JPH09132775A - Stabilizing agent for oily physiologically active substance - Google Patents
Stabilizing agent for oily physiologically active substanceInfo
- Publication number
- JPH09132775A JPH09132775A JP8016409A JP1640996A JPH09132775A JP H09132775 A JPH09132775 A JP H09132775A JP 8016409 A JP8016409 A JP 8016409A JP 1640996 A JP1640996 A JP 1640996A JP H09132775 A JPH09132775 A JP H09132775A
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- Prior art keywords
- physiologically active
- active substance
- oily
- preparation
- component
- Prior art date
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- Meat, Egg Or Seafood Products (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Edible Oils And Fats (AREA)
- Jellies, Jams, And Syrups (AREA)
- General Preparation And Processing Of Foods (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Fats And Perfumes (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】この発明は油状生理活性物質
の安定化剤、それを含有する製剤に関するものである。TECHNICAL FIELD The present invention relates to a stabilizer for an oily physiologically active substance, and a preparation containing the same.
【０００２】[0002]
【従来の技術】および2. Description of the Related Art
【発明が解決しようとする課題】従来油状の生理活性物
質（例えばＤＨＡ等）は取扱いにくく、服用を助ける方
法としてカプセルに封入するか、他の粉体に吸着させた
後コーテイングを施すなどの方法が行われていたが、こ
れらは安定性が不十分であったり、加工後の顆粒、錠剤
などが大きく、一般食品への添加には全く不適当である
場合が多かった。この問題を解決すべくミルクカルシウ
ムを主体としたカルシウム殻形成法が開発されたが（Ｎ
ｅｗ Ｆｏｏｄ Ｉｎｄｕｓｔｒｙ １９９４，ｖｏ
ｌ．３６，Ｎｏ．９，３８−４２）、この方法で得られ
た製剤でも、これを例えばドリンク剤に添加使用する場
合には不安定で臭い等が出てくるという問題点があり、
解決されるべき課題である。Conventionally, oily physiologically active substances (such as DHA) are difficult to handle, and as a method for assisting the administration, they are encapsulated or coated with other powders after being adsorbed. However, they were often unsuitable for addition to general foods because of insufficient stability and large granules and tablets after processing. In order to solve this problem, a calcium shell forming method mainly composed of milk calcium was developed (N
ew Food Industry 1994, vo
l. 36, no. 9, 38-42), even the preparation obtained by this method has a problem that when it is added to, for example, a drink, it is unstable and gives off an odor.
It is a problem to be solved.
【０００３】[0003]
【課題を解決するための手段】この発明者等は、上記課
題解決のため、鋭意研究の結果、グルコン酸カルシウム
が油状生理活性物質の安定化剤として極めて優れている
という新知見を得、さらにこのグルコン酸カルシウムと
網状マトリックス形成剤および（または）固着剤とを併
用すると、前記問題点を有しない極めて安定な製剤を得
ることができることを見出した。Means for Solving the Problems The inventors of the present invention, as a result of earnest research for solving the above-mentioned problems, have obtained a new finding that calcium gluconate is extremely excellent as a stabilizer for oily physiologically active substances, and It has been found that when this calcium gluconate is used in combination with a reticulated matrix forming agent and / or a sticking agent, an extremely stable preparation free from the above problems can be obtained.
【０００４】即ちグルコン酸カルシウムは比較的水溶性
の高いカルシウム剤で、水１リットル中に１００ｇを投
入した場合、３０ｇ程度は溶解し、７０ｇ位は懸濁して
いる。この液に油状生理活性物質を加えて撹拌、乳化す
ると、水に溶けてないカルシウムは油滴の表面に吸着
し、殻を形成する。溶けているグルコン酸カルシウムは
殻形成粒子の間隙に入り込み穴をうめる。このような状
態の混合液を速やかに乾燥すると、油状生理活性物質が
完全にマスクされた粉体が出来るという新知見を得た。That is, calcium gluconate is a relatively highly water-soluble calcium agent, and when 100 g is added to 1 liter of water, about 30 g is dissolved and about 70 g is suspended. When an oily physiologically active substance is added to this liquid and stirred and emulsified, calcium that is not dissolved in water is adsorbed on the surface of oil droplets to form a shell. The dissolved calcium gluconate enters the interstices of the shell-forming particles and fills the holes. We have obtained a new finding that a powder in which an oily physiologically active substance is completely masked can be obtained by rapidly drying the mixed liquid in such a state.
【０００５】そしてさらに上記グルコン酸カルシウムに
加えて、網状マトリックス形成剤および（または）固着
剤を併用すると製剤の安定性がさらに向上し、このよう
にして得られた製剤をドリンク剤等に添加しても臭いの
ない安定な製剤が得られることを見出した。Furthermore, in addition to the above-mentioned calcium gluconate, when a reticulated matrix forming agent and / or a sticking agent are used in combination, the stability of the preparation is further improved, and the preparation thus obtained is added to a drink preparation or the like. However, it was found that a stable formulation having no odor can be obtained.
【０００６】この発明で使用、適用される油状生理活性
物質としては、油状の生理活性物質であって、特有の異
味、異臭を有し、また酵素、酸素、光、熱等に不安定な
物質がとくに好ましい例として挙げられ、そのような具
体例として、ＤＨＡ（ドコサヘキサエン酸）、ＥＰＡ
（エイコサペンタエン酸）等の高度不飽和脂肪酸、ビタ
ミンＤ、ビタミンＥおよびビタミンＫ等の脂溶性ビタミ
ン、β−カロチンのようなカロチン類等が挙げられる。
ここで、ＤＨＡ、ＥＰＡ等は魚油中に多く含まれ、通常
トリグリセライドとして存在するが、この発明でＤＨ
Ａ、ＥＰＡという場合、ＤＨＡ、ＥＰＡそのものおよび
ＤＨＡ、ＥＰＡそれぞれのグリセリンエステル（例えば
トリグリセライド）、エチルエステル等のエステル等を
含むものとする。また、ＤＨＡやＥＰＡはこれらを２０
〜１００％含有の精製魚油が市販されており、これらを
使用することができる。The oily physiologically active substance used and applied in the present invention is an oily physiologically active substance, which has a peculiar taste and smell and is unstable to enzymes, oxygen, light, heat and the like. Are mentioned as particularly preferable examples, and specific examples thereof include DHA (docosahexaenoic acid) and EPA.
Polyunsaturated fatty acids such as (eicosapentaenoic acid), fat-soluble vitamins such as vitamin D, vitamin E and vitamin K, and carotene such as β-carotene.
Here, DHA, EPA and the like are contained in fish oil in a large amount and usually exist as triglycerides.
References to A and EPA include DHA, EPA itself and glycerol esters (eg, triglyceride) of DHA and EPA, and esters such as ethyl ester. In addition, DHA and EPA have these 20
Purified fish oil containing ~ 100% is commercially available, and these can be used.
【０００７】この発明で使用する網状マトリックス形成
剤としては、ミルクカルシウム、ミルクカゼインまたは
その水解物［例えば、カゼインに蛋白分解酵素（例えば
トリプシン）を作用させて得られる部分分解物であるカ
ゼインホスホペプチド（ＣＰＰ）（ＣＰＰ−Ｉ、ＣＰＰ
−ＩＩ、ＣＰＰ−ＩＩＩ等）（Ｎｅｗ Ｆｏｏｄ Ｉｎ
ｄｕｓｔｒｙ Ｖｏｌ．３５ Ｎｏ．９（１９９３），
Ｐ．１−８）等］、ペクチンのような多糖類等が挙げら
れ、これらのうち、ミルクカルシウム、ＣＰＰは網状マ
トリックス形成能を有するとともに、後述の固着剤とし
ての機能を有するので、これらは網状マトリックス形成
剤および固着剤として兼用できる。As the reticulated matrix forming agent used in the present invention, milk calcium, milk casein or a hydrolyzate thereof [eg, casein phosphopeptide, which is a partial hydrolyzate obtained by allowing a protease to act on casein (eg trypsin)] (CPP) (CPP-I, CPP
-II, CPP-III, etc.) (New Food In
dusty Vol. 35 No. 9 (1993),
P. 1-8) etc.], polysaccharides such as pectin, and the like. Among them, milk calcium and CPP have a network matrix-forming ability and also have a function as a sticking agent described later. Can also be used as a forming agent and a fixing agent.
【０００８】また、固着剤としては、増粘剤（例えば、
ＣＭＣ、デンプン、デキストリン、プルラン、アラビア
ガム等）、ゲル剤（例えば、ゼラチン、カラギナン、ア
ルギン酸塩等の単独または混合物等）等が挙げられる。Further, as the fixing agent, a thickener (for example,
CMC, starch, dextrin, pullulan, gum arabic, etc.), gelling agents (eg, gelatin, carrageenan, alginate, etc. alone or as a mixture) and the like.
【０００９】この発明のグルコン酸カルシウムあるいは
グルコン酸カルシウムと網状マトリックス形成剤および
固着剤とを含有する油状生理活性物質の安定化剤は、そ
のまま単独あるいは任意の担体との製剤を油状生理活性
物質に添加、混合し、常法により各種の製剤として得る
ことができる。油状生理活性物質含有製剤としては、散
剤（粉末）、球型粒、細粒剤、顆粒剤、錠剤、カプセル
剤等の通常の固形製剤が挙げられる。この発明の油状生
理活性物の固形製剤を製造する場合には必要により、通
常の希釈剤、賦形剤、崩壊剤等を使用することができ
る。また、キサンタンガム、レシチン、ヨーグルト、蔗
糖脂肪酸エステル、グリセリン脂肪酸エステル等の乳化
剤、分散剤を使用すると好結果が得られることが多い。The stabilizer for an oily physiologically active substance containing calcium gluconate or calcium gluconate of the present invention and a reticulated matrix forming agent and a sticking agent can be used as it is or as a formulation with any carrier to prepare an oily physiologically active substance. Various formulations can be obtained by adding and mixing and by a conventional method. Examples of the preparation containing an oily physiologically active substance include usual solid preparations such as powder (powder), spherical particles, fine granules, granules, tablets and capsules. When manufacturing the solid preparation of the oily physiologically active substance of the present invention, usual diluents, excipients, disintegrating agents and the like can be used, if necessary. In addition, emulsifiers and dispersants such as xanthan gum, lecithin, yogurt, sucrose fatty acid ester and glycerin fatty acid ester are often used to obtain good results.
【００１０】グルコン酸カルシウムの使用量は、製剤
中、２０〜９０％（重量％、以下同じ）、好ましくは５
０〜９０％程度である。網状マトリックス形成剤の使用
量は、１〜２０％、固着剤の使用量は０．２〜８％程度
が好ましい。The amount of calcium gluconate used is 20 to 90% (weight%, the same applies hereinafter), preferably 5 in the preparation.
It is about 0 to 90%. The amount of the reticulated matrix forming agent used is preferably 1 to 20%, and the amount of the fixing agent used is preferably about 0.2 to 8%.
【００１１】この発明の油状生理活性物質、グルコン酸
カルシウムならびに網状マトリックス形成剤および（ま
たは）固着剤を含有する製剤（粉剤）の製造例を示す
と、次の通りである。精製水に網状マトリックス形成剤
（例えばＣＰＰ）、キサンタンガム、レシチン等の乳化
剤、分散剤を混合する。次いで油状生理活性物質（例え
ばＤＨＡ含有魚油）を投入し、撹拌、混合したあと、グ
ルコン酸カルシウム及び固着剤を加え、強撹拌または高
圧ホモゲナイザーに通した（これらの処理により、ゼー
ター電位を−３０ｍＶ以上、好ましくは−１００ｍＶ以
上にする）あと、乾燥粉末化する。ここで乾燥は、通常
の通風、真空、凍結、噴霧等の乾燥法が適用される。A production example of a preparation (powder) containing the oily physiologically active substance of the present invention, calcium gluconate, a reticulated matrix forming agent and / or a sticking agent is as follows. A reticulated matrix forming agent (for example, CPP), an emulsifier such as xanthan gum and lecithin, and a dispersant are mixed with purified water. Then, an oily physiologically active substance (for example, DHA-containing fish oil) was added, and after stirring and mixing, calcium gluconate and a fixing agent were added, and the mixture was subjected to strong stirring or a high-pressure homogenizer (the zeta potential was -30 mV or more by these treatments. , Preferably -100 mV or more), and then dried and powdered. Here, for the drying, ordinary drying methods such as ventilation, vacuum, freezing, and spraying are applied.
【００１２】次にこの発明の製剤と従来品との比較を試
験例により説明する。 試験例１： この発明の製剤：実施例１で得られた製剤 従来の製剤：下記の方法で得られた製剤 精製ＤＨＡ含有魚油（ＤＨＡを２７％含有）１００ｇ
と、２００メッシュ下のミルクカルシウム微粉末（株式
会社ヘルスウェイ製の「食用乳清カルシウム粉」）３０
０ｇと、水１．０リットルをビーカーに入れ、高速ホモ
ジナイザーにより８０００ｒｐｍで１０分間撹拌した。
次いで、０．３％アルギン酸ナトリウム水溶液２００ｍ
ｌを添加し、２０００ｒｐｍで５分間撹拌した。その後
に、噴霧乾燥機を使用し、入口温度１２０℃以下で処理
することによりＤＨＡ含有精製魚油封入カルシウム微粒
子１８０ｇを得た。Next, the comparison between the preparation of the present invention and the conventional product will be described with reference to test examples. Test Example 1: Formulation of the present invention: formulation obtained in Example 1 Conventional formulation: formulation obtained by the following method Purified DHA-containing fish oil (containing 27% DHA) 100 g
And milk calcium fine powder under 200 mesh (“Edible whey calcium powder” manufactured by Healthway Co., Ltd.) 30
0 g and 1.0 liter of water were placed in a beaker, and the mixture was stirred by a high-speed homogenizer at 8000 rpm for 10 minutes.
Next, 200m of 0.3% sodium alginate aqueous solution
1 was added and stirred at 2000 rpm for 5 minutes. Thereafter, a spray dryer was used to perform treatment at an inlet temperature of 120 ° C. or lower to obtain 180 g of DHA-containing purified fish oil-encapsulated calcium fine particles.
【００１３】[0013]
【表１】 [Table 1]
【００１４】[0014]
【表２】 [Table 2]
【００１５】試験例２ 試験例１と同様に本発明のＤＨＡ含有製剤（実施例１で
得られた製剤）と従来の製剤（試験例１のものと同じ）
をそれぞれ添加したゼリーを製造し、両者の魚臭の強さ
を官能検査により評価した。 （ゼリーの組成）Test Example 2 As in Test Example 1, the DHA-containing preparation of the present invention (the preparation obtained in Example 1) and the conventional preparation (the same as in Test Example 1)
Was added to each to prepare a jelly, and the intensity of the fishy odor of both was evaluated by a sensory test. (Composition of jelly)
【００１６】[0016]
【表３】 （ゼリーの製造法）グラニュー糖、カラギナン、第１リ
ン酸カリウム、クエン酸ナトリウム、ＤＨＡ製剤をあら
かじめよく混合しておき、これに半量の水を加えて粉末
をよく分散させる。次に濃縮ジュースと残りの水を混合
したものを加え、８５℃以上に加熱し完全に溶解させた
後荒熱を取り、容器に移し、冷却してゼリーを調製し
た。[Table 3] (Method for producing jelly) Granulated sugar, carrageenan, potassium monophosphate, sodium citrate and DHA preparation are mixed well in advance, and half the amount of water is added thereto to disperse the powder well. Next, a mixture of concentrated juice and the remaining water was added, and the mixture was heated to 85 ° C. or higher to completely dissolve it, then removed from heat, transferred to a container, and cooled to prepare a jelly.
【００１７】（官能検査の方法）無添加区のゼリーを対
照に下記の基準で評価した。パネル数１０ （結果）(Method of sensory test) The following criteria were used to evaluate jelly in the non-additive group as a control. Number of panels 10 (result)
【表４】 この発明のＤＨＡ製剤を添加したゼリーの魚臭は従来公
知のＤＨＡ製剤添加区に比べて明らかに改善されてい
た。[Table 4] The fish odor of jelly to which the DHA formulation of the present invention was added was clearly improved as compared with the conventionally known DHA formulation addition group.
【００１８】試験例３ 試験例１と同様に本発明のＤＨＡ含有製剤（実施例１で
得られた製剤）と従来の製剤（試験例１のものと同じ）
をそれぞれ豆乳に添加し、魚臭の強さを官能検査により
評価した。 （官能検査の方法）無添加区の豆乳を対照に試験例２と
同様の基準で評価した。パネル数４ （結果）Test Example 3 As in Test Example 1, the DHA-containing preparation of the present invention (the preparation obtained in Example 1) and the conventional preparation (the same as in Test Example 1)
Was added to each soymilk, and the intensity of fish odor was evaluated by sensory test. (Method of sensory test) Soymilk in the non-addition group was used as a control and evaluated in the same manner as in Test Example 2. Number of panels 4 (Result)
【表５】 この発明のＤＨＡ含有製剤を添加した豆乳は、従来の製
剤添加区に比べて、魚臭は明らかに弱く、より高濃度の
添加が可能であることが分かる。[Table 5] It can be seen that the soymilk to which the DHA-containing preparation of the present invention is added has a significantly less fishy odor than the conventional preparation-added section, and a higher concentration can be added.
【００１９】試験例４ この発明のビタミンＥ含有製剤（実施例４で得られた製
剤）と下記の方法で得られた従来公知のビタミンＥ含有
製剤をそれぞれ牛乳およびドリンクヨーグルト（明治乳
業「ブルガリアのむヨーグルト」）に１００ｇ当り１．
２５ｇ（ビタミンＥとして１００ｍｇ）添加した時の飲
料のにおい、食感を無添加区を対照に評価した。また、
沈澱物の生成については、飲料を４℃で２４時間静置し
た後、肉眼で観察した。 （従来のビタミンＥ含有製剤）実施例４における殻形成
物質としてグルコン酸カルシウムの代りにミルクカルシ
ウム粉末（株式会社ヘルスウエイ製の「食用乳清カルシ
ウム粉」）を使用して、実施例４と同様の方法でビタミ
ンＥ含有粉末製剤を製造した。Test Example 4 Vitamin E-containing preparation of the present invention (preparation obtained in Example 4) and conventionally known vitamin E-containing preparation obtained by the following method were added to milk and drink yogurt (Meiji Dairy Industries "Bulgarian Mumu yogurt ") per 100g 1.
The odor and texture of the beverage when 25 g (100 mg as vitamin E) was added was evaluated using the non-addition group as a control. Also,
Regarding the formation of precipitate, the beverage was allowed to stand at 4 ° C. for 24 hours and then visually observed. (Conventional Vitamin E-Containing Formulation) Milk calcium powder (“edible whey calcium powder” manufactured by Health Way Co., Ltd.) was used as the shell-forming substance in Example 4 instead of calcium gluconate, and the same as in Example 4. Vitamin E-containing powder formulations were manufactured by the method described in 1.
【００２０】（結果）(Results)
【表６】 この発明によるビタミンＥ含有粉末製剤を添加した試験
区は、従来の技術で製造したビタミンＥ含有粉末製剤に
比べて食感は良好であり、沈澱物が生成しない点でも優
れているといえる。[Table 6] It can be said that the test section to which the vitamin E-containing powder preparation according to the present invention is added has a better texture than the conventional vitamin E-containing powder preparation and is excellent in that no precipitate is formed.
【００２１】試験例５ 本発明のＤＨＡ製剤（実施例１で得られた製剤）と従来
の製剤（試験例１のものと同じ）をそれぞれビーカーに
採り、開封状態で３０℃、湿度９０％で２ケ月間保存
し、ＤＨＡ含量および過酸化物価（ＰＯＶ）を測定し
た。 （結果）Test Example 5 The DHA preparation of the present invention (preparation obtained in Example 1) and the conventional preparation (the same as in Test Example 1) were placed in beakers, respectively, and they were opened at 30 ° C. and humidity of 90%. After being stored for 2 months, the DHA content and the peroxide value (POV) were measured. (result)
【表７】 この発明のＤＨＡ製剤は従来の製剤に比べて酸化安定性
も優れている。以上のように、この発明による製剤は従
来公知の製剤に比べ、マスキング性、水親和性にもすぐ
れ、ドリンク剤に添加しても悪い臭いもない。この発明
の製剤は、製剤それ自体としてあるいは各種食品に添加
して使用することができる。とくに各種飲料に添加して
も悪い臭いの発生がないので、広く食品、飲料等に添加
使用できる。また、この発明の製剤は、各生理活性物質
に基づく生理作用に加えて、カルシウムの補給、腸内ビ
フィズス菌の活性を有するので、健康食品として有用で
ある。[Table 7] The DHA formulation of this invention is also superior in oxidative stability as compared to conventional formulations. As described above, the preparation according to the present invention has excellent masking properties and water affinity as compared with conventionally known preparations, and has no bad odor when added to a drink. The preparation of the present invention can be used as the preparation itself or added to various foods. In particular, since it does not produce a bad odor when added to various beverages, it can be widely added and used in foods, beverages and the like. Moreover, the preparation of the present invention has calcium supplementation and intestinal bifidobacteria activity in addition to the physiological action based on each physiologically active substance, and is therefore useful as a health food.
【００２２】次にこの発明の実施例を示す。 実施例１（ＤＨＡ含有粉末の製造） 精製水３，０００ｋｇ中にカゼインホスホペプチド、明
治ＣＰＰ−Ｉ（商品名，明治製菓（株）製）１６０ｋ
ｇ、キサンタンガム １．３ｋｇ，レシチン ８．５ｋ
ｇ、固着剤としてゼラチンとカラギナンとの混合物
（９：１）１．８ｋｇを混合（７００〜１，５００ｒｐ
ｍ．で撹拌）、溶解する。ついでＤＨＡ含有魚油（ハリ
マ化成（株）製、ＤＨＡ含量２３％）１７０ｋｇを混液
中に投入し、２，０００〜５，０００ｒｐｍ，の回転数
で予備乳化する。最後にグルコン酸カルシウム微粉末６
５０ｋｇを加え１，０００ｒｐｍ．で撹拌した後、高圧
ホモゲナイザーを２００ｋｇ／ｃｍ2 の加圧下に通過さ
せてからノズル型噴霧乾燥機にて粉末化して、ＤＨＡ含
有粉末製剤８１０ｋｇを得た。Next, an embodiment of the present invention will be shown. Example 1 (Production of DHA-containing powder) Casein phosphopeptide, Meiji CPP-I (trade name, manufactured by Meiji Seika Co., Ltd.) 160 k in 3,000 kg of purified water
g, xanthan gum 1.3 kg, lecithin 8.5 k
g, 1.8 kg of a mixture of gelatin and carrageenan (9: 1) as a fixing agent was mixed (700 to 1,500 rp)
m. Stir) and dissolve. Then, 170 kg of DHA-containing fish oil (Harima Kasei Co., Ltd., DHA content 23%) is put into the mixed solution, and pre-emulsified at a rotation speed of 2,000 to 5,000 rpm. Finally calcium gluconate fine powder 6
Add 50 kg and 1,000 rpm. After stirring at 1, the mixture was passed through a high-pressure homogenizer under a pressure of 200 kg / cm 2 and then pulverized with a nozzle type spray dryer to obtain 810 kg of a DHA-containing powder formulation.
【００２３】実施例２（ＥＰＡ含有粉末の製造） 実施例１におけるＤＨＡ含有魚油にかえて、ＥＰＡ４０
％を含む精製魚油１９０ｋｇを使用して、実施例１と全
く同じ条件下で製造を行い、ＥＰＡ含有粉末８４５ｋｇ
を得た。Example 2 (Production of EPA-containing powder) Instead of the DHA-containing fish oil in Example 1, EPA40 was used.
% Of purified fish oil was used to produce under exactly the same conditions as in Example 1, and 845 kg of EPA-containing powder.
I got
【００２４】実施例３（β−カロチン含有粉末の製造） 実施例１におけるＤＨＡ含有魚油にかえて、２０％のβ
−カロチンを含む大豆油（ロッシュ（株）製）１２０ｋ
ｇを用い実施例１と同様に製造を行いβ−カロチン含有
粉末６２３ｋｇを得た。Example 3 (Production of β-carotene-containing powder) In place of the DHA-containing fish oil in Example 1, 20% β was used.
-Soybean oil containing carotene (Roche Co., Ltd.) 120k
The same procedure as in Example 1 was carried out using g to obtain 623 kg of β-carotene-containing powder.
【００２５】実施例４ 精製水７０ｇ中にカゼインナトリウム１．５ｇ、キサン
タンガム０．０４ｇ、レシチン０．２５ｇおよびゼラチ
ン、プルラン、Ｋ−カラギナンの混合物（１３．２：１
２．０：１．３）１．２ｇを入れ撹拌混合する。つい
で、ビタミンＥ含有油（ビタミンＥ含量４０％）６ｇを
混液中に投入し、高速ホモミキサーを用いて予備乳化す
る。最後にグルコン酸カルシウム粉末２１．０１ｇを加
え、高速ホモミキサーで乳化した後、乳化液を熱風乾燥
し、ビタミンＥ含有粉末製剤約３０ｇを得た。EXAMPLE 4 1.5 g of sodium caseinate, 0.04 g of xanthan gum, 0.25 g of lecithin and a mixture of gelatin, pullulan and K-carrageenan in 70 g of purified water (13.2: 1).
2.0: 1.3) Add 1.2 g and stir to mix. Then, 6 g of vitamin E-containing oil (vitamin E content 40%) is put into the mixed solution, and preliminarily emulsified using a high-speed homomixer. Finally, 21.01 g of calcium gluconate powder was added and emulsified with a high speed homomixer, and then the emulsion was dried with hot air to obtain about 30 g of a vitamin E-containing powder preparation.
【００２６】精製水７０ｇ中に網上マトリックス形成剤
としてミルクカルシウム粉末（株式会社ヘルスウエイ製
の「食用乳清カルシウム粉」）１．５ｇ、キサンタンガ
ム０．０４ｇ、レシチン０．２５ｇ、デキストリン１．
２ｇを入れ撹拌混合する。ついで、ビタミンＤ3 ６．
０ｇを混液中に投入し、高速ホモミキサーを用いて予備
乳化する。最後にグルコン酸カルシウム粉末２１．０１
ｇを加え、高速ホモミキサーで乳化した後、乳化液を熱
風乾燥し、ビタミンＤ3 含有粉末製剤約３０ｇを得た。In 70 g of purified water, 1.5 g of milk calcium powder (“edible whey calcium powder” manufactured by Healthway Co., Ltd.) as a net matrix forming agent, 0.04 g of xanthan gum, 0.25 g of lecithin, and 1. dextrin.
Add 2 g and mix with stirring. Then, vitamin D 3 6.
0 g is added to the mixed solution and pre-emulsified by using a high speed homomixer. Finally calcium gluconate powder 21.01
After adding g and emulsifying with a high speed homomixer, the emulsion was dried with hot air to obtain about 30 g of a vitamin D 3 -containing powder preparation.
【００２７】実施例６ 精製水８５ｇ中にペクチン０．７５ｇ、キサンタンガム
０．０２ｇ、レシチン０．１３ｇ、アルギン酸ナトリウ
ム０．６ｇを入れ撹拌混合する。ついで、生ローヤルゼ
リー３．０ｇを混液中に投入し、高速ホモミキサーで予
備乳化する。最後にグルコン酸カルシウム粉末１０．５
ｇを加え、高速ホモミキサーで乳化した後、乳化液を熱
風乾燥し、ローヤルゼリー含有粉末製剤約１３ｇを得
た。Example 6 In 85 g of purified water, 0.75 g of pectin, 0.02 g of xanthan gum, 0.13 g of lecithin and 0.6 g of sodium alginate are put and mixed with stirring. Then, 3.0 g of raw royal jelly is put into the mixed solution and preliminarily emulsified by a high speed homomixer. Finally calcium gluconate powder 10.5
After adding g and emulsifying with a high-speed homomixer, the emulsion was dried with hot air to obtain about 13 g of a royal jelly-containing powder preparation.
【００２８】実施例７ 精製水７０ｇ中にキサンタンガム０．０４ｇ、レシチン
０．２５ｇ、ＤＨＡ含有魚油（ＤＨＡ含量２０％）６．
０ｇ、グルコン酸カルシウム粉末２２．５１ｇおよびゼ
ラチン、プルラン、Ｋ−カラギナンの混合物（１３．
２：１２．０：１．３）１．２ｇを一括投入し、高速ホ
モミキサーで乳化した後、乳化液を熱風乾燥しＤＨＡ含
有粉末製剤約３０ｇを得た。Example 7 Xanthan gum 0.04 g, lecithin 0.25 g, DHA-containing fish oil (DHA content 20%) in 70 g of purified water.
0 g, calcium gluconate powder 22.51 g and a mixture of gelatin, pullulan and K-carrageenan (13.
(2: 12.0: 1.3) 1.2 g was added all at once, and the mixture was emulsified with a high-speed homomixer, and then the emulsion was dried with hot air to obtain about 30 g of a DHA-containing powder preparation.
フロントページの続き (51)Int.Cl.6 識別記号 庁内整理番号 ＦＩ 技術表示箇所 Ａ６１Ｋ 35/60 Ａ６１Ｋ 35/60 Ａ６１Ｌ 9/01 Ａ６１Ｌ 9/01 Ｈ Ｃ１１Ｂ 5/00 Ｃ１１Ｂ 5/00 15/00 15/00 // Ａ２３Ｌ 1/327 Ａ２３Ｌ 1/327 (72)発明者 白井 純 横浜市港北区綱島西６−10−18−303Continuation of the front page (51) Int.Cl. 6 Identification code Office reference number FI Technical display location A61K 35/60 A61K 35/60 A61L 9/01 A61L 9/01 H C11B 5/00 C11B 5/00 15/00 15/00 // A23L 1/327 A23L 1/327 (72) Inventor Jun Shirai 6-10-18-303 Tsunashima Nishi, Kohoku Ward, Yokohama City
Claims (11)
理活性物質の安定化剤。1. A stabilizer for an oily physiologically active substance containing calcium gluconate.
ックス形成剤を含有するか、またはグルコン酸カルシウ
ム、網状マトリックス形成剤および固着剤を含有する油
状生理活性物質の安定化剤。2. A stabilizer for an oily physiologically active substance, which contains calcium gluconate and a network matrix forming agent, or contains calcium gluconate, a network matrix forming agent and a sticking agent.
ムとを含有する油状生理活性物質の固形製剤。3. A solid preparation of an oily physiologically active substance containing an oily physiologically active substance and calcium gluconate.
ムおよび網状マトリックス形成剤を含有するか、または
油状生理活性物質、グルコン酸カルシウム、網状マトリ
ックス形成剤および固着剤を含有する油状生理活性物質
の固形製剤。4. A solid preparation of an oily physiologically active substance containing an oily physiologically active substance, calcium gluconate and a network matrix forming agent, or containing an oily physiologically active substance, calcium gluconate, a network matrix forming agent and a sticking agent. .
ムとを混合撹拌したあと乾燥することを特徴とする油状
生理活性物質の固形製剤の製造法。5. A method for producing a solid preparation of an oily physiologically active substance, which comprises mixing and stirring an oily physiologically active substance and calcium gluconate and then drying.
ムならびに網状マトリックス形成剤および（または）固
着剤を混合撹拌したあと乾燥することを特徴とする油状
生理活性物質の固形製剤の製造法。6. A method for producing a solid preparation of an oily physiologically active substance, which comprises mixing and stirring an oily physiologically active substance, calcium gluconate, a network matrix-forming agent and / or a sticking agent, and then drying.
る請求項１の安定化剤。7. The stabilizer according to claim 1, wherein the oily physiologically active substance is DHA-containing fish oil.
る請求項２の安定化剤。8. The stabilizer according to claim 2, wherein the oily physiologically active substance is DHA-containing fish oil.
る請求項３の固形製剤。9. The solid preparation according to claim 3, wherein the oily physiologically active substance is DHA-containing fish oil.
ある請求項４の固形製剤。10. The solid preparation according to claim 4, wherein the oily physiologically active substance is DHA-containing fish oil.
網状マトリックス形成剤がカゼインホスホペプチド、固
着剤がゼラチンとカラギナンの混合物である請求項４の
固形製剤。11. An oily physiologically active substance is DHA-containing fish oil,
The solid preparation according to claim 4, wherein the reticulated matrix forming agent is casein phosphopeptide, and the sticking agent is a mixture of gelatin and carrageenan.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8016409A JPH09132775A (en) | 1995-02-13 | 1996-02-01 | Stabilizing agent for oily physiologically active substance |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2382495 | 1995-02-13 | ||
| JP7-231127 | 1995-09-08 | ||
| JP23112795 | 1995-09-08 | ||
| JP7-23824 | 1995-09-08 | ||
| JP8016409A JPH09132775A (en) | 1995-02-13 | 1996-02-01 | Stabilizing agent for oily physiologically active substance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH09132775A true JPH09132775A (en) | 1997-05-20 |
Family
ID=27281393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8016409A Pending JPH09132775A (en) | 1995-02-13 | 1996-02-01 | Stabilizing agent for oily physiologically active substance |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH09132775A (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003518509A (en) * | 1999-12-23 | 2003-06-10 | アベンティス・アニマル・ニユートリシヨン・エス・エー | Granular vitamin composition |
| JP2004520355A (en) * | 2001-01-17 | 2004-07-08 | アール．ピー． シェーラー テクノロジーズ インコーポレイテッド | Ingestible composition containing odorous oil |
| JP2007527862A (en) * | 2003-07-15 | 2007-10-04 | ディーエスエム アイピー アセッツ ビー．ブイ． | Powdered formulation of fat-soluble active ingredients |
| JP2008259519A (en) * | 2004-10-22 | 2008-10-30 | Access Business Group Internatl Llc | Omega-3 fatty acid-containing food |
| JP2009149584A (en) * | 2007-12-21 | 2009-07-09 | Kaneka Corp | Reduced coenzyme q10-containing particulate composition and its manufacturing method |
| JP2012095645A (en) * | 2010-10-05 | 2012-05-24 | Moriyama Nyugyo Kk | Gel-like nutritional food |
| JP5140585B2 (en) * | 2006-06-22 | 2013-02-06 | 株式会社カネカ | Reduced coenzyme Q10-containing composition and method for producing the same |
| JP2014526268A (en) * | 2011-09-23 | 2014-10-06 | ナチュラル バイオテクノロジー エスペエールエル | Preservative composition for beverages and sauces |
| JP2015128419A (en) * | 2013-12-05 | 2015-07-16 | 三栄源エフ・エフ・アイ株式会社 | solid composition |
| JP2020513236A (en) * | 2016-12-13 | 2020-05-14 | ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． | PUFA salt formulation (I) |
| JP2020184978A (en) * | 2019-05-17 | 2020-11-19 | ミヨシ油脂株式会社 | Powder oil and fat |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02693A (en) * | 1988-01-29 | 1990-01-05 | Nisshin Baadeishie Kk | Stable composition of oxidation-sensitive compound |
| JPH06303902A (en) * | 1993-04-19 | 1994-11-01 | Kiteii:Kk | Emulsified food containing docosahexaenoic acid |
-
1996
- 1996-02-01 JP JP8016409A patent/JPH09132775A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02693A (en) * | 1988-01-29 | 1990-01-05 | Nisshin Baadeishie Kk | Stable composition of oxidation-sensitive compound |
| JPH06303902A (en) * | 1993-04-19 | 1994-11-01 | Kiteii:Kk | Emulsified food containing docosahexaenoic acid |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003518509A (en) * | 1999-12-23 | 2003-06-10 | アベンティス・アニマル・ニユートリシヨン・エス・エー | Granular vitamin composition |
| JP2004520355A (en) * | 2001-01-17 | 2004-07-08 | アール．ピー． シェーラー テクノロジーズ インコーポレイテッド | Ingestible composition containing odorous oil |
| JP2007527862A (en) * | 2003-07-15 | 2007-10-04 | ディーエスエム アイピー アセッツ ビー．ブイ． | Powdered formulation of fat-soluble active ingredients |
| JP2008259519A (en) * | 2004-10-22 | 2008-10-30 | Access Business Group Internatl Llc | Omega-3 fatty acid-containing food |
| JP5140585B2 (en) * | 2006-06-22 | 2013-02-06 | 株式会社カネカ | Reduced coenzyme Q10-containing composition and method for producing the same |
| US9295656B2 (en) | 2006-06-22 | 2016-03-29 | Kaneka Corporation | Composition containing reduced coenzyme Q10 and production method thereof |
| US9981899B2 (en) | 2006-06-22 | 2018-05-29 | Kaneka Corporation | Composition containing reduced coenzyme Q10 and production method thereof |
| JP2009149584A (en) * | 2007-12-21 | 2009-07-09 | Kaneka Corp | Reduced coenzyme q10-containing particulate composition and its manufacturing method |
| JP2012095645A (en) * | 2010-10-05 | 2012-05-24 | Moriyama Nyugyo Kk | Gel-like nutritional food |
| JP2014526268A (en) * | 2011-09-23 | 2014-10-06 | ナチュラル バイオテクノロジー エスペエールエル | Preservative composition for beverages and sauces |
| JP2015128419A (en) * | 2013-12-05 | 2015-07-16 | 三栄源エフ・エフ・アイ株式会社 | solid composition |
| JP2020513236A (en) * | 2016-12-13 | 2020-05-14 | ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． | PUFA salt formulation (I) |
| JP2020184978A (en) * | 2019-05-17 | 2020-11-19 | ミヨシ油脂株式会社 | Powder oil and fat |
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