JPH09221429A - Melanogenesis suppressing agent - Google Patents
Melanogenesis suppressing agentInfo
- Publication number
- JPH09221429A JPH09221429A JP8026709A JP2670996A JPH09221429A JP H09221429 A JPH09221429 A JP H09221429A JP 8026709 A JP8026709 A JP 8026709A JP 2670996 A JP2670996 A JP 2670996A JP H09221429 A JPH09221429 A JP H09221429A
- Authority
- JP
- Japan
- Prior art keywords
- extract
- agent
- melanin
- camocamo
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、しみ、そばかすな
どの色素沈着症の原因となるメラニン抑制剤に関し、さ
らに詳しくはカモカモの抽出物を有効成分として含有す
るメラニン抑制剤に係るものである。TECHNICAL FIELD The present invention relates to a melanin inhibitor that causes pigmentation such as spots and freckles, and more particularly to a melanin inhibitor containing an extract of a duck as an active ingredient.
【０００２】[0002]
【従来の技術】しみ、そばかす、肝斑および日焼け後の
色素沈着は、加齢に伴い発生、増加あるいは消失しにく
くなり、中高年齢層の肌の悩みのひとつとなっている。
これらの色素沈着症の発症メカニズムは、いまだ明確に
はされていないが、紫外線、メラノサイト刺激ホルモン
（ＭＳＨ）などの作用によりメラノサイトのメラニン合
成機能が亢進したためと考えられている。また、表皮角
化細胞（ケラチノサイト）の加齢に伴う角化遅延傾向
も、メラニンの表皮外への***速度を遅延させ、メラニ
ン合成機能の亢進と合わせて、表皮内のメラニン顆粒密
度の増加によるものと考えられている。さらにそれらの
色素沈着部は局部的に存在し、周囲の正常皮膚色と明ら
かな差異が生じることから、局部的なメラニン合成機能
の亢進、あるいはメラニン合成をコントロ−ルする機構
の変調の結果とも考えられている。従来から、これらの
後天的な色素、すなわちメラニンの沈着部を正常な皮膚
色にまで回復させる研究が行われ、これまでに数多くの
提案が報告されている。2. Description of the Related Art Stain, freckles, melasma and pigmentation after sunburn are less likely to occur, increase or disappear with age, which is one of the troubles of the skin in the middle and old age groups.
Although the mechanism of the onset of these pigmentation diseases has not been clarified yet, it is considered that the melanin synthetic function of melanocytes is enhanced by the action of ultraviolet rays, melanocyte stimulating hormone (MSH) and the like. In addition, the tendency of keratinocytes to delay keratinization with aging also delays the excretion rate of melanin to the outside of the epidermis, and increases the melanin granule density in the epidermis along with the increase in melanin synthesis function. Is believed to be. Furthermore, since these pigmented parts are locally present and have a clear difference from the surrounding normal skin color, it is also a result of the local enhancement of the melanin synthesis function or the modulation of the mechanism controlling melanin synthesis. It is considered. Conventionally, studies have been conducted to restore the deposits of these acquired pigments, that is, melanin, to a normal skin color, and many proposals have been reported so far.
【０００３】例えば、アシタバの茎、葉または根の熱水
またはエタノール抽出物を化粧料基剤に配合してなる、
メラニン抑制作用を有する色白化粧料（特開昭６０−２
０９５０９号公報参照）、オグルマ及び／又はその同属
植物の抽出物を含有してなる、皮膚の炎症を防止、緩和
すると共に、日焼けによる皮膚の黒色化、シミ、ソバカ
スの防止及び改善効果をも有する皮膚外用剤（特開昭６
３−３０３９１９号公報参照）、また霊芝の子実体から
の抽出成分を配合した化粧料であって、メラニン生成抑
制作用、メラニン淡色化作用を有する製剤（特開平２−
１２４８０９号公報参照）等が提案されている。For example, hot water or ethanol extract of acacia stem, leaf or root is blended with a cosmetic base.
Fair-white cosmetics having melanin-suppressing action (JP-A-60-2
(See Japanese Patent Publication No. 09509), which has an effect of preventing and alleviating skin inflammation, which contains an extract of Oguruma and / or its homologous plant, and also has an effect of preventing and improving skin blackening, stains and freckles due to sunburn. Topical skin preparation
(See JP-A-3-303919), and a cosmetic having a component extracted from the fruiting body of Ganoderma lucidum, which has a melanin production suppressing action and a melanin lightening action (JP-A-2-
Japanese Patent No. 124809) is proposed.
【０００４】[0004]
【発明が解決しようとする課題】しかしながら、これら
のメラニン抑制剤の抑制効果は、必ずしも満足できるも
のではなく、更に優れた効果を有するメラニン抑制剤の
開発が強く求められている。However, the inhibitory effects of these melanin inhibitors are not always satisfactory, and there is a strong demand for the development of melanin inhibitors having even more excellent effects.
【０００５】[0005]
【課題を解決するための手段】そこで本発明者らは上記
課題を解決するため、安全性、安定性が高く、メラニン
抑制効果に優れた機能を有するメラニン抑制物質、得に
該機能を有する種々の植物の抽出物について鋭意研究の
結果、カモカモ（ＭＹＲＣＩＡＲＩＡ ＤＵＢＩＡ）の
抽出物が、メラニンの生成を抑制する機能を保有するこ
と、美白作用、さらには保湿作用、皮膚の老化防止にも
有効であることを見いだし、本発明に至った。In order to solve the above-mentioned problems, the present inventors have proposed a melanin-inhibiting substance having a high safety and stability and an excellent melanin-inhibiting effect, and particularly various melanin-inhibiting substances having the function. As a result of diligent research on the plant extract, the extract of duck (MYRCIARIA DUBIA) has the function of suppressing the production of melanin, is effective for whitening, moisturizing, and preventing skin aging. After finding out the above, the present invention was achieved.
【０００６】カモカモはフトモモ科に属する食用植物で
あって、ペルー東部からブラジル西北部のアマゾン盆地
の河岸又は流水のある湖沼の岸に生える潅木で、その果
実のビタミンＣ含有量はレモンの約１００倍に達すると
言われ、又、ミネラルの含有量も高く、その他有効成分
が多く含まれていることが知られている。現地ではその
果実をそのまま食用に、または果汁を絞ってジュースな
どとして飲用に供されている。カモカモは、上述のよう
にフトモモ科の果実であり、本発明においては、生、半
乾燥、乾燥品のいずれでも使用でき、これらの原料は粉
砕して用いるのが好適である。Duck ducks are edible plants belonging to the family Myrtaceae, and are shrubs that grow on the banks of the Amazon basin in the eastern part of Peru to the northwestern part of Brazil or on the banks of lakes with flowing water. The vitamin C content of fruits is about 100 of lemon. It is said that the amount is twice as high, the content of minerals is high, and it is known that a large amount of other active ingredients are contained. At the site, the fruits are used as they are or as juices after squeezing the juice. As described above, the duck is a fruit of the Myrtaceae family, and in the present invention, any of raw, semi-dried and dried products can be used, and it is preferable to use these raw materials after crushing.
【０００７】すなわち、本発明は、カモカモの抽出物を
有効成分として含有するメラニン抑制剤を要旨とするも
のである。[0007] That is, the gist of the present invention is a melanin inhibitor containing a duck-duck extract as an active ingredient.
【０００８】[0008]
【発明の実施の形態】本発明のカモカモエキスは、水、
親水性有機溶媒またはこれらの混合物で抽出処理するこ
とにより容易に得ることができる。かかる抽出処理に用
いる親水性有機溶媒としては、例えば、メタノール、エ
タノール、ｎ−プロピルアルコール、アセトン、プロピ
レングリコール、グリセリンなどの溶媒を挙げることが
できる。これらの溶媒は、例えば水と任意の割合で混合
した含水溶剤の形で用いることもできるが、約１０〜約
９９．９％の含水溶媒で抽出を行うのが好ましい。BEST MODE FOR CARRYING OUT THE INVENTION
It can be easily obtained by extraction treatment with a hydrophilic organic solvent or a mixture thereof. Examples of the hydrophilic organic solvent used for such extraction treatment include solvents such as methanol, ethanol, n-propyl alcohol, acetone, propylene glycol, and glycerin. These solvents can be used, for example, in the form of a water-containing solvent mixed with water at an arbitrary ratio, but it is preferable to perform extraction with a water-containing solvent of about 10 to about 99.9%.
【０００９】抽出操作および抽出条件は用いる抽出溶剤
の種類に応じて、種々変更することができるが、抽出溶
剤として前記の如き親水性有機溶媒またはそれと水との
混合液を用いて抽出を行う場合には、例えば、カモカモ
に約１．５倍〜約５０倍量の溶媒を加え、室温ないし使
用溶媒の沸点温度で、約５分ないし約２４時間、静置も
しくは撹拌して行うことができる。このようにして抽出
操作を行った後、例えば遠心分離、ろ過、圧搾その他の
固液分離手段によって不溶性残渣を除去することによ
り、カモカモエキスを得ることができる。さらに必要な
らば、不溶性抽出残渣に抽出溶剤を加えて、同様の操作
をくり返し、抽出することもできる。また更に、該抽出
操作の際に、ペクチナーゼなどの酵素を添加して、酵素
処理を行うことにより、抽出効率を上げることができ
る。The extraction operation and the extraction conditions can be variously changed according to the kind of the extraction solvent to be used. When the extraction is carried out using the hydrophilic organic solvent as described above or a mixed solution of the same with water as the extraction solvent. For example, about 1.5 to about 50 times the amount of the solvent is added to the duck and the reaction can be performed by standing or stirring at room temperature to the boiling point of the solvent used for about 5 minutes to about 24 hours. After performing the extraction operation in this way, the insoluble residue can be obtained by removing the insoluble residue by, for example, solid-liquid separation means such as centrifugation, filtration, compression or the like. If necessary, an extraction solvent may be added to the insoluble extraction residue and the same operation may be repeated to perform extraction. Furthermore, extraction efficiency can be increased by adding an enzyme such as pectinase and performing an enzyme treatment during the extraction operation.
【００１０】本発明においては、カモカモから上記のご
とき方法で得られる抽出液をそのまま本発明の抽出物と
して使用してもよく、或いは該抽出液から溶剤を除去す
ることにより得られる濃縮物、さらには、それを減圧乾
燥または凍結乾燥して得られる乾燥物を本発明の抽出物
として利用することもできる。In the present invention, the extract obtained from duck with the above method may be used as it is as the extract of the present invention, or a concentrate obtained by removing a solvent from the extract, The dried product obtained by drying it under reduced pressure or freeze-drying can also be used as the extract of the present invention.
【００１１】さらに、上記のような方法によって得られ
る抽出物を、シリカゲル、活性炭、活性アルミナ、ベン
トナイト、酸性白土、珪藻土などの吸着剤により、脱
色、脱臭を行ってもよい。吸着操作は、抽出物をそのま
まあるいは濃縮した濃縮物を水など適当な溶媒に溶解し
た溶液に、適当量の吸着剤を添加することにより行うこ
とができる。吸着処理液は、そのまま或いは減圧下に濃
縮して得られる濃縮液、さらにそれを、例えば減圧乾燥
または凍結乾燥して得られる乾燥物を抽出物として利用
することもできる。Further, the extract obtained by the above method may be decolorized and deodorized with an adsorbent such as silica gel, activated carbon, activated alumina, bentonite, acid clay and diatomaceous earth. The adsorption operation can be carried out by adding an appropriate amount of an adsorbent to a solution obtained by dissolving the extract as it is or concentrating the concentrate in a suitable solvent such as water. As the adsorption treatment liquid, a concentrated liquid obtained by concentrating as it is or under reduced pressure, and a dried product obtained by further drying it, for example, under reduced pressure or freeze-drying can also be used as an extract.
【００１２】さらにまた、上記の脱色、脱臭処理前また
は処理後の抽出物を、例えば適当量の水に溶解して、ス
チレンビニルベンゼン、メタクリル酸エステルなどの樹
脂よりなる合成吸着剤を用いて有効成分を吸着処理し、
次いで例えば、エタノール、メタノール、アセトン、酢
酸エチルのごとき親水性有機溶媒あるいはこれらと水と
の混合溶媒で脱着操作を行って精製し、カモカモの抽出
物中の有効成分を濃縮して、本発明の抽出物として利用
することもできる。吸着、脱着操作は、バッチ方式また
はカラムによる連続方式で行うことができ、好ましくは
カラムによる連続方式が採用される。この操作後の脱着
液は、そのまま本発明の抽出物として利用することがで
きるが、また減圧下に濃縮して得られる濃縮液、更にこ
れを、例えば減圧乾燥または凍結乾燥して得られる乾燥
物を本発明の抽出物として利用することもできる。Furthermore, the extract before or after the decolorization or deodorization treatment is dissolved in, for example, an appropriate amount of water, and it is effective by using a synthetic adsorbent made of a resin such as styrene vinylbenzene or methacrylic acid ester. Adsorption treatment of components,
Then, for example, desorption is performed with a hydrophilic organic solvent such as ethanol, methanol, acetone, or ethyl acetate or a mixed solvent of these and water to purify, and the active ingredient in the extract of the duck is concentrated to obtain the present invention. It can also be used as an extract. The adsorption and desorption operations can be performed by a batch system or a continuous system using a column, and preferably a continuous system using a column is adopted. The desorption solution after this operation can be used as it is as the extract of the present invention, but it is also a concentrated solution obtained by concentrating under reduced pressure, and a dried product obtained by subjecting this to a reduced pressure drying or freeze drying. Can also be used as the extract of the present invention.
【００１３】以上述べたようにして調製されるカモカモ
の抽出物は、優れたメラニン抑制能を有する。本発明の
メラニン抑制剤は、その他の任意成分を加えて種々の形
態にすることができるが、一般的には例えば、ロ−ショ
ン、乳液状、クリ−ム状、軟膏状、スティック状、有機
溶剤による溶液状、パック状、ゲル状等とすることが好
ましい。また、該カモカモ抽出物以外に配合することの
できるその他の任意成分としては、化粧品に通常配合し
て使用されている成分、例えば、精製水、エタノール、
油性物質、保湿剤、美白剤、増粘剤、防腐剤、乳化剤、
薬効成分、粉体、紫外線吸収剤、色素、香料、乳化安定
剤、ｐＨ調整剤等を挙げることができる。上記の保湿剤
としては、例えば、γ−リノレイン酸、スフィンゴ脂
質、キサンタンガム、ヒアルロン酸、牛骨髄抽出物、水
溶性コラーゲン、キチン、キトサン、ムチン、乳酸菌培
養液、ビフィズス菌代謝物、酵母発酵代謝物、酵母抽出
物、ピロリドンカルボン酸、プルラン、マルトース、ヘ
チマエキス；美白剤としては、例えば、プラセンターエ
キス、コウジ酸、桑白皮、当帰抽出物、ワレモコウ、イ
ブキトラノオ、ビタミンＣおよびその誘導体などと本発
明のカモカモ抽出物を併用すれば、美白作用、保湿作
用、皮膚の老化防止の効果を増強することができる。こ
のようにして得られる本発明のメラニン抑制剤は、皮膚
のしみ、そばかす、日焼け後の色素沈着部などの患部に
局所的に適用される。また一般にその使用量は、特に限
定されないが、通常クリーム状、軟膏状製剤の場合は皮
膚面１ｃｍ2当たり約０. ５〜１０ｍｇ、液状製剤の場
合は約１〜１５ｍｇ程度の範囲で使用される。The duckweed extract prepared as described above has an excellent ability to suppress melanin. The melanin inhibitor of the present invention can be made into various forms by adding other optional components, but generally, for example, lotion, emulsion, cream, ointment, stick, organic It is preferable to prepare a solution form, a pack form, a gel form, etc. by a solvent. In addition, as other optional components that can be blended in addition to the duck duck extract, components that are commonly used in cosmetics, for example, purified water, ethanol,
Oily substances, moisturizers, whitening agents, thickeners, preservatives, emulsifiers,
Examples include medicinal components, powders, ultraviolet absorbers, dyes, fragrances, emulsion stabilizers, pH adjusters and the like. Examples of the moisturizers include γ-linolenic acid, sphingolipid, xanthan gum, hyaluronic acid, bovine bone marrow extract, water-soluble collagen, chitin, chitosan, mucin, lactic acid bacterium culture solution, bifidobacterial metabolites, yeast fermentation metabolites. , Yeast extract, pyrrolidonecarboxylic acid, pullulan, maltose, loofah extract; whitening agents include, for example, placenta extract, kojic acid, mulberry bark, toki extract, waremoko, ibukitoranoo, vitamin C and its derivatives, etc. When used together with the duckweed extract of the present invention, the effects of whitening, moisturizing, and preventing skin aging can be enhanced. The melanin inhibitor of the present invention thus obtained is topically applied to affected areas such as skin spots, freckles, and pigmented areas after sunburn. In general, the amount used is not particularly limited, but is usually in the range of about 0.5 to 10 mg per 1 cm 2 of skin surface in the case of creamy or ointment type preparations, and about 1 to 15 mg in the case of liquid preparations. .
【００１４】[0014]
【実施例】以下、実施例により、本発明の実施の態様に
ついて更に詳細に説明する。 実施例 （カモカモ抽出物試料の調製）カモカモ粉砕物５０ｇ
に、５０％エタノール水溶液４００ｇを添加し、時々撹
拌しながら３日間抽出処理を行い、遠心分離、濾過処理
して濾液３５０ｇを得た。この濾液を減圧下に濃縮乾固
して乾燥抽出物４５ｇを得た。この抽出物について、メ
ラニン生成を抑制する能力即ち、チロシナーゼ活性阻害
能を測定する。 （チロシナーゼ活性阻害能の測定）上記の抽出物試料
０. ４ｍｇに酵素溶液（和光純薬工業社製 25,000unit
のチロシナーゼを 0.1Ｍリン酸緩衝液(pH7.0)20 ミリリ
ットルに溶解したもの）０.１ミリリットルを加え、さ
らに 0.1Ｍリン酸緩衝液(pH7.0）を加え４ミリリットル
とし、これを２５℃で１０分間インキュベートした。こ
れに予め２５℃に保っておいた基質溶液［L-DOPA( 東京
化成社製)198.0ｍｇを 0.1Ｍリン酸緩衝液(pH7.0)100ミ
リリットルに溶解したもの］１. ０ミリリットルを加え
１０分間反応せしめた。次いで、475 ｎｍにおける吸光
度を測定しこれをＯＤC 、さらに加熱失活させた前記酵
素を用いて同様に反応させたものの吸光度ＯＤD 、試料
の代わりに水を加えた時の吸光度をＯＤA 、試料の代わ
りに水を加え、かつ失活酵素を用いた時の吸光度をＯＤ
B として、これらを測定し、次の数式によるチロシナー
ゼ活性阻害率を求めた。 チロシナーゼ活性阻害率（％）＝［｛ODA-ODB-(ODC-O
DD) ｝／（ODA-ODB ）］× 100＝８２. ６（％） ただし、ODA ：（水＋酵素＋基質）の吸光度 ODB ：（水＋失活酵素＋基質）の吸光度 ODC ：（試料＋酵素＋基質）の吸光度 ODD ：（試料＋失活酵素＋基質）の吸光度 この結果からカモカモの抽出物は、優れたメラニン生成
抑制機能を有することがわかる。EXAMPLES Hereinafter, the embodiments of the present invention will be described in more detail with reference to examples. Example (Preparation of Duck Duck Extract Sample) Duck Duck 50g
Then, 400 g of 50% ethanol aqueous solution was added thereto, extraction treatment was carried out for 3 days with occasional stirring, and centrifugation and filtration treatment were carried out to obtain 350 g of a filtrate. The filtrate was concentrated to dryness under reduced pressure to obtain 45 g of a dry extract. The ability of the extract to suppress melanin production, that is, the ability to inhibit tyrosinase activity is measured. (Measurement of tyrosinase activity inhibition ability) 0.4 mg of the above extract sample was used as an enzyme solution (25,000 unit manufactured by Wako Pure Chemical Industries, Ltd.).
0.1 ml of 0.1 M phosphate buffer (pH 7.0) in 20 ml) was added, and 0.1 M phosphate buffer (pH 7.0) was added to make 4 ml. And incubated for 10 minutes. To this, 1.0 ml of a substrate solution [198.0 mg of L-DOPA (manufactured by Tokyo Chemical Industry Co., Ltd.) dissolved in 100 ml of 0.1 M phosphate buffer (pH 7.0)] preliminarily kept at 25 ° C. was added 10 Reacted for a minute. Then, the absorbance at 475 nm was measured, and the absorbance was measured at OD C , the absorbance OD D of the same reaction using the enzyme deactivated by heating, and the absorbance at the time when water was added instead of the sample was OD A , Water was added instead of the sample, and the absorbance when the deactivating enzyme was used was OD
These were measured as B and the tyrosinase activity inhibition rate was calculated by the following formula. Tyrosinase activity inhibition rate (%) = [{OD A -OD B- (OD C -O
D D )} / (OD A -OD B )] × 100 = 82.6 (%) where, OD A : Absorbance of (water + enzyme + substrate) OD B : Absorbance of (water + deactivating enzyme + substrate) OD C : (Sample + Enzyme + Substrate) Absorbance OD D : (Sample + Inactivating Enzyme + Substrate) Absorbance From these results, it is understood that the duck extract has an excellent melanin production suppressing function.
【００１５】[0015]
【発明の効果】本発明によれば、メラニン生成を効果的
に抑制する優れたチロシナーゼ活性阻害能を有するメラ
ニン抑制剤を提供することができる。INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide a melanin inhibitor having an excellent ability to inhibit tyrosinase activity, which effectively inhibits melanin production.
Claims (1)
するメラニン抑制剤。1. A melanin inhibitor containing an extract of duck as an active ingredient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP02670996A JP3431383B2 (en) | 1996-02-14 | 1996-02-14 | Melanin inhibitor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP02670996A JP3431383B2 (en) | 1996-02-14 | 1996-02-14 | Melanin inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH09221429A true JPH09221429A (en) | 1997-08-26 |
| JP3431383B2 JP3431383B2 (en) | 2003-07-28 |
Family
ID=12200909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP02670996A Expired - Lifetime JP3431383B2 (en) | 1996-02-14 | 1996-02-14 | Melanin inhibitor |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3431383B2 (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11246336A (en) * | 1998-02-27 | 1999-09-14 | Ichimaru Pharcos Co Ltd | Activated oxygen scavenger and skin beautifying cosmetic composition |
| JP2001031580A (en) * | 1999-05-19 | 2001-02-06 | Kose Corp | Preparation for external use for skin |
| JP2001031558A (en) * | 1999-05-19 | 2001-02-06 | Kose Corp | Skin lotion |
| WO2004054520A1 (en) * | 2002-12-13 | 2004-07-01 | Nichirei Biosciences Inc. | Whitening agent, skin preparation for external use and cosmetic |
| WO2013029634A2 (en) | 2011-09-03 | 2013-03-07 | Pharmabrand S.A. | Natural antioxidant anti-influenza composition |
| JP2016041668A (en) * | 2014-08-19 | 2016-03-31 | 株式会社山田養蜂場本社 | Skin whitening composition |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070166275A1 (en) | 2006-01-19 | 2007-07-19 | Mary Kay Inc. | Compositions comprising kakadu plum extract or acai berry extract |
| KR101772139B1 (en) | 2009-08-28 | 2017-08-28 | 마리 케이 인코포레이티드 | Skin care formulations |
| FR3077204B1 (en) | 2018-01-30 | 2021-09-17 | Isp Investments Llc | MYRCIARIA DUBIA FRUIT EXTRACTS RICH IN ORGANIC ACIDS, COSMETIC COMPOSITIONS CONTAINING IT AND THEIR COSMETIC USES |
-
1996
- 1996-02-14 JP JP02670996A patent/JP3431383B2/en not_active Expired - Lifetime
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11246336A (en) * | 1998-02-27 | 1999-09-14 | Ichimaru Pharcos Co Ltd | Activated oxygen scavenger and skin beautifying cosmetic composition |
| JP2001031580A (en) * | 1999-05-19 | 2001-02-06 | Kose Corp | Preparation for external use for skin |
| JP2001031558A (en) * | 1999-05-19 | 2001-02-06 | Kose Corp | Skin lotion |
| WO2004054520A1 (en) * | 2002-12-13 | 2004-07-01 | Nichirei Biosciences Inc. | Whitening agent, skin preparation for external use and cosmetic |
| US7192617B2 (en) | 2002-12-13 | 2007-03-20 | Nichirei Biosciences Inc. | Whitening agent, skin preparation for external use and cosmetic |
| CN100415206C (en) * | 2002-12-13 | 2008-09-03 | 株式会社日冷生物科学 | Whitening agent, skin preparation for external use and cosmetic |
| WO2013029634A2 (en) | 2011-09-03 | 2013-03-07 | Pharmabrand S.A. | Natural antioxidant anti-influenza composition |
| JP2016041668A (en) * | 2014-08-19 | 2016-03-31 | 株式会社山田養蜂場本社 | Skin whitening composition |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3431383B2 (en) | 2003-07-28 |
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