JPH08505134A - レントゲン撮影造影剤としてヨウ化芳香族化合物を使用する放射線診断用注射剤水溶液 - Google Patents
レントゲン撮影造影剤としてヨウ化芳香族化合物を使用する放射線診断用注射剤水溶液Info
- Publication number
- JPH08505134A JPH08505134A JP6514796A JP51479694A JPH08505134A JP H08505134 A JPH08505134 A JP H08505134A JP 6514796 A JP6514796 A JP 6514796A JP 51479694 A JP51479694 A JP 51479694A JP H08505134 A JPH08505134 A JP H08505134A
- Authority
- JP
- Japan
- Prior art keywords
- groups
- compound
- substituted
- iodine
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0452—Solutions, e.g. for injection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. (a)トリヨウ化芳香環を持ち、該芳香環がヨウ素置換されていない位置に官 能基で置換された直鎖または分岐の有機残基を有する有機化合物と、 (b)ヨウ素置換されていない位置の一つで、官能基で置換された直鎖または 分岐の有機残基を介して共有結合的に結合している少なくとも2個のトリヨウ化 芳香環を持ち、該芳香環が、残りの位置で、前記化合物(a)で規定された有機 残基によってさらに置換されている有機化合物 の混合物が水系媒体中に溶解してなる組成物であって、 前記化合物(b)のヨウ素量を、組成物中に存在する総ヨウ素量の10〜90 重量%、好ましくは20〜75%とするような比率で、前記化合物(a)と化合 物(b)が混合物中に存在する、X線検査撮像用注射剤組成物水溶液。 2.化合物(a)が下記一般式(I)で表される構造を有する請求項1記載の 組成物。 (ただし式中、A,B,Dは同一であっても異なっていてもよく、−CON( R)R1または−N(R)−CO−R2であり、 Rは水素あるいは直鎖または分岐のアルキル基(C1〜C6)であり、1〜5 個のOH基および/またはアルコキシ基および/またはヒドロキシアルコキシ基 で置換されていてもよく、 R1は、1〜5個のOH基および/またはアルコキシ基および/またはヒドロ キシアルコキシ基あるいは−NH−CO−R1および−CO−N(R)R1の2つ の基のうちの一つで置換されていてもよい直鎖または分岐アルキル基(C2〜C 6)、あるいはR1は炭水化物の残基であり、もしくはR1とRとでO、S、Nを 中間に有してもよいアルキレン鎮(C3〜C7)を形成していてもよく、 R2は、直鎖または分岐アルキル基(C1−C6)であって、1〜5個のOH 基および/またはアルコキシ基および/またはヒドロキシアルコキシ基で置換さ れていても良く、オキソ基を有していてもよい。) 3.化合物(b)が下記一般式(II)で表される請求項1記載の組成物。 (ただし式中、A,B,Dは同一であっても異なっていてもよく、前記一般式 (I)の場合と同一であり、 Eは同一であっても異なっていてもよく、−CO−N(R)−、−N(R)− CO−、−N(COR3)−基の中から選択され、Rは前記一般式(I)の場合 と同一であり、R3はアルキル基(C1−C3)であり、1〜2個のOH基また はアルコキシ基あるいはヒドロキシアルコキシ基で置換されていてもよく、 Xは共有結合、あるいは直鎖または分岐アルキレン基(C1−C8)であり、 該アルキレン基は1〜6個のOH基および/または−CO−NHR基で置換され ていてもよく、中間に−O−,−S−,−N−,−N(R)−CO基を有してい てもよく、 Rは式(I)で定義した通りである。) 4.化合物(a)が、イオパミドール、メトリザミド(metrizamid e)、イオダミド(iodamide)、イオメプロール、イオプロマイド、イ オヴェルソール(ioversol)、イオグルナイド(ioglunide) 、イオシミド(iosimide)、イオヘキソール、イオグラマイド(iog ulamide)から選択され、化合物(b)がイオトロラン(iotrola n)、イオディキサノール、イオフラトール、1,3−ビス−[N−(3,5− ビス−(2,3−ジヒドロキシプロピル−アミノカルボニル)−2,4,6−ト リヨードフェニル)−N−ヒドロキシアセチルーアミノ]−プロパンから選択さ れる請求項1記載の組成物。 5.重量オスモル濃度が250〜600ミリモル/kg、好ましくは280〜 400ミリモル/kg、特に好ましくは280〜320ミリモル/kgの範囲に ある請求項1ないし4のいずれかに記載の組成物。 6.さらに賦形剤、安定化剤、溶解調節剤、凝固防止剤、生理的に耐容される 水溶性無機塩から選択される添加剤を含有する請求項1記載の組成物。 7.無機塩が、Na、K、Mg、Caのハロゲン化物、炭酸塩、重炭酸塩、硫 酸塩、燐酸塩から選択される請求項6記載の組成物。 8.凝固防止剤がヘパリンおよびヒルジンから選択される請求項6記載の組成 物。 9.賦形剤が、グリセリン、ポリエチレングリコール、デキストランから選択 される請求項6記載の組成 物。 10.安定化剤が、トロメタモール、EDTA、EDTA・CaNa2、燐酸 ナトリウムから選択される請求項6記載の組成物。 11.化合物(a)および(b)の2つの化合物の総濃度が、ヨウ素濃度を2 00〜450g(ヨウ素)/L以上とし、しかも重量オスモル濃度を生理的値の 0.8〜1.5倍に維持するものである請求項1記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI922964A IT1256248B (it) | 1992-12-24 | 1992-12-24 | Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x |
IT92A002964 | 1992-12-24 | ||
PCT/EP1993/003613 WO1994014478A1 (en) | 1992-12-24 | 1993-12-20 | Aqueous injectable formulations useful for radio-diagnosis comprising iodinated aromatic compounds used as x-ray contrast media |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH08505134A true JPH08505134A (ja) | 1996-06-04 |
JP3585233B2 JP3585233B2 (ja) | 2004-11-04 |
Family
ID=11364538
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51479694A Expired - Fee Related JP3585233B2 (ja) | 1992-12-24 | 1993-12-20 | レントゲン撮影造影剤としてヨウ化芳香族化合物を使用する放射線診断用注射剤水溶液 |
Country Status (22)
Country | Link |
---|---|
US (1) | US5695742A (ja) |
EP (1) | EP0675738B1 (ja) |
JP (1) | JP3585233B2 (ja) |
CN (1) | CN1100329A (ja) |
AT (1) | ATE166234T1 (ja) |
AU (1) | AU5833294A (ja) |
BR (1) | BR9307734A (ja) |
CA (1) | CA2152480A1 (ja) |
CZ (1) | CZ165595A3 (ja) |
DE (2) | DE675738T1 (ja) |
ES (1) | ES2077554T1 (ja) |
FI (1) | FI953124A0 (ja) |
GR (1) | GR950300061T1 (ja) |
HU (1) | HUT72304A (ja) |
IL (1) | IL108158A0 (ja) |
IS (1) | IS4114A (ja) |
IT (1) | IT1256248B (ja) |
MX (1) | MX9400185A (ja) |
NO (1) | NO952533L (ja) |
PL (1) | PL309395A1 (ja) |
WO (1) | WO1994014478A1 (ja) |
ZA (1) | ZA939666B (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2012514622A (ja) * | 2009-01-09 | 2012-06-28 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影製剤組成物 |
JP2015007084A (ja) * | 2007-07-12 | 2015-01-15 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1256248B (it) * | 1992-12-24 | 1995-11-29 | Bracco Spa | Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x |
US5686061A (en) * | 1994-04-11 | 1997-11-11 | The Board Of Regents Of The University Of Texas System | Particulate contrast media derived from non-ionic water soluble contrast agents for CT enhancement of hepatic tumors |
GB9419203D0 (en) * | 1994-09-23 | 1994-11-09 | Nycomed Innovation Ab | Contrast media |
GB9419206D0 (en) * | 1994-09-23 | 1994-11-09 | Nycomed Innovation Ab | Contrast media |
US5575905A (en) * | 1995-05-24 | 1996-11-19 | Nycomed Imaging As | Iodination process |
WO1997000240A1 (en) * | 1995-06-16 | 1997-01-03 | Biophysica Foundation | Formyl derivatives as nonionic contrast media |
ATE251893T1 (de) * | 1996-01-25 | 2003-11-15 | Schering Ag | Verbesserte kontrastmittenlösungen für die intravasale anwendung |
DE19648650C2 (de) * | 1996-01-29 | 1998-07-02 | Schering Ag | Puffersysteme und deren Verwendung zur Stabilisierung pharmazeutischer Zubereitung |
DE19627309C2 (de) * | 1996-06-27 | 1999-07-29 | Schering Ag | Wäßrige injizierbare Formulierungen verwendbar als Kontrastmittel |
DE19736472C1 (de) * | 1997-08-21 | 1999-04-22 | Bernhard Dr Sixt | Verfahren zum Herstellen von weitgehend nebenwirkungsfreien Kontrastmitteln |
US6406680B1 (en) * | 1999-09-17 | 2002-06-18 | Nycomed Imaging As | X-ray contrast agents |
SE520688C2 (sv) | 2000-04-11 | 2003-08-12 | Bone Support Ab | Ett injicerbart ersättningsmaterial för benmineral |
SE517168C2 (sv) | 2000-07-17 | 2002-04-23 | Bone Support Ab | En komposition för ett injicerbart ersättningsmaterial för benmineral |
US6832220B1 (en) * | 2000-08-03 | 2004-12-14 | Microsoft Corporation | Method and apparatus for file searching, accessing file identifiers from reference page |
SE522098C2 (sv) | 2001-12-20 | 2004-01-13 | Bone Support Ab | Ett nytt benmineralsubstitut |
ES2289172T3 (es) | 2001-12-20 | 2008-02-01 | Bone Support Ab | Un nuevo sustituto mineral de hueso. |
GB0228410D0 (en) | 2002-12-05 | 2003-01-08 | Glaxo Group Ltd | Novel Compounds |
SE0300620D0 (sv) | 2003-03-05 | 2003-03-05 | Bone Support Ab | A new bone substitute composition |
SE0302983D0 (sv) | 2003-11-11 | 2003-11-11 | Bone Support Ab | Anordning för att förse spongiöst ben med benersättnings- och/eller benförstärkningsmaterial och förfarande i samband därmed |
CA2559628A1 (en) | 2004-03-11 | 2005-09-22 | Mallinckrodt Inc. | X-ray contrast formulation comprising a mixture of iodinated monomer and dimer |
SE527528C2 (sv) * | 2004-06-22 | 2006-04-04 | Bone Support Ab | Anordning för framställning av härdbar massa samt användning av anordningen |
FR2899581B1 (fr) * | 2006-04-07 | 2008-06-27 | Guerbet Sa | Procede d'atomisation du ioxilan |
WO2009005365A1 (en) * | 2007-06-29 | 2009-01-08 | Ge Healthcare As | Contrast agents |
ES2413160T3 (es) * | 2007-10-12 | 2013-07-15 | Ge Healthcare As | Agentes de contraste |
CN101820923A (zh) * | 2007-10-12 | 2010-09-01 | 通用电气医疗集团股份有限公司 | 对比剂 |
WO2009071605A1 (en) * | 2007-12-05 | 2009-06-11 | Ge Healthcare As | Contrast agents |
EP2247314A4 (en) * | 2008-02-01 | 2013-11-27 | Univ Boston | CATIONIC CONTRASTING AGENTS AND METHOD FOR THEIR USE |
EP2093206A1 (en) | 2008-02-20 | 2009-08-26 | BRACCO IMAGING S.p.A. | Process for the iodination of aromatic compounds |
WO2009106552A2 (en) * | 2008-02-27 | 2009-09-03 | Ge Healthcare As | Contrast agents |
WO2009106551A2 (en) * | 2008-02-27 | 2009-09-03 | Ge Healthcare As | Contrast agents |
WO2010060941A2 (en) * | 2008-11-27 | 2010-06-03 | Ge Healthcare As | Contrast agents |
EP2230227A1 (en) | 2009-03-20 | 2010-09-22 | Bracco Imaging S.p.A | Process for the preparation of triiodinated carboxylic aromatic derivatives |
EP2243767A1 (en) | 2009-04-21 | 2010-10-27 | Bracco Imaging S.p.A | Process for the iodination of aromatic compounds |
KR101699065B1 (ko) | 2009-07-07 | 2017-01-23 | 브라코 이미징 에스.피.에이. | 요오드화제의 제조방법 |
US9180137B2 (en) | 2010-02-09 | 2015-11-10 | Bone Support Ab | Preparation of bone cement compositions |
PL2958603T3 (pl) | 2013-02-20 | 2018-10-31 | Bone Support Ab | Ulepszone zestalanie utwardzalnego materiału zastępczego kości |
JP6425375B2 (ja) * | 2013-10-11 | 2018-11-21 | 新光電気工業株式会社 | コイル基板及びその製造方法、インダクタ |
US10610366B2 (en) | 2015-01-29 | 2020-04-07 | Theracell, Inc. | Demineralized bone fiber composition for use in minimally invasive surgery |
WO2018104228A1 (en) | 2016-12-05 | 2018-06-14 | Bracco Imaging Spa | Mechanochemical synthesis of radiographic agents intermediates |
US10639157B2 (en) | 2017-03-14 | 2020-05-05 | Theracell, Inc. | Demineralized bone fiber composition for use in minimally invasive surgery |
WO2023209165A1 (en) | 2022-04-29 | 2023-11-02 | Bracco Imaging Spa | Process for the preparation of 2,4,6-triiodophenol derivatives |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2613172A (en) * | 1949-08-10 | 1952-10-07 | American Cystoscope Makers Inc | X-ray contrast compositions |
CH608189A5 (ja) * | 1974-12-13 | 1978-12-29 | Savac Ag | |
NL8002388A (nl) * | 1979-05-21 | 1980-11-25 | Mallinckrodt Inc | Roentgencontrastmiddel. |
FR2511871A1 (fr) * | 1981-08-28 | 1983-03-04 | Guerbet Sa | Procede pour augmenter la tolerance des produits opacifiants et produits opacifiants ainsi obtenus |
GB8906130D0 (en) * | 1989-03-17 | 1989-05-04 | Nycomed As | Compositions |
US5191120A (en) * | 1989-12-13 | 1993-03-02 | Mallinckrodt Medical, Inc. | Process for preparing nonionic X-ray contrast agents |
US5075502A (en) * | 1989-12-13 | 1991-12-24 | Mallinckrodt, Inc. | Nonionic x-ray contrast agents, compositions and methods |
GB9020091D0 (en) * | 1990-09-14 | 1990-10-24 | Nycomed As | Contrast media |
WO1994005337A1 (en) * | 1992-09-02 | 1994-03-17 | Mallinckrodt Medical, Inc. | Nonionic x-ray contrast agents, compositions and methods |
US5260478A (en) * | 1992-12-08 | 1993-11-09 | Sterling Winthrop Inc. | Iodinated aroyloxy carboxamides |
NZ250063A (en) * | 1992-12-14 | 1996-03-26 | Eastman Kodak Co | Iodinated aromatic acid ester derivatives; x-ray contrast compositions |
IT1256248B (it) * | 1992-12-24 | 1995-11-29 | Bracco Spa | Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x |
-
1992
- 1992-12-24 IT ITMI922964A patent/IT1256248B/it active IP Right Grant
-
1993
- 1993-12-20 CZ CZ951655A patent/CZ165595A3/cs unknown
- 1993-12-20 ES ES94904159T patent/ES2077554T1/es active Pending
- 1993-12-20 JP JP51479694A patent/JP3585233B2/ja not_active Expired - Fee Related
- 1993-12-20 EP EP94904159A patent/EP0675738B1/en not_active Expired - Lifetime
- 1993-12-20 AU AU58332/94A patent/AU5833294A/en not_active Abandoned
- 1993-12-20 HU HU9501850A patent/HUT72304A/hu unknown
- 1993-12-20 AT AT94904159T patent/ATE166234T1/de not_active IP Right Cessation
- 1993-12-20 CA CA002152480A patent/CA2152480A1/en not_active Abandoned
- 1993-12-20 PL PL93309395A patent/PL309395A1/xx unknown
- 1993-12-20 US US08/448,509 patent/US5695742A/en not_active Expired - Lifetime
- 1993-12-20 BR BR9307734-3A patent/BR9307734A/pt not_active Application Discontinuation
- 1993-12-20 WO PCT/EP1993/003613 patent/WO1994014478A1/en active IP Right Grant
- 1993-12-20 DE DE0675738T patent/DE675738T1/de active Pending
- 1993-12-20 DE DE69318727T patent/DE69318727T2/de not_active Expired - Lifetime
- 1993-12-23 CN CN93115336A patent/CN1100329A/zh active Pending
- 1993-12-23 ZA ZA939666A patent/ZA939666B/xx unknown
- 1993-12-23 IL IL10815893A patent/IL108158A0/xx unknown
- 1993-12-23 IS IS4114A patent/IS4114A/is unknown
-
1994
- 1994-01-03 MX MX9400185A patent/MX9400185A/es unknown
-
1995
- 1995-06-22 FI FI953124A patent/FI953124A0/fi not_active Application Discontinuation
- 1995-06-23 NO NO952533A patent/NO952533L/no unknown
- 1995-11-30 GR GR950300061T patent/GR950300061T1/el unknown
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015007084A (ja) * | 2007-07-12 | 2015-01-15 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
US9738596B2 (en) | 2007-07-12 | 2017-08-22 | Ge Healthcare As | Contrast agents |
JP2012514622A (ja) * | 2009-01-09 | 2012-06-28 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影製剤組成物 |
Also Published As
Publication number | Publication date |
---|---|
CN1100329A (zh) | 1995-03-22 |
HUT72304A (en) | 1996-04-29 |
FI953124A (fi) | 1995-06-22 |
CZ165595A3 (en) | 1995-12-13 |
DE69318727D1 (de) | 1998-06-25 |
HU9501850D0 (en) | 1995-08-28 |
IS4114A (is) | 1994-06-25 |
DE675738T1 (de) | 1996-02-29 |
AU5833294A (en) | 1994-07-19 |
PL309395A1 (en) | 1995-10-02 |
ZA939666B (en) | 1994-08-29 |
WO1994014478A1 (en) | 1994-07-07 |
ITMI922964A0 (it) | 1992-12-24 |
JP3585233B2 (ja) | 2004-11-04 |
ITMI922964A1 (it) | 1994-06-24 |
ES2077554T1 (es) | 1995-12-01 |
BR9307734A (pt) | 1999-08-31 |
NO952533D0 (no) | 1995-06-23 |
ATE166234T1 (de) | 1998-06-15 |
IL108158A0 (en) | 1994-04-12 |
DE69318727T2 (de) | 1998-09-17 |
EP0675738B1 (en) | 1998-05-20 |
MX9400185A (es) | 1994-07-29 |
NO952533L (no) | 1995-08-16 |
GR950300061T1 (en) | 1995-11-30 |
EP0675738A1 (en) | 1995-10-11 |
FI953124A0 (fi) | 1995-06-22 |
IT1256248B (it) | 1995-11-29 |
US5695742A (en) | 1997-12-09 |
CA2152480A1 (en) | 1994-07-07 |
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