JPH08276130A - Manufacture of microcapsule - Google Patents
Manufacture of microcapsuleInfo
- Publication number
- JPH08276130A JPH08276130A JP8091809A JP9180996A JPH08276130A JP H08276130 A JPH08276130 A JP H08276130A JP 8091809 A JP8091809 A JP 8091809A JP 9180996 A JP9180996 A JP 9180996A JP H08276130 A JPH08276130 A JP H08276130A
- Authority
- JP
- Japan
- Prior art keywords
- microcapsule
- wall material
- substance
- phase separation
- polyvinyl acetal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Grain Derivatives (AREA)
- General Preparation And Processing Of Foods (AREA)
- Formation And Processing Of Food Products (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する利用分野】本発明は、塩基の添加による
相分離によってマイクロカプセルを製造する方法に関す
るものであって、医薬品、食品、製紙、写真用フィルム
などの各分野において利用することができる。とりわ
け、生体に対して安全性の高い物質を、相分離による壁
物質として使用するので、医薬品などの分野において特
に有用である。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for producing microcapsules by phase separation by addition of a base, and can be used in various fields such as pharmaceuticals, foods, papermaking and photographic films. In particular, since a substance that is highly safe for living organisms is used as a wall substance by phase separation, it is particularly useful in the field of pharmaceuticals and the like.
【０００２】[0002]
【従来の技術】マイクロカプセルの製法については、従
来から多数の方法が提供されている。これらを大別する
と、化学的方法、物理化学的方法（相分離法）、及び物
理機械的方法など、並びにこれらの任意組み合わせの方
法がある。2. Description of the Related Art Many conventional methods for producing microcapsules have been provided. When roughly classified, there are a chemical method, a physicochemical method (phase separation method), a physico-mechanical method, and the like, and a method of any combination thereof.
【０００３】しかしながら、これら従来の方法では、医
薬品などの分野への応用に関して難点がある。However, these conventional methods have drawbacks in application to the fields of medicine and the like.
【０００４】例えば、相分離方法について述べると、操
作が複雑であり、長時間を要するという欠点がある。For example, the phase separation method has the drawbacks that the operation is complicated and it takes a long time.
【０００５】また、相分離法において有機溶媒として、
ホルムアルデヒド、ジクロロエタン、シクロヘキサン等
の如く、毒性の高い物質を使用するため、医薬品などの
分野では採用し難い欠点がある。何故ならば、これらの
物質を完全に除去することは困難だからである。Further, as an organic solvent in the phase separation method,
Since highly toxic substances such as formaldehyde, dichloroethane, cyclohexane, etc. are used, there is a drawback that they are difficult to adopt in the field of medicine and the like. This is because it is difficult to completely remove these substances.
【０００６】ここに相分離とは、高分子物質含有溶液や
親水性コロイド溶液が、コロイドに富む液相と、コロイ
ドに乏しい液相との二種の液相に分離する現象のことで
あって、いわゆるコアセルベーションとも言われるもの
である。Here, the phase separation is a phenomenon in which a polymer substance-containing solution or a hydrophilic colloid solution is separated into two liquid phases, a liquid phase rich in colloid and a liquid phase poor in colloid. It is also called so-called coacervation.
【０００７】[0007]
【発明が解決しようとする課題】本発明が解決しようと
する課題は、操作が簡単で、壁物質として、毒性のない
化合物を使用して優れた物性を有するマイクロカプセル
の製法を提供することである。The problem to be solved by the present invention is to provide a method for producing microcapsules which are easy to operate and have excellent physical properties by using a non-toxic compound as a wall substance. is there.
【０００８】[0008]
【課題を解決するための手段】本発明者等は鋭意研究の
結果、塩基の添加による相分離に当り、ある特定の壁物
質を使用することによってマイクロカプセルを製造する
方法を開発し、本発明を完成するに至った。As a result of earnest research, the present inventors have developed a method for producing microcapsules by using a specific wall material for phase separation by addition of a base, and the present invention Has been completed.
【０００９】本発明のマイクロカプセルの製造方法にお
いては、壁物質として次に掲げる化合物の１種又はそれ
らの混合物を使用する。In the method for producing microcapsules of the present invention, one of the following compounds or a mixture thereof is used as the wall substance.
【００１０】ポリビニルアセタールジエチルアミノアセ
テート、Polyvinyl acetal diethylaminoacetate,
【００１１】ジメチルアミノエチルメタアクリレート・
メチルメタアクリレートコポリマー。Dimethylaminoethyl methacrylate
Methyl methacrylate copolymer.
【００１２】これらの物質は毒性がないので、医薬品な
どの分野で応用するのに特に有用である。Since these substances have no toxicity, they are particularly useful for application in the fields of medicine and the like.
【００１３】本発明のマイクロカプセルの製造方法にお
いては、上記壁物質を使用して相分離を行う。そしてこ
の場合の相分離は塩基の添加によって行う。In the method for producing microcapsules of the present invention, phase separation is performed using the above wall substance. The phase separation in this case is performed by adding a base.
【００１４】塩基は、医薬品などの添加物として無毒の
もの、例えば苛性ソーダ、メグルミンなどのような塩基
が使用される。As the base, non-toxic bases such as caustic soda and meglumine are used as additives for medicines and the like.
【００１５】これらの塩基の添加量に特に制限はなく、
それぞれの目的に応じてｐＨ値を任意に調節する量であ
る。There are no particular restrictions on the amount of these bases added,
It is an amount for arbitrarily adjusting the pH value according to each purpose.
【００１６】本発明方法によって得られるマイクロカプ
セルは、平均直径が例えば１００〜２００ミクロンの球
形又は紡錘形の粒子である。The microcapsules obtained by the method of the present invention are spherical or spindle-shaped particles having an average diameter of, for example, 100 to 200 microns.
【００１７】本発明方法によれば、その特徴の一つは、
マイクロカプセルの平均直径を数ミクロンから数ミリメ
ートルの範囲に亘って任意に調節することである。According to the method of the present invention, one of the features is that
Arbitrarily adjusting the average diameter of the microcapsules over the range of a few microns to a few millimeters.
【００１８】本発明のマイクロカプセルの壁物質内に、
埋設すべき物質、いわゆる「芯物質」は、固体状、半固
体状、或いは液体状のいずれも使用することができる。In the wall material of the microcapsules of the invention,
The substance to be embedded, a so-called "core substance", may be in a solid state, a semi-solid state or a liquid state.
【００１９】例えば、固体状物質としては、澱粉類、無
機塩類などが挙げられる。Examples of the solid substance include starches and inorganic salts.
【００２０】半固体状物質としては、モノグリセライド
などのワックス類がある。Examples of the semi-solid substance include waxes such as monoglyceride.
【００２１】また、液状物質としては、ビタミンＡ、
Ｄ、Ｅ、Ｋなどの脂溶性ビタミン類、水難溶性ビタミン
類、動物油、植物油、鉱物油、合成油などを挙げること
ができる。As the liquid substance, vitamin A,
Examples include fat-soluble vitamins such as D, E, and K, poorly water-soluble vitamins, animal oils, vegetable oils, mineral oils, synthetic oils, and the like.
【００２２】更に、乳糖、マンニトール、ソルビトール
等の糖類等も使用可能である。Further, sugars such as lactose, mannitol and sorbitol can be used.
【００２３】[0023]
【発明の実施の形態】次に、実施例を掲げて本発明を更
に具体的に説明する。ただし、本発明は、これらの実施
例のみに限定されるものではない。BEST MODE FOR CARRYING OUT THE INVENTION Next, the present invention will be described more specifically with reference to Examples. However, the present invention is not limited to these examples.
【００２４】[0024]
実施例１ あらかじめ１０ｇのポリビニールアセタールジエチルア
ミノアセテート及びクエン酸１０ｇを２００ｍｌの水に
溶解した。この溶液中に１０ｇの酢酸トコフェロールを
加えポリトロンを用いて高速で１分間撹拌し、数μｍの
エマルジョンを得た。このエマルジョン溶液にあらかじ
め１０ｇのメグルミンを１００ｍｌの水に溶解した溶液
を、室温下スターラーを用いて攪拌しながらペリスタポ
ンプで徐々に加えた。ｐＨ６〜７でポリビニールアセタ
ールジエチルアミノアセテートのコアセルベートが生じ
始め、エマルジョン油滴を捕集し始めた。メグルミン溶
液１００ｍｌを加え終えた後のｐＨは、約１０で顕微鏡
観察の結果、酢酸トコフェロールの油滴を捕集した粒径
１００〜５００μｍの多核マイクロカプセルの生成を確
認した。その後、３００メッシュの篩を用いて濾過し、
水で洗浄した後、五酸化リンを装填したデシケーター中
で真空乾燥し、１００〜５００μｍの球状マイクロカプ
セルの粉末を得た。Example 1 10 g of polyvinyl acetal diethylaminoacetate and 10 g of citric acid were dissolved in 200 ml of water in advance. To this solution, 10 g of tocopherol acetate was added and stirred at high speed for 1 minute using a polytron to obtain an emulsion of several μm. To this emulsion solution, a solution prepared by previously dissolving 10 g of meglumine in 100 ml of water was gradually added with a peristaltic pump at room temperature while stirring using a stirrer. At pH 6-7, polyvinyl acetal diethylaminoacetate coacervate began to form and emulsion oil drops began to collect. After adding 100 ml of the meglumine solution, the pH was about 10. As a result of microscopic observation, formation of polynuclear microcapsules having a particle size of 100 to 500 μm in which oil droplets of tocopheryl acetate were collected was confirmed. Then, filter using a 300 mesh sieve,
After washing with water, it was vacuum dried in a desiccator loaded with phosphorus pentoxide to obtain a powder of spherical microcapsules of 100 to 500 μm.
【００２５】実施例２ １０ｇのポリビニールアセタールジエチルアミノアセテ
ートの代わりに１０ｇのジメチルアミノエチルメタアク
リレート・メチルメタアクリレートコポリマーを用いた
以外は実施例１に準じて行なった。得られたマイクロカ
プセル化粉末は球状で１００〜５００μｍであった。Example 2 Example 2 was repeated except that 10 g of polyvinyl acetal diethylaminoacetate was replaced with 10 g of dimethylaminoethyl methacrylate / methyl methacrylate copolymer. The obtained microencapsulated powder was spherical and had a diameter of 100 to 500 μm.
【００２６】実施例３ 酸性物質として１０ｇのクエン酸を溶解した２００ｍｌ
のクエン酸溶液の代わりに0.１Ｎの硝酸溶液２００ｍｌ
を、又アルカリ性物質として１０ｇのメグルミンを溶解
した１００ｍｌのメグルミン水溶液の代わりに0.１Ｎの
水酸化ナトリウム溶液１００ｍｌを用いた以外は実施例
１に準じて行なった。得られたマイクロカプセル化粉末
は球状で１００〜４００μｍであった。Example 3 200 ml in which 10 g of citric acid was dissolved as an acidic substance
200 ml of 0.1N nitric acid solution instead of the citric acid solution
Was carried out in the same manner as in Example 1 except that 100 ml of a 0.1 N sodium hydroxide solution was used instead of 100 ml of a meglumine aqueous solution in which 10 g of meglumine was dissolved as an alkaline substance. The obtained microencapsulated powder was spherical and had a diameter of 100 to 400 μm.
【００２７】[0027]
【発明の効果】本発明のマイクロカプセルの製造方法で
は、壁物質として無毒な化合物を使用するので、医薬品
などの分野で特に有用である。しかも、得られるマイク
ロカプセルは、油状物質の粉末化、不安定物質の経時的
安定化、利用物質の味や臭いの隠蔽化などが達成される
ので、産業上貢献するところ絶大である。INDUSTRIAL APPLICABILITY In the method for producing microcapsules of the present invention, a non-toxic compound is used as a wall substance, and thus it is particularly useful in the field of medicine and the like. Moreover, the obtained microcapsules achieve powderization of oily substances, stabilization of unstable substances over time, concealment of taste and odor of used substances, and the like, which makes a great industrial contribution.
Claims (1)
カプセルを製造するに当り、壁物質としてポリビニルア
セタールジエチルアミノアセテート又はジメチルアミノ
エチルメタアクリレート・メチルメタアクリレートコポ
リマーの１種以上を使用することを特徴とするマイクロ
カプセルの製法。1. A method for producing microcapsules by phase separation by adding a base, wherein at least one of polyvinyl acetal diethylaminoacetate or dimethylaminoethyl methacrylate / methyl methacrylate copolymer is used as a wall material. How to make microcapsules.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8091809A JP2873933B2 (en) | 1996-03-22 | 1996-03-22 | Manufacturing method of microcapsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8091809A JP2873933B2 (en) | 1996-03-22 | 1996-03-22 | Manufacturing method of microcapsules |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62120178A Division JPS63287543A (en) | 1987-05-19 | 1987-05-19 | Production of microcapsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH08276130A true JPH08276130A (en) | 1996-10-22 |
| JP2873933B2 JP2873933B2 (en) | 1999-03-24 |
Family
ID=14036964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8091809A Expired - Lifetime JP2873933B2 (en) | 1996-03-22 | 1996-03-22 | Manufacturing method of microcapsules |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2873933B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10227224A1 (en) * | 2002-06-18 | 2004-01-15 | Daimlerchrysler Ag | Granules for 3D binder printing, manufacturing processes and applications therefor |
| CN102188037A (en) * | 2010-03-08 | 2011-09-21 | 宏芳香料（昆山）有限公司 | Microcapsule granule and preparation process thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62215538A (en) * | 1986-03-17 | 1987-09-22 | Taisho Pharmaceut Co Ltd | Method for coating solid drug with high polymer compound soluble in stomach |
-
1996
- 1996-03-22 JP JP8091809A patent/JP2873933B2/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62215538A (en) * | 1986-03-17 | 1987-09-22 | Taisho Pharmaceut Co Ltd | Method for coating solid drug with high polymer compound soluble in stomach |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10227224A1 (en) * | 2002-06-18 | 2004-01-15 | Daimlerchrysler Ag | Granules for 3D binder printing, manufacturing processes and applications therefor |
| DE10227224B4 (en) * | 2002-06-18 | 2005-11-24 | Daimlerchrysler Ag | Use of a granulate for producing an article with a 3D binder printing process |
| CN102188037A (en) * | 2010-03-08 | 2011-09-21 | 宏芳香料（昆山）有限公司 | Microcapsule granule and preparation process thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2873933B2 (en) | 1999-03-24 |
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