998-09-24 | Diabact Ab | A pharmaceutical composition having a rapid action |
US20040258750A1 (en) * | 1999-06-28 | 2004-12-23 | Gerard Alaux | Timed dual release dosage forms comprising a short acting hypnotic or a salt thereof |
ATE526950T1 (de) | 1999-10-29 | 2011-10-15 | Euro Celtique Sa | Hydrocodon-formulierungen mit gesteuerter freisetzung |
US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
AU5066101A (en) * | 2000-04-13 | 2001-10-30 | Synthon B.V. | Modified release formulations containing a hypnotic agent |
CA2427815C (en) | 2000-10-30 | 2007-07-10 | Euro-Celtique S.A. | Controlled release hydrocodone formulations |
US20030070584A1 (en) | 2001-05-15 | 2003-04-17 | Cynthia Gulian | Dip coating compositions containing cellulose ethers |
US7645442B2 (en) | 2001-05-24 | 2010-01-12 | Alexza Pharmaceuticals, Inc. | Rapid-heating drug delivery article and method of use |
US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
US20030051728A1 (en) | 2001-06-05 | 2003-03-20 | Lloyd Peter M. | Method and device for delivering a physiologically active compound |
US8329216B2 (en) | 2001-07-06 | 2012-12-11 | Endo Pharmaceuticals Inc. | Oxymorphone controlled release formulations |
BR0210855A (pt) * | 2001-07-06 | 2006-10-24 | Penwest Pharmaceuticals Compan | Método de fabricação de formulações de liberação prolongada |
ES2284888T3 (es) * | 2001-07-06 | 2007-11-16 | Endo Pharmaceuticals Inc. | Administracion oral de 6-hidroxi-oximorfona utilizada como analgesico. |
US7842307B2 (en) | 2001-08-06 | 2010-11-30 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and gelling agent |
US7332182B2 (en) | 2001-08-06 | 2008-02-19 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant |
US20030068375A1 (en) | 2001-08-06 | 2003-04-10 | Curtis Wright | Pharmaceutical formulation containing gelling agent |
US20030068276A1 (en) | 2001-09-17 | 2003-04-10 | Lyn Hughes | Dosage forms |
FR2829933B3 (fr) * | 2001-09-21 | 2004-03-12 | Ellipse Pharmaceuticals | Procede de fabrication d'un produit pharmaceutique administrable par voie orale avec des agents detrompeurs notamment de gout et produit obtenu |
US8309118B2 (en) | 2001-09-28 | 2012-11-13 | Mcneil-Ppc, Inc. | Film forming compositions containing sucralose |
US8101209B2 (en) | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
KR20050005437A (ko) | 2002-04-09 | 2005-01-13 | 플라멜 테크놀로지스 | 아목시실린의 변형 방출을 위한 마이크로캡슐 수성 현탁액형태의 경구 제약학적 제제 |
ES2320438T7 (es) | 2002-04-09 | 2013-02-14 | Flamel Technologies | Formulación farmaceútica oral de suspensión acuosa de microcápsulas que permiten la liberación modificada de principio(s) activo(s) |
US10004729B2 (en) | 2002-07-05 | 2018-06-26 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
US8557291B2 (en) * | 2002-07-05 | 2013-10-15 | Collegium Pharmaceutical, Inc. | Abuse-deterrent pharmaceutical compositions of opioids and other drugs |
US8840928B2 (en) | 2002-07-05 | 2014-09-23 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
US7913688B2 (en) | 2002-11-27 | 2011-03-29 | Alexza Pharmaceuticals, Inc. | Inhalation device for producing a drug aerosol |
EP1473030B2 (en) * | 2003-05-02 | 2014-05-14 | Dexcel Ltd. | Extended release Venlafaxine tablet formulation |
EP1622593A1 (en) * | 2003-05-02 | 2006-02-08 | Warner-Lambert Company LLC | Confectionery products for delivery of pharmaceutically active agents to the throat |
US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
DE102004020220A1 (de) * | 2004-04-22 | 2005-11-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
US7201920B2 (en) | 2003-11-26 | 2007-04-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of opioid containing dosage forms |
WO2005061033A1 (en) * | 2003-12-15 | 2005-07-07 | Alexza Pharmaceuticals, Inc. | Treatment of breakthrough pain by drug aerosol inhalation |
US20050165038A1 (en) † | 2004-01-22 | 2005-07-28 | Maxwell Gordon | Analgetic dosage forms that are resistant to parenteral and inhalation dosing and have reduced side effects |
KR20070030178A (ko) * | 2004-02-17 | 2007-03-15 | 트랜스오랄 파마슈티칼스, 인코포레이티드 | 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의사용 방법 |
EP1740156B8 (de) * | 2004-04-22 | 2012-07-11 | Grünenthal GmbH | Verfahren zur herstellung einer gegen missbrauch gesicherten, festen darreinchungsform |
US7780985B2 (en) * | 2005-07-12 | 2010-08-24 | Accu-Break Technologies, Inc. | Tablets having a printed separation mark to guide breaking |
US7318935B2 (en) * | 2004-05-21 | 2008-01-15 | Accu-Break Technologies, Inc. | Pharmaceutical tablets with active and inactive segments |
US7329418B2 (en) * | 2004-05-21 | 2008-02-12 | Accu Break Technologies, Inc. | Pharmaceutical tablets having height greater than width |
US8158148B2 (en) * | 2004-05-21 | 2012-04-17 | Accu-Break Technologies, Inc. | Pharmaceutical tablets comprising two or more unitary segments |
US7838031B2 (en) | 2004-05-21 | 2010-11-23 | Lawrence Solomon | Method of administering a partial dose using a segmented pharmaceutical tablet |
US7713547B2 (en) | 2004-05-21 | 2010-05-11 | Accu-Break Pharmaceuticals, Inc. | Method of administering a partial dose of a segmented pharmaceutical tablet |
US7622137B2 (en) * | 2004-05-21 | 2009-11-24 | Accu-Break Technologies, Inc. | Dosage forms contained within a capsule or sachet |
US8216610B2 (en) * | 2004-05-28 | 2012-07-10 | Imaginot Pty Ltd. | Oral paracetamol formulations |
JP2008500288A (ja) * | 2004-05-28 | 2008-01-10 | イメイジノット ピーティーワイ エルティーディー | 経口治療用化合物の供給系 |
US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
WO2005123039A1 (en) * | 2004-06-12 | 2005-12-29 | Collegium Pharmaceutical, Inc. | Abuse-deterrent drug formulations |
ITMI20041317A1 (it) * | 2004-06-30 | 2004-09-30 | Ibsa Inst Biochimique Sa | Formulazioni farmaceutiche per la somministrazione sicura di farmaci utilizzati nel trattamento della tossicodipendenza e procedimento per il loro ottenimento |
EP1781262A1 (en) * | 2004-07-29 | 2007-05-09 | Sanofi-Aventis | Pharmaceutical multilayer tablet for controlled_release of active ingredients with highly ph-dependent solubility |
EP1776094A2 (en) * | 2004-08-06 | 2007-04-25 | Grain Processing Corporation | Tablet coating composition |
FR2878161B1 (fr) * | 2004-11-23 | 2008-10-31 | Flamel Technologies Sa | Forme medicamenteuse orale, solide et concue pour eviter le mesusage |
US20060110327A1 (en) * | 2004-11-24 | 2006-05-25 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of orally administered pharmaceutical products |
US20060177380A1 (en) * | 2004-11-24 | 2006-08-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of orally administered pharmaceutical products |
US20080152595A1 (en) * | 2004-11-24 | 2008-06-26 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of orally administered pharmaceutical products |
FR2878158B1 (fr) * | 2004-11-24 | 2009-01-16 | Flamel Technologies Sa | Forme pharmaceutique orale, microparticulaire solide concue pour eviter le mesusage |
US20070231268A1 (en) * | 2004-11-24 | 2007-10-04 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of orally administered pharmaceutical products |
GB0506982D0 (en) * | 2005-04-06 | 2005-05-11 | Mw Encap Ltd | Abuse resistant capsules |
KR100714616B1 (ko) * | 2005-06-23 | 2007-05-07 | 삼성전기주식회사 | 지수 함수 발생기 및 이를 이용한 가변 이득 증폭기 |
US20090082466A1 (en) * | 2006-01-27 | 2009-03-26 | Najib Babul | Abuse Resistant and Extended Release Formulations and Method of Use Thereof |
US8329744B2 (en) * | 2005-11-02 | 2012-12-11 | Relmada Therapeutics, Inc. | Methods of preventing the serotonin syndrome and compositions for use thereof |
WO2008134071A1 (en) * | 2007-04-26 | 2008-11-06 | Theraquest Biosciences, Inc. | Multimodal abuse resistant extended release formulations |
WO2007056142A2 (en) * | 2005-11-02 | 2007-05-18 | Theraquest Biosciences, Llc | Methods of preventing the serotonin syndrome and compositions for use therefor |
US8652529B2 (en) | 2005-11-10 | 2014-02-18 | Flamel Technologies | Anti-misuse microparticulate oral pharmaceutical form |
US8148393B2 (en) * | 2005-11-18 | 2012-04-03 | Synthon Bv | Zolpidem tablets |
WO2007058660A1 (en) * | 2005-11-18 | 2007-05-24 | Accu-Break Technologies, Inc. | Segmented pharmaceutical dosage forms |
CA2629904C (en) | 2005-11-28 | 2018-07-10 | Imaginot Pty Ltd. | Oral therapeutic compound delivery system |
US8691272B2 (en) * | 2005-12-30 | 2014-04-08 | Intelgenx Corp. | Multilayer tablet |
US20070264346A1 (en) * | 2006-02-16 | 2007-11-15 | Flamel Technologies | Multimicroparticulate pharmaceutical forms for oral administration |
US20070237815A1 (en) * | 2006-04-06 | 2007-10-11 | Lawrence Solomon | Dosage forms and methods comprising amlodipine and chlorthalidone |
JP4720620B2 (ja) * | 2006-05-30 | 2011-07-13 | コニカミノルタビジネステクノロジーズ株式会社 | カール補正装置及びこれを備えた画像形成装置 |
US20080069891A1 (en) | 2006-09-15 | 2008-03-20 | Cima Labs, Inc. | Abuse resistant drug formulation |
EP2049089A4 (en) * | 2006-08-08 | 2012-07-04 | Accu Break Technologies Inc | PHARMACEUTICAL TABLET CONTAINING A PLURALITY OF ACTIVE SEGMENTS |
SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
WO2008033351A2 (en) * | 2006-09-11 | 2008-03-20 | Theraquest Biosciences, Inc. | Multimodal abuse resistant and extended release formulations |
US8445018B2 (en) | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
US8187636B2 (en) * | 2006-09-25 | 2012-05-29 | Atlantic Pharmaceuticals, Inc. | Dosage forms for tamper prone therapeutic agents |
WO2008067485A1 (en) * | 2006-11-30 | 2008-06-05 | Accu-Break Technologies, Inc. | Divisible osmotic dosage forms and methods of use |
US20080145425A1 (en) * | 2006-12-15 | 2008-06-19 | Pliva Research & Development Limited | Pharmaceutical composition of zolpidem |
US20080216828A1 (en) | 2007-03-09 | 2008-09-11 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
ES2612032T3 (es) * | 2007-06-04 | 2017-05-11 | Shear/Kershman Laboratories, Inc. | Formas farmacéuticas orales basadas en lípidos inviolables para agonistas opiáceos |
WO2008155620A1 (en) * | 2007-06-20 | 2008-12-24 | Develco Pharma Schweiz Ag | Dosage form containing dispersible matrix of sustained release granules |
US20080318993A1 (en) * | 2007-06-21 | 2008-12-25 | Endo Pharmaceuticals, Inc. | Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instruction on Dosing for Hepatic Impairment |
US20080318994A1 (en) * | 2007-06-21 | 2008-12-25 | Endo Pharmaceuticals, Inc. | Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instruction on Dosing for Renal Impairment |
US20090004231A1 (en) | 2007-06-30 | 2009-01-01 | Popp Shane M | Pharmaceutical dosage forms fabricated with nanomaterials for quality monitoring |
AU2008338207A1 (en) | 2007-12-17 | 2009-06-25 | Labopharm (Barbados) Limited | Misuse preventative, controlled release formulation |
JP2011511782A (ja) | 2008-02-12 | 2011-04-14 | アボット・ラボラトリーズ | 長期放出性ヒドロコドンアセトアミノフェンならびにその関連方法および用途 |
US8420700B1 (en) * | 2008-06-04 | 2013-04-16 | James M. Bausch | Tamper resistant lipid-based oral dosage form for sympathomimetic amines |
PT2352494T (pt) | 2008-10-30 | 2019-11-15 | Gruenenthal Gmbh | Novas e potentes formas de dosagem de tapentadol |
WO2010066034A1 (en) * | 2008-12-12 | 2010-06-17 | Paladin Labs Inc. | Methadone formulation |
CN102355892B (zh) * | 2009-01-30 | 2014-10-22 | 桑诺维恩药品公司 | 6-(5-氯-2-吡啶基)-5-[(4-甲基-1-哌嗪基)羰氧基]-7-氧代-6,7-二氢-5H-吡咯并[3,4-b]吡嗪的包衣片剂及测量包衣有效性的方法 |
WO2011041414A1 (en) | 2009-09-30 | 2011-04-07 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse |
US20110136815A1 (en) | 2009-12-08 | 2011-06-09 | Horst Zerbe | Solid oral film dosage forms and methods for making same |
US10610528B2 (en) | 2009-12-08 | 2020-04-07 | Intelgenx Corp. | Solid oral film dosage forms and methods for making same |
US10668060B2 (en) | 2009-12-10 | 2020-06-02 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
CN102821757B (zh) | 2010-02-03 | 2016-01-20 | 格吕伦塔尔有限公司 | 通过挤出机制备粉末状药物组合物 |
EP2544667B1 (en) * | 2010-03-09 | 2018-11-14 | Alkermes Pharma Ireland Limited | Alcohol resistant enteric pharmaceutical compositions |
EP2568977A1 (en) | 2010-05-11 | 2013-03-20 | Cima Labs Inc. | Alcohol-resistant metoprolol-containing extended- release oral dosage forms |
RS56344B1 (sr) | 2010-12-22 | 2017-12-29 | Purdue Pharma Lp | Obloženi dozni oblici sa kontrolisanim oslobađanjem otporni na zloupotrebu |
CN103327969A (zh) | 2010-12-23 | 2013-09-25 | 普渡制药公司 | 抗篡改固体口服剂型 |
US20120328697A1 (en) * | 2011-06-01 | 2012-12-27 | Fmc Corporation | Controlled Release Solid Dose Forms |
EP3078370B1 (en) * | 2011-09-16 | 2018-11-07 | Purdue Pharma L.P. | Tamper resistant immediate release formulations |
EP2838516B1 (en) | 2012-04-18 | 2018-10-17 | SpecGx LLC | Immediate release, abuse deterrent pharmaceutical compositions |
JP6031599B2 (ja) | 2012-07-12 | 2016-11-24 | マリンクロッド エルエルシー | 長期放出性、濫用抑止特性薬学的組成物 |
MX366159B (es) | 2012-11-30 | 2019-07-01 | Acura Pharmaceuticals Inc | Liberacion autorregulada de ingrediente farmaceutico activo. |
CN105120846B (zh) | 2013-02-05 | 2019-10-18 | 普渡制药公司 | 抗篡改的药物制剂 |
US10751287B2 (en) | 2013-03-15 | 2020-08-25 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
BR112015021002B8 (pt) | 2013-03-15 | 2023-03-28 | Mallinckrodt Llc | Forma de dosagem sólida farmacêutica compreendendo um ingrediente farmacêutico ativo |
CA2907428A1 (en) | 2013-03-15 | 2014-09-18 | Inspirion Delivery Technologies, Llc | Abuse deterrent compositions and methods of use |
CA2923721A1 (en) * | 2013-09-09 | 2015-03-12 | Nova Southeastern University | Deterring abuse of pharmaceutical products and alcohol |
ES2855978T3 (es) | 2013-10-13 | 2021-09-27 | Univ Nova Southeastern | Aplicación terapéutica de IL-15 para la modulación de la función de células NK en pacientes con la enfermedad de la Guerra del Golfo |
WO2015065547A1 (en) | 2013-10-31 | 2015-05-07 | Cima Labs Inc. | Immediate release abuse-deterrent granulated dosage forms |
EP3062778A4 (en) * | 2013-10-31 | 2017-07-19 | Cima Labs Inc. | Immediate release abuse-deterrent granulated dosage forms |
EP3079661B1 (de) | 2013-12-11 | 2021-05-05 | Algobate AG | Naloxon-monopräparat und mehrschichttablette |
EP3079676A1 (en) | 2013-12-11 | 2016-10-19 | Sun Pharmaceutical Industries Ltd | Crush-resistant solid oral dosage form |
US10105360B2 (en) | 2013-12-11 | 2018-10-23 | Develco Pharma Schweiz Ag | Method and composition for the treatment of opioid induced constipation |
US9062063B1 (en) | 2014-03-21 | 2015-06-23 | Johnson Matthey Public Limited Company | Forms of oxymorphone hydrochloride |
JP6510628B2 (ja) | 2014-03-26 | 2019-05-15 | サン・ファーマ・アドバンスト・リサーチ・カンパニー・リミテッド | 乱用防止即時放出性被覆リザーバ固体剤形 |
ES2963078T3 (es) | 2014-07-03 | 2024-03-25 | SpecGx LLC | Formulaciones de liberación inmediata disuasorias del abuso que comprenden polisacáridos no celulósicos |
CA2910865C (en) | 2014-07-15 | 2016-11-29 | Isa Odidi | Compositions and methods for reducing overdose |
US9132096B1 (en) | 2014-09-12 | 2015-09-15 | Alkermes Pharma Ireland Limited | Abuse resistant pharmaceutical compositions |
US10729685B2 (en) | 2014-09-15 | 2020-08-04 | Ohemo Life Sciences Inc. | Orally administrable compositions and methods of deterring abuse by intranasal administration |
US9918979B2 (en) | 2015-01-29 | 2018-03-20 | Johnson Matthey Public Limited Company | Process of preparing low ABUK oxymorphone hydrochloride |
US11103581B2 (en) | 2015-08-31 | 2021-08-31 | Acura Pharmaceuticals, Inc. | Methods and compositions for self-regulated release of active pharmaceutical ingredient |
US9737530B1 (en) | 2016-06-23 | 2017-08-22 | Collegium Pharmaceutical, Inc. | Process of making stable abuse-deterrent oral formulations |
WO2020068510A1 (en) | 2018-09-25 | 2020-04-02 | SpecGx LLC | Abuse deterrent immediate release capsule dosage forms |
GR1009791B (el) | 2019-03-26 | 2020-08-03 | Φαρματεν Α.Β.Ε.Ε. | Σκευασμα παρατεταμενης αποδεσμευσης που περιλαμβανει ταπενταδολη και μεθοδος παρασκευης αυτου |
EP3965733A4 (en) | 2019-05-07 | 2023-01-11 | Clexio Biosciences Ltd. | ABUSE DETERRENT DOSAGE FORMS CONTAINING ESKETAMINE |
US20220062200A1 (en) | 2019-05-07 | 2022-03-03 | Clexio Biosciences Ltd. | Abuse-deterrent dosage forms containing esketamine |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE664908C (de) * | 1935-07-13 | 1938-09-07 | Joh Paul Schoenthan Von Pernwa | Verfahren zur Herstellung leicht schluckbarer Arzneigaben |
US3980766A (en) | 1973-08-13 | 1976-09-14 | West Laboratories, Inc. | Orally administered drug composition for therapy in the treatment of narcotic drug addiction |
DE2530563C2 (de) * | 1975-07-09 | 1986-07-24 | Bayer Ag, 5090 Leverkusen | Analgetische Arzneimittel mit vermindertem Mißbrauchspotential |
JPS5843915A (ja) * | 1981-09-09 | 1983-03-14 | Teijin Ltd | 口腔粘膜接着形製剤 |
JPS5858146A (ja) * | 1981-10-05 | 1983-04-06 | Tanabe Seiyaku Co Ltd | 速放性マイクロカプセル |
US4728512A (en) * | 1985-05-06 | 1988-03-01 | American Home Products Corporation | Formulations providing three distinct releases |
JPS6327424A (ja) | 1986-07-17 | 1988-02-05 | Shionogi & Co Ltd | 徐放性製剤およびその製造法 |
JPS6344125A (ja) | 1986-08-12 | 1988-02-25 | Tama Denki Kogyo Kk | ガラスパイプ被覆型センサ− |
US4753790A (en) * | 1986-12-16 | 1988-06-28 | Warner-Lambert Company | Sorbitol coated comestible and method of preparation |
IT1201136B (it) | 1987-01-13 | 1989-01-27 | Resa Farma | Compressa per uso farmaceutico atta al rilascio in tempi successivi di sostanze attive |
US4786503A (en) * | 1987-04-06 | 1988-11-22 | Alza Corporation | Dosage form comprising parallel lamine |
US4814178A (en) * | 1987-07-01 | 1989-03-21 | Sanford Bolton | Floating sustained release therapeutic compositions |
DE3814532A1 (de) | 1988-04-29 | 1989-11-09 | Bayer Ag | Dhp-retard-zubereitung |
US5417985A (en) * | 1989-07-20 | 1995-05-23 | Farmalyoc | Solid and porous single dosage form comprising particles in the form of beads and its preparation |
US5474784A (en) * | 1990-03-02 | 1995-12-12 | British Technology Group Limited | Dispensing device |
EP0546593B1 (en) | 1991-10-30 | 1997-09-03 | Glaxo Group Limited | Multi-layered compositions containing histamine or serotonin antagonists |
IT1255522B (it) | 1992-09-24 | 1995-11-09 | Ubaldo Conte | Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita' |
-
1994
- 1994-02-01 GB GB9401894A patent/GB9401894D0/en active Pending
-
1995
- 1995-01-24 US US08/676,113 patent/US6309668B1/en not_active Expired - Fee Related
- 1995-01-24 AT AT95906418T patent/ATE177630T1/de not_active IP Right Cessation
- 1995-01-24 EP EP95906418A patent/EP0742711B1/en not_active Expired - Lifetime
- 1995-01-24 DE DE69508385T patent/DE69508385T2/de not_active Expired - Lifetime
- 1995-01-24 AU AU14616/95A patent/AU696005B2/en not_active Ceased
- 1995-01-24 ES ES95906418T patent/ES2132626T3/es not_active Expired - Lifetime
- 1995-01-24 CZ CZ19962260A patent/CZ291980B6/cs not_active IP Right Cessation
- 1995-01-24 WO PCT/GB1995/000137 patent/WO1995020947A1/en active IP Right Grant
- 1995-01-24 JP JP7520437A patent/JPH09508410A/ja not_active Ceased
- 1995-01-24 DK DK95906418T patent/DK0742711T3/da active
- 1995-01-24 CA CA002182508A patent/CA2182508C/en not_active Expired - Fee Related
- 1995-01-24 PL PL95315709A patent/PL178572B1/pl not_active IP Right Cessation
- 1995-01-24 HU HU9602103A patent/HU223144B1/hu not_active IP Right Cessation
- 1995-01-24 NZ NZ278643A patent/NZ278643A/en unknown
- 1995-01-31 IL IL11250195A patent/IL112501A/xx not_active IP Right Cessation
- 1995-02-01 ZA ZA95800A patent/ZA95800B/xx unknown
-
1996
- 1996-07-31 FI FI963025A patent/FI963025A/fi not_active IP Right Cessation
- 1996-07-31 NO NO19963202A patent/NO313267B1/no not_active IP Right Cessation
-
1999
- 1999-03-19 GR GR990400819T patent/GR3029734T3/el unknown
Cited By (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002531499A (ja) * | 1998-12-04 | 2002-09-24 | サノフィ−サンテラボ | ゾルピデムまたはその塩からなる制御放出剤形 |
US9675610B2 (en) | 2002-06-17 | 2017-06-13 | Grünenthal GmbH | Abuse-proofed dosage form |
JP2005534664A (ja) * | 2002-06-17 | 2005-11-17 | グリューネンタ−ル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 乱用が防止された製剤 |
US10369109B2 (en) | 2002-06-17 | 2019-08-06 | Grünenthal GmbH | Abuse-proofed dosage form |
JP2011251982A (ja) * | 2002-06-17 | 2011-12-15 | Gruenenthal Gmbh | 乱用が防止された剤形 |
JP2006500426A (ja) * | 2002-07-05 | 2006-01-05 | コルジェジウム ファーマシューティカル | オピオイドおよび他の薬物に関する乱用抑止性の薬学的組成物 |
JP4694207B2 (ja) * | 2002-07-05 | 2011-06-08 | コルジウム ファーマシューティカル, インコーポレイテッド | オピオイドおよび他の薬物に関する乱用抑止性の薬学的組成物 |
JP2006502192A (ja) * | 2002-09-23 | 2006-01-19 | ベリオン インコーポレイテッド | 乱用抵抗性の医薬組成物 |
JP4751613B2 (ja) * | 2002-10-25 | 2011-08-17 | グリューネンタ−ル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 乱用が防止された剤形 |
JP2006506374A (ja) * | 2002-10-25 | 2006-02-23 | グリューネンタ−ル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 乱用が防止された製剤 |
US9629807B2 (en) | 2003-08-06 | 2017-04-25 | Grünenthal GmbH | Abuse-proofed dosage form |
US10130591B2 (en) | 2003-08-06 | 2018-11-20 | Grünenthal GmbH | Abuse-proofed dosage form |
US10058548B2 (en) | 2003-08-06 | 2018-08-28 | Grünenthal GmbH | Abuse-proofed dosage form |
US11224576B2 (en) | 2003-12-24 | 2022-01-18 | Grünenthal GmbH | Process for the production of an abuse-proofed dosage form |
US11844865B2 (en) | 2004-07-01 | 2023-12-19 | Grünenthal GmbH | Abuse-proofed oral dosage form |
US10729658B2 (en) | 2005-02-04 | 2020-08-04 | Grünenthal GmbH | Process for the production of an abuse-proofed dosage form |
US10675278B2 (en) | 2005-02-04 | 2020-06-09 | Grünenthal GmbH | Crush resistant delayed-release dosage forms |
JP2008529990A (ja) * | 2005-02-08 | 2008-08-07 | フラメル・テクノロジー | 誤用防止用の微小粒子状経口薬物形態 |
US8722086B2 (en) | 2007-03-07 | 2014-05-13 | Gruenenthal Gmbh | Dosage form with impeded abuse |
JP2010536770A (ja) * | 2007-08-13 | 2010-12-02 | アビューズ ディタレント ファーマスティカル エルエルシー | 乱用抵抗性医薬組成物、その使用方法および作製方法 |
JP2016138126A (ja) * | 2007-08-13 | 2016-08-04 | インスピリオン デリバリー テクノロジーズ エルエルシー | 乱用抵抗性医薬組成物、その使用方法および作製方法 |
US9750701B2 (en) | 2008-01-25 | 2017-09-05 | Grünenthal GmbH | Pharmaceutical dosage form |
US9161917B2 (en) | 2008-05-09 | 2015-10-20 | Grünenthal GmbH | Process for the preparation of a solid dosage form, in particular a tablet, for pharmaceutical use and process for the preparation of a precursor for a solid dosage form, in particular a tablet |
JP2012512139A (ja) * | 2008-12-16 | 2012-05-31 | ラボファーム インコーポレイテッド | 誤用を防止する放出制御製剤 |
US10080721B2 (en) | 2009-07-22 | 2018-09-25 | Gruenenthal Gmbh | Hot-melt extruded pharmaceutical dosage form |
US9925146B2 (en) | 2009-07-22 | 2018-03-27 | Grünenthal GmbH | Oxidation-stabilized tamper-resistant dosage form |
US10493033B2 (en) | 2009-07-22 | 2019-12-03 | Grünenthal GmbH | Oxidation-stabilized tamper-resistant dosage form |
US10300141B2 (en) | 2010-09-02 | 2019-05-28 | Grünenthal GmbH | Tamper resistant dosage form comprising inorganic salt |
US9636303B2 (en) | 2010-09-02 | 2017-05-02 | Gruenenthal Gmbh | Tamper resistant dosage form comprising an anionic polymer |
US10864164B2 (en) | 2011-07-29 | 2020-12-15 | Grünenthal GmbH | Tamper-resistant tablet providing immediate drug release |
US10201502B2 (en) | 2011-07-29 | 2019-02-12 | Gruenenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
US10695297B2 (en) | 2011-07-29 | 2020-06-30 | Grünenthal GmbH | Tamper-resistant tablet providing immediate drug release |
JP2015500264A (ja) * | 2011-12-06 | 2015-01-05 | エティファルムEthypharm | 注射による誤用に対処可能な錠剤 |
US9655853B2 (en) | 2012-02-28 | 2017-05-23 | Grünenthal GmbH | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
US10335373B2 (en) | 2012-04-18 | 2019-07-02 | Grunenthal Gmbh | Tamper resistant and dose-dumping resistant pharmaceutical dosage form |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
US9737490B2 (en) | 2013-05-29 | 2017-08-22 | Grünenthal GmbH | Tamper resistant dosage form with bimodal release profile |
US10154966B2 (en) | 2013-05-29 | 2018-12-18 | Grünenthal GmbH | Tamper-resistant dosage form containing one or more particles |
US10624862B2 (en) | 2013-07-12 | 2020-04-21 | Grünenthal GmbH | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
US10449547B2 (en) | 2013-11-26 | 2019-10-22 | Grünenthal GmbH | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
US9913814B2 (en) | 2014-05-12 | 2018-03-13 | Grünenthal GmbH | Tamper resistant immediate release capsule formulation comprising tapentadol |
US9872835B2 (en) | 2014-05-26 | 2018-01-23 | Grünenthal GmbH | Multiparticles safeguarded against ethanolic dose-dumping |
US9855263B2 (en) | 2015-04-24 | 2018-01-02 | Grünenthal GmbH | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
US10842750B2 (en) | 2015-09-10 | 2020-11-24 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
JP2020090464A (ja) * | 2018-12-06 | 2020-06-11 | 日本ケミファ株式会社 | ゾピクロン、その光学異性体又はこれらの塩の何れかを有効成分として含有する錠剤 |
Also Published As
Publication number | Publication date |
---|---|
DK0742711T3 (da) | 1999-10-11 |
FI963025A0 (fi) | 1996-07-31 |
EP0742711B1 (en) | 1999-03-17 |
HU223144B1 (hu) | 2004-03-29 |
US6309668B1 (en) | 2001-10-30 |
PL178572B1 (pl) | 2000-05-31 |
ZA95800B (en) | 1996-08-01 |
GB9401894D0 (en) | 1994-03-30 |
CA2182508C (en) | 2005-08-09 |
EP0742711A1 (en) | 1996-11-20 |
IL112501A (en) | 2000-08-13 |
WO1995020947A1 (en) | 1995-08-10 |
GR3029734T3 (en) | 1999-06-30 |
NO963202L (no) | 1996-09-30 |
PL315709A1 (en) | 1996-11-25 |
ATE177630T1 (de) | 1999-04-15 |
DE69508385T2 (de) | 1999-08-26 |
NO963202D0 (no) | 1996-07-31 |
AU696005B2 (en) | 1998-08-27 |
NZ278643A (en) | 1997-12-19 |
HUT74903A (en) | 1997-03-28 |
CZ226096A3 (en) | 1997-01-15 |
IL112501A0 (en) | 1995-03-30 |
ES2132626T3 (es) | 1999-08-16 |
HU9602103D0 (en) | 1996-09-30 |
FI963025A (fi) | 1996-07-31 |
DE69508385D1 (de) | 1999-04-22 |
AU1461695A (en) | 1995-08-21 |
CZ291980B6 (cs) | 2003-06-18 |
NO313267B1 (no) | 2002-09-09 |
CA2182508A1 (en) | 1995-08-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPH09508410A (ja) | 乱用防止錠剤 | |
JP5730572B2 (ja) | 濫用抵抗性製剤 | |
US8927014B2 (en) | Misuse preventative, controlled release formulation | |
JP5828737B2 (ja) | 医薬製品 | |
CN105534936B (zh) | 抗滥用药物、使用方法和制备方法 | |
JP3015105B2 (ja) | 粉末被覆経口投与剤形 | |
AU741361B2 (en) | Modified release matrix formulation of cefaclor and cephalexin | |
JPH09502738A (ja) | 制御放出のための新規ビーズおよびそれらを含有する医薬製剤 | |
KR20100121463A (ko) | 오용 예방적 방출 제어형 제제 | |
UA79069C2 (en) | Peroral composition preventing from abuse of opioid agonists contained therein | |
CA2888278A1 (en) | Oral drug delivery formulations | |
CN101686930A (zh) | 新颖的药物组合物 | |
JP2011513391A (ja) | ミコフェノラートを含有する徐放性医薬組成物およびその方法 | |
CN108201534A (zh) | 一种瑞卡帕布口服缓控释药物组合物及其用途 | |
KR20100063059A (ko) | 마이폴틱 장용정을 함유하는 서방출형 조성물 및 이의 조제방법 | |
US4851233A (en) | Sustained release formulations | |
US20010001658A1 (en) | Granule modulating hydrogel system | |
WO2003074033A1 (en) | Sustained/controlled release solid formulation as a novel drug delivery system with reduced risk of dose dumping | |
CN108201535A (zh) | 一种维利帕尼缓控释药物组合物及其用途 | |
JPH0625055B2 (ja) | 持続性錠剤 | |
JP2007523140A (ja) | 圧縮コーティング錠剤とその製造 | |
JP4400941B2 (ja) | 漢方含有錠剤および漢方充填カプセル剤および生薬含有錠剤および生薬充填カプセル剤および漢方含有錠剤の製造方法および漢方充填カプセル剤の製造方法および生薬含有錠剤の製造方法および生薬充填カプセル剤の製造方法 | |
JPH02282323A (ja) | 徐放性錠剤の製造方法 | |
WO2004024138A1 (ja) | ジオクチルソジウムスルホサクシネート配合固形製剤 | |
Sanghi et al. | FORMULATION AND EVALUTATION OF DUAL RELEASE MULTIPLE UNIT TABLET FORMULATION |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20041207 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20050307 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20050418 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20050607 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20070313 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20070613 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20070730 |
|
A313 | Final decision of rejection without a dissenting response from the applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A313 Effective date: 20071024 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20071211 |